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PowerPoint-Präsentation
PowerPoint-Präsentation

... al, 2009). The alternative sigma factor RpoH was discovered in the context of the heat-shock response in E. coli (Erickson et al, 1987; Grossman et al, 1984) and subsequently identified in P. aeruginosa (Allan et al, 1988; Benvenisti et al, 1995) and many other Gram-negative bacteria (Nakahigashi et ...
Human Genetics
Human Genetics

... and DNA molecules grow by adding new nucleotides at the 3’ end. Nucleic acids are oriented and by convention sequences are always written 5’ to 3’. Thus, ATTGCA 6= ACGTTA. The addition of new nucleotides is catalyzed by a polymerase. Nucleotides can be removed by nucleases. ...
PDF
PDF

... two different programs called ChIPmix (Martin-Magniette et al., 2008) and Chipotle (Buck et al., 2005), which are based on totally different algorithms: the former is based on a linear regression mixture model and identifies significant probes, whereas the latter uses a sliding window approach and i ...
Transcriptional Repression of Hox Genes by C. elegans HP1/HPL
Transcriptional Repression of Hox Genes by C. elegans HP1/HPL

... according to mass spectrometry-based protein expression data (Figure 1). By microarray we observed very few changes in the gene expression profiles of either single, double, or triple mutants when compared with wild type animals at L4 larval stages. Among the 16,278 target probe sets assayed, we ide ...
Genetics- Ch. 5 text notes
Genetics- Ch. 5 text notes

... • Frequency of recombination is based on percentage of meiotic divisions that result in breakage of linkage between parental alleles • The frequency of recombination between two genes is proportional to the distance between the genes ...
on Mendel`s principles of heredity
on Mendel`s principles of heredity

... •As a substitute teacher at a technical school, Mendel conducted experiments on thousands of plants between 1856-1863. •These lead to discovery of the basic principles of heredity, also called Mendel’s laws of heredity. ...
Heredity
Heredity

... Genes – sequence of triplets on DNA Humans have about – 23,000 genes Each chromosome contains many genes Like the chromosomes they are part of, genes occur in pairs of two. – Alleles - alternate forms of a gene ...
The Nuclear Topography of ABL, BCR, PML, and
The Nuclear Topography of ABL, BCR, PML, and

... Irrespective of the exact nature of the biological mechanisms responsible for the occurrence of chromosomal translocations in somatic cells, a widely accepted assumption is that the spatial proximity of the involved chromosomal regions is likely to be an obligatory requirement for the exchange event ...
Chapter 11:
Chapter 11:

... • After showing that alleles segregate during the formation of gametes, Mendel wondered if they did so independently. • In other words, does the segregation of one pair of alleles affect the segregation of another pair of alleles? • For example, does the gene that determines whether a seed is round ...
Graphical Exploration of Gene Expression Data: A
Graphical Exploration of Gene Expression Data: A

... matrix A is obtained whose elements aij = log xij . For this operation to be valid, measurements must be made on a ratio scale and the values must be positive. Logarithmic re-expression allows data in different physical units to be compared to one another as the logarithm of their ratios. In additio ...
Members of the RKD transcription factor family induce an egg cell
Members of the RKD transcription factor family induce an egg cell

... on the notion that most cDNA libraries are made from tissues or plant organs in which egg cells and their transcripts are highly diluted or not present, the analysis was focused on 125 unique sequences which did not show any significant sequence similarity to more than one million publicly available ...
Disproportionate Roles for the X Chromosome and
Disproportionate Roles for the X Chromosome and

... genetics. By measuring intraspecific polymorphism and interspecific divergence across genomes, evolutionary properties of those mutations targeted by natural selection can be discovered. Under this framework as well, generalities are widely sought and difficult to identify. A useful way to make progres ...
Interacting Gene Clusters and the Evolution of the Vertebrate
Interacting Gene Clusters and the Evolution of the Vertebrate

... amplified (fig. 2C). The amplified gene clusters are likely to have biological meaning because they were derived from existing gene clusters. Therefore, we treated the amplified gene clusters the same as the other interacting gene clusters, although they were not many (5 in our data set). Identifica ...
BLAST_and_Genome_Browser_tutorial
BLAST_and_Genome_Browser_tutorial

... features identified from rice as well as from maize, sorghum, barley and wheat that were mapped on the rice genome. Some of these features are sequenced genetic markers, ESTs, cDNAs, CDSs, genes, insertion and repeat elements. The browser is another option for investigating the organization of rice ...
PSet - CS109
PSet - CS109

... decimal. For even more extra credit, calculate the probability analytically. This question is optional, but a good way to get your head around data. Localization In this multi part problem you are going to solve key components for “Localization” which is the computer science problem of tracking the ...
slides
slides

... Micro-arrays are still quite costly per array (but not per gene). Large data sets have about 100 arrays data sets with only a few arrays are very common Study designs depend on the field of application (plants/animals/human). In non-human applications material is often pooled to reduce the number of ...
S1 Appendix.
S1 Appendix.

... chromosome number, type of feature, start/end coordinates, strand and attributes (shown as bold red colors in Figure B). The name of chromosomes, types of feature, and attributes are often annotation-specific, and should be optimized if custom annotation files are used. The current script can be use ...
11-5 Linkage and Gene Maps
11-5 Linkage and Gene Maps

... They seemed to violate the principle of independent assortment. Example: Fruit flies with reddish-orange eyes and miniature wings Genes for these traits were almost inherited together Slide 5 of 18 Copyright Pearson Prentice Hall ...
Sexually reproducing organisms in nearly all cases have termed
Sexually reproducing organisms in nearly all cases have termed

... as the ’father of genetics’, He carried out some pioneering work using pea p~ants to study the inheritance pa~erns of a number of traits (characteristics). Mendel observed that characters could be masked in one generation of peas but could reappear in later generations. He showed that inheritance in ...
Combined expression patterns of QTL
Combined expression patterns of QTL

... For instance, catecholamines up (catsup) is associated with naturally occurring variation in multiple traits such as locomotor behavior and longevity (Carbone et al., 2006), Additionally, we also tested two genes that are either up-regulated (CG10383) and down-regulated (cyp6a13) early in the heat-s ...
Proposal 3: Polygene
Proposal 3: Polygene

... genes are involved. The exact number of genes involved is unknown, however. To the resistance genes of bread wheat (Triticum aestivum) we will add resistance genes of the emmer wheat (Triticum dicoccon) common in the Middle East. Emmer is known to possess many resistance genes. One gene, Sr2, origin ...
Chromosomal
Chromosomal

... Morgan’s Experimental Evidence: Scientific Inquiry • The first solid evidence associating a specific gene with a specific chromosome came from Thomas Hunt Morgan, an embryologist • Morgan’s experiments with fruit flies provided convincing evidence that chromosomes are the location of Mendel’s herit ...
How functions are combined within the ABC model
How functions are combined within the ABC model

... expression in the flower meristem Therefore in an agamous mutant wuschel activity would be increased and would persist for longer. This may explain why agamous mutant flowers do not stop after 4 ...
Bacteria, Sex, and Systematics - Center for Philosophy of Biology at
Bacteria, Sex, and Systematics - Center for Philosophy of Biology at

... alternative pragmatic approaches to bacterial species advocated by contemporary biologists. 2. Biological Preliminaries a. inheritance Bacteria are single-celled organisms that reproduce via binary fission, in which a single parent cell divides to form two more-or-less equivalent progeny cells. DNA ...
BWS - Beckwith-Wiedemann Syndrome support
BWS - Beckwith-Wiedemann Syndrome support

... • A growth promoting gene Insulin-like Growth Factor II (IGF2 which is active from the paternal chromosome). It can be predicted that genetic changes that result in reduced activity of CDKN1C or increased activity of IGF2 (or both!) would cause overgrowth. The activity of both of CDKN1C and IGF2 is ...
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Minimal genome

The concept of minimal genome assumes that genomes can be reduced to a bare minimum, given that they contain many non-essential genes of limited or situational importance to the organism. Therefore, if a collection of all the essential genes were put together, a minimum genome could be created artificially in a stable environment. By adding more genes, the creation of an organism of desired properties is possible. The concept of minimal genome arose from the observations that many genes do not appear to be necessary for survival. In order to create a new organism a scientist must determine the minimal set of genes required for metabolism and replication. This can be achieved by experimental and computational analysis of the biochemical pathways needed to carry out basic metabolism and reproduction. A good model for a minimal genome is Mycoplasma genitalium, the organism with the smallest known genome. Most genes that are used by this organism are usually considered essential for survival; based on this concept a minimal set of 256 genes has been proposed.
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