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Immunologic Disorders
Immunologic Disorders

... – Differences between donor and recipient tissues (MHC) – Mainly type IV reaction: combination of Tc cells and NK cells ...
Some Basic Rules on how Cancer behaves
Some Basic Rules on how Cancer behaves

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HIV (AIDS) - Austin Community College
HIV (AIDS) - Austin Community College

... Of the 3,330 people who received AIDSVAX, 5.7 percent had nonetheless become infected with HIV within three years, a rate almost identical to the 5.8 percent seen among 1,679 individuals who received a placebo. [4] Even though the vaccine proved relatively ineffective, there was a silver lining. App ...
“Sebaceaous Adenitis” – a mysterious skin disease Overview
“Sebaceaous Adenitis” – a mysterious skin disease Overview

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Lymphatic System
Lymphatic System

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Model systems for studying virus entry: roles of lipid rafts in
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... Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine ...
How HIV replicates and how drugs work to control it
How HIV replicates and how drugs work to control it

positive selection - immunology.unideb.hu
positive selection - immunology.unideb.hu

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potential treatment for MS - National Multiple Sclerosis Society
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... ingest the innocuous eggs in a sports drink. The eggs hatch into larvae, which travel to the large intestine where they are killed during interaction with the gut immune system. Dr. Fleming explains, “The gut and microorganisms at that site may be a key to how the whole immune system functions. For ...
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... they are also readily identified by their multilobal nucleus; thus, they are also called polymorphonuclear neutrophils or polymorphs. Neutrophils are motile cells; they leave the circulation and migrate to their site of action in the connective tissue. Neutrophils are active phagocytes that utilize ...
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An Innate Immune System for the Protection of
An Innate Immune System for the Protection of

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T cells - UCLA.edu
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... • There, they interact with antigen-presenting cells (dendritic cells, macrophages) that express selfantigens + MHC class I or MHC class II molecules. • Thymocytes that bind to self + MHC too strongly are eliminated as possibly self-reactive cells, and undergo apoptosis. • If self-reactive T cells ...
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... • T cell development in the thymus and B cell development in the bone marrow produce populations of naïve circulating lymphocytes • Naïve T and B cells are cells that have not yet encountered their antigen • For any particular antigen (pathogen), the frequency of naïve T and B cells is very low • Na ...
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The Immune System: Innate and Adaptive Body Defenses Part A
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... Antibodies themselves do not destroy antigen; they inactivate and tag it for destruction All antibodies form an antigen-antibody (immune) complex Defensive mechanisms used by antibodies are neutralization, agglutination, precipitation, and complement fixation Complement Fixation and Activation Compl ...
Full Text - PDF - Global Advanced Research Journals
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... Major modifications of immune system have been observed in Human African Trypanosomiasis. These immune reactions do not lead to protection and are also involved in immunopathology disorders. The major surface component (variable surface glycoprotein, VSG) is associated with escape to immune reaction ...
Hyposplenism
Hyposplenism

... Causes slower and incomplete adaptive immune response against bacteria Low levels of tuftsin, which stimulates phagocytosis by neutrophils, macrophages, and monocytes Decreased neutrophil and macrophage activity Increased NK cell activity Limited capacity of circulating B-cells to differentiate into ...
PDF - Arteriosclerosis, Thrombosis, and Vascular Biology
PDF - Arteriosclerosis, Thrombosis, and Vascular Biology

... atherosclerosis was obtained in studies of mice deficient in functional macrophage-colony stimulating factor.4 When such mice were crossed with atherosclerosis-prone apolipoprotein E– deficient (apoE⫺/⫺) mice, the offspring developed little, if any, atherosclerosis. This implies that monocyte differ ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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