Genetics of dementia (405)
... maintain our bodies. While much of our DNA is the same for all of us, many genes will differ slightly from person to person. These differences partly account for the physical differences that make each of us unique. They also affect our chances of developing many common diseases. There are two types ...
... maintain our bodies. While much of our DNA is the same for all of us, many genes will differ slightly from person to person. These differences partly account for the physical differences that make each of us unique. They also affect our chances of developing many common diseases. There are two types ...
Messenger RNA reprogramming by spliceosome-mediated
... domains provide PTMs with the cis elements required for spliceosome recognition and splicing. A PTM with a 5′ splice site domain can trans-splice to a 3′ splice site in the target pre-mRNA (ii in Figure 5); a PTM with a 3′ splice site domain can trans-splice to a 5′ splice site in the target (iii); ...
... domains provide PTMs with the cis elements required for spliceosome recognition and splicing. A PTM with a 5′ splice site domain can trans-splice to a 3′ splice site in the target pre-mRNA (ii in Figure 5); a PTM with a 3′ splice site domain can trans-splice to a 5′ splice site in the target (iii); ...
H4K20me1 Contributes to Downregulation of X
... performed immunofluorescence experiments using two different antibodies specific for H4K20me1. In embryos prior to the 30-cell stage, neither DPY-27 nor H4K20me1 was concentrated in any subnuclear region (Figure 2A). However, we observed that nuclear staining of H4K20me1 increased dramatically durin ...
... performed immunofluorescence experiments using two different antibodies specific for H4K20me1. In embryos prior to the 30-cell stage, neither DPY-27 nor H4K20me1 was concentrated in any subnuclear region (Figure 2A). However, we observed that nuclear staining of H4K20me1 increased dramatically durin ...
515-527 - CiteSeerX
... particular whorl specifies the type of organ that develops in that whorl, e.g., A class alone specifies sepals, classes A + Β specify petals, classes Β + C specify stamens, and C class alone specifies carpels; and (iii) the class A and class C activities are mutually antagonistic such that loss of A ...
... particular whorl specifies the type of organ that develops in that whorl, e.g., A class alone specifies sepals, classes A + Β specify petals, classes Β + C specify stamens, and C class alone specifies carpels; and (iii) the class A and class C activities are mutually antagonistic such that loss of A ...
LIMIX: genetic analysis of multiple traits
... Supplementary Figure 2). As expected from previous results for single trait LMMs [9], accounting for hidden confounding increased power in multiple trait LMMs. Moreover, the observed power increase was even marginally larger in the multiple trait case than in the single trait case (Figure 2a; see Su ...
... Supplementary Figure 2). As expected from previous results for single trait LMMs [9], accounting for hidden confounding increased power in multiple trait LMMs. Moreover, the observed power increase was even marginally larger in the multiple trait case than in the single trait case (Figure 2a; see Su ...
DRACULA2 is a dynamic nucleoporin with a role in
... trafficking between the cytoplasm and the nucleus. Despite structural differences, there are conserved functional similarities between NPCs from plants and other organisms (Raices and D’Angelo, 2012; Parry, 2013; Tamura and Hara-Nishimura, 2013). The NPC consists of multiple copies of at least 30 di ...
... trafficking between the cytoplasm and the nucleus. Despite structural differences, there are conserved functional similarities between NPCs from plants and other organisms (Raices and D’Angelo, 2012; Parry, 2013; Tamura and Hara-Nishimura, 2013). The NPC consists of multiple copies of at least 30 di ...
C.W. Cunningham 2004
... well understood (Hoeh et al. 1997; Saavedra et al. 1997; Ladoukakis and Zouros 2001). In this study, we focus on the ‘‘standard’’ M-mtDNA, which is easily distinguished from F-mtDNA at the DNA sequence level. For the remainder of this paper, M-mtDNA will refer to ‘‘standard’’ M-mtDNA. An important c ...
... well understood (Hoeh et al. 1997; Saavedra et al. 1997; Ladoukakis and Zouros 2001). In this study, we focus on the ‘‘standard’’ M-mtDNA, which is easily distinguished from F-mtDNA at the DNA sequence level. For the remainder of this paper, M-mtDNA will refer to ‘‘standard’’ M-mtDNA. An important c ...
Molecular Evolution of the Endosperm Starch Synthesis Pathway
... Only samples with less than 50-bp missing data were included in the analyses. The missing data are due to the heterozygosity of indels in some samples or to various other reasons during the sequencing process. Therefore, slightly different sample set were used for different starch genes. Statistics ...
... Only samples with less than 50-bp missing data were included in the analyses. The missing data are due to the heterozygosity of indels in some samples or to various other reasons during the sequencing process. Therefore, slightly different sample set were used for different starch genes. Statistics ...
IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS)
... which can be differentiate from other Aeromonas sp. as it can produce gas from glucose but does not hydrolyze esculin [12], whereas, other Aeromonas sp. produce gas from glucose and hydrolyze esculin. Similar identification protocols for identification of Aeromonas sp. were also followed by other re ...
... which can be differentiate from other Aeromonas sp. as it can produce gas from glucose but does not hydrolyze esculin [12], whereas, other Aeromonas sp. produce gas from glucose and hydrolyze esculin. Similar identification protocols for identification of Aeromonas sp. were also followed by other re ...
The Evolutionary Dynamics of Digital and Nucleotide Codes: A
... of menus. Adaptation can also be achieved by random processes using a computerized search strategy consisting of repeated cycles of random variation of control parameters or (de)activation of program modules followed by selection of a combination of advantageous parameters or modules, until an optim ...
... of menus. Adaptation can also be achieved by random processes using a computerized search strategy consisting of repeated cycles of random variation of control parameters or (de)activation of program modules followed by selection of a combination of advantageous parameters or modules, until an optim ...
Wright, Sewall Evolution in Mendelian populations. Genetics, 16:97
... a stock beyond the original limits of variation. This effectiveness turned out to depend not so much on variability of the principal genes concerned as on residual heredity. As genetic studies continued, ever smaller differences were found to mendelize, and any character, sufficiently investigated, ...
... a stock beyond the original limits of variation. This effectiveness turned out to depend not so much on variability of the principal genes concerned as on residual heredity. As genetic studies continued, ever smaller differences were found to mendelize, and any character, sufficiently investigated, ...
Analysis of 16S ribosomal RNA gene segments for the diagnosis of
... sequence library. The process has been done by using broad-range PCR primers (universal primers) to recognize conserved sequences in a variety of bacteria, while amplifying highly variable regions between the primer binding sites. The amplified segment is sequenced and compared with known databases ...
... sequence library. The process has been done by using broad-range PCR primers (universal primers) to recognize conserved sequences in a variety of bacteria, while amplifying highly variable regions between the primer binding sites. The amplified segment is sequenced and compared with known databases ...
Scientist finds the gene that determines major sensitivity to bitter taste
... around the world who are non-tasters descended from a common ancestor who emerged from Africa far back in prehistory. Human DNA sequences are overwhelmingly similar, with some small, but sometimes important differences. For example, variations in DNA sequence can have a major impact on how humans re ...
... around the world who are non-tasters descended from a common ancestor who emerged from Africa far back in prehistory. Human DNA sequences are overwhelmingly similar, with some small, but sometimes important differences. For example, variations in DNA sequence can have a major impact on how humans re ...
Biosynthesis of the Antibiotic Nonribosomal Peptide Penicillin in
... efficient expression and subcellular localisation, we here engineer the baker’s yeast Saccharomyces cerevisiae to produce and secrete the antibiotic penicillin, a betalactam nonribosomal peptide. Using synthetic biology tools combined with long-read DNA sequencing, we optimise productivity by 50-fol ...
... efficient expression and subcellular localisation, we here engineer the baker’s yeast Saccharomyces cerevisiae to produce and secrete the antibiotic penicillin, a betalactam nonribosomal peptide. Using synthetic biology tools combined with long-read DNA sequencing, we optimise productivity by 50-fol ...
Primary ciliary dyskinesia: genes, candidate genes
... mutations of as many as 250 different genes coding for various ciliary proteins cause the same or similar pathologic consequences of the ciliary dysfunction. If that was true, one might expect the incidence of PCD to be much higher than actually reported (McKusick 2002). It is possible that many cil ...
... mutations of as many as 250 different genes coding for various ciliary proteins cause the same or similar pathologic consequences of the ciliary dysfunction. If that was true, one might expect the incidence of PCD to be much higher than actually reported (McKusick 2002). It is possible that many cil ...
Article The Effect of Selection Environment on the
... the expected negative relationship between distance to the optimum and the degree of parallelism (Gresham et al. 2008), whereas another observed no evidence of a relationship (Kryazhimskiy et al. 2014). Now, imagine the population inhabits a spatially heterogeneous environment composed of many diffe ...
... the expected negative relationship between distance to the optimum and the degree of parallelism (Gresham et al. 2008), whereas another observed no evidence of a relationship (Kryazhimskiy et al. 2014). Now, imagine the population inhabits a spatially heterogeneous environment composed of many diffe ...
genetic and metabolic testing of children with global developmental
... the fetus from alcohol the pregnant woman consumes. In some cases GDD develops soon after birth. This typically happens because of serious medical problems related to a premature (early) birth. This evidence report focuses on GDD caused by genetic and metabolic disorders. Genetic disorders involve p ...
... the fetus from alcohol the pregnant woman consumes. In some cases GDD develops soon after birth. This typically happens because of serious medical problems related to a premature (early) birth. This evidence report focuses on GDD caused by genetic and metabolic disorders. Genetic disorders involve p ...
The Advantage and Application of Genetically Humanized Mouse
... cDNA was placed under control of a small heterologous promoter to drive ubiquitous or tissue-specific transgene expression and inserted randomly into the genome. Alternatively, cDNA containing the human transgene and small promoter fragment can be targeted to a specific location within the genome. S ...
... cDNA was placed under control of a small heterologous promoter to drive ubiquitous or tissue-specific transgene expression and inserted randomly into the genome. Alternatively, cDNA containing the human transgene and small promoter fragment can be targeted to a specific location within the genome. S ...
Nucleotide Sequence and Organization of the Rat Heme Oxygenase
... Lane I, the protected fragmentswith spleen RNA, andlane 2, control quence several times using different subclones. Interestingly, the same deviation of donor sequences was reported in four sample with yeast tRNA. other examples: chick (38) and duck aD-globin genes (39), murine a*-crystallin gene (40 ...
... Lane I, the protected fragmentswith spleen RNA, andlane 2, control quence several times using different subclones. Interestingly, the same deviation of donor sequences was reported in four sample with yeast tRNA. other examples: chick (38) and duck aD-globin genes (39), murine a*-crystallin gene (40 ...
Heliconius wing patterns: an evo-devo model for understanding
... Initially, the observation that adaptive variation in wing patterns in Heliconius was the result of a small number of major ‘switch’ loci was thought to be an unusual artefact of Müllerian mimicry selection, where the adaptive landscape was envisioned to be more rugged than that for most adaptive t ...
... Initially, the observation that adaptive variation in wing patterns in Heliconius was the result of a small number of major ‘switch’ loci was thought to be an unusual artefact of Müllerian mimicry selection, where the adaptive landscape was envisioned to be more rugged than that for most adaptive t ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.