BIOINFORMATICS
... expression data for DLBCL and FL cases which were obtained by using different Affymetrix chips (HuGeneFL chip for WI dataset and Hu95Av2 for the CU dataset). We also show that one can combine the two datasets into a single meta-dataset, while maintaining the accuracy of predictions. To address the p ...
... expression data for DLBCL and FL cases which were obtained by using different Affymetrix chips (HuGeneFL chip for WI dataset and Hu95Av2 for the CU dataset). We also show that one can combine the two datasets into a single meta-dataset, while maintaining the accuracy of predictions. To address the p ...
Mutations in SIN4 and RGR1 Cause Constitutive Expression of MAL
... MAL61promoter-lacZ reporter using the standard -galactosidase plate assay and MAL12 expression by assaying maltase activity levels in galactose-grown cells. Cloning of wild-type alleles of a mutant gene in strains CM-31 and CM-33: Constitutive mutants CM-31 and CM-33 were chosen as representatives ...
... MAL61promoter-lacZ reporter using the standard -galactosidase plate assay and MAL12 expression by assaying maltase activity levels in galactose-grown cells. Cloning of wild-type alleles of a mutant gene in strains CM-31 and CM-33: Constitutive mutants CM-31 and CM-33 were chosen as representatives ...
chapter thirteen
... The number of combinations possible when chromosomes assort independently into gametes is 2n, where n is the haploid number of the organism. If n = 3, there are 23 = 8 possible combinations. For humans with n = 23, there are 223, or more than 8 million possible combinations of chromosomes. ...
... The number of combinations possible when chromosomes assort independently into gametes is 2n, where n is the haploid number of the organism. If n = 3, there are 23 = 8 possible combinations. For humans with n = 23, there are 223, or more than 8 million possible combinations of chromosomes. ...
Insulin gene polymorphism and premature male pattern baldness in
... investigate the possibility of functional mutations elsewhere in the INS gene. The FokI and PstI RFLPs were in strong allelic association but were not associated with MPB in our population. Our interest in the INS gene arose because of reported genetic linkage with PCOS. PCOS is reportedly one of th ...
... investigate the possibility of functional mutations elsewhere in the INS gene. The FokI and PstI RFLPs were in strong allelic association but were not associated with MPB in our population. Our interest in the INS gene arose because of reported genetic linkage with PCOS. PCOS is reportedly one of th ...
Oligogenic basis of isolated gonadotropin
... raditionally, deleterious rare variants—DNA sequence variations with minor allele frequency (MAF) <1% in the general population—have been incriminated as causes of rare genetic diseases in which each patient harbors mutations in a single gene (monogenic diseases) (1). An important paradigm shift in ...
... raditionally, deleterious rare variants—DNA sequence variations with minor allele frequency (MAF) <1% in the general population—have been incriminated as causes of rare genetic diseases in which each patient harbors mutations in a single gene (monogenic diseases) (1). An important paradigm shift in ...
Meiosis: vive la difference! Peter Shaw* and Graham Moore
... and yeast [15•], the chromosomes are in a Rabl configuration prior to meiosis, that is, with the centromeres clustered at one pole and telomeres spread around the other pole. This is not absolutely required for meiosis, however, as other species, such as mouse and human, do not display a clear Rabl ...
... and yeast [15•], the chromosomes are in a Rabl configuration prior to meiosis, that is, with the centromeres clustered at one pole and telomeres spread around the other pole. This is not absolutely required for meiosis, however, as other species, such as mouse and human, do not display a clear Rabl ...
Loss of Function but No Gain of Function Caused by
... determined by the so-called homeotic code (2, 10). The numerous Hox gene inactivations performed to date further support the notion that some of these genes also contribute to patterning the proximodistal axis of the limbs, are involved in several steps of organogenesis, and may fulfill specific rol ...
... determined by the so-called homeotic code (2, 10). The numerous Hox gene inactivations performed to date further support the notion that some of these genes also contribute to patterning the proximodistal axis of the limbs, are involved in several steps of organogenesis, and may fulfill specific rol ...
The p53 Protein: From Cell Regulation to Cancer
... I. The Structure and Functions of the p53 Protein. This section (chapters by Aylon and Oren, Chillemi et al., Joruiz and Bourdon, Raj and Attardi, Pfister and Prives, and Aubrey et al.) elucidates and updates new and fundamental observations made over the past few years. II. The Regulation of Cellul ...
... I. The Structure and Functions of the p53 Protein. This section (chapters by Aylon and Oren, Chillemi et al., Joruiz and Bourdon, Raj and Attardi, Pfister and Prives, and Aubrey et al.) elucidates and updates new and fundamental observations made over the past few years. II. The Regulation of Cellul ...
Document
... genes which results in chromosomes that consist of segments from one homolog intermixed with segments from the other • In the first nuclear division, the homologous chromosomes are separated from each other, one member of each pair going to opposite poles of the ...
... genes which results in chromosomes that consist of segments from one homolog intermixed with segments from the other • In the first nuclear division, the homologous chromosomes are separated from each other, one member of each pair going to opposite poles of the ...
C-Collate3 740..903
... and readily accessed within seconds, and neatly so that at other times the 46 chromosomes can be easily removed from the boat. With this perspective, the mechanisms by which DNA is organized within the cell nucleus now appear impressive and complex. Abundant, structural chromosomal proteins must bin ...
... and readily accessed within seconds, and neatly so that at other times the 46 chromosomes can be easily removed from the boat. With this perspective, the mechanisms by which DNA is organized within the cell nucleus now appear impressive and complex. Abundant, structural chromosomal proteins must bin ...
Disruption of bacterial quorum sensing by other organisms
... specifically inhibited AHL-regulated behaviors in a variety of Gram-negative bacteria [8]. Thus, the furanones appear to mimic the AHL signals of these bacteria, and most likely do so by binding to the AHL receptor proteins [9]. The furanone QS signal-mimics of Delisea appear to have potent effects ...
... specifically inhibited AHL-regulated behaviors in a variety of Gram-negative bacteria [8]. Thus, the furanones appear to mimic the AHL signals of these bacteria, and most likely do so by binding to the AHL receptor proteins [9]. The furanone QS signal-mimics of Delisea appear to have potent effects ...
Genetics Review Problems
... P = purple, pp = white. The offspring of a cross between two heterozygous purple-flowering plants (Pp Pp) results in a. all purple-flowered plants. b. purple-flowered plants and white-flowered plants. c. two types of white-flowered plants: PP and Pp. d. all white-flowered plants. e. all pink-flowere ...
... P = purple, pp = white. The offspring of a cross between two heterozygous purple-flowering plants (Pp Pp) results in a. all purple-flowered plants. b. purple-flowered plants and white-flowered plants. c. two types of white-flowered plants: PP and Pp. d. all white-flowered plants. e. all pink-flowere ...
Multifactorial Traits - U
... of many genes often produces a continuum of the phenotype, which is called a continuously varying or quantitative trait. The parts of chromosomes that contribute to polygenic traits are therefore called quantitative trait loci, or QTLs. A multifactorial trait is continuously varying only if it is al ...
... of many genes often produces a continuum of the phenotype, which is called a continuously varying or quantitative trait. The parts of chromosomes that contribute to polygenic traits are therefore called quantitative trait loci, or QTLs. A multifactorial trait is continuously varying only if it is al ...
Heredity + Nucleic Acids
... Discovering how nucleic acids store genetic information To follow the historical pathway that led to our understanding of how heredity works, we have to start back at the cell. As it became more firmly established that all organisms were composed of cells, and all cells were derived from pre-existi ...
... Discovering how nucleic acids store genetic information To follow the historical pathway that led to our understanding of how heredity works, we have to start back at the cell. As it became more firmly established that all organisms were composed of cells, and all cells were derived from pre-existi ...
Contrasting Effects of ENU Induced Embryonic Lethal Mutations of
... (U44942) and includes the ATG start codon and 730 bases of the first intron. We have identified six exons common to all transcripts, and all five of the internal exons are flanked by recognizable splice sites (see AJ012812–AJ012816). PCR amplification from genomic DNA verifies that all introns are a ...
... (U44942) and includes the ATG start codon and 730 bases of the first intron. We have identified six exons common to all transcripts, and all five of the internal exons are flanked by recognizable splice sites (see AJ012812–AJ012816). PCR amplification from genomic DNA verifies that all introns are a ...
Package `acde` - USTC Open Source Software Mirror
... Description This package provides a multivariate inferential analysis method for detecting differentially expressed genes in gene expression data. It uses artificial components, close to the data's principal components but with an exact interpretation in terms of differential genetic expression, to ...
... Description This package provides a multivariate inferential analysis method for detecting differentially expressed genes in gene expression data. It uses artificial components, close to the data's principal components but with an exact interpretation in terms of differential genetic expression, to ...
Gene Expression in Prokaryotes
... An operon can be defined as a cluster gene that encode the proteins necessary to perform coordinated function Genes of the same operon have related functions within the cell and are turned on (expressed) and off together (suppressed). The first operon discovered was the lac operon so named because i ...
... An operon can be defined as a cluster gene that encode the proteins necessary to perform coordinated function Genes of the same operon have related functions within the cell and are turned on (expressed) and off together (suppressed). The first operon discovered was the lac operon so named because i ...
Using articles to explain possible causes of genetic
... A disease called “lobster claw hand” 2. The mutation that is caused ESR There are five different genetic mutations associated with it Mutation on chromosome 7 in a region that contains two homeobox genes 3. The cause of the mutation ESR DNA building mistake Inherited 4. The affect of the m ...
... A disease called “lobster claw hand” 2. The mutation that is caused ESR There are five different genetic mutations associated with it Mutation on chromosome 7 in a region that contains two homeobox genes 3. The cause of the mutation ESR DNA building mistake Inherited 4. The affect of the m ...
Har Gobind Khorana
... literature, Khorana wanted to do postdoctoral research in a German-speaking country. So he went to the Swiss Federal Institute of Technology (ETH) in Zurich, where he worked for 11 months on alkaloid chemistry with Vladimir Prelog. His stay was short — he received no stipend and had to sustain himse ...
... literature, Khorana wanted to do postdoctoral research in a German-speaking country. So he went to the Swiss Federal Institute of Technology (ETH) in Zurich, where he worked for 11 months on alkaloid chemistry with Vladimir Prelog. His stay was short — he received no stipend and had to sustain himse ...
Genes involved in ovulation rate and litter size in sheep
... Follicle development includes a series of stages and takes place in the ovaries. Follicles contain oocytes, or egg cells, that are the haploid female reproductive gametes and are surrounded by epithelial cells. Development of follicles and the process of ovulation are influenced by endocrine factors ...
... Follicle development includes a series of stages and takes place in the ovaries. Follicles contain oocytes, or egg cells, that are the haploid female reproductive gametes and are surrounded by epithelial cells. Development of follicles and the process of ovulation are influenced by endocrine factors ...
What is the Gene Trying to Do?
... the theorem ignores the existence of two sexes and assumes that the fitness of any genotype is a fixed constant (and is not, for example, frequency-dependent) which remains unchanged from generation to generation. Only viability fitnesses are considered. The FTNS also assumes in effect an infinitely lar ...
... the theorem ignores the existence of two sexes and assumes that the fitness of any genotype is a fixed constant (and is not, for example, frequency-dependent) which remains unchanged from generation to generation. Only viability fitnesses are considered. The FTNS also assumes in effect an infinitely lar ...
Poster: Litter size in Norwegian White Sheep
... ewes older than six years was discarded. The mean litter size in 2015 was 2.33. One year old ewes had the lowest mean (1.88), increasing the second year (to 2.29), while older ewes had the highest mean (2.59). Twins are the most frequent litter size for one year old ewes, while triplets are slightly ...
... ewes older than six years was discarded. The mean litter size in 2015 was 2.33. One year old ewes had the lowest mean (1.88), increasing the second year (to 2.29), while older ewes had the highest mean (2.59). Twins are the most frequent litter size for one year old ewes, while triplets are slightly ...
EUMORPHIA Understanding human molecular physiology and
... genes i.e. alleles of existing mutations for which the gene may or may not have been characterised ...
... genes i.e. alleles of existing mutations for which the gene may or may not have been characterised ...
Visualization with the Integrative Genomics Viewer (IGV)
... For the (gray) coverage track: this track should always be available once a BAM file is loaded on IGV (if not, right click on the BAM track and select “Show coverage track”). It gives at every position the number of alignments covering the base and if you hover over a specific position you’ll have t ...
... For the (gray) coverage track: this track should always be available once a BAM file is loaded on IGV (if not, right click on the BAM track and select “Show coverage track”). It gives at every position the number of alignments covering the base and if you hover over a specific position you’ll have t ...
Genetic analysis of a congenital nephrogenic diabetes insipidus
... patients were delayed to diagnosis in their adults. In the present study, the 33-year-old proband and his brother had the characteristics of congenital diabetes insipidus such as persistent polyuria, repeat fever from their infancy. The proband’s mother and daughter had negative clinical manifestati ...
... patients were delayed to diagnosis in their adults. In the present study, the 33-year-old proband and his brother had the characteristics of congenital diabetes insipidus such as persistent polyuria, repeat fever from their infancy. The proband’s mother and daughter had negative clinical manifestati ...
Genome evolution
Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.