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(DTH) mouse model for atopic dermatitis
(DTH) mouse model for atopic dermatitis

... Delayed type hypersensitivity (DTH) mouse model for atopic dermatitis Species: mice Fields of application: Inflammation Dermatitis is a broad term covering a variety of different inflammatory skin diseases. The etiology of widely prevalent atopic dermatitis (up to 15%) is unknown, but a genetically ...
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... recognize and make antibodies against. This helps the immune system recognize these as foreign and thus allows the immune system to eliminate them from the body. All cells, bacteria and virus contain these antigen proteins on the surface of the cell, bacteria or virus. To make a vaccine the manufact ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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