MONOCYTE AND MACROPHAGE HETEROGENEITY
... sites4, where differentiation into macrophages and DCs occurs, contributing to host defence, and tissue remodelling and repair. Studies of the mononuclear-phagocyte system, using monoclonal antibodies specific for various cell-surface receptors and differentiation antigens, have shown that there is ...
... sites4, where differentiation into macrophages and DCs occurs, contributing to host defence, and tissue remodelling and repair. Studies of the mononuclear-phagocyte system, using monoclonal antibodies specific for various cell-surface receptors and differentiation antigens, have shown that there is ...
Pascale G. Charest and Michel Bouvier Activation
... receptor desensitization is now well established (1). Upon activation, GPCRs become phosphorylated by both second messenger-activated and GPCR kinases on serine and threonine residues located in the third intracellular loop and/or carboxylterminal tail of the receptors. These phosphorylation events ...
... receptor desensitization is now well established (1). Upon activation, GPCRs become phosphorylated by both second messenger-activated and GPCR kinases on serine and threonine residues located in the third intracellular loop and/or carboxylterminal tail of the receptors. These phosphorylation events ...
Characterization of the Acid Stability of Glycosidically Linked
... The glycosidic linkage of sialic acids is much more sensitive to acid hydrolysis than those of other monosaccharides in vertebrates. The commonest sialic acids in nature are neuraminic acid (Neu)-based and are typically N-acylated at the C5 position. Unsubstituted Neu is thought to occur on native g ...
... The glycosidic linkage of sialic acids is much more sensitive to acid hydrolysis than those of other monosaccharides in vertebrates. The commonest sialic acids in nature are neuraminic acid (Neu)-based and are typically N-acylated at the C5 position. Unsubstituted Neu is thought to occur on native g ...
Monoclonal antibody 7G3 recognizes the N
... Although some of the effects of IL-3 may be desirable and have prompted its clinical use in bone marrow reconstitution following chemotherapy,' it is also apparent that abnormal or excessive production of IL-3 has the potential to lead to disease states. For example, some acute myeloid leukemias pro ...
... Although some of the effects of IL-3 may be desirable and have prompted its clinical use in bone marrow reconstitution following chemotherapy,' it is also apparent that abnormal or excessive production of IL-3 has the potential to lead to disease states. For example, some acute myeloid leukemias pro ...
Protective effects of sphingosine-1
... Aims Several experimental studies have demonstrated protection against cardiac ischaemia–reperfusion injury achieved by pre-treatment with exogenous sphingosine-1-phosphate (S1P). We tested the hypothesis that pharmacological S1P receptor agonists improve recovery of function when applied with reper ...
... Aims Several experimental studies have demonstrated protection against cardiac ischaemia–reperfusion injury achieved by pre-treatment with exogenous sphingosine-1-phosphate (S1P). We tested the hypothesis that pharmacological S1P receptor agonists improve recovery of function when applied with reper ...
No Slide Title
... • Lysozyme digests debris from cell walls of bacteria that have already been processed by other enzymes. • Another function of lysozyme is to modulate inflammation by suppressing neutrophil chemotaxis and oxidative metabolism. ...
... • Lysozyme digests debris from cell walls of bacteria that have already been processed by other enzymes. • Another function of lysozyme is to modulate inflammation by suppressing neutrophil chemotaxis and oxidative metabolism. ...
Recognition of complex carbohydrates by the macrophage mannose
... Mannose receptors have been isolated from macrophages [7, 81 and from placenta [9]. The receptor from both sources is a glycoprotein consisting of a single subunit with a molecular mass of about 175 m a . Mannose receptors from human placenta [ 101 and human monocyte-derived macrophages [ 111 have b ...
... Mannose receptors have been isolated from macrophages [7, 81 and from placenta [9]. The receptor from both sources is a glycoprotein consisting of a single subunit with a molecular mass of about 175 m a . Mannose receptors from human placenta [ 101 and human monocyte-derived macrophages [ 111 have b ...
Loss-of-Function Polymorphic Variants of the Human Angiotensin II
... hypertension (Stankovic et al., 2003), aortic stiffness with age in hypertensive subjects (Lajemi et al., 2001), post-translational renal dysfunction and hypertension (Abdi et al., 2001), diabetic nephropathy (Doria et al., 1997; Antonellis et al., 2002), coronary artery vasoconstriction (Amant et a ...
... hypertension (Stankovic et al., 2003), aortic stiffness with age in hypertensive subjects (Lajemi et al., 2001), post-translational renal dysfunction and hypertension (Abdi et al., 2001), diabetic nephropathy (Doria et al., 1997; Antonellis et al., 2002), coronary artery vasoconstriction (Amant et a ...
Reversible translocation of cytidylyltransferase between cytosol and
... increased in the same range of time in the particulate fraction. Subcellular fractionation indicated that endoplasmic reticulum was the unique binding site for cytidylyltransferase even after 1 min of incubation. Also, [3H]oleic acid accumulated mainly in the same internal membrane. Addition of exog ...
... increased in the same range of time in the particulate fraction. Subcellular fractionation indicated that endoplasmic reticulum was the unique binding site for cytidylyltransferase even after 1 min of incubation. Also, [3H]oleic acid accumulated mainly in the same internal membrane. Addition of exog ...
Not Signaling Mechanisms of Innate Immune Sensing but Human
... www.jimmunol.org/cgi/doi/10.4049/jimmunol.0901888 ...
... www.jimmunol.org/cgi/doi/10.4049/jimmunol.0901888 ...
Signaling Complexes Human IgG and Formation of Inflammatory
... Crystals of the FcgRIIa-HR–IgG1-Fc complex proved extremely sensitive to cryopreservation, with evident large increases in mosaic spread and uneven shrinkage of the unit cell such that different cryopreserved crystals were generally nonisomorphous. Moreover, the volumes of the crystals that were ess ...
... Crystals of the FcgRIIa-HR–IgG1-Fc complex proved extremely sensitive to cryopreservation, with evident large increases in mosaic spread and uneven shrinkage of the unit cell such that different cryopreserved crystals were generally nonisomorphous. Moreover, the volumes of the crystals that were ess ...
Mouse and human FcR effector functions
... but FcRs are triggered in all these cases. mTRIM21, however, appears to discriminate, and selectively binds to opsonized particles (e.g. opsonized viruses), but not to immune complexes made of soluble antigen and antibodies (18, 20). Mouse FcR expression patterns The portfolio of biological function ...
... but FcRs are triggered in all these cases. mTRIM21, however, appears to discriminate, and selectively binds to opsonized particles (e.g. opsonized viruses), but not to immune complexes made of soluble antigen and antibodies (18, 20). Mouse FcR expression patterns The portfolio of biological function ...
Exocytosis acts as a modulator of the ILT4
... As shown in Table 1 and Fig. 1A, neither ILT2 nor KIR2DL4 were expressed on neutrophils. The myelomonoblast PLB-985 cell line is considered as an appropriate model to generate neutrophil-like cells upon differentiation with Dimethylformamide (DMF) or Dimethylsulfoxide (DMSO) treatment. As shown in F ...
... As shown in Table 1 and Fig. 1A, neither ILT2 nor KIR2DL4 were expressed on neutrophils. The myelomonoblast PLB-985 cell line is considered as an appropriate model to generate neutrophil-like cells upon differentiation with Dimethylformamide (DMF) or Dimethylsulfoxide (DMSO) treatment. As shown in F ...
First Line of Defense in Early Human Life
... LL-37 is upregulated in keratinocytes of the epidermis in certain inflammatory skin disorders.42 Both HBD1 and HBD2 exhibit bactericidal activity predominantly against Gram-negative bacteria such as E. coli and P. aeruginosa,43 whereas HBD3 is highly effective against the Gram-positive bacteria S. a ...
... LL-37 is upregulated in keratinocytes of the epidermis in certain inflammatory skin disorders.42 Both HBD1 and HBD2 exhibit bactericidal activity predominantly against Gram-negative bacteria such as E. coli and P. aeruginosa,43 whereas HBD3 is highly effective against the Gram-positive bacteria S. a ...
Pharmacological Characterization and Identification of Amino Acids
... ␣-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ionotropic glutamate receptors, with activities similar to cyclothiazide and aniracetam, have also been developed (Shepherd et al., 2002). Galanthamine, which is an acetylcholinesterase inhibitor, has also been reported to be an allosteric modulat ...
... ␣-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ionotropic glutamate receptors, with activities similar to cyclothiazide and aniracetam, have also been developed (Shepherd et al., 2002). Galanthamine, which is an acetylcholinesterase inhibitor, has also been reported to be an allosteric modulat ...
Glycosylation and Fc Receptors
... (DC-SIGN) are also C-type lectins which recognize mannose type sugars on bacteria, viruses and fungi (Figdor et al. 2002). Galectins are widely distributed proteins that bind galactose and its derivatives and function in cell–cell and cell–matrix interactions and cell signaling (Barondes et al. 1994 ...
... (DC-SIGN) are also C-type lectins which recognize mannose type sugars on bacteria, viruses and fungi (Figdor et al. 2002). Galectins are widely distributed proteins that bind galactose and its derivatives and function in cell–cell and cell–matrix interactions and cell signaling (Barondes et al. 1994 ...
Arachidonic Acid Mediates Interleukin-1 and Tumor
... Effect of arachidonic acid on JNK protein kinases. Our recent studies suggested that a signal transduction pathway involving a tyrosine kinase cascade mediated arachidonic acid-induced c-jun transcription.” To further elucidate the components of the signaling route to c-jun transcription by arachido ...
... Effect of arachidonic acid on JNK protein kinases. Our recent studies suggested that a signal transduction pathway involving a tyrosine kinase cascade mediated arachidonic acid-induced c-jun transcription.” To further elucidate the components of the signaling route to c-jun transcription by arachido ...
Role of Phospholipase D in the cAMP Signal Transduction Pathway
... A2 before and during contraction to learn whether there were overall changes in enzyme activity or a shift in enzyme location from the cytoplasmic fraction to the membrane-bound fraction. In these experiments, cells were extracted under conditions where Ca 2+ was chelated, which results in maximal e ...
... A2 before and during contraction to learn whether there were overall changes in enzyme activity or a shift in enzyme location from the cytoplasmic fraction to the membrane-bound fraction. In these experiments, cells were extracted under conditions where Ca 2+ was chelated, which results in maximal e ...
Molecular Cloning and Pharmacological Characterization of a
... receptor (Tyr/Oct-Dro) (12, 13), the Locusta tyramine receptor (Tyr-Loc) (14), and the vertebrate a-adrenergic receptors. When only the TM regions are considered, overall identities are 50% (Tyr/Oct-Dro), 53% (Tyr-Loc), and ;40% (human a2-adrenergic receptors). A comparison of these amino acid seque ...
... receptor (Tyr/Oct-Dro) (12, 13), the Locusta tyramine receptor (Tyr-Loc) (14), and the vertebrate a-adrenergic receptors. When only the TM regions are considered, overall identities are 50% (Tyr/Oct-Dro), 53% (Tyr-Loc), and ;40% (human a2-adrenergic receptors). A comparison of these amino acid seque ...
Functional Characterization of the CD300e Leukocyte Receptor Tamara Brckalo
... All immune cells develop from hematopoietic stem cells (HSCs) that can be subdivided in long-term HSCs (LT-HSCs), short-term repopulating HSCs (ST-HSCs), and multipotent progenitor (MPP), as defined by combinations of cell surface markers. Progenitors with a more restricted differentiation potential ...
... All immune cells develop from hematopoietic stem cells (HSCs) that can be subdivided in long-term HSCs (LT-HSCs), short-term repopulating HSCs (ST-HSCs), and multipotent progenitor (MPP), as defined by combinations of cell surface markers. Progenitors with a more restricted differentiation potential ...
Saturated and polyunsaturated fatty acids reciprocally modulate
... TLRs provide critical signals to induce innate immune responses in APCs such as dendritic cells (DCs) that in turn link to adaptive immune responses. Results from our previous studies demonstrated that saturated fatty acids activate TLRs, whereas n-3 polyunsaturated fatty acids inhibit agonist-induc ...
... TLRs provide critical signals to induce innate immune responses in APCs such as dendritic cells (DCs) that in turn link to adaptive immune responses. Results from our previous studies demonstrated that saturated fatty acids activate TLRs, whereas n-3 polyunsaturated fatty acids inhibit agonist-induc ...
The humoral pattern recognition receptor PTX3 is stored in
... 200 μg/ml of human IgG for saturation, showing that the detection of intracellular PTX3 in neutrophils is not related to nonspecific binding of the anti-PTX3 mAb (not depicted). To confirm this observation, PTX3 expression was analyzed by Western blotting. Human neutrophils and DCs express two or th ...
... 200 μg/ml of human IgG for saturation, showing that the detection of intracellular PTX3 in neutrophils is not related to nonspecific binding of the anti-PTX3 mAb (not depicted). To confirm this observation, PTX3 expression was analyzed by Western blotting. Human neutrophils and DCs express two or th ...
Mice
... serum from these mice causes a similar arthritis in a wide range of mouse strains, due to autoantibodies recognizing glucose-6-phosphate isomerase (GPI) Antibodies against GPI selectively deposit in the joints as immune complexes and fix complement lipid chemoattractant leukotriene B4 (LTB4) a ...
... serum from these mice causes a similar arthritis in a wide range of mouse strains, due to autoantibodies recognizing glucose-6-phosphate isomerase (GPI) Antibodies against GPI selectively deposit in the joints as immune complexes and fix complement lipid chemoattractant leukotriene B4 (LTB4) a ...
The Role of T-Cell Leukemia Translocation
... MacDonald et al. reported the formation of multinucleated cells that respond to osteotropic hormones in long-term human bone marrow cultures (MacDonald et al. 1987). In 1988, Takahashi et al. and in 1989, Hattersley et al. used marrow cells of mice to examine osteoclast-like cell formation from thei ...
... MacDonald et al. reported the formation of multinucleated cells that respond to osteotropic hormones in long-term human bone marrow cultures (MacDonald et al. 1987). In 1988, Takahashi et al. and in 1989, Hattersley et al. used marrow cells of mice to examine osteoclast-like cell formation from thei ...