• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Transcription - Lake Station Community Schools
Transcription - Lake Station Community Schools

... contains sections of nucleotides called introns -they are extras and must be removed before the protein can be built  Pre-mRNA also contains sections called exons -these contain the protein recipe and are joined to form the finished or mature mRNA ...
Biology 2.3 2.4 - Sleeping Dog Studios
Biology 2.3 2.4 - Sleeping Dog Studios

... Lipids are nonpolar molecules that are not soluble or mostly insoluble in water. They will not dissolve into water! ...
Macromolecules PPT
Macromolecules PPT

...  More specifically- polypeptides ...
Sequence Alignment 1
Sequence Alignment 1

... Human DNA • There are about 3bn (3  109) nucleotides in the nucleus of almost all of the trillions (3.5  1012 ) of cells of a human body (an exception is, for example, red blood cells which have no nucleus and therefore no DNA) – a total of ~1022 nucleotides! • Many DNA regions code for proteins, ...
Gene Section GLMN (glomulin) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Gene Section GLMN (glomulin) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... suggesting that glomulin expression is ubiquitous. This could be due to the presence of glomulin-expressing blood vessels in the various tissues analysed. By in situ hybridisation on murine embryos, glomulin expression was evident at embryonic E10.5 days postcoitum (dpc) and localized to the cardiac ...
Slide 1 - The Fluorescence Foundation
Slide 1 - The Fluorescence Foundation

... Novel fluorescent proteins are incorporated into many of the our popular vectors, designed for: constitutive fusion protein expression in mammalian cells, subcellular localization of organelles or targeting of fusion proteins to a specific location, transcriptional reporting bacterial expression and ...
HGSS Chapter 6: Alzheimer`s Disease (Graduate students)
HGSS Chapter 6: Alzheimer`s Disease (Graduate students)

... Figure 1. Development of the Transgenic Mouse Model of Alzheimer's Disease. The transgene consists of the human APP gene containing a mutation causing a rare form of early-onset familial Alzheimer's disease (Val717Phe). The transgene, whose expression is driven by the platelet-derived growth factor ...
Expression of an aphid-induced barley methyltransferase in
Expression of an aphid-induced barley methyltransferase in

...  The purified enzyme was going through several freeze-thaw cycles between the first measurement with AMI and MAMI as substrate and those with caffeic acid.  This could have resulted in the loss of enzymatic activity.  These experiments have to be repeated with freshly purified enzyme. ...
Powerpoint template for scientific posters
Powerpoint template for scientific posters

... and estimate that the catalogue of human ECM proteins and their interactors may exceed 2500 proteins. If current estimates for the number of genes in the human genome are true (approximately 30,000) this implies that approaching 10% of the human genome is dedicated to dealing with extracellular orga ...
Amino acids and prot..
Amino acids and prot..

... hooves, or soft, as is the case with skin. It is difficult to dissolve keratin because it contains non polar amino acids plus cysteine, which means that it is able to form disulfide bridges. These bridges create a thread shape that is extremely strong, as sulfur atoms bond to each other, creating a ...
The Protoeomics and Lipidomics Center Mass Spectrometer Facility
The Protoeomics and Lipidomics Center Mass Spectrometer Facility

... The Protoeomics and Lipidomics Center Mass Spectrometer Facility is to provide state of the art mass spectrometers to the University of Miami community. This facility provides various types of techniques such as proteomics and metabolomics (especially lipidomics). The facility provides hands on trai ...
Physics Update: A nanoscale mosaic model of static
Physics Update: A nanoscale mosaic model of static

... The proteins would have suffered a similar fate had the egg white been whipped into a foamy meringue or soaked in lime juice. Indeed, the precise biological work of folding a protein can be undone by any number of environmental stresses, including heat, acidity, and mechanical strain. Proteins, like ...
Genetics worksheet - School of Medical Sciences
Genetics worksheet - School of Medical Sciences

... Scientists have found more than 1000 different mutations of the CFTR gene; Some have little or no effect on CTFR function, while others cause cystic fibrosis on a spectrum that varies from mild to severe. Click on this link to view a database of all known mutations in the CFTR gene. http://www.genet ...
Protein kinases
Protein kinases

... • Ultimately, a signal transduction pathway leads to regulation of one or more cellular activities • The response may occur in the cytoplasm or in the nucleus • Many signaling pathways regulate the synthesis of enzymes or other proteins, usually by turning genes on or off in the nucleus • The final ...
chapter 9 homeostasis & the plasma membrane
chapter 9 homeostasis & the plasma membrane

...  2. Adhesion Proteins - composed of glycoproteins attached to oligosaccharides. Serve as the “glue” to hold cells together. ...
File - El Paso High School
File - El Paso High School

... • DNA carries information and is expressed through RNA Nucleotides consist of a nitrogen-containing base, a pentose sugar, and phosphate groups. They are linked by phosphodiester linkages in condensation reactions to form RNA and DNA. Complementary base pairing by hydrogen bonding is the key to stru ...
GOPoster - Computational Biology and Informatics Laboratory
GOPoster - Computational Biology and Informatics Laboratory

... to protein domains as listed in ProDom and CDD is described. The algorithm generates rules for function-domain association based on the intersection of functions assigned to gene products by GO that contain ProDom and/or CDD domains at varying levels of sequence similarity. The hierarchical nature o ...
Parsek slide handout
Parsek slide handout

... A central theme that runs through many regulatory mechanisms is the role that low molecular substances, made by cells or present in environment, have in mediating control. These low molecular weight molecules, called effector molecules or ligands, interact with specific proteins called allosteric pr ...
BCH 401G Lecture 44 Eukaryotic gene expression Andres
BCH 401G Lecture 44 Eukaryotic gene expression Andres

... first approximation) for different classes of RNA. RNA polymerase II is used to transcribe mRNA. Two types of generalized RNA polymerase II promoters and regulatory regions are diagrammed above. TATA Box: (consensus sequence TATAAAA) TATA boxes are located 2530 base pairs from the mRNA initiation si ...
Reticulons (RTNs) are endomembrane bound proteins with a
Reticulons (RTNs) are endomembrane bound proteins with a

... products were analyzed by Mass Spectrometry (MS). This approach identified a set of proteins, majority of which had been classified as signal transduction, cytoskeleton dynamics related, and synaptic-vesicle and vesicle trafficking (endocytosis/exocytosis) associated. Identification of these novel p ...
STUDIES ON SURFACE PROTEINS OF
STUDIES ON SURFACE PROTEINS OF

... antigens. The 59,000 and 43,000 molecular weight proteins were shown to be parasite synthesized proteins. The results suggest there are cross7reacting surface antigens on geographically different isolates. ...
pancreatic beta cells - Wiley Online Library
pancreatic beta cells - Wiley Online Library

... protein disulfide isomerases as well as serveral proteins regulating unfolded protein response. In this study, we compared two different approaches to isolate rER from a pancreatic beta cell line, MIN6 cells. We found both methods yielded highly enriched rER fractions and identified similar numbers ...
File - Alzheimer`s Disease:the influence of presenilin I
File - Alzheimer`s Disease:the influence of presenilin I

... Approach: use GEO datasets to identify genes involved in the upregulation of APP and PSEN1—finding additional proteins targeted by presenilin protein (PSEN1) Hypothesis: there will be additional proteins involved with Alzheimer’s and PSEN1, indicating the direction future experiments should undergo ...
No Slide Title
No Slide Title

... Mast cell - example of regulated exocytosis Histamine released in response to binding of specific ligands Gives many of symptoms of allergic reactions Mast cell ...
Gene Section PPP1R9B (protein phosphatase 1, regulatory subunit 9B)
Gene Section PPP1R9B (protein phosphatase 1, regulatory subunit 9B)

... 15 highly polymorphic markers, 7 of which span 17q11-24 region. The higher LOH value appeared with the D17S588 marker, showing a 53% of loss. The D17S588 marker locates exactly within the PPP1R9B locus. These data provided the first robust data implicating PPP1R9B LOH in cancer. Closer tumor suppres ...
< 1 ... 278 279 280 281 282 283 284 285 286 ... 456 >

Protein moonlighting



Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report