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Integrin inside-out signaling and
Integrin inside-out signaling and

... Introduction Integrins integrate the extracellular and intracellular environments. Their extracellular domains bind to ligands on the surface of other cells or in the extracellular matrix, while their cytoplasmic domains bind to cytoskeletal-associated proteins. ‘Outside-in’ signals received by cell ...
Recombinant human GM-CSF
Recombinant human GM-CSF

... and is a key factor in differentiation pathways leading form stem cells. GMCSF is produced by several cell types as monocytes, fibroblast, endothelial cells and T- Lymphocytes in response to a number of inflammatory mediators present in the hemopoietic environment and peripheral site of inflammation ...
Novel eukaryotic enzymes modifying cell
Novel eukaryotic enzymes modifying cell

... microbial eukaryotes, and cell walls and waxes of plants and fungi. Not only do these play a major structural role in both unicellular and multicellular eukaryotes, but they are also important in the defense against parasites or interactions of parasites with their hosts. The enzymatic components of ...
Cell Factory Project
Cell Factory Project

... Cell Factory Project Imagine the cell to be a factory such as one that makes “running shoes”. There must be a head office (nucleus) that has blueprints (chromosomes) etc… Using your cell chart and the following list of organelles, illustrate a factory within your lab group, labeling each part. This ...
Exit from dormancy in microbial organisms
Exit from dormancy in microbial organisms

... As peptidoglycan is an extremely wellconserved molecule, these muropeptides could serve as an interspecies signal of the presence of conditions that support microbial growth. Consistent with the information provided by this signal, peptidoglycan derived from growing cells is a much more effective in ...
Regulation of Breathing
Regulation of Breathing

... 2. This group of chemoreceptors are sensitive to  Decreased PaO2 (less than 60 mmHg)  Increased PaCO2  Decreased pH (acidosis) 3. Changes in pH must be as large 4. When the Central Chemoreceptors do not respond 5. CO2 retainer II. ...
The Nervous System
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... 7. Explain osmosis in terms of isotonic, hypotonic, and hypertonic solutions. Describe what happens to a plant and an animal cell in each solution. 8. How do carrier proteins function in facilitated diffusion and what type of molecules are they responsible for moving across the cell membrane. 9. How ...
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To Fold or Not To Fold
To Fold or Not To Fold

... other to form a a specific protein, they do so through a special kind of covalent bond that is called “peptide bonds”. • In the formation of the bond, water is released. What remains is called a “residue”. Residues are the beads of the ...
Therapeutic opportunities for cell cycle re-entry
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... cycle by sequestering E2F transcription factors, particularly E2F-1, via its large A/B pocket domain (amino acid residues 379–869). Hypophosphorylated pRb sequesters E2F1 in G0 and G1. The phosphorylation of pRb by G1 cyclins (D1, D2, D3, and E)/Cdk complexes promotes the release of E2F-1 from the i ...
Ludwig Institute for Cancer Research Brussels Branch
Ludwig Institute for Cancer Research Brussels Branch

... clinicians from around the world. Many Ludwig investigators are leaders in many areas of science, involving genetics, bioinformatics, immunology, virology, cell biology and signal transduction. Faithful to the organizing principles laid down by Mr. Ludwig, the Institute conducts its research through ...
Biology 11 - hrsbstaff.ednet.ns.ca
Biology 11 - hrsbstaff.ednet.ns.ca

... Explain how unicellular organisms differ from multicellular organisms with respect to how they perform their life processes. Describe how cells are arranged into increasingly complex levels of cellular organization in multicellular organisms - tissues; organs; organ systems Explain why it is necessa ...
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Antimicrobial mechanisms of phagocytes and bacterial evasion

... microbial antigens on their surface, eliciting acquired immune responses. To survive this hostile response, certain bacterial species have developed evasive strategies that often involve the secretion of effectors to co-opt the cellular machinery of the host. In this Review, we present an overview o ...
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sbs-017 basic biochemistry - Personal Webspace for QMUL

... of the module organiser (otherwise it is plagiarism). Also, you are not allowed to copy some part or all of another student’s report and present it as your own work (this is also plagiarism). For students with serious medical, or other, problems leading to extensive absence(s) you need to record tha ...
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... the GSP. Secretion of the S-protein of Aeromonas hydrophila is dependent on protein SpsD, a homologue of the PulD family of secretion proteins which have been implicated in the formation of channels in the outer membrane (Pugsley, 1993; Thomas and Trust, 1995). Protein ApsE, sharing sequence homolog ...
Proc. Natl. Acad. Sci. USA
Proc. Natl. Acad. Sci. USA

... The product of the src gene of Rous sarcoma virus (RSV) is a 60,000-dalton phosphoprotein, pp6Osrc (1-4), which is necessary for the transformation of cells in culture and for the formation of sarcomas in birds (5). Immunoprecipitates containing pp6Osrc invariably have a protein kinase activity that ...
molecular mechanisms of mechanoperception in plants
molecular mechanisms of mechanoperception in plants

... Pioneering studies of mechanotransduction measured the production of action and receptor potentials in giant algal cells such as Chara and Nitella (reviewed in Shimmen, 2006; Wayne, 1994). The large internodal cells of Chara allow researchers to observe the activation of Cl- and Ca2+ fluxes both im ...
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... • The chromosomes line up across the center of the cell. • Centromeres of all chromosomes are aligned with one another, and ...
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... Ad), which plays a crucial role in endocytosis, has been shown to bind several mammalian network proteins, and it also interacts with At-AP180, a monomeric adaptor homologue from Arabidopsis that functions as a plant clathrin assembly protein (Barth and Holstein, 2004). On the other hand, direct inv ...
prokaryotic cells
prokaryotic cells

... made of phospholipids around the cell (just inside the cell wall OR the outside border of animal cells)  Function: controls what enters and leaves the cell; support and protection  Type of Cell: found in all cells  Analogy: it is like the security guard of a ...
Proteomics - University of Warwick
Proteomics - University of Warwick

... An Organism is typically an individual life form composed of interdependent parts (organs). The organs have specific functions and they are composed by cells. A cell is the smallest structural and functional unit of an organ and is microscopic. Proteins do most of the work in cells and are required ...
InduciI)le Expression of Calcyclin, a Gene with
InduciI)le Expression of Calcyclin, a Gene with

... al. (9) and Ciccarone et al. (10) have shown that the three different cell types have different surface antigens and biochem ical properties. It has been suggested that N, I. and S cells are multipotent cells able to differentiate one from the other. In any case, they are clearly different and may r ...
hemp seed: the most nutritionally complete food source in the world
hemp seed: the most nutritionally complete food source in the world

... The body needs the necessary kinds of amino acids in sufficient quantity in order to make proteins such as the globulins. Proper quantities of the right kinds may not be available to the body much of the time. So even though the body has enough essential amino acids available to prevent deficiency d ...
NVCC Bio 211 - gserianne.com
NVCC Bio 211 - gserianne.com

... • Caused by various stimuli • chemicals • temperature changes • mechanical forces ...
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Signal transduction



Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
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