Adaptive evolution drives divergence of a hybrid inviability gene
... One of the long-standing goals of speciation research is to establish the molecular identities, functions and evolutionary histories of the genes that cause hybrid sterility and inviability1,2. So far, however, only three putative hybrid incompatibility genes have been identified3–5. One reason for ...
... One of the long-standing goals of speciation research is to establish the molecular identities, functions and evolutionary histories of the genes that cause hybrid sterility and inviability1,2. So far, however, only three putative hybrid incompatibility genes have been identified3–5. One reason for ...
Down syndrome genetics: unravelling a multifactorial disorder
... Mice other than the single gene transgenics also contribute to our understanding of the molecular genetics of DS and gene dosage effects from particular genomic regions. One of the first mice to be studied extensively in relation to DS was the trisomy 16 mouse, because a large portion of mouse chrom ...
... Mice other than the single gene transgenics also contribute to our understanding of the molecular genetics of DS and gene dosage effects from particular genomic regions. One of the first mice to be studied extensively in relation to DS was the trisomy 16 mouse, because a large portion of mouse chrom ...
Genetic testing in couples with infertility
... well as in spontaneous abortions, (Wieacker et al. 2005; Steck 2006; DGGG 2008), genetic testing after adequate consultation is consistently recommended or even demanded in couples with unexplained infertility. The guidelines of the German Medical Association on assisted reproduction (2006) request ...
... well as in spontaneous abortions, (Wieacker et al. 2005; Steck 2006; DGGG 2008), genetic testing after adequate consultation is consistently recommended or even demanded in couples with unexplained infertility. The guidelines of the German Medical Association on assisted reproduction (2006) request ...
Text S1: Genome-Wide High-Resolution Mapping of UV
... was heterozygous for all SNPs on chromosome V, and the red and white sectors had reciprocal patterns of LOH. Since this result indicates that a crossover was induced in one of the daughter cells, recombinogenic DNA damage persisted into the second cell cycle. We also examined the three sectors of 78 ...
... was heterozygous for all SNPs on chromosome V, and the red and white sectors had reciprocal patterns of LOH. Since this result indicates that a crossover was induced in one of the daughter cells, recombinogenic DNA damage persisted into the second cell cycle. We also examined the three sectors of 78 ...
Xylitol production using recombinant Saccharomyces
... selection marker neo r and an auxotrophic marker URA3. The multiple XYL1 genes were stably maintained on the chromosome even after 21 and 10 days in the non-selective sequential batch and chemostat cultures, respectively, whereas S. cere6isiae 2805:pVTXR, which harbors the episomal plasmid pVTXR hav ...
... selection marker neo r and an auxotrophic marker URA3. The multiple XYL1 genes were stably maintained on the chromosome even after 21 and 10 days in the non-selective sequential batch and chemostat cultures, respectively, whereas S. cere6isiae 2805:pVTXR, which harbors the episomal plasmid pVTXR hav ...
1. The evolutionary process that favors individuals of a species that
... B. Fraternal twins develop from a single zygote that splits into two genetically identical replicas. C. For each genotype, only a corresponding phenotype can be expressed. D. Identical twins develop from separate eggs and separate sperm. 21. A _____ is a permanently altered segment of DNA that can g ...
... B. Fraternal twins develop from a single zygote that splits into two genetically identical replicas. C. For each genotype, only a corresponding phenotype can be expressed. D. Identical twins develop from separate eggs and separate sperm. 21. A _____ is a permanently altered segment of DNA that can g ...
Development Duplication
... Developmental Duplication (“DD”). The studies were conducted by Dr. Jonathan Beever of the University of Illinois, at the request of Angus Australia. The results of Dr. Beever’s study are available onl ...
... Developmental Duplication (“DD”). The studies were conducted by Dr. Jonathan Beever of the University of Illinois, at the request of Angus Australia. The results of Dr. Beever’s study are available onl ...
Lecture NoteIV
... 4-1.2.1. Growth and harvest of bacterial culture Bacterial cell culture is more convenient than any other microbe, as it requires only liquid medium (broth) containing essential nutrients at optimal concentrations, for the growth and division of bacterial cells. The bacterial cells are usually grown ...
... 4-1.2.1. Growth and harvest of bacterial culture Bacterial cell culture is more convenient than any other microbe, as it requires only liquid medium (broth) containing essential nutrients at optimal concentrations, for the growth and division of bacterial cells. The bacterial cells are usually grown ...
Familial Aortopathy — Gene Panels
... The panel proposed by the CHUS group is composed of the genes most commonly associated with syndromic and nonsyndromic TAAD, whereas that of the CHU Sainte-Justine group is more comprehensive, as it contains genes for which mutations have rarely been described and genes not associated with TAAD but ...
... The panel proposed by the CHUS group is composed of the genes most commonly associated with syndromic and nonsyndromic TAAD, whereas that of the CHU Sainte-Justine group is more comprehensive, as it contains genes for which mutations have rarely been described and genes not associated with TAAD but ...
Ends-out, or replacement, gene targeting in Drosophila
... first in yeast and then in mice (1, 2), but the difficulty of introducing a linear DNA molecule into germ-line cells hindered its development for Drosophila. Recently, a method to generate such a linear fragment in vivo was reported, accompanied by a demonstration of ends-in or insertional gene targ ...
... first in yeast and then in mice (1, 2), but the difficulty of introducing a linear DNA molecule into germ-line cells hindered its development for Drosophila. Recently, a method to generate such a linear fragment in vivo was reported, accompanied by a demonstration of ends-in or insertional gene targ ...
Biology 409 - CSU, Chico
... Provide an explanation for the origin of repetitive sequences in the human genome and summarize functions for repetitive DNA in chromosome functioning. ...
... Provide an explanation for the origin of repetitive sequences in the human genome and summarize functions for repetitive DNA in chromosome functioning. ...
"Vectors in Gene Therapy". In: An Introduction to Molecular Medicine
... studies, immediate or immediate early genes were deleted. These vectors could potentially undergo recombination to produce a wild-type virus capable of multiple rounds of replication. These viral vectors replaced one or more viral genes with a promoter and coding sequence of interest. Competent repl ...
... studies, immediate or immediate early genes were deleted. These vectors could potentially undergo recombination to produce a wild-type virus capable of multiple rounds of replication. These viral vectors replaced one or more viral genes with a promoter and coding sequence of interest. Competent repl ...
Damage Control: The Pleiotropy of DNA Repair Genes
... cells. This result has been confirmed and extended to cells in the eye imaginal disc (M. Brodsky and G. M. Rubin, personal communication). Thus the function of the MEI-41 protein may not be in the repair of damage per se, but in triggering a DNA damage-dependent cellcycle checkpoint. Activation of t ...
... cells. This result has been confirmed and extended to cells in the eye imaginal disc (M. Brodsky and G. M. Rubin, personal communication). Thus the function of the MEI-41 protein may not be in the repair of damage per se, but in triggering a DNA damage-dependent cellcycle checkpoint. Activation of t ...
BPA leaflet testing and inheritance
... and “Drugs and Porphyria” leaflets. Relatives need a genetic test, to find if they have an acute porphyria, so they can avoid the triggers. (Women are particularly at risk hormone changes can help trigger attacks.) This may not prevent attacks entirely but, if the porphyria is known, an attack can b ...
... and “Drugs and Porphyria” leaflets. Relatives need a genetic test, to find if they have an acute porphyria, so they can avoid the triggers. (Women are particularly at risk hormone changes can help trigger attacks.) This may not prevent attacks entirely but, if the porphyria is known, an attack can b ...
Possible consequences of the overlap between the CaMV 35S
... allergenic properties of CaMV and no similarities have been shown to know allergens, it can be concluded that the P6 protein is most likely not an allergen. In addition, a toxin database was constructed, and no significant sequence similarity with the P35S variants was detected. These data suggest t ...
... allergenic properties of CaMV and no similarities have been shown to know allergens, it can be concluded that the P6 protein is most likely not an allergen. In addition, a toxin database was constructed, and no significant sequence similarity with the P35S variants was detected. These data suggest t ...
Egg production
... double yolked eggs were analysed on an age basis relative to first egg using AFE and egg production as a covariate. Background genetic effects were also fitted. Method: ii) Candidate genes. i) Candidate genes were selected because of their function alone or because of their function combined with th ...
... double yolked eggs were analysed on an age basis relative to first egg using AFE and egg production as a covariate. Background genetic effects were also fitted. Method: ii) Candidate genes. i) Candidate genes were selected because of their function alone or because of their function combined with th ...
Hox, ParaHox, ProtoHox: facts and guesses
... Intermediate hypotheses can also be advanced, for example, a ProtoHox cluster with three genes (Anterior, Group3 and Posterior). In this case, Cnidarians would have lost PG3 and Xlox, and the increase in complexity at the origin of Bilaterians would have been linked only to the origin of a Central H ...
... Intermediate hypotheses can also be advanced, for example, a ProtoHox cluster with three genes (Anterior, Group3 and Posterior). In this case, Cnidarians would have lost PG3 and Xlox, and the increase in complexity at the origin of Bilaterians would have been linked only to the origin of a Central H ...
DEVELOPMENT OF AN ORAL SUBMUCOUS FIBROSIS-SPECIFIC HAPLOTYPIC SIGNATURE – Reveiw Article
... Further, TGF-1 -a pleiotropic cytokine, among other functions including immuno-suppression, is associated with an increase in TIMP genes (TIMP-1 and TIMP-2) as well as a Plasminogen activator inhibitor I. Hence, polymorphism-associated changes in this growth factor may alter an important upstream a ...
... Further, TGF-1 -a pleiotropic cytokine, among other functions including immuno-suppression, is associated with an increase in TIMP genes (TIMP-1 and TIMP-2) as well as a Plasminogen activator inhibitor I. Hence, polymorphism-associated changes in this growth factor may alter an important upstream a ...
Solid Tumour Section Nervous system: Astrocytic tumors Atlas of Genetics and Cytogenetics
... system (CNS), age and gender distribution, growth potential, extent of invasiveness, morphological features, tendency for progression and clinical course; there is increasing evidence that these differences reflect the type and sequence of genetic alterations acquired during the process of transform ...
... system (CNS), age and gender distribution, growth potential, extent of invasiveness, morphological features, tendency for progression and clinical course; there is increasing evidence that these differences reflect the type and sequence of genetic alterations acquired during the process of transform ...
Translational Termination
... • Three codons are the natural stop signals at the ends of coding regions in mRNA – UAG – UAA – UGA ...
... • Three codons are the natural stop signals at the ends of coding regions in mRNA – UAG – UAA – UGA ...
Genomic Analysis of Hox Clusters in the Sea Lamprey
... amphioxus genes, one or more lamprey homeodomains clustered with the complete complement of mouse cognates for groups 1, 2, 3, 8, and 11 with bootstrap confidence levels of 97% or greater. Groups 4, 9, and 10 are recovered at lower bootstrap proportions. Because of the high degree of amino acid simi ...
... amphioxus genes, one or more lamprey homeodomains clustered with the complete complement of mouse cognates for groups 1, 2, 3, 8, and 11 with bootstrap confidence levels of 97% or greater. Groups 4, 9, and 10 are recovered at lower bootstrap proportions. Because of the high degree of amino acid simi ...
post-transcription
... 1. Small dsRNA fragments can silence the expression of a matching gene. This is RNA interference (RNAi), recently discovered in C. elegans. a. Injecting dsRNA into adult worms results in specific loss of the corresponding mRNA in the worm and its progeny. b. RNAi also occurs in many other organisms, ...
... 1. Small dsRNA fragments can silence the expression of a matching gene. This is RNA interference (RNAi), recently discovered in C. elegans. a. Injecting dsRNA into adult worms results in specific loss of the corresponding mRNA in the worm and its progeny. b. RNAi also occurs in many other organisms, ...
Spectrum of mutations in the familial Mediterranean
... eastern Mediterranean region where the incidence of FMF is high. However, MEFV mutations can be detected in a defined group of patients clinically diagnosed as having FMF. Thus, MEFV mutations were detected only in (51.5%) of 1579 cases examined in our study and no mutations were detected in the rem ...
... eastern Mediterranean region where the incidence of FMF is high. However, MEFV mutations can be detected in a defined group of patients clinically diagnosed as having FMF. Thus, MEFV mutations were detected only in (51.5%) of 1579 cases examined in our study and no mutations were detected in the rem ...
Modulation of CTCF Insulator Function by
... genes, including regulation of enhancerpromoter interactions, imprinting, inhibition of nucleolar transcription, and coactivation of unlinked genes (Wallace and Felsenfeld, 2007). These diverse functions are in part mediated by the ability of CTCF to stabilize long-range chromatin contacts and organ ...
... genes, including regulation of enhancerpromoter interactions, imprinting, inhibition of nucleolar transcription, and coactivation of unlinked genes (Wallace and Felsenfeld, 2007). These diverse functions are in part mediated by the ability of CTCF to stabilize long-range chromatin contacts and organ ...
RT-PCR Analysis - Shiu Lab - Michigan State University
... developmental stages during floral organ abscission (Figure 6A). During the abscission process there are discrete stages when cell wall loosening and cell wall dissolution occurs, thus providing an excellent biological system to look at more subtle changes in the regulation of cell separation. And i ...
... developmental stages during floral organ abscission (Figure 6A). During the abscission process there are discrete stages when cell wall loosening and cell wall dissolution occurs, thus providing an excellent biological system to look at more subtle changes in the regulation of cell separation. And i ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.