Clinical Toxicology Innate Immune System Research Article
... activity, Freitas et al. (2010) reported that exposure of isolated human neutrophils to CdCl2 caused increases in the production of ROS, specifically O2 −, H2O2, and HOCl, both spontaneously and following activation of the cells with the phorbol ester, phorbol myristate acetate (PMA) [21]. The latte ...
... activity, Freitas et al. (2010) reported that exposure of isolated human neutrophils to CdCl2 caused increases in the production of ROS, specifically O2 −, H2O2, and HOCl, both spontaneously and following activation of the cells with the phorbol ester, phorbol myristate acetate (PMA) [21]. The latte ...
isolation, characterization, and expression of mouse icam
... a cell leukocyte integrins is demonstrated by a n inherited husurface glycoprotein, is a second counter-receptor man genetic deficiency, leukocyte adhesion deficiency, forlymphocyte function-associated Ag-1 (LFA-1). in whichlack of surface expressionof LFA- 1, Mac- 1, and We report here the isolatio ...
... a cell leukocyte integrins is demonstrated by a n inherited husurface glycoprotein, is a second counter-receptor man genetic deficiency, leukocyte adhesion deficiency, forlymphocyte function-associated Ag-1 (LFA-1). in whichlack of surface expressionof LFA- 1, Mac- 1, and We report here the isolatio ...
Novel Antipeptide Antibodies to the Human Glucocorticoid Receptor
... crucial for the specific interaction of receptor with DNA sequences that contain glucocorticoid regulatory elements (GRE) (6, 7). The carboxyl-terminus of the GR contains the ligand-binding domain and is thought to be involved in the process of receptor activation (8). Although mutational analysis h ...
... crucial for the specific interaction of receptor with DNA sequences that contain glucocorticoid regulatory elements (GRE) (6, 7). The carboxyl-terminus of the GR contains the ligand-binding domain and is thought to be involved in the process of receptor activation (8). Although mutational analysis h ...
Regulation of the cytoplasmic accumulation of 5
... however, these agents have no effect on receptor movement, which suggests a key role for protons in the cytoplasmic delivery step (8). If the folate receptor delivers 5-methyltetrahydrofolic acid to a vacuolar compartment, how does 5-methyltetrahydrofolate then traverse the membrane to reach the cyt ...
... however, these agents have no effect on receptor movement, which suggests a key role for protons in the cytoplasmic delivery step (8). If the folate receptor delivers 5-methyltetrahydrofolic acid to a vacuolar compartment, how does 5-methyltetrahydrofolate then traverse the membrane to reach the cyt ...
Mutation of a Highly Conserved Aspartic Acid in the Adrenergic
... accompanying photoactivation of rhodopsin (Farrens et al., 1996). Using site-selective incorporation of pairs of sulfhydryl-reactive spin labels, they have demonstrated that photoactivation of rhodopsin involves rigid-body movement of transmembrane segment (TM) 6 relative to TM 3 (Farrens et al., 19 ...
... accompanying photoactivation of rhodopsin (Farrens et al., 1996). Using site-selective incorporation of pairs of sulfhydryl-reactive spin labels, they have demonstrated that photoactivation of rhodopsin involves rigid-body movement of transmembrane segment (TM) 6 relative to TM 3 (Farrens et al., 19 ...
Blood-Brain Barrier and Immune Cell Transmigration Neuroscience Immunology
... the CNS. As a result, resident immune cells, such as microglia, are the initial responders to pathogens or tissue damage. However, prolonged tissue insult triggers inflammatory conditions that cause the BBB to lose its restrictive features, resulting in the subsequent infiltration of peripheral immu ...
... the CNS. As a result, resident immune cells, such as microglia, are the initial responders to pathogens or tissue damage. However, prolonged tissue insult triggers inflammatory conditions that cause the BBB to lose its restrictive features, resulting in the subsequent infiltration of peripheral immu ...
May 2006 - InvivoGen
... cells, that are known to express endogenous levels of TLR1 and TLR6, transfected with human TLR2 and an NF-κB-inducible SEAP plasmid. Polyclonal antibodies against human TLR1 and TLR2 (PAb-hTLR1 and PAb-hTLR2) blocked the responses induced by both LAM-MS and LM-MS whereas PAb-hTLR6 had no effect (Fi ...
... cells, that are known to express endogenous levels of TLR1 and TLR6, transfected with human TLR2 and an NF-κB-inducible SEAP plasmid. Polyclonal antibodies against human TLR1 and TLR2 (PAb-hTLR1 and PAb-hTLR2) blocked the responses induced by both LAM-MS and LM-MS whereas PAb-hTLR6 had no effect (Fi ...
Thomas Davis, MD Celldex Therapeutics, Inc.
... Flt3L: potent stem cell mobilizer and dendritic cell growth factor Previous clinical studies (Immunex/Amgen) demonstrated safety and biological activity (>500 subjects dosed) ...
... Flt3L: potent stem cell mobilizer and dendritic cell growth factor Previous clinical studies (Immunex/Amgen) demonstrated safety and biological activity (>500 subjects dosed) ...
Kynurenines and Multiple Sclerosis: The Dialogue between the
... that such an inflammatory reaction is no longer reflected by contrast enhancement on MRI, and drugs that target this type of inflammation should be able to enter the CNS through an intact blood-brain barrier [2]. Another pathological feature of progressive MS is cortical demyelination, which is prob ...
... that such an inflammatory reaction is no longer reflected by contrast enhancement on MRI, and drugs that target this type of inflammation should be able to enter the CNS through an intact blood-brain barrier [2]. Another pathological feature of progressive MS is cortical demyelination, which is prob ...
Cooperation of Mast Cells and Basophils in Allergy
... [8,7]. VEGF may be released by MCs by exocytosis or in the absence of degranulation. Selective release of VEGF by human MCs is mediated by CRH or by activation of the EP(2) receptor by PGE2 [48,49]. VEGF is also produced by human basophils [8], which express the tyrosine kinase VEGF-A receptor VEGFR ...
... [8,7]. VEGF may be released by MCs by exocytosis or in the absence of degranulation. Selective release of VEGF by human MCs is mediated by CRH or by activation of the EP(2) receptor by PGE2 [48,49]. VEGF is also produced by human basophils [8], which express the tyrosine kinase VEGF-A receptor VEGFR ...
The homeostatic properties of the mannose receptor in health and
... 180, PLA 2R and DEC205 would interact with collagens through this domain and this property has now been established in the case of PLA2R, Endo 180 and MR(1, 6-8). If the ability of the FNII domain of DEC205 to bind collagen is confirmed, this would be the first description of a natural ligand for th ...
... 180, PLA 2R and DEC205 would interact with collagens through this domain and this property has now been established in the case of PLA2R, Endo 180 and MR(1, 6-8). If the ability of the FNII domain of DEC205 to bind collagen is confirmed, this would be the first description of a natural ligand for th ...
Inflammatory response to infectious pulmonary injury C. Delclaux , E. Azoulay *
... Cytokines constitute another group of soluble mediators [10]. Cytokines that have been shown to fulfil an important role in the innate immunity of the lung include TNF-a, IL-10, IL-12, IL-6, the chemokines (IL-8), IFN-c and granulocyte colony-stimulating factor (G-CSF). The role of some of them has ...
... Cytokines constitute another group of soluble mediators [10]. Cytokines that have been shown to fulfil an important role in the innate immunity of the lung include TNF-a, IL-10, IL-12, IL-6, the chemokines (IL-8), IFN-c and granulocyte colony-stimulating factor (G-CSF). The role of some of them has ...
Natural Product Anacardic Acid from Cashew Nut Shells
... these mechanisms, anacardic acid may induce autophagy (11) and enhance apoptosis (12) of mammalian cells. It has been proposed that the potentiation of apoptosis by anacardic acid results from inhibition of genes involved in cell survival and proliferation (9). Although anacardic acid has antioxidan ...
... these mechanisms, anacardic acid may induce autophagy (11) and enhance apoptosis (12) of mammalian cells. It has been proposed that the potentiation of apoptosis by anacardic acid results from inhibition of genes involved in cell survival and proliferation (9). Although anacardic acid has antioxidan ...
purification and amino acid analysis of two human glioma
... 5), and both were chemotactic for monocytes but not neutrophils. It is possible that the two peptides differ only by post-translational modifications, such as phosphorylation, glycosylation, or degradation. Based on the amino acid composition, our estimate of the molecular mass of GDCF is 8,400 dalt ...
... 5), and both were chemotactic for monocytes but not neutrophils. It is possible that the two peptides differ only by post-translational modifications, such as phosphorylation, glycosylation, or degradation. Based on the amino acid composition, our estimate of the molecular mass of GDCF is 8,400 dalt ...
Serine and Cysteine Proteases and Their Inhibitors as Antimicrobial
... 4 Proteases and Maladaptive Inflammation Proteases produced by inflammatory cells such as neutrophils and macrophages play a crucial role in the first line of defense against invading bacteria, fungi and protozoa, either by directly killing pathogens or by inducing immune recognition, e.g., via TLRs ...
... 4 Proteases and Maladaptive Inflammation Proteases produced by inflammatory cells such as neutrophils and macrophages play a crucial role in the first line of defense against invading bacteria, fungi and protozoa, either by directly killing pathogens or by inducing immune recognition, e.g., via TLRs ...
Physiology Objectives 33
... Titratable acid: amount of filtered acid that has been changed from salt to acid form as it accepts H+ from tubular secretion ...
... Titratable acid: amount of filtered acid that has been changed from salt to acid form as it accepts H+ from tubular secretion ...
Human Monocytes Arachidonic Acid Reacylation Reactions in
... reacylation back into PLs, no net accumulation of free fatty acid occurs. Cell stimulation by a variety of agonist receptors leads to the activation of another PLA2 form, the group IVA, calcium-dependent cytosolic PLA2a (cPLA2a), which then becomes the dominant PLA2 involved in AA release (15–19). U ...
... reacylation back into PLs, no net accumulation of free fatty acid occurs. Cell stimulation by a variety of agonist receptors leads to the activation of another PLA2 form, the group IVA, calcium-dependent cytosolic PLA2a (cPLA2a), which then becomes the dominant PLA2 involved in AA release (15–19). U ...
Lactate production and exercise-induced metabolic acidosis: guilty or not guilty?
... monoclonal mouse IgG1 anti-fetuin with fluoresceinconjugated fetuin in conditions of antigen excess, and then subjected to centrifugation at 14,0006g or 300,0006g for 20 or 60 min, respectively. Binding of immune complexes in the post-centrifugation supernatants to apoptotic human neutrophils was me ...
... monoclonal mouse IgG1 anti-fetuin with fluoresceinconjugated fetuin in conditions of antigen excess, and then subjected to centrifugation at 14,0006g or 300,0006g for 20 or 60 min, respectively. Binding of immune complexes in the post-centrifugation supernatants to apoptotic human neutrophils was me ...
Chemokines, innate and adaptive immunity, and respiratory disease REVIEW I. Sabroe
... ("chemokines") are present, and how many receptors they may act through. However, science is a long way from understanding the detail of these systems, even though receptor antagonists for many of the receptors are currently in development. The impact of a better understanding of these pathways on r ...
... ("chemokines") are present, and how many receptors they may act through. However, science is a long way from understanding the detail of these systems, even though receptor antagonists for many of the receptors are currently in development. The impact of a better understanding of these pathways on r ...
1 |Recombinant Human GM
... P04141 3. Background Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a pleiotropic cytokine and a member of a family of endogenous cytokines of the hematopoietic system. GM-CSF is produced as a response to immune or inflammatory stimuli by monocytes, T cells, macrophages as well as fi ...
... P04141 3. Background Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a pleiotropic cytokine and a member of a family of endogenous cytokines of the hematopoietic system. GM-CSF is produced as a response to immune or inflammatory stimuli by monocytes, T cells, macrophages as well as fi ...
PGD2 for WAO
... • Primary function appears to be vasodilation but may also mediate bronchodilation • In vitro down-regulates Th1 and dendritic cell function possibly leading to increased Th2 responses. • DP1 gene deleted mouse had reduced inflammation and AHR in the mouse model of asthma as did mice and sheep treat ...
... • Primary function appears to be vasodilation but may also mediate bronchodilation • In vitro down-regulates Th1 and dendritic cell function possibly leading to increased Th2 responses. • DP1 gene deleted mouse had reduced inflammation and AHR in the mouse model of asthma as did mice and sheep treat ...
Nonredox 5-Lipoxygenase Inhibitors Require Glutathione
... 1993)]. In vivo, there is an enhanced formation of activated oxygen species at inflammatory sites which, among other signals, are involved in 5-LO activation and subsequent leukotriene synthesis in activated leukocytes. The biological profile of leukotrienes suggests that inhibitors of the 5-LO path ...
... 1993)]. In vivo, there is an enhanced formation of activated oxygen species at inflammatory sites which, among other signals, are involved in 5-LO activation and subsequent leukotriene synthesis in activated leukocytes. The biological profile of leukotrienes suggests that inhibitors of the 5-LO path ...
Recombinant Human Erythropoietin (EPO) (carrier-free)
... carbohydrates, and its molecular weight varies from 30-34 kD depending on the carbohydrate percentage. Hypoxia induces erythropoiesis, and hypoxia inducible factor (HIF) is directly involved in EPO expression. HIF is a heterodimer (HIF-1α, HIF-2α, and β subunits) transcription factor, and it is regu ...
... carbohydrates, and its molecular weight varies from 30-34 kD depending on the carbohydrate percentage. Hypoxia induces erythropoiesis, and hypoxia inducible factor (HIF) is directly involved in EPO expression. HIF is a heterodimer (HIF-1α, HIF-2α, and β subunits) transcription factor, and it is regu ...