How elephants beat cancer
... have this significantly reduced risk of cancer by replicating the tumor suppressor gene TP53. Whales appear to have evolved other solutions, which remain unknown. This model and figure are adapted from Caulin and Maley ...
... have this significantly reduced risk of cancer by replicating the tumor suppressor gene TP53. Whales appear to have evolved other solutions, which remain unknown. This model and figure are adapted from Caulin and Maley ...
The Cell Cycle Stages of the cell cycle
... •Some of these are growth factors that activate receptor tyrosine kinases (RTK proteins). This initiates a signal cascade that affects the configuration of many different transcription factors, affecting the gene activity in the cell •apoptosis positive controls: leakage of cytochrome c from defecti ...
... •Some of these are growth factors that activate receptor tyrosine kinases (RTK proteins). This initiates a signal cascade that affects the configuration of many different transcription factors, affecting the gene activity in the cell •apoptosis positive controls: leakage of cytochrome c from defecti ...
Transcriptional Functionality of Germ Line p53 Mutants Influences
... Purpose: The TP53 tumor suppressor gene encodes a sequence-specific transcription factor that is able to transactivate several sets of genes, the promoters of which include appropriate response elements. Although human cancers frequently contain mutated p53, the alleles as well as the clinical expre ...
... Purpose: The TP53 tumor suppressor gene encodes a sequence-specific transcription factor that is able to transactivate several sets of genes, the promoters of which include appropriate response elements. Although human cancers frequently contain mutated p53, the alleles as well as the clinical expre ...
Translational Repression of C. elegans p53 by GLD
... 2003; Vassilev et al., 2004). Such a therapeutic approach highlights the need to uncover additional pathways and mechanisms that negatively regulate p53 levels or activity. Most studies on p53 signaling have been conducted in cell culture-based systems, and their translation into mouse models is oft ...
... 2003; Vassilev et al., 2004). Such a therapeutic approach highlights the need to uncover additional pathways and mechanisms that negatively regulate p53 levels or activity. Most studies on p53 signaling have been conducted in cell culture-based systems, and their translation into mouse models is oft ...
Erdal, Hamdiye et al. (2005) Proc. Natl. Acad. Sci. USA 102, 192
... family (includes ATM (ataxia telangiectasia mutated), DNA-PK, and ATR (ataxia telangectasia Rad 3 related))causing activation of a checkpoint and phosphorylation of p53. ...
... family (includes ATM (ataxia telangiectasia mutated), DNA-PK, and ATR (ataxia telangectasia Rad 3 related))causing activation of a checkpoint and phosphorylation of p53. ...
Leukaemia Section del(17p) in myeloïd malignancies Atlas of Genetics and Cytogenetics
... cytogenetic anomaly consisting of a deletion of the short arm of chromosome 17), and a particular form of morphological dysgranulopoiesis, we also found in such cases a strong correlation between 17p deletion and p53 mutation; these correlations suggest that ANLL and MDS with 17p deletion constitute ...
... cytogenetic anomaly consisting of a deletion of the short arm of chromosome 17), and a particular form of morphological dysgranulopoiesis, we also found in such cases a strong correlation between 17p deletion and p53 mutation; these correlations suggest that ANLL and MDS with 17p deletion constitute ...
Np73 is capable of inducing apoptosis by co
... N isoforms, lacking the TA domain but harbouring a DNAbinding domain and an oligomerization domain (OD), act as dominant negatives of the TA isoforms, binding to them and competing for the binding sites, but impairing transactivation. Thus, by interfering the proapoptotic and cell cycle regulatory ...
... N isoforms, lacking the TA domain but harbouring a DNAbinding domain and an oligomerization domain (OD), act as dominant negatives of the TA isoforms, binding to them and competing for the binding sites, but impairing transactivation. Thus, by interfering the proapoptotic and cell cycle regulatory ...
Expression of p53 Target Genes in the Early Phase of Long
... a rate of 2 mL/min with fresh, oxygenated ACSF at room temperature (22–24∘ C) for 30 min; then the perfusion rate was reduced to 1.5 mL/min, and the temperature was raised to 32-33∘ C. For extracellular recordings, the recording electrode, which was filled with ACSF, was placed in the CA1 pyramidal ...
... a rate of 2 mL/min with fresh, oxygenated ACSF at room temperature (22–24∘ C) for 30 min; then the perfusion rate was reduced to 1.5 mL/min, and the temperature was raised to 32-33∘ C. For extracellular recordings, the recording electrode, which was filled with ACSF, was placed in the CA1 pyramidal ...
Estrogen receptor prevents p53-dependent apoptosis in breast cancer
... lthough breast cancer is often curable when it is treated at an early stage, metastatic disease is almost uniformly fatal due to the development of therapeutic resistance (1). Approximately twothirds of all breast cancer cases are attributed to the dysregulation of estrogen receptor (ER) signaling ( ...
... lthough breast cancer is often curable when it is treated at an early stage, metastatic disease is almost uniformly fatal due to the development of therapeutic resistance (1). Approximately twothirds of all breast cancer cases are attributed to the dysregulation of estrogen receptor (ER) signaling ( ...
Winata et al - Merit Research Journals
... stage (Marcus et al., 2010). In this research we not found any relationship between the expression of p53 with staging of ovarian cancer, possibly because carcinogenesis of ovarian cancer are multistep, where various lines of carcinogenesis played an important role in determining the occurrence of o ...
... stage (Marcus et al., 2010). In this research we not found any relationship between the expression of p53 with staging of ovarian cancer, possibly because carcinogenesis of ovarian cancer are multistep, where various lines of carcinogenesis played an important role in determining the occurrence of o ...
Metallothionein functions and structural characteristics
... pathological disorders, including neurodegenerative diseases [22] and senescence [23]; it is not surprising that MT expression varies extensively in several diseases. Neurodegenerative diseases: Cu(II)-binding amyloid-b peptides and the production of ROS have been reported to play a significant role ...
... pathological disorders, including neurodegenerative diseases [22] and senescence [23]; it is not surprising that MT expression varies extensively in several diseases. Neurodegenerative diseases: Cu(II)-binding amyloid-b peptides and the production of ROS have been reported to play a significant role ...
APOPTOSIS: An overview
... Amyloid β can exert neurotoxic effects by generation of intracellular oxidative stress increases in calcium ions ...
... Amyloid β can exert neurotoxic effects by generation of intracellular oxidative stress increases in calcium ions ...
BRCA2 and p53 Mutations in Primary Breast
... only three had p53 mutations, and there was one additional case of p53 overexpression. Soboi et al. (16) suggest that specific mutations in the BRCAI gene are more often associated with p53 abnormalities as meas ured by abnormal staining. Because all of the BRCA2 mutation carriers in our study have ...
... only three had p53 mutations, and there was one additional case of p53 overexpression. Soboi et al. (16) suggest that specific mutations in the BRCAI gene are more often associated with p53 abnormalities as meas ured by abnormal staining. Because all of the BRCA2 mutation carriers in our study have ...
Access Presentation
... – Prevents it from binding p53 – Sequesters it in nucleolus • p53 escapes ubiquitylation, can rise to high cellular levels ...
... – Prevents it from binding p53 – Sequesters it in nucleolus • p53 escapes ubiquitylation, can rise to high cellular levels ...
A Mammalian Cell Cycle Checkpoint Pathway - Wafik S. El
... induction of GADD45 is dependent on a wild-type p53 phenotype, a conserved p53-binding site was identified in the human and hamster GAD045 genes and binding of p53 protein to this sequence was evaluated. Based on the results of these investigations, a model for the steps in this DNA damage-inducible ...
... induction of GADD45 is dependent on a wild-type p53 phenotype, a conserved p53-binding site was identified in the human and hamster GAD045 genes and binding of p53 protein to this sequence was evaluated. Based on the results of these investigations, a model for the steps in this DNA damage-inducible ...
Role of the p53 Tumor Suppressor Gene in Cell Cycle Arrest and
... was to determine whether the presence of a normal p53 gene was essential for cell cycle arrest in G, following DNA damage and whether the functional status of the p53 gene product would correlate with the sensitivity of cells to ionizing radiation. The ability of cells to arrest in G, following radi ...
... was to determine whether the presence of a normal p53 gene was essential for cell cycle arrest in G, following DNA damage and whether the functional status of the p53 gene product would correlate with the sensitivity of cells to ionizing radiation. The ability of cells to arrest in G, following radi ...
The Role of TP53 in Cervical Carcinogenesis
... efficient way is to mediate the degradation of this cellular protein via the ubiquitin pathway, which is an exclusive property of E6s from the high-risk HPV types. In addition, E6 is able to alter the transcriptional activity of p53 by distinct mechanisms, either by direct association with the C ter ...
... efficient way is to mediate the degradation of this cellular protein via the ubiquitin pathway, which is an exclusive property of E6s from the high-risk HPV types. In addition, E6 is able to alter the transcriptional activity of p53 by distinct mechanisms, either by direct association with the C ter ...
Cytoplasmic sequestration of the tumor suppressor p53 by a heat
... With nuclear and cytoplasmic protein fractions successfully separated, mortalin was detected exclusively in the cytoplasmic fractions of all the colorectal carcinoma cell lines while p53 was detected in the cytoplasmic fraction of six of the eight cell lines. Exceptions were the cytoplasmic fraction ...
... With nuclear and cytoplasmic protein fractions successfully separated, mortalin was detected exclusively in the cytoplasmic fractions of all the colorectal carcinoma cell lines while p53 was detected in the cytoplasmic fraction of six of the eight cell lines. Exceptions were the cytoplasmic fraction ...
Materials and Methods
... irradiation. Compared to non-irradiated cells (a−c), a single dose of 5 Gy induces many apoptotic cells (d−f) that show characteristic nuclear condensation upon DAPI (e), and are also positive for TUNEL (f). A single dose of 5 Gy induces a significant increase in the number of apoptotic cells in neu ...
... irradiation. Compared to non-irradiated cells (a−c), a single dose of 5 Gy induces many apoptotic cells (d−f) that show characteristic nuclear condensation upon DAPI (e), and are also positive for TUNEL (f). A single dose of 5 Gy induces a significant increase in the number of apoptotic cells in neu ...
Modulation of the ARF-p53 Pathway by the Small DNA Tumor Viruses
... proliferation, RB is inactivated by a series of phosphorylation events, mediated in a staged and tightly regulated manner, by cyclin dependent kinase (cdk) complexes.18 The small DNA viruses infect quiescent cells, but unlike DNA viruses with larger genomes, have a limited genetic capacity, and do n ...
... proliferation, RB is inactivated by a series of phosphorylation events, mediated in a staged and tightly regulated manner, by cyclin dependent kinase (cdk) complexes.18 The small DNA viruses infect quiescent cells, but unlike DNA viruses with larger genomes, have a limited genetic capacity, and do n ...
What is p53
... the term "p53" appears in the title! This massive interest in a single protein is almost unprecedented and reflects the central place of p53 in the regulation of cell number and the frequency with which abnormalities of p53 occur in human tumours. p53 has been named Molecule of the Year by the edito ...
... the term "p53" appears in the title! This massive interest in a single protein is almost unprecedented and reflects the central place of p53 in the regulation of cell number and the frequency with which abnormalities of p53 occur in human tumours. p53 has been named Molecule of the Year by the edito ...
1. dia
... http://www.genome.jp/aaindex A number is associated with every amino acid, which quantitatively describes how characteristic the given feature is to the AA (has 517 different scales at present) ...
... http://www.genome.jp/aaindex A number is associated with every amino acid, which quantitatively describes how characteristic the given feature is to the AA (has 517 different scales at present) ...
Other Support (DOC)
... change since the last reporting period. Provide only active support for all new senior/key personnel. Provide updated other supported for all senior/key personnel for whom there has been a change in other support. If a previously active grant has terminated and/or if a previously pending grant is no ...
... change since the last reporting period. Provide only active support for all new senior/key personnel. Provide updated other supported for all senior/key personnel for whom there has been a change in other support. If a previously active grant has terminated and/or if a previously pending grant is no ...
Selective Mutation of Codons 204 and 213 of the
... clarified whether these double mutations are present in the an inactivation of thep53 gene in one alÃ-elebut a normal (wildsame tumor cell population or whether there are different type) sequence in the other. In the present study, sequencing neoplastic cell types containing point mutations at eithe ...
... clarified whether these double mutations are present in the an inactivation of thep53 gene in one alÃ-elebut a normal (wildsame tumor cell population or whether there are different type) sequence in the other. In the present study, sequencing neoplastic cell types containing point mutations at eithe ...
P53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. As such, p53 has been described as ""the guardian of the genome"" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.The name p53 was given in 1979 describing the apparent molecular mass; SDS-PAGE analysis indicates that it is a 53-kilodalton (kDa) protein. In addition to the full length protein, the human TP53 gene encodes at least 15 protein isoforms, ranging in size from 3.5 to 53 kDa. All these p53 proteins are called the p53 isoforms.The International Cancer Genome Consortium has established that the TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation.TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome.