Unexpected Complexity of Poly(A)-Binding Protein Gene Families in
... raises the question as to which of them is essential for viability. Using cross-species complementation of the yeast pab1 null mutant by the Arabidopsis PAB3 cDNA, it was shown that rescue of viability required neither the restoration of poly(A)-dependent translation nor the protection of the 5⬘ cap ...
... raises the question as to which of them is essential for viability. Using cross-species complementation of the yeast pab1 null mutant by the Arabidopsis PAB3 cDNA, it was shown that rescue of viability required neither the restoration of poly(A)-dependent translation nor the protection of the 5⬘ cap ...
Genetic consequences of directional selection in
... of a southern (Plech, Germany) and a northern (Spiterstulen, Norway) population. I also studied the current response potential to changing conditions in the marginal Spiterstulen population. Adaptation potential was characterized by assessing plasticity and amount of additive genetic variation, focu ...
... of a southern (Plech, Germany) and a northern (Spiterstulen, Norway) population. I also studied the current response potential to changing conditions in the marginal Spiterstulen population. Adaptation potential was characterized by assessing plasticity and amount of additive genetic variation, focu ...
Introduction to molecular and cell biology
... to understand the regulation, one studied the growth-phase regulatory factors and gene expression in response to specific environmental differences within the host a novel growth phase assosiated two-component-type regulator was identified ...
... to understand the regulation, one studied the growth-phase regulatory factors and gene expression in response to specific environmental differences within the host a novel growth phase assosiated two-component-type regulator was identified ...
Traits and Families
... A gene is a recipe for a protein. It is used by the cell to make that protein. In achondroplasia, the normal allele (FGRF3) codes for a protein (fibroblast growth factor) that is part of the structure of normal bones, including those of the arms and legs. The achondroplasia allele produces a protein ...
... A gene is a recipe for a protein. It is used by the cell to make that protein. In achondroplasia, the normal allele (FGRF3) codes for a protein (fibroblast growth factor) that is part of the structure of normal bones, including those of the arms and legs. The achondroplasia allele produces a protein ...
Nutritional Genomics
... Conclusions Although the embryos showed identical morphological appearance (same grading for developmental stage and quality), they showed significant transcriptomic differences Expression of several genes that are critical for embryonic and adult function were decreased ...
... Conclusions Although the embryos showed identical morphological appearance (same grading for developmental stage and quality), they showed significant transcriptomic differences Expression of several genes that are critical for embryonic and adult function were decreased ...
Case Report Section
... the karyotype 46,Y,t(X;11)(q22;q23) in 25 out of 30 metaphases. Fluorescence in situ hybridization study showed rearrangement of the MLL gene in interphase and metaphase cells revealing that the break-apart 5'MLL segment is translocated to the derivative X chromosome. The patient achieved a complete ...
... the karyotype 46,Y,t(X;11)(q22;q23) in 25 out of 30 metaphases. Fluorescence in situ hybridization study showed rearrangement of the MLL gene in interphase and metaphase cells revealing that the break-apart 5'MLL segment is translocated to the derivative X chromosome. The patient achieved a complete ...
View
... H2AX organization around the tss in the replicating genome is noteworthy. The canonical nucleosome and the H2AZ variant typically display the arrangement of −1 nucleosome and nucleosome-free region (NFR) upstream of the tss, and +1 nucleosome stably residing just downstream of the tss (17,25) (Suppl ...
... H2AX organization around the tss in the replicating genome is noteworthy. The canonical nucleosome and the H2AZ variant typically display the arrangement of −1 nucleosome and nucleosome-free region (NFR) upstream of the tss, and +1 nucleosome stably residing just downstream of the tss (17,25) (Suppl ...
Ch. 15 Chromosomal Basis of Inheritance
... genes act as if found on separate chromosomes and are inherited independently. • In fact, several genes studies by Mendel are located on the same chromosome. • For example, seed color and flower color are far enough apart that linkage is not observed. • Plant height and pod shape should show linkage ...
... genes act as if found on separate chromosomes and are inherited independently. • In fact, several genes studies by Mendel are located on the same chromosome. • For example, seed color and flower color are far enough apart that linkage is not observed. • Plant height and pod shape should show linkage ...
Multiple Avirulence Loci and Allele-Specific Effector
... evidence for the concept that specificity of R proteins is the sum of avirulence protein recognition plus activation of the resistance protein (Steinbrenner et al., 2015). This translates into a quantitative variation in the level of virulence in natural isolates, as described by Brunner et al. (2010 ...
... evidence for the concept that specificity of R proteins is the sum of avirulence protein recognition plus activation of the resistance protein (Steinbrenner et al., 2015). This translates into a quantitative variation in the level of virulence in natural isolates, as described by Brunner et al. (2010 ...
evolutionary computation - Algorithms and Complexity
... phylogenies7, to predict protein structures14, or to infer metabolic pathways8. It would be natural to use trees or graphs rather than sequences. For such chromosomes special recombination OPERATORS would be required. In GAs, chromosomes are chosen stochastically for replication into the next genera ...
... phylogenies7, to predict protein structures14, or to infer metabolic pathways8. It would be natural to use trees or graphs rather than sequences. For such chromosomes special recombination OPERATORS would be required. In GAs, chromosomes are chosen stochastically for replication into the next genera ...
Bio II Ch 15 Chromosomal Basis of Inheritance
... offspring that had a combination of traits that did not match either parent in the P generation. • If the P generation consists of a yellow-round parent (YYRR) crossed with a green-wrinkled seed parent (yyrr), all F1 plants have yellow-round seeds (YyRr). • A cross between an F1 plant and a homozygo ...
... offspring that had a combination of traits that did not match either parent in the P generation. • If the P generation consists of a yellow-round parent (YYRR) crossed with a green-wrinkled seed parent (yyrr), all F1 plants have yellow-round seeds (YyRr). • A cross between an F1 plant and a homozygo ...
RNA-Seq Alignment v1.0 App Guide
... Alignment to ERCC—If selected, STAR aligns all reads to the ERCC RNA spike-in sequences, independent of alignment to the transcriptome. The aligner counts reads that align to each spike-in sequence, calculates FPKMs, and computes the correlation between FPKMs and the expected spike-in concentrations ...
... Alignment to ERCC—If selected, STAR aligns all reads to the ERCC RNA spike-in sequences, independent of alignment to the transcriptome. The aligner counts reads that align to each spike-in sequence, calculates FPKMs, and computes the correlation between FPKMs and the expected spike-in concentrations ...
Supertaster
... substances pleasant and consuming other substances unpleasant – the ability to taste. Special receptors in the taste buds on our tongues allow us to taste five different flavors – sweet, salty, bitter, sour, and umami (savory). Without this ability, Brussel sprouts would taste exactly the same as cu ...
... substances pleasant and consuming other substances unpleasant – the ability to taste. Special receptors in the taste buds on our tongues allow us to taste five different flavors – sweet, salty, bitter, sour, and umami (savory). Without this ability, Brussel sprouts would taste exactly the same as cu ...
Using Computer Simulation to Understand Mutation
... beneficial and to vary in expression from fully dominant to fully recessive. Each mutation’s unique identifier encodes its genotypic fitness effect, whether it is recessive or dominant, and its location within the genome (the specific linkage block where it resides within a specific chromosome). Thi ...
... beneficial and to vary in expression from fully dominant to fully recessive. Each mutation’s unique identifier encodes its genotypic fitness effect, whether it is recessive or dominant, and its location within the genome (the specific linkage block where it resides within a specific chromosome). Thi ...
Brief Rapid Communications
... Background—The delivery of recombinant genes to cardiomyocytes holds promise for the treatment of a variety of cardiovascular diseases. Previous gene transfer approaches that used direct injection of plasmid DNA or replicationdefective adenovirus vectors have been limited by low transduction frequen ...
... Background—The delivery of recombinant genes to cardiomyocytes holds promise for the treatment of a variety of cardiovascular diseases. Previous gene transfer approaches that used direct injection of plasmid DNA or replicationdefective adenovirus vectors have been limited by low transduction frequen ...
The Answer Is Fifteen Percent - CHEST Journal
... respiratory illness. These studies have not been conclusive. Because inflammatory processes are likely to be important in the pathogenesis of COPD, genetic polymorphisms that effect inflammatory mediators or the immune response may be of interest. Candidate genes that are involved with inflammatory ...
... respiratory illness. These studies have not been conclusive. Because inflammatory processes are likely to be important in the pathogenesis of COPD, genetic polymorphisms that effect inflammatory mediators or the immune response may be of interest. Candidate genes that are involved with inflammatory ...
Chapter 18: Gene Mutation and DNA Repair
... 5. In the 1950s, Joshua and Esther Lederberg developed a technique called ________, which involved the use of a velvet cloth to make copies of a master plate. 6. A region of a gene that is more likely to mutate than another region is called a ________. ...
... 5. In the 1950s, Joshua and Esther Lederberg developed a technique called ________, which involved the use of a velvet cloth to make copies of a master plate. 6. A region of a gene that is more likely to mutate than another region is called a ________. ...
Pole Region-Dependent Repression of the Drosophila Gap Gene
... protein domain in pum embryos is only slightly enlarged, but the entire domain is shifted backward (Table 1; Figure 2). The most prominent changes were found in stau embryos. The anterior and posterior borders are both shifted toward the poles. This results in an enlarged Krprotein domain that is ab ...
... protein domain in pum embryos is only slightly enlarged, but the entire domain is shifted backward (Table 1; Figure 2). The most prominent changes were found in stau embryos. The anterior and posterior borders are both shifted toward the poles. This results in an enlarged Krprotein domain that is ab ...
Title Heterochromatin Blocks Constituting the Entire
... contain tandem repeats. Our previous study19 identified two types of alpha satellite DNA as large-scale repetitive sequences, using the method described herein. These sequences had been named OwlAlp1 and OwlAlp2, and their repeat units were 185 and 344 bp in length, respectively. Of the eight clones ...
... contain tandem repeats. Our previous study19 identified two types of alpha satellite DNA as large-scale repetitive sequences, using the method described herein. These sequences had been named OwlAlp1 and OwlAlp2, and their repeat units were 185 and 344 bp in length, respectively. Of the eight clones ...
Requirements for Human Medical Genome
... Medical testing by genomic methods shares many ethical, legal and social issues with other forms of clinical investigation. Existing issues of informed consent, incidental findings, the right not to know, family studies and re-contacting are potentially magnified due to the volume of information tha ...
... Medical testing by genomic methods shares many ethical, legal and social issues with other forms of clinical investigation. Existing issues of informed consent, incidental findings, the right not to know, family studies and re-contacting are potentially magnified due to the volume of information tha ...
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... (COPD), which is a heritable multi-factorial disease. We present genome-wide association study (GWAS) to map the genetic architecture of this trait and investigate the networks between the external factors (smoking and gender) and genetic factors. By using a mixed linear model and a conditional mode ...
... (COPD), which is a heritable multi-factorial disease. We present genome-wide association study (GWAS) to map the genetic architecture of this trait and investigate the networks between the external factors (smoking and gender) and genetic factors. By using a mixed linear model and a conditional mode ...
A B - Drug Metabolism and Disposition
... c.449TG>A could substantially affect drug metabolism in monkeys, the origin of animals used is one of the most important factors for a successful study on drug metabolism. Inactivation of species-specific genes such as CYP2C76 could lead to a better animal model in monkeys. However, the techniques o ...
... c.449TG>A could substantially affect drug metabolism in monkeys, the origin of animals used is one of the most important factors for a successful study on drug metabolism. Inactivation of species-specific genes such as CYP2C76 could lead to a better animal model in monkeys. However, the techniques o ...
Genetic Analyses of Agronomic Traits Controlled by Wheat
... determined by heading date; however, none of the previous research was designed to determine the number of loci affecting the trait. A unimodal normal distribution was observed for grain yield, kernel number per spike, kernel weight, spike number per square meter, grain volume weight, and plant heig ...
... determined by heading date; however, none of the previous research was designed to determine the number of loci affecting the trait. A unimodal normal distribution was observed for grain yield, kernel number per spike, kernel weight, spike number per square meter, grain volume weight, and plant heig ...
Seed-Specific Gene Activation Mediated by the Cre//ox Site
... cauliflower mosaic virus 35s promoter, were studied in developing transgenic tobacco embryos using the same visual marker. These seed-specific promoters were expressed earlier than anticipated. l h e 35s promoter was expressed earlier than the seed-specific promoters, but not in globular-stage embry ...
... cauliflower mosaic virus 35s promoter, were studied in developing transgenic tobacco embryos using the same visual marker. These seed-specific promoters were expressed earlier than anticipated. l h e 35s promoter was expressed earlier than the seed-specific promoters, but not in globular-stage embry ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.