The Role of Patched in Basal Cell Carcinoma
... Patch is a key suppressor in the SHH pathway and essential for embryonic growth Patch directly regulates cell cycle progression Basal cell carcinoma is the most common type of cancer Patch can still be present and cause BCC Other mutations in the SHH pathway along with decreased expression of Patch ...
... Patch is a key suppressor in the SHH pathway and essential for embryonic growth Patch directly regulates cell cycle progression Basal cell carcinoma is the most common type of cancer Patch can still be present and cause BCC Other mutations in the SHH pathway along with decreased expression of Patch ...
• Cell proliferation • Cell specialization • Cell interactions • Cell
... Gallus gallus (Chick) Limb Development-Retinoic Acid and Sonic Hedgehog (SHH) To the left is a chick embryo (sans shell) with normal wing development. Courtesy of Dr. Fallon, Univ. of Wisconsin ...
... Gallus gallus (Chick) Limb Development-Retinoic Acid and Sonic Hedgehog (SHH) To the left is a chick embryo (sans shell) with normal wing development. Courtesy of Dr. Fallon, Univ. of Wisconsin ...
• Cell proliferation • Cell specialization • Cell interactions • Cell
... Gallus gallus (Chick) Limb Development-Retinoic Acid and Sonic Hedgehog (SHH) To the left is a chick embryo (sans shell) with normal wing development. Courtesy of Dr. Fallon, Univ. of Wisconsin ...
... Gallus gallus (Chick) Limb Development-Retinoic Acid and Sonic Hedgehog (SHH) To the left is a chick embryo (sans shell) with normal wing development. Courtesy of Dr. Fallon, Univ. of Wisconsin ...
What are the phases of prenatal neurodevelopment?
... and proliferate. The anterior end of the neural tube ultimately develops into the forebrain, midbrain, and hindbrain. The posterior end of the neural tube ultimately develops into the cerebral ventricles and central canal of the spinal cord. ...
... and proliferate. The anterior end of the neural tube ultimately develops into the forebrain, midbrain, and hindbrain. The posterior end of the neural tube ultimately develops into the cerebral ventricles and central canal of the spinal cord. ...
Basic Science for Clinicians
... Especially interesting to the scope of this review is the involvement of Hh in the morphogenesis of the heart and blood vessels. A clue to this involvement was the ability of Shh to induce vascular endothelial growth factor and angiopoietins in human fibroblasts,30 but a more definite answer came fr ...
... Especially interesting to the scope of this review is the involvement of Hh in the morphogenesis of the heart and blood vessels. A clue to this involvement was the ability of Shh to induce vascular endothelial growth factor and angiopoietins in human fibroblasts,30 but a more definite answer came fr ...
Rohatgi Lab - Stanford Biochemistry
... Background Developmental signaling pathways, initially studied for their roles in embryogenesis, have been implicated in adult organ regeneration, stem-cell function, and cancer. Our long term goal is to understand the spatial, temporal, and biochemical regulation of these pathways as a step towards ...
... Background Developmental signaling pathways, initially studied for their roles in embryogenesis, have been implicated in adult organ regeneration, stem-cell function, and cancer. Our long term goal is to understand the spatial, temporal, and biochemical regulation of these pathways as a step towards ...
Chapter 10 Genetics
... The process by which ordered spatial arrangements of differentiated cells create tissues and organs is called pattern formation. Regional specification takes place in several steps: definition of the cells of a region, establishment of signaling centers that provide positional information, and diffe ...
... The process by which ordered spatial arrangements of differentiated cells create tissues and organs is called pattern formation. Regional specification takes place in several steps: definition of the cells of a region, establishment of signaling centers that provide positional information, and diffe ...
The Sonic Hedgehog
... caused by sun exposure, specifically UVB rays • These rays cause mutations in DNA including deletions and substitutions ...
... caused by sun exposure, specifically UVB rays • These rays cause mutations in DNA including deletions and substitutions ...
Caspary T, Garc a-Garc a MJ, Eggenschwiler JR, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Alcorn HL, Anderson KV. Curr Biol. 2002 Sep 17;12(18):1628-32. Mouse Dispatched homologue1 is required for long-range, but not juxtacrine, Hh signaling.
... Chromosome 6 (Figure 1). This region included the mouse Smo gene, and a targeted null allele of mouse Smo causes a phenotype very similar to that of bnb [4]. Smo is a membrane protein that is required for the response to Hh [5–7]. Mouse mutants that lack Smo die earlier than Shh mutants, apparently ...
... Chromosome 6 (Figure 1). This region included the mouse Smo gene, and a targeted null allele of mouse Smo causes a phenotype very similar to that of bnb [4]. Smo is a membrane protein that is required for the response to Hh [5–7]. Mouse mutants that lack Smo die earlier than Shh mutants, apparently ...
PDF
... and Paola Bovolenta uncover a role for autonomous Shh signalling in the growth and guidance of mouse retinal ganglion cell (RGC) axons (see p. 3531). In mammals, the axons of contralateral RGCs (C-RGCs) cross the developing brain’s midline (a source of Shh signals), whereas ipsilateral RGC (I-RGC) a ...
... and Paola Bovolenta uncover a role for autonomous Shh signalling in the growth and guidance of mouse retinal ganglion cell (RGC) axons (see p. 3531). In mammals, the axons of contralateral RGCs (C-RGCs) cross the developing brain’s midline (a source of Shh signals), whereas ipsilateral RGC (I-RGC) a ...
PDF
... express the TE marker Cdx2, which suggests that organised epithelium formation is not necessary for TE-specific gene expression. Furthermore, individual cells in these embryos still generate an apical membrane domain that correlates with Cdx2 expression. Thus, the epithelial integrity mediated by E- ...
... express the TE marker Cdx2, which suggests that organised epithelium formation is not necessary for TE-specific gene expression. Furthermore, individual cells in these embryos still generate an apical membrane domain that correlates with Cdx2 expression. Thus, the epithelial integrity mediated by E- ...
Neurodevelopment I
... the floor of the midbrain becomes the tegmentum, and projection fibers accumulate on the lateral ...
... the floor of the midbrain becomes the tegmentum, and projection fibers accumulate on the lateral ...
Tran 9/22 Slides
... • Reelin is a large extracellular matrix protein, expressed by the CajalRetzius cells during development. Receptors for reelin, VLDL and APOE2, are expressed by migrating cortical neurons. Reeler is the naturally occurring mutation that lacks reelin. ...
... • Reelin is a large extracellular matrix protein, expressed by the CajalRetzius cells during development. Receptors for reelin, VLDL and APOE2, are expressed by migrating cortical neurons. Reeler is the naturally occurring mutation that lacks reelin. ...
PDF
... Long-range Shh message dispatched The secreted morphogen sonic hedgehog (Shh) and other hedgehog (Hh) proteins control many aspects of normal development through short- and long-range signalling. But, before being released from its source cells, two lipid moieties are added to Shh that probably make ...
... Long-range Shh message dispatched The secreted morphogen sonic hedgehog (Shh) and other hedgehog (Hh) proteins control many aspects of normal development through short- and long-range signalling. But, before being released from its source cells, two lipid moieties are added to Shh that probably make ...
Literature Review #3 Article
... Since publication of her article, the author reports no further but rather as an easy cure for cancer. potential conflict of interest. ...
... Since publication of her article, the author reports no further but rather as an easy cure for cancer. potential conflict of interest. ...
PDF
... transcriptional output in responding cells? On p. 4051, Johan Ericson and colleagues reveal that a homeodomain transcription factor feedback circuit is involved in the interpretation of the Sonic hedgehog (Shh) gradient that patterns the vertebrate ventral neural tube. They report that Nkx2 homeodom ...
... transcriptional output in responding cells? On p. 4051, Johan Ericson and colleagues reveal that a homeodomain transcription factor feedback circuit is involved in the interpretation of the Sonic hedgehog (Shh) gradient that patterns the vertebrate ventral neural tube. They report that Nkx2 homeodom ...
lecture notes
... tube, SHH is unable to induce Nkx6 in the limbs. Similarly, BMP works in concert with SoxB1 to activate Msx in the neural tube, but not in any of the other tissues receiving BMP signals. 7. There are many other examples of signaling pathways working in concert with localized TFs to obtain tissue-spe ...
... tube, SHH is unable to induce Nkx6 in the limbs. Similarly, BMP works in concert with SoxB1 to activate Msx in the neural tube, but not in any of the other tissues receiving BMP signals. 7. There are many other examples of signaling pathways working in concert with localized TFs to obtain tissue-spe ...
Lec222
... Hedgehog signaling pathway • Indian hedgehog: expressed in gut and chondrocytes • Desert hedgehog: expressed in sertoli cells of the testes • Sonic hedgehog: Involved in many developmental processes. Best characterized ...
... Hedgehog signaling pathway • Indian hedgehog: expressed in gut and chondrocytes • Desert hedgehog: expressed in sertoli cells of the testes • Sonic hedgehog: Involved in many developmental processes. Best characterized ...
PDF
... pioneer axon. Finally, by examining AVM regeneration in worms that lack various axonal guidance molecules, the researchers show that neural wiring during development and rewiring during regeneration have different molecular requirements. Thus, they suggest, C. elegans could be used in genetic screen ...
... pioneer axon. Finally, by examining AVM regeneration in worms that lack various axonal guidance molecules, the researchers show that neural wiring during development and rewiring during regeneration have different molecular requirements. Thus, they suggest, C. elegans could be used in genetic screen ...
PDF
... pioneer axon. Finally, by examining AVM regeneration in worms that lack various axonal guidance molecules, the researchers show that neural wiring during development and rewiring during regeneration have different molecular requirements. Thus, they suggest, C. elegans could be used in genetic screen ...
... pioneer axon. Finally, by examining AVM regeneration in worms that lack various axonal guidance molecules, the researchers show that neural wiring during development and rewiring during regeneration have different molecular requirements. Thus, they suggest, C. elegans could be used in genetic screen ...
Sonic Hedgehog (Shh) Human E. coli
... share a high degree of amino acid sequence identity (e.g. Shh and Ihh are 93% identical). The biologically active form of each Hh molecule is obtained by autocatalytic cleavage of their precursor proteins, and each corresponds to approximately one half of the N-terminal portion of the precursor mole ...
... share a high degree of amino acid sequence identity (e.g. Shh and Ihh are 93% identical). The biologically active form of each Hh molecule is obtained by autocatalytic cleavage of their precursor proteins, and each corresponds to approximately one half of the N-terminal portion of the precursor mole ...
New Product Highlights Monoclonal Anti
... Isotype: rat IgG2a Species Cross Reactivity: Human and mouse Shh Sonic hedgehog (Shh) is an important cell signaling molecule expressed during embryonic development. Shh is involved in the patterning of the developing embryonic nervous system, somite and limb. The N-terminal peptide of Shh is releas ...
... Isotype: rat IgG2a Species Cross Reactivity: Human and mouse Shh Sonic hedgehog (Shh) is an important cell signaling molecule expressed during embryonic development. Shh is involved in the patterning of the developing embryonic nervous system, somite and limb. The N-terminal peptide of Shh is releas ...
Sonic hedgehog
Sonic hedgehog is a protein that in humans is encoded by the SHH (""sonic hedgehog"") gene. Both the gene and the protein may also be found notated alternatively as ""Shh"".Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in the development of some cancers.