Lactobacillus acidophilus 48-1e TM
... he immune system is controlled by compounds known as cytokines. Cytokines are hormone-like proteins made by cells that affect the behaviour of other cells and, thereby, play an important role in the regulation of immune system functions. In vitro studies In vitro assays are widely used to define t ...
... he immune system is controlled by compounds known as cytokines. Cytokines are hormone-like proteins made by cells that affect the behaviour of other cells and, thereby, play an important role in the regulation of immune system functions. In vitro studies In vitro assays are widely used to define t ...
Structural Insights into the Amino-Terminus of the Secretin Receptor
... these domains. Under nonreducing conditions, the amino terminus was released from the receptor body, supporting the absence of covalent association between these domains. Quantitative [14C]iodoacetamide incorporation into the isolated amino-terminal domain of the receptor in the absence and presence ...
... these domains. Under nonreducing conditions, the amino terminus was released from the receptor body, supporting the absence of covalent association between these domains. Quantitative [14C]iodoacetamide incorporation into the isolated amino-terminal domain of the receptor in the absence and presence ...
Effects of phytanic acid on the vitamin E status, lipid composition and
... polarizer orientated parallel (I) and perpendicular (IU) to the direction of polarization of the excitation beam. All measurements were performed using a PerkinElmer LS3 fluorescence spectrophotometer, with excitation and emission wavelengths of 360 nm and 430 nm respectively and band widths of 10 ...
... polarizer orientated parallel (I) and perpendicular (IU) to the direction of polarization of the excitation beam. All measurements were performed using a PerkinElmer LS3 fluorescence spectrophotometer, with excitation and emission wavelengths of 360 nm and 430 nm respectively and band widths of 10 ...
With Friends Like These: The Complex Role of Neutrophils in the
... of morbidity and mortality. Here, we review the complex role of neutrophils during severe pneumonia by highlighting specific molecules and processes that contribute to pulmonary immunity, but can also drive progression of severe disease. Depending on the identity of the infectious agent, enhancing o ...
... of morbidity and mortality. Here, we review the complex role of neutrophils during severe pneumonia by highlighting specific molecules and processes that contribute to pulmonary immunity, but can also drive progression of severe disease. Depending on the identity of the infectious agent, enhancing o ...
Neutrophil function in the healing wound: adding insult to injury?
... epithelial healing in the absence of neutrophils. Somewhat surprisingly, we found that neutrophil-depleted mice displayed significantly accelerated wound re-epithelialization. In genetically diabetic mice, an example of delayed healing associated with an aberrant and excessive neutrophilic response, ...
... epithelial healing in the absence of neutrophils. Somewhat surprisingly, we found that neutrophil-depleted mice displayed significantly accelerated wound re-epithelialization. In genetically diabetic mice, an example of delayed healing associated with an aberrant and excessive neutrophilic response, ...
Neutrophils injure cultured skeletal myotubes
... Downloaded from http://ajpcell.physiology.org/ by 10.220.33.2 on June 16, 2017 ...
... Downloaded from http://ajpcell.physiology.org/ by 10.220.33.2 on June 16, 2017 ...
Expression of biologically active mouse ciliary neutrophic factor
... activate cells expressing only LIFRb and gp130 [47]. Conversely, the membrane IL-6Ra can substitute CNTFRa to form a receptor for human but not rat CNTF [48]. This particular property of human CNTF has been mapped to Gln-63 [48], which is replaced by an arginine in rat [32] and mouse CNTF [39]. Thes ...
... activate cells expressing only LIFRb and gp130 [47]. Conversely, the membrane IL-6Ra can substitute CNTFRa to form a receptor for human but not rat CNTF [48]. This particular property of human CNTF has been mapped to Gln-63 [48], which is replaced by an arginine in rat [32] and mouse CNTF [39]. Thes ...
Human HL-60 Myeloid Leukemia Cells Transport
... accumulation of vitamin C by normal human neutrophils using specific inhibitors of facilitated glucose uptake." These studies showed that both cell types accumulated the reduced form of ascorbic acid when incubated in the presenceof DHA. Theidentity of thetransported form of ascorbicacidhas been a c ...
... accumulation of vitamin C by normal human neutrophils using specific inhibitors of facilitated glucose uptake." These studies showed that both cell types accumulated the reduced form of ascorbic acid when incubated in the presenceof DHA. Theidentity of thetransported form of ascorbicacidhas been a c ...
Neutrophils in tuberculosis: heterogeneity shapes the way?
... Overall, neutrophils have evolved into efficient pathogenkilling machinery. Their essential role in the resistance to various bacterial and fungal infections is confirmed by the development of progressive infections with a wide range of organisms in neutropenia conditions [22]. 2.2. Bactericidal Activi ...
... Overall, neutrophils have evolved into efficient pathogenkilling machinery. Their essential role in the resistance to various bacterial and fungal infections is confirmed by the development of progressive infections with a wide range of organisms in neutropenia conditions [22]. 2.2. Bactericidal Activi ...
Immune complexes formed following the binding of
... arterial and venular circulation. This can lead to limb- and life-threatening complications. Although the precise mechanism(s) of thrombosis is yet unestablished, evidence in literature supports a role for activated platelets, resulting procoagulants, and microparticles.13 Immune complexes also bind ...
... arterial and venular circulation. This can lead to limb- and life-threatening complications. Although the precise mechanism(s) of thrombosis is yet unestablished, evidence in literature supports a role for activated platelets, resulting procoagulants, and microparticles.13 Immune complexes also bind ...
PDF - International Journal of Biological Sciences
... [5, 6]. Such mechanical events are orchestrated to generate cells’ directional movements. Thus, the elastic properties of the neutrophils are strongly associated with their immune responsive functions through mechanically mediated signaling pathways. The neutrophils often circulate through the micro ...
... [5, 6]. Such mechanical events are orchestrated to generate cells’ directional movements. Thus, the elastic properties of the neutrophils are strongly associated with their immune responsive functions through mechanically mediated signaling pathways. The neutrophils often circulate through the micro ...
A Molecular Model of Agonist and Nonpeptide Antagonist Binding to
... (AVP) is a cyclic nonapeptide (Fig. 1) whose actions are mediated by stimulation of specific G protein-coupled receptors (GPCRs) currently classified into V1 vascular (V1R), V2 renal (V2R), and V3 pituitary (V3R) AVP receptors (Thibonnier et al., 1998b). AVP is involved in numerous physiological fun ...
... (AVP) is a cyclic nonapeptide (Fig. 1) whose actions are mediated by stimulation of specific G protein-coupled receptors (GPCRs) currently classified into V1 vascular (V1R), V2 renal (V2R), and V3 pituitary (V3R) AVP receptors (Thibonnier et al., 1998b). AVP is involved in numerous physiological fun ...
The effect of Centella asiatica, vitamins, glycolic acid and their
... The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations hydroxylase, which are the two enzymes essential for collagen biosynthesis (Pinnel, 1985). As such in our study, vitamin C was used as a positive control as well as vitamin treatment to the cells. CA with the a ...
... The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations hydroxylase, which are the two enzymes essential for collagen biosynthesis (Pinnel, 1985). As such in our study, vitamin C was used as a positive control as well as vitamin treatment to the cells. CA with the a ...
Structure-Function Relationships of Stem Cell Factor
... cytokines as diverse as growth hormone, GM-CSF, and interleukin (IL)-4, our resultssuggest that cytokinesof multiple classes share a common functional organization. 0 1996 by The American Society of Hematology. ...
... cytokines as diverse as growth hormone, GM-CSF, and interleukin (IL)-4, our resultssuggest that cytokinesof multiple classes share a common functional organization. 0 1996 by The American Society of Hematology. ...
- Wiley Online Library
... efficacy by up to 50%. Substitutions of S/C7.45 did not produce a significant change in the basal activity of either receptor. All mutants tested exhibited levels of receptor expression similar to the corresponding wildtype based on measurements of specific [3H]-mesulergine binding or flow cytometry ...
... efficacy by up to 50%. Substitutions of S/C7.45 did not produce a significant change in the basal activity of either receptor. All mutants tested exhibited levels of receptor expression similar to the corresponding wildtype based on measurements of specific [3H]-mesulergine binding or flow cytometry ...
Expression of Efflux Transporters in Human Ocular Tissues
... The multidrug resistance (MDR) phenotype, a major type of cell resistance toward xenobiotics, remains the main cause of failure in cancer chemotherapy (Wu et al., 2011). The MDR phenomenon is associated with a decrease in intracellular xenobiotics/drug accumulation by efflux transporters, such as mu ...
... The multidrug resistance (MDR) phenotype, a major type of cell resistance toward xenobiotics, remains the main cause of failure in cancer chemotherapy (Wu et al., 2011). The MDR phenomenon is associated with a decrease in intracellular xenobiotics/drug accumulation by efflux transporters, such as mu ...
Late Endosomal/Lysosomal Targeting and Lack of Recycling of the
... endothelin receptors, the mode of internalization has been analyzed only for the ETA receptor. In stably transfected Chinese hamster ovary (CHO) cells, the receptor was found to reside in caveolae and to be internalized after binding of ET1 (Chun et al., 1994). Because a significant portion of the i ...
... endothelin receptors, the mode of internalization has been analyzed only for the ETA receptor. In stably transfected Chinese hamster ovary (CHO) cells, the receptor was found to reside in caveolae and to be internalized after binding of ET1 (Chun et al., 1994). Because a significant portion of the i ...
... activating factor (PAF)-activated intact eosinophils has been shown to imitate the characteristic pathological findings of airway epithelium in asthma [330]. In addition to their cytotoxic action, eosinophil cationic proteins at certain subtoxic concentrations also stimulate other inflammatory cells ...
Cholesterol and bile acids regulate xenosensor signaling in
... Cytochromes P450 (CYPs)1 are heme-containing enzymes responsible for the hydroxylation of lipophilic substrates in all species. In the liver, a subset of members of the CYP gene superfamily metabolize xenobiotics such as drugs, food additives and pollutants (1). Some of these CYPs can be transcripti ...
... Cytochromes P450 (CYPs)1 are heme-containing enzymes responsible for the hydroxylation of lipophilic substrates in all species. In the liver, a subset of members of the CYP gene superfamily metabolize xenobiotics such as drugs, food additives and pollutants (1). Some of these CYPs can be transcripti ...
The neutrophil in vascular inflammation
... advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these settings, neutrophils are recruited by various mechanisms depending on the situation. We also describe how these ...
... advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these settings, neutrophils are recruited by various mechanisms depending on the situation. We also describe how these ...
Immune modulation of some autoimmune diseases: the critical role
... In general, monocytes/macrophages contribute to the modulation of the immune response can lead to autoimmunity. These cells are dynamic as to polarize phenotypes of pro-inflammatory and anti-inflammatory cytokines depending on the microenvironment, acting with different physiological functions [31]. ...
... In general, monocytes/macrophages contribute to the modulation of the immune response can lead to autoimmunity. These cells are dynamic as to polarize phenotypes of pro-inflammatory and anti-inflammatory cytokines depending on the microenvironment, acting with different physiological functions [31]. ...
Bradykinin stimulates IL-6 and IL-8 production by human lung
... generated from kininogens by the action of plasma and tissue kallikreins. It has been postulated that the kallikreinkinin system is important in the pathophysiology of acute lung injury, acute (adult) respiratory distress syndrome (ARDS) and multiple organ failure. Experimental endotoxin shock, bact ...
... generated from kininogens by the action of plasma and tissue kallikreins. It has been postulated that the kallikreinkinin system is important in the pathophysiology of acute lung injury, acute (adult) respiratory distress syndrome (ARDS) and multiple organ failure. Experimental endotoxin shock, bact ...
Bioassay-Validated Recombinant Cytokines
... Mouse FGF-basic Other names: Fibroblast growth factor 2, Fgf-2, Fgfb, bFGF FGF-basic (FGFb) is a member of the fibroblast growth factor (FGF) family which includes 23 members. It is also known as fibroblast growth factor 2, Fgf-2, Fgfb, and bFGF. FGFb is expressed in almost all tissues and plays an ...
... Mouse FGF-basic Other names: Fibroblast growth factor 2, Fgf-2, Fgfb, bFGF FGF-basic (FGFb) is a member of the fibroblast growth factor (FGF) family which includes 23 members. It is also known as fibroblast growth factor 2, Fgf-2, Fgfb, and bFGF. FGFb is expressed in almost all tissues and plays an ...
Pathogenesis of Bronchial Asthma
... Understanding asthma as an episodic, reversible bronchoconstriction caused by increased responsiveness of the tracheobronchial tree to various stimuli. Knowing that asthma is divided into two basic types: extrinsic or atopic allergic and intrinsic asthma. Understanding the morphological changes seen ...
... Understanding asthma as an episodic, reversible bronchoconstriction caused by increased responsiveness of the tracheobronchial tree to various stimuli. Knowing that asthma is divided into two basic types: extrinsic or atopic allergic and intrinsic asthma. Understanding the morphological changes seen ...
MONOCYTE AND MACROPHAGE HETEROGENEITY
... sites4, where differentiation into macrophages and DCs occurs, contributing to host defence, and tissue remodelling and repair. Studies of the mononuclear-phagocyte system, using monoclonal antibodies specific for various cell-surface receptors and differentiation antigens, have shown that there is ...
... sites4, where differentiation into macrophages and DCs occurs, contributing to host defence, and tissue remodelling and repair. Studies of the mononuclear-phagocyte system, using monoclonal antibodies specific for various cell-surface receptors and differentiation antigens, have shown that there is ...