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Premature ovarian failure: Think `autoimmune disorder`
Premature ovarian failure: Think `autoimmune disorder`

... nearly 1.1 million women with premature ovarian autoimmunity in the United States, compared to about 1.4 million women with Hashimoto’s thyroiditis.5 Viewed in this way, POF is a fairly common autoimmune disease. Possessing an autoantibody does not prove that one has clinical evidence of a disease. ...
Sepsis severity predicts outcome in community-acquired pneumococcal pneumonia
Sepsis severity predicts outcome in community-acquired pneumococcal pneumonia

... sepsis score and the Confusion, Respiratory rate (o30 breaths?min-1), Blood pressure (systolic value ,90 mmHg or diastolic value f60 mmHg) and age o65 yrs (CRB-65) score in 105 patients with community-acquired pneumococcal pneumonia. In addition, the influence of timing of the antimicrobial treatmen ...
Prognostic Factors and Clinical Features of Non
Prognostic Factors and Clinical Features of Non

... All adult patients, older than 18 years, admitted during the study period (January 2004 to December 2006) to the hospital were considered eligible if they had had at least 1 blood set positive for NTS. The hospital is a 2,900-bed tertiary referral medical center and has specialized units for solid o ...
(SLE).
(SLE).

... those of the hand, knees, and wrists. • People with lupus can suffer from a certain type of low blood flow injury to a joint causing death of the bone in the joint. • The muscle involvement was reported in 30-50% of lupus patients ...
Management Of Cold Haemolytic Syndrome
Management Of Cold Haemolytic Syndrome

... Between 1960 and 2005, physicians at Mayo Clinic have treated 34 633 patients with monoclonal gammopathies. Approximately 16% of these patients had an IgM monoclonal protein. Under the current classification scheme developed at the Second International Waldenström Workshop (Owen et al, 2003), patie ...
Oxidative Stress in Cardiovascular Inflammation: Its Involvement in
Oxidative Stress in Cardiovascular Inflammation: Its Involvement in

... antigens [13]. However, studies performed on hypercholesterolaemic mice deficient in different components of innate and adaptive immunity uniformly indicate that the net effect of immune activation is proatherogenic [13, 14] and that atherosclerosis, at least to some extent, should be regarded as an a ...
Natural Medicine and Nutritional Therapy as an Alternative
Natural Medicine and Nutritional Therapy as an Alternative

... to be a major risk factor for avascular necrosis.6-8 Musculoskeletal involvement is very common in SLE, and may include muscle atrophy or weakness, erosive arthritis, and osteoporosis. It is difficult to determine if these symptoms are a result of the disease or from corticosteroid usage. In either ...
Standard PDF - Wiley Online Library
Standard PDF - Wiley Online Library

... source such as bird droppings or soil. Although rare, cases of transmission from donor organ and tissue grafts have also been recognized (10–13). Donor-derived cryptococco242 ...
Search for the laboratory parameters of
Search for the laboratory parameters of

... in blood serum and stool are reproducible and allow the diagnosis of the specific pathological process and the estimation of its activity, evolution and prognosis, including the prediction of the response to treatment. In clinical practice, they have the advantage of being a non-invasive diagnostic ...
Document
Document

... Physical therapy, daily exercise, splinting, joint protection Salicylates, NSAIDS, DMARDs , hydroxychloroquine, immunosuppressive agents , Steroids Cyclosporin-A Prognosis  10-15 yrs of disease ...


... acid (DNA), for example, was detected using the polymerase chain reaction (PCR) in biopsies with sarcoid lesions. Other authors, however, could not confirm these results, as recently reviewed [8]. Furthermore, elevated titres of antibodies against Mycoplasma pneumoniae have been described [3]. The h ...
High prevalence of abnormal gastrointestinal permeability in
High prevalence of abnormal gastrointestinal permeability in

... Limitations of this work include our small sample size (unfunded study, learner-driven project), and as well the retrospective design of the study employed. It is possible that abnormal GIP may have an association with the development and propagation asthma; however, experimental numbers are too sma ...
clin exp rheum 27/1 - Clinical and Experimental Rheumatology
clin exp rheum 27/1 - Clinical and Experimental Rheumatology

... and environmental triggering agents is likely involved in their etiopathogenesis. Abnormal immune regulation patterns and persistent inflammation are ACTD hallmarks (1). In such a context, autoimmunity/inflammation-associated cellular and molecular networks drive a variety of reactions that may involv ...
Delivery of Antibodies to the Gastrointestinal Tract
Delivery of Antibodies to the Gastrointestinal Tract

... bioactive F(ab’)2 and Fab fragments and inactive Fc 2. The results from the IgG stability study confirmed that after 2 hours incubation at 37oC in SIF with pancreatin, more than 65% of the initial Fab specific IgG activity still remained, although some proteolytic enzyme degradation had occurred whi ...
MS Fact Sheet 2015
MS Fact Sheet 2015

... Many patients who start LDN do not experience any severe side effects. As mentioned earlier, your symptoms may become worse – in MS, this can be characterised by increased fatigue, or increased spasticity. In CFS/ME, this can be the onset of apparent 'flu like symptoms. LDN can cause sleep disturban ...
THE KEY ROLE OF PREVENTATIVE STRATEGIES IN CHRONIC
THE KEY ROLE OF PREVENTATIVE STRATEGIES IN CHRONIC

... last year and 13% have had hospital or emergency department visits. In addition, shortness of breath is reported to affect quality of life (QoL) in 58% of patients.1,2 In the USA, direct and indirect costs, 75% of which are due to exacerbations, amount to approximately $30 billion and $20 billion pe ...
Vestibular neuritis and labyrinthitis
Vestibular neuritis and labyrinthitis

... resulting from a systemic virus such as influenza (‘the flu’) or the herpes viruses, which causes chickenpox, shingles and cold sores. Bacterial labyrinthitis can originate from an untreated middle ear infection, or in rare cases, as a result of meningitis. The infections that cause vestibular neuri ...
Pediatr Infect Dis J 2007 Aug 26(8) 728 32
Pediatr Infect Dis J 2007 Aug 26(8) 728 32

... nant.5,10 They persist longer than minor aphthae and can last for weeks or months and often leave a scar after healing. These lesions cause substantial pain associated with fever, dysphagia, and malaise. They have a predilection for the posterior part of the month, particularly the soft palate and p ...
Efficacy of tocilizumab, a humanized anti-IL
Efficacy of tocilizumab, a humanized anti-IL

... that the inhibition may be attributable to prevention of Th17 cell development [18,19]. Although results obtained in animal studies should be carefully considered, tocilizumab is possibly more than just an anti-inflammatory agent and could affect the underlying etiology of RA. In fact, long-term tre ...
Microbes in Colon Cancer and Inflammatory Bowel Disease
Microbes in Colon Cancer and Inflammatory Bowel Disease

... Clinical cancer ...
Autoimmune Disease is Causing Your Hashimoto Thyroiditis And How to Stop It!
Autoimmune Disease is Causing Your Hashimoto Thyroiditis And How to Stop It!

... without the fever. Still not willing to admit I was seriously ill, I tried to do step classes and Zumba at the gym with always disastrous results Post exercise, I would have to recover by staying in bed for a couple of days. I had to finally admit that I was no longer able to continue strenuous phys ...
PDF
PDF

... Patients (20 females and 33 males) with no HIV co-infection and newly diagnosed pulmonary TB were included. Diagnosis was based on clinical and radiological data together with the identification of TB bacilli in sputum. Age of the patients ranged from 18 to 71 years -one case- (37616 years, mean 6 s ...
The Diagnosis, Staging, and Treatment Options for Mycosis Fungoides
The Diagnosis, Staging, and Treatment Options for Mycosis Fungoides

... to 60 years). Children and adolescents are rarely affected. Approximately 1,000 new cases are diagnosed each year in the United States.12 The course of MF is usually indolent, with slow progression over years to decades, but it can be unpredictable. It usually demonstrates epidermotropism by involvi ...
Single-nucleotide polymorphisms of toll
Single-nucleotide polymorphisms of toll

... Background with Objective: Ulcerative colitis patients have a high risk to develop colorectal cancer. Toll-like receptor 9 (TLR9) plays a key role in the innate immune system in gastroenterological tract and TLR9 polymorphisms could contribute to development of ulcerative colitis. We carried out thi ...
Induction of tolerance in autoimmune diseases by hematopoietic
Induction of tolerance in autoimmune diseases by hematopoietic

... cell transplantation (HSCT). By percentage of transplantations performed, autoimmune diseases are the most rapidly expanding indication for stem cell transplantation. Although numerous editorials or commentaries have been previously published, no prior review has focused on the immunology of transpl ...
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Neuromyelitis optica

Neuromyelitis optica (NMO), also known as Devic's disease or Devic's syndrome, is a heterogeneous condition consisting of the simultaneous inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis). It can be monophasic or recurrent.Currently at least two different causes are proposed based on the presence of autoantibodies against AQP4. AQP4+ NMO is currently considered an autoimmune disease (autoimmune astrocytopathy, or autoimmune astrocytic channelopathy) in which a person's own immune system attacks the astrocytes of the optic nerves and spinal cord. The cause of the AQP4- variants is unknown.Although inflammation may also affect the brain, the lesions are different from those observed in the related condition, multiple sclerosis. Spinal cord lesions lead to varying degrees of weakness or paralysis in the legs or arms, loss of sensation (including blindness), and/or bladder and bowel dysfunction.Devic's disease is now studied along a collection of similar diseases called ""Neuromyelitis optica spectrum diseases"". Some cases of this spectrum resemble multiple sclerosis (MS) in several ways, but require a different course of treatment for optimal results.In 2004, NMO-IgG (currently known as Anti-AQP IgG) was first described leading to the distinction between positive and negative cases.In Anti-AQP positive variants, CNS astrocytes, which are the basis for the glymphatic system are the target of the autoimmune attack. NMO-IgG-negative cases are less understood. It seems currently that astrocytes are spared in these IgG negative cases
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