2014 issue of Current Diabetes Reports
... Heparanase . Islet . Islet infiltration . Diabetes . Immune regulation ...
... Heparanase . Islet . Islet infiltration . Diabetes . Immune regulation ...
The Impact of Stress
... frequency of the stressors involved. How does the body respond? Under normal conditions, the body functions in a highly complex, integrated conglomeration of rhythms: heartbeats, respiration, digestion, seasonal changes, monthly cycles, hunger, sleep, work and play. Although these are the most famil ...
... frequency of the stressors involved. How does the body respond? Under normal conditions, the body functions in a highly complex, integrated conglomeration of rhythms: heartbeats, respiration, digestion, seasonal changes, monthly cycles, hunger, sleep, work and play. Although these are the most famil ...
Immune modulation as cancer treatment using gene therapy
... Improving expression (surface display) of antigens Improving the number and sensitivity of antigen-presenting cells Creating antigenic peptides in order to stimulate antigen-presenting cells (in vitro) Altering MHC so that antigenic peptides can be exposed, thereby uncloaking malignant cell identity ...
... Improving expression (surface display) of antigens Improving the number and sensitivity of antigen-presenting cells Creating antigenic peptides in order to stimulate antigen-presenting cells (in vitro) Altering MHC so that antigenic peptides can be exposed, thereby uncloaking malignant cell identity ...
Manipulating the in vivo immune response by targeted gene
... The rapidity and success of aptamer selection has dramatically improved in the last few years. With high throughput sequencing and bioinformatics, enriched sequences can often be identified after only 5–6 rounds of selection with a much improved success rate [18–20]. Sequences that might have been l ...
... The rapidity and success of aptamer selection has dramatically improved in the last few years. With high throughput sequencing and bioinformatics, enriched sequences can often be identified after only 5–6 rounds of selection with a much improved success rate [18–20]. Sequences that might have been l ...
Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis
... proteomics approach to identify bacterial proteins that are involved in the attachment of Bcc bacteria to lung epithelial cells. Fourteen proteins were reproducibly identified by two-dimensional gel electrophoresis from four Bcc strains representative of two Bcc species: Burkholderia cenocepacia, th ...
... proteomics approach to identify bacterial proteins that are involved in the attachment of Bcc bacteria to lung epithelial cells. Fourteen proteins were reproducibly identified by two-dimensional gel electrophoresis from four Bcc strains representative of two Bcc species: Burkholderia cenocepacia, th ...
HIV/AIDS: What People with Substance Use Disorders Need to
... – Site of attachment is the CD4 antigen found on a variety of cells helper T cells macrophages monocytes B cells microglial brain cells ...
... – Site of attachment is the CD4 antigen found on a variety of cells helper T cells macrophages monocytes B cells microglial brain cells ...
Natural killer cell receptors: new biology and
... receptor/ligand signals with the net result of NK cell activation and target cell lysis. This net result may occur when activation receptors and ligands are up-regulated, thereby amplifying the net activation signal to exceed the inhibitory signal. For example, the activating ligands MICA/B and ULBP ...
... receptor/ligand signals with the net result of NK cell activation and target cell lysis. This net result may occur when activation receptors and ligands are up-regulated, thereby amplifying the net activation signal to exceed the inhibitory signal. For example, the activating ligands MICA/B and ULBP ...
cell biology of cancer
... pharmacology was observed using the Chou-Talalay combination index method. Such results suggested that B-I09 can decelerate the growth of CLL either as a single agent or in combination with ibrutinib. Our finding in synergism may be important because B-I09 may help ibrutinib to achieve higher cytoto ...
... pharmacology was observed using the Chou-Talalay combination index method. Such results suggested that B-I09 can decelerate the growth of CLL either as a single agent or in combination with ibrutinib. Our finding in synergism may be important because B-I09 may help ibrutinib to achieve higher cytoto ...
The intestinal barrier function and its involvement in digestive disease
... digestive, metabolic, and barrier physical integrity maintenance dunctions. They also play a role in the development of immune activity as they express receptors involved in the innate immune response (23), act as non-professional antigen-presenting cells, and release several cytokines and chemokine ...
... digestive, metabolic, and barrier physical integrity maintenance dunctions. They also play a role in the development of immune activity as they express receptors involved in the innate immune response (23), act as non-professional antigen-presenting cells, and release several cytokines and chemokine ...
Document
... • 2% meiotic recombination rate generates population diversity •Crossover: Haplotypes, normally, are inherited intact and hence antigens encoded by different loci are inherited together (e.g., A2; B27; Cw2; DPw6; DQw9; DRw2). However, on occasions, there is crossing over between two parental chromos ...
... • 2% meiotic recombination rate generates population diversity •Crossover: Haplotypes, normally, are inherited intact and hence antigens encoded by different loci are inherited together (e.g., A2; B27; Cw2; DPw6; DQw9; DRw2). However, on occasions, there is crossing over between two parental chromos ...
IFN-γ-STIMULATED TRYPTOPHAN DEGRADATION BY
... IDO is a 42 kDa heme-containing enzyme – activated in cases of inflammation and expressed on the surface of dendritic cells (DC) [2], in the epydidimis, thymus, spleen, lungs, placenta [4]. One of the growth factors activating IDO is the ...
... IDO is a 42 kDa heme-containing enzyme – activated in cases of inflammation and expressed on the surface of dendritic cells (DC) [2], in the epydidimis, thymus, spleen, lungs, placenta [4]. One of the growth factors activating IDO is the ...
Identification of the Transformation-associated
... surface antigens (3-9). These antigens are oncogene products (10), heat shock proteins (11), and the product of an activated endogenous provirus (12). It is also possible that the product of particular genomic DNA of the cells could be expressed as a result of the gene activation dependent on the sp ...
... surface antigens (3-9). These antigens are oncogene products (10), heat shock proteins (11), and the product of an activated endogenous provirus (12). It is also possible that the product of particular genomic DNA of the cells could be expressed as a result of the gene activation dependent on the sp ...
The Global Leader in Liver Cell Therapies
... To our knowledge no compound in entire NASH field has the tissue repair potential HepaStem or second generation cells might have Tissue repair ...
... To our knowledge no compound in entire NASH field has the tissue repair potential HepaStem or second generation cells might have Tissue repair ...
Fungal Keratitis
... • The initial corneal lesion is a superficial Punctate keratitis— – numerous minute whitish plaques , arranged in rows or groups. – Desquamate erosions heal rapidly leaving no opacity, but are accompanied by great irritation, lacrimation and blepharospasm. – In all cases the cornea is relatively ...
... • The initial corneal lesion is a superficial Punctate keratitis— – numerous minute whitish plaques , arranged in rows or groups. – Desquamate erosions heal rapidly leaving no opacity, but are accompanied by great irritation, lacrimation and blepharospasm. – In all cases the cornea is relatively ...
Golli Protein Negatively Regulates Store Depletion
... and provides a means of replenishing intracellular Ca2+ stores. The mechanism by which ER Ca2+ store depletion is coupled to external Ca2+ entry is not clear. In this study, we investigated the role that a golli protein, a product of the myelin basic protein (mbp) gene, plays in the regulation of st ...
... and provides a means of replenishing intracellular Ca2+ stores. The mechanism by which ER Ca2+ store depletion is coupled to external Ca2+ entry is not clear. In this study, we investigated the role that a golli protein, a product of the myelin basic protein (mbp) gene, plays in the regulation of st ...
blood
... Crucial in the body’s defense against disease These are complete cells, with a nucleus and organelles Able to move into and out of blood vessels (diapedesis) Can move by ameboid motion-(pseudopods) Can respond to chemicals released by damaged tissues Their numbers can double within a few ...
... Crucial in the body’s defense against disease These are complete cells, with a nucleus and organelles Able to move into and out of blood vessels (diapedesis) Can move by ameboid motion-(pseudopods) Can respond to chemicals released by damaged tissues Their numbers can double within a few ...
Intertwined pathways of programmed cell death in immunity
... within the slug, engulfing bacteria and sequestering toxins. A TIR-domain containing protein, TirA, was found to be necessary for at least some of these functions. Whether sentinel cells also maintain and utilize PCD as a means of sequestering pathogenic bacteria is unknown. Regardless, this observa ...
... within the slug, engulfing bacteria and sequestering toxins. A TIR-domain containing protein, TirA, was found to be necessary for at least some of these functions. Whether sentinel cells also maintain and utilize PCD as a means of sequestering pathogenic bacteria is unknown. Regardless, this observa ...
Pathogen evolution and the immunological niche
... Box 1. A primer on host defense Immune systems have evolved, at great cost, partly to attenuate the impacts of pathogens on host fitness.142,143 In vertebrates, they accomplish this goal by reducing the growth rates of pathogen populations through innate and adaptive mechanisms.57 This description f ...
... Box 1. A primer on host defense Immune systems have evolved, at great cost, partly to attenuate the impacts of pathogens on host fitness.142,143 In vertebrates, they accomplish this goal by reducing the growth rates of pathogen populations through innate and adaptive mechanisms.57 This description f ...
Tetanus Toxoid Pulsed Monocyte Vaccination For Augmentation Of
... local inflammation may represent the best stimulus for arteriogenesis. We have exploited the homing of Mo to areas of collateral growth for cell transplantation studies.21 Intriguingly, transplantation of allogeneic Mo resulted in the strongest arteriogenic response, implying that, indeed, targeting ...
... local inflammation may represent the best stimulus for arteriogenesis. We have exploited the homing of Mo to areas of collateral growth for cell transplantation studies.21 Intriguingly, transplantation of allogeneic Mo resulted in the strongest arteriogenic response, implying that, indeed, targeting ...
Lab on a Chip PAPER - Mechanical Engineering
... while conjugating cell-secreted cytokines with assay beads, which enabled in situ cell-secreted cytokine detections with the MIPA device. We used a canonical stimulant, lipopolysaccharide (LPS), to trigger a human immune response that is routinely characterized by cytokine production.17 The detected ...
... while conjugating cell-secreted cytokines with assay beads, which enabled in situ cell-secreted cytokine detections with the MIPA device. We used a canonical stimulant, lipopolysaccharide (LPS), to trigger a human immune response that is routinely characterized by cytokine production.17 The detected ...
An Overview of Autoimmune Disorders
... Immunity is a mechanism working out to eliminate and destroy the foreign particles or antigens to sustain the health and longevity of the host [9-12]. Antigens can be cancerous cells, parasites, bacteria, fungi, virus, etc. To destroy these antigens, immune system works in organized way and produces ...
... Immunity is a mechanism working out to eliminate and destroy the foreign particles or antigens to sustain the health and longevity of the host [9-12]. Antigens can be cancerous cells, parasites, bacteria, fungi, virus, etc. To destroy these antigens, immune system works in organized way and produces ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑