inflammatory arthropathies, inflammatory arthropathies, or
... Between 10-20% of persons with HLAB 27 have ankylosing spondylitis Less than 1% of persons without HLA B27 have ankyosing spondylitis HLA B27 pos monozygotic twins have 75% concordance for AS, and dizygotic twins only 25%, indicating that other genes are important as well. ...
... Between 10-20% of persons with HLAB 27 have ankylosing spondylitis Less than 1% of persons without HLA B27 have ankyosing spondylitis HLA B27 pos monozygotic twins have 75% concordance for AS, and dizygotic twins only 25%, indicating that other genes are important as well. ...
psoriasis associated with chronic periodontitis: a rare
... Chronic periodontitis is a consequence of a persistent bacterial infection and chronic inflammation of the supportive tissues surrounding the tooth, including the periodontal ligament, cementum and alveolar bone. Psoriasis is a chronic, remitting and relapsing inflammatory skin disorder with a stron ...
... Chronic periodontitis is a consequence of a persistent bacterial infection and chronic inflammation of the supportive tissues surrounding the tooth, including the periodontal ligament, cementum and alveolar bone. Psoriasis is a chronic, remitting and relapsing inflammatory skin disorder with a stron ...
Anti-idiotypes and Immunity
... may underline autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and myasthenia gravis, which stem from an immunological attack on the body itself. These interactions, known as idiotype-anti-idiotype reactions, can be exploited to manipulate the immune system. ...
... may underline autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and myasthenia gravis, which stem from an immunological attack on the body itself. These interactions, known as idiotype-anti-idiotype reactions, can be exploited to manipulate the immune system. ...
Multiple Sclerosis Disease Report
... PAS provides two types of reports—disease and organization reports. Disease Reports discuss the burden, progression, and existing treatments for a given disease; highlight priority research areas; and provide an overview of relevant activities in the commercial and nonprofit research sectors. These ...
... PAS provides two types of reports—disease and organization reports. Disease Reports discuss the burden, progression, and existing treatments for a given disease; highlight priority research areas; and provide an overview of relevant activities in the commercial and nonprofit research sectors. These ...
Two models of multiple sclerosis: Experimental allergic
... appear and quickly worsen thereafter. By 3-4 weeks, lesions may already be coalescent to occupy the majority of the anterior and lateral columns (Fig. 2). One feature which is particularly evident in SJL/J mice is the presence of large numbers of macrophages which quickly populate the spinal cord co ...
... appear and quickly worsen thereafter. By 3-4 weeks, lesions may already be coalescent to occupy the majority of the anterior and lateral columns (Fig. 2). One feature which is particularly evident in SJL/J mice is the presence of large numbers of macrophages which quickly populate the spinal cord co ...
Inflammation and autoimmunity in cerebral small vessel disease
... disease, is unknown. Hypotheses include atheroma, endothelial dysfunction, blood brain barrier dysfunction, or other as yet unknown process. Inflammation is thought to play a role. The imaging features of cerebral small vessel disease combined with symptoms such as dizziness or cognitive decline poi ...
... disease, is unknown. Hypotheses include atheroma, endothelial dysfunction, blood brain barrier dysfunction, or other as yet unknown process. Inflammation is thought to play a role. The imaging features of cerebral small vessel disease combined with symptoms such as dizziness or cognitive decline poi ...
(STEC) in Germany - ECDC
... virulence characteristics of the bacteria. The patient’s age and the infecting dose also play an important role. Children under the age of 5 years are at higher risk of developing clinical disease when infected, and infants are at increased risk of death from dehydration and septicaemia. While the c ...
... virulence characteristics of the bacteria. The patient’s age and the infecting dose also play an important role. Children under the age of 5 years are at higher risk of developing clinical disease when infected, and infants are at increased risk of death from dehydration and septicaemia. While the c ...
Supplement to Supplement to Rheumatology News
... he pathogenesis of rheumatoid arthritis (RA) is characterized by a continuous interaction of numerous cells, molecules, and processes. A striking pathological change is the transition of the synovial lining from 2 to 3 layers of fibroblast-like synoviocytes (FLS) into several layers of macrophage-li ...
... he pathogenesis of rheumatoid arthritis (RA) is characterized by a continuous interaction of numerous cells, molecules, and processes. A striking pathological change is the transition of the synovial lining from 2 to 3 layers of fibroblast-like synoviocytes (FLS) into several layers of macrophage-li ...
Robert Friedland - ICAD-Me
... • We have more nucleotide sequences in our gut than in our own cells • We evolved with these organisms – they are not there “by accident” • Evolutionary conserved proteins are widespread and can lead to diseases via molecular mimicry through similarity of tertiary structures • Gut bacteria may be in ...
... • We have more nucleotide sequences in our gut than in our own cells • We evolved with these organisms – they are not there “by accident” • Evolutionary conserved proteins are widespread and can lead to diseases via molecular mimicry through similarity of tertiary structures • Gut bacteria may be in ...
Lesson 64. Auto Immunity and auto immune diseases
... defends the body against infections and certain other diseases by identifying, attacking, and destroying germs and other foreign substances. Sometimes the immune system makes a mistake and starts attacking the body’s own tissues or organs. This is called autoimmunity. There are many autoimmune disea ...
... defends the body against infections and certain other diseases by identifying, attacking, and destroying germs and other foreign substances. Sometimes the immune system makes a mistake and starts attacking the body’s own tissues or organs. This is called autoimmunity. There are many autoimmune disea ...
Treating Clostridium difficile Infection with Fecal Microbiota
... b. At least 2 episodes of severe CDI resulting in hospitalization and associated with significant morbidity. 2. Moderate CDI not responding to standard therapy (vancomycin) for at least a week. 3. Severe (and perhaps even fulminant C difficile colitis) with no response to standard therapy after 48 h ...
... b. At least 2 episodes of severe CDI resulting in hospitalization and associated with significant morbidity. 2. Moderate CDI not responding to standard therapy (vancomycin) for at least a week. 3. Severe (and perhaps even fulminant C difficile colitis) with no response to standard therapy after 48 h ...
- Brain
... might better be described as a syndrome rather than a single disease entity—a concept that has important implications with respect to the development of effective therapeutic strategies. The clinical heterogeneity of multiple sclerosis has been recognized for many years, but it is now apparent that ...
... might better be described as a syndrome rather than a single disease entity—a concept that has important implications with respect to the development of effective therapeutic strategies. The clinical heterogeneity of multiple sclerosis has been recognized for many years, but it is now apparent that ...
Clustering and commonalities among autoimmune diseases
... 1.1.1. Nomenclature of diseases First, there is the haphazard nomenclature of disease, calling for a latter-day Linnaeus for a logical taxonomy in the clinical arena, applicable particularly to the autoimmune diseases. Nomenclature includes the ‘traditional’ (lupus, diabetes, rheumatoid), ‘eponymous ...
... 1.1.1. Nomenclature of diseases First, there is the haphazard nomenclature of disease, calling for a latter-day Linnaeus for a logical taxonomy in the clinical arena, applicable particularly to the autoimmune diseases. Nomenclature includes the ‘traditional’ (lupus, diabetes, rheumatoid), ‘eponymous ...
Primary Immunodeficiency and Autoimmunity: Lessons From Human
... All percentages in the table are rounded up to whole numbers. The focus is on monogenic PIDs, however Omenn syndrome, ALPS, CVID and IgAD are considered as polygenic. Sp. = sporadic (i.e. has been described in some references and may represent a weak association or simply case reports). For other ab ...
... All percentages in the table are rounded up to whole numbers. The focus is on monogenic PIDs, however Omenn syndrome, ALPS, CVID and IgAD are considered as polygenic. Sp. = sporadic (i.e. has been described in some references and may represent a weak association or simply case reports). For other ab ...
Therapies for Chronic Lyme Disease Kent Holtorf, MD
... Borrelia takes 12-24 hours (35-75 times longer--can be much longer when antibiotics are introduced) • The standard 10-14 days of antibiotics needed to reliably clear most “regular” infections would require the antibiotic to be present 24 hours per day for 1½ to 3 years for the same curative potentia ...
... Borrelia takes 12-24 hours (35-75 times longer--can be much longer when antibiotics are introduced) • The standard 10-14 days of antibiotics needed to reliably clear most “regular” infections would require the antibiotic to be present 24 hours per day for 1½ to 3 years for the same curative potentia ...
The Lung Immunology Group Department of Biological Sciences
... • Associated with autoimmune disease such as the inflammatory bowel disease, ulcerative colitis • Neutrophils are markedly raised, as predicted from high local levels IL-8 • Associated with immune deficiency syndromes such as TAP deficiency syndrome ...
... • Associated with autoimmune disease such as the inflammatory bowel disease, ulcerative colitis • Neutrophils are markedly raised, as predicted from high local levels IL-8 • Associated with immune deficiency syndromes such as TAP deficiency syndrome ...
The spectrum of CMV disease in solid organ transplant recipients
... (6). Symptoms of CMV disease can range from a viral syndrome to tissue-invasive disease and severe end-organ involvement (e.g., pancreatitis, pneumonitis, hepatitis, myocarditis, nephritis, or gastrointestinal disease) (1). In addition to directly attributable morbidity, CMV may also have an immunom ...
... (6). Symptoms of CMV disease can range from a viral syndrome to tissue-invasive disease and severe end-organ involvement (e.g., pancreatitis, pneumonitis, hepatitis, myocarditis, nephritis, or gastrointestinal disease) (1). In addition to directly attributable morbidity, CMV may also have an immunom ...
Granulomatous Reactivation during the Course of a Leprosy
... during treatment. These reactions may be either attributed to an improvement in the immunological reactivity of the patient along with the treatment, or to relapse of the disease due to the proliferation of remaining bacilli. In certain patients these two conditions may be difficult to differentiate ...
... during treatment. These reactions may be either attributed to an improvement in the immunological reactivity of the patient along with the treatment, or to relapse of the disease due to the proliferation of remaining bacilli. In certain patients these two conditions may be difficult to differentiate ...
ANA – Antinuclear Antibodies
... Interpretation: No clinically significant antinuclear antibody is detected by IFA. A negative result suggests an absence of connective tissue disease. False negatives may occur, especially in scleroderma, polymyositis/dermatomyositis, or inactive systemic lupus erythematosus. False positive ANA EI ...
... Interpretation: No clinically significant antinuclear antibody is detected by IFA. A negative result suggests an absence of connective tissue disease. False negatives may occur, especially in scleroderma, polymyositis/dermatomyositis, or inactive systemic lupus erythematosus. False positive ANA EI ...
Mayo Clinic Series - Fibrosing Mediastinitis
... exceedingly rare. Only 3 of 100,000 patients with histoplasmosis developed FM during an outbreak of this fungal infection in Indianapolis between 1978 and 1979.40 The precise pathogenetic mechanisms of FM remain unknown. The exuberant mediastinal fibrosis has been attributed to chronic inflammation ...
... exceedingly rare. Only 3 of 100,000 patients with histoplasmosis developed FM during an outbreak of this fungal infection in Indianapolis between 1978 and 1979.40 The precise pathogenetic mechanisms of FM remain unknown. The exuberant mediastinal fibrosis has been attributed to chronic inflammation ...
Embryogenesis of the Kidneys and Ureters
... characterized histologically by primitive ducts and cartilage. • Most hypodysplastic kidneys have ectopic ureteral orifices. • The more ectopic the orifice, the greater the degree of dysplasia ...
... characterized histologically by primitive ducts and cartilage. • Most hypodysplastic kidneys have ectopic ureteral orifices. • The more ectopic the orifice, the greater the degree of dysplasia ...
Personalised medicine in exacerbations of COPD: the beginnings EDITORIAL Sanjay Sethi
... Can we better target systemic steroid use in exacerbations? Although a short course of systemic steroids is often regarded as benign, there is emerging evidence that this may not be the case in the setting of an exacerbation of COPD. The best described adverse effect is hyperglycaemia [6]. High-dose ...
... Can we better target systemic steroid use in exacerbations? Although a short course of systemic steroids is often regarded as benign, there is emerging evidence that this may not be the case in the setting of an exacerbation of COPD. The best described adverse effect is hyperglycaemia [6]. High-dose ...
Epstein-Barr Virus (EBV) Infections in Patients
... chronic-active infection and become undetectable weeks to months after onset. Elevated EBV-IgG antibodies suggest a past infection. In the patient population treated at The Center, elevated EBV antibody titer is a common finding. During a recent 33 day period, 32 patients seen at The Center had sero ...
... chronic-active infection and become undetectable weeks to months after onset. Elevated EBV-IgG antibodies suggest a past infection. In the patient population treated at The Center, elevated EBV antibody titer is a common finding. During a recent 33 day period, 32 patients seen at The Center had sero ...
Inflammation response in AD - UvA-DARE
... C3 convertase, which cleaves complement component C3 into C3b and C3a. C3a is a peptide mediator of local inflammation. C3b binds covalently to the pathogen membrane and opsonises it enabling phagocytes. C3b also activates another series of cleavage reactions resulting in more cytokines and a membra ...
... C3 convertase, which cleaves complement component C3 into C3b and C3a. C3a is a peptide mediator of local inflammation. C3b binds covalently to the pathogen membrane and opsonises it enabling phagocytes. C3b also activates another series of cleavage reactions resulting in more cytokines and a membra ...
How chronic inflammation can affect the brain and support the
... as for complement cascade proteins C1qB, C3 and C4, the IL1 receptor and receptor antagonist, and TGFβ have been observed in AD microglia (Walker et al., 1995; Shen et al., 1997; Strohmeyer et al., 2000). In peripheral monocytes a similar proinflammatory response has been demonstrated following stim ...
... as for complement cascade proteins C1qB, C3 and C4, the IL1 receptor and receptor antagonist, and TGFβ have been observed in AD microglia (Walker et al., 1995; Shen et al., 1997; Strohmeyer et al., 2000). In peripheral monocytes a similar proinflammatory response has been demonstrated following stim ...