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A Modern Approach to Microbiology
A Modern Approach to Microbiology

... The spleen is the most highly organized secondary lymphoid organ. It is a large organ located in the abdominal cavity that functions to filter the blood and trap blood-borne particles to be assessed for foreignness by phagocytes (figure 33.14). Macrophages and dendritic cells are present in abundanc ...
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Curriculum Vitae Prof. Dr. Bruce Beutler

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... requirements other than glucose, a source of nitrogen and phosphate. However, all microorganism need iron for growth. The host effectively chelates iron with transferrin (serum) or lactoferrin (mucosal surfaces). Many pathogens have mechanisms which allow them to obtain iron from host transferrin or ...
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Immunology Practice Exam - Website of Neelay Gandhi

... damage and internal bleeding without breaking the skin or infecting the wound with foreign material. Which of the following is the MOST likely explanation for the resulting inflammation? A. The inflammation must be the result of nonimmunologic mechanisms because there are no foreign antigens present ...
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... The complement system (Abbr. C): • A group of proteins present in the plasma of all individuals. Part of the innate immune system. • A major biological effector system of both the innate and the adaptive immune responses. • The C components are present in the plasma in an inactive state. • Upon acti ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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