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- bzh - Uni Heidelberg
- bzh - Uni Heidelberg

... Despite the advances in our compositional understanding of pre-ribosomal particles, only little structural data is available for nascent ribosomes. Hence, we purified the pre-60S particle and could obtain the first cryo-EM structure of a native pre60S subunit in association with the assembly factor ...
STRUCTURE AND FUNCTION
STRUCTURE AND FUNCTION

... Formation of the Amt/GlnK Complex It has been found that in general that GlnK and PII proteins regulate Amt-dependent ammonia uptake in prokaryotes. From the results it has also been seen that the GlnK and Amt bind in a one-to-one ratio of two trimers. It was also found that GlnK and Amt bound in th ...
Immunodetection of PR-1-Iike proteins in grapevine leaves infected
Immunodetection of PR-1-Iike proteins in grapevine leaves infected

... the grapevine PR-1 are stress-related proteins because the present work showed that these proteins can in fact be induced by stress other than pathogen infection. In contrast, the findings that heat-shock did not induce the expression oftobacco PR-1 protein (ÜHASHI and MATSUOKA 1985) and on the othe ...
Academic Half-Day Neurophysiology 101
Academic Half-Day Neurophysiology 101

... Metabotropic/G-protein coupled receptors: ligand binds, activates GTP-binding protein which in term activates a channel via phosphorylation.  Slower synaptic potentials lasting seconds or minutes  Involved in strengthening synaptic connections of basic neural circuitry  Role in modulating synapti ...
STRUCTURE OF SYNAPSES: OVERVIEW
STRUCTURE OF SYNAPSES: OVERVIEW

... releasing their content into the synaptic cleft to act on receptors specific for the neurotransmitters in the postsynaptic membrane. Thus synaptic transmission relies on the vesicle mediated exocytosis of neurotransmitter. There is usually only one small molecule transmitter for a specific neuron ty ...
Proteins
Proteins

...  Software used to generate theoretical peptide mass fingerprint (PMF) for all proteins in database  Match of experimental readout to database PMF allows researchers to identify the protein ...
Brief pause after coalescence to allow the growth by monomer
Brief pause after coalescence to allow the growth by monomer

... Nanocrystal growth by monomer addition, single coalescence, or multiple coalescence events ...
Supplementary figure legends
Supplementary figure legends

... by another. One common evolutionary mechanism that gives rise to redundant or partially overlapping gene functions is gene duplication8. To identify related kinases or phosphatases that are essential for cell cycle progression and have redundant function, we generated a dendrogram tree of the kinas ...
Chapter 13: Peripheral Nervous System
Chapter 13: Peripheral Nervous System

...  Enhance “rest-and-digest” activities  Mechanisms that help conserve and restore body energy during times of rest  Normally dominate over sympathetic impulses  SLUDD type responses = salivation, lacrimation, urination, digestion ...
Effect of ±5ºC difference from physiologic temperature on surface
Effect of ±5ºC difference from physiologic temperature on surface

... activity in a dose-dependent manner up to 44°C. However, the temperature increase did not induce widespread transport increase of all other nutrients tested [15]. In human, promonocytic U937 heat-treated cells displayed a lower intracellular pH (pHi) than untreated cells [14]. On the other hand, hyp ...
DESI - plaza
DESI - plaza

... No need for Matrix unlike MALDI Multiple charge ions is an advantage to extend mass range (proteins) Variable distance and angel allows different energy levels and makes it proper for a wider range of molecules (Proteins) ...
Chapter 3 Biological Aspects of Psychology
Chapter 3 Biological Aspects of Psychology

... Figure 3.2 The neural impulse. The electrochemical properties of the neuron allow it to transmit signals. The electric charge of a neuron can be measured with a pair of electrodes connected to a device called an oscilloscope, as Hodgkin and Huxley showed with a squid axon. Because of its exceptional ...
The Inflammatory Response
The Inflammatory Response

... Cytokines are small signalling molecules that attract phagocytes to the site of infection. Phagocytes are white blood cells that engulf and destroy the bacteria that have caused the infection, they also engulf and destroy damaged tissue cells. The presence of bacteria at the site of infection stimul ...
6 Characterization of Casein and Bovine Serum Albumin (BSA)
6 Characterization of Casein and Bovine Serum Albumin (BSA)

... structural complexity is due to the composition and sequence of the amino acids that make up proteins. The composition and sequence of amino acids is different for every protein. As such, the unique chemical and physical characteristics of a protein can be used to isolate it from other cellular comp ...
Prokaryotes
Prokaryotes

... Prokaryotes are generally single celled organisms, although some occur as aggregates, colonies, or simple multi-cellular forms. The three most common prokaryotic shapes are spherical (cocci) , rod shaped (bacilli), and helical forms. Nearly all prokaryotes have external cell walls, which protect and ...
Ref ID: 368
Ref ID: 368

... toxic forms. We have correlated drug resistance in neuroblastoma (NB) cell lines with mRNA overexpression of g-glutamylcysteine synthetase (g-GCS) and GSH-s-transferase µ (GSTµ), that code for glutathione synthesis and utilization enzymes. METHODS: We studied 20 NB cell lines containing 10 sensitive ...
Principles of Neural Science
Principles of Neural Science

Viral hepatitis and fatty liver disease: how an
Viral hepatitis and fatty liver disease: how an

... LXREs and SREs (sterol-response elements) in the SREBP1c promoter [7]. In addition, HCV core protein and non-structural protein-4b also activated SREBPs [8]. In the light of Kim et al.’s study on HBx [2], it would be interesting to determine whether any of these HCV proteins also act through binding ...
Knox RTN in PD final accepted revision with figures
Knox RTN in PD final accepted revision with figures

... The degree of membrane constriction produced by RTNs is dependent on their concentration (Hu et al., 2008). Our experiments provide no information on whether or not RTNLBs are enriched within PD. However, the ability of RTNLBs to constrict ER tubules depends on their oligomerisation, which in turn c ...
Structural Biology in the Pharmaceutical Industry
Structural Biology in the Pharmaceutical Industry

... putative target indeed results in the expected effects in cellular assays (e.g. slowing down the proliferation rate of cancer cell lines, while not affecting non-tumor cell lines). Even at this early stage, long before a decision has been made to clone, express and crystallize this protein, Structur ...
Key Residues Defining the ~.t-OpioidReceptor Binding Pocket: A
Key Residues Defining the ~.t-OpioidReceptor Binding Pocket: A

... domains of the opioid receptors are exchanged to examine receptor selectivity (Kong et al., 1994; Wang et al., 1994; Xue et al., 1994, 1995; Fukuda et al., 1995; Hjorth et al., 1995; Meng et al., 1995; Minami et al., 1995; Onogi et al., 1995). The second approach involves three-dimensional computer ...
Diffusion, Osmosis, Active Transport
Diffusion, Osmosis, Active Transport

... and the cell membrane will form little spikes as water is lost and the cell shrinks, a process called crenation. The cell dies eventually Spikes form in a solution with low water potential ...
Consensus model for FSHD identifies opportunities
Consensus model for FSHD identifies opportunities

... Candidate Mechanisms for FSHD •  Activation of a germline program muscle cells –  Confusion causes death and dysfunction •  Immune response to germline proteins –  FSHD cells express Cancer Testis Antigens •  DUX4 genes can suppress muscle repair –  Defensin protein blocks new muscle formation •  D ...
2nd 9 weeks
2nd 9 weeks

... I can identify the organelles of photosynthesis and respiration and describe how their structure relates to their function. I can compare and contrast photosynthesis and cellular respiration in terms of energy transformation, reactants and products. I can demonstrate the relatedness of the equations ...
ppt
ppt

... 1 CO2 incorporated Organic acid into four-carbon organic acids (carbon fixation) 2 Organic acids release CO2 to Calvin cycle ...
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Signal transduction



Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
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