Disruption of a Dynamin Homologue Affects Endocytosis, Organelle
... to elucidate its function in this genetically tractable, unicellular organism. These highly motile cells have proven to be a useful system in which to investigate the molecular mechanisms regulating protein and vesicular trafficking along the biosynthetic and endosomal pathways. There is good eviden ...
... to elucidate its function in this genetically tractable, unicellular organism. These highly motile cells have proven to be a useful system in which to investigate the molecular mechanisms regulating protein and vesicular trafficking along the biosynthetic and endosomal pathways. There is good eviden ...
LIGHT MICROSCOPIC STUDY OF PORELLA PLATYPHYLLA (L
... (Smirnoff 1992, Marschall et al. 1998). There is a great relevance in liverwort taxonomy of observing and typing oil bodies (Kis and Pócs 1997, Sass-Gyarmati 2015). The biogenesis, their detailed constituents, the possible biological function of oil bodies in stress tolerance (i. e. in DT) is still ...
... (Smirnoff 1992, Marschall et al. 1998). There is a great relevance in liverwort taxonomy of observing and typing oil bodies (Kis and Pócs 1997, Sass-Gyarmati 2015). The biogenesis, their detailed constituents, the possible biological function of oil bodies in stress tolerance (i. e. in DT) is still ...
Class I MHC Molecule Protein in Association with an Allogeneic
... proteins (3). 2C CTL specifically responds to Ld in association with the naturally processed peptide LSPFPFDL (p2Ca), isolated from spleen and other tissues (4), or the longer natural peptide VAITRIEQLSPFPFDL (p2Cb), isolated from the same source and containing the entire sequence of p2Ca (5). Both ...
... proteins (3). 2C CTL specifically responds to Ld in association with the naturally processed peptide LSPFPFDL (p2Ca), isolated from spleen and other tissues (4), or the longer natural peptide VAITRIEQLSPFPFDL (p2Cb), isolated from the same source and containing the entire sequence of p2Ca (5). Both ...
The role of Mitogen Activated Protein Kinase (MAPK) - UiO
... The best characterized adipokine was cloned in 1994 and identified as the product of the ob gene responsible for genetic obesity in deficient mice (ob/ob mice) [18]. Shortly after it was given the name leptin after “leptos” Greek for thin, as injections of a recombinant form of the protein reversed ...
... The best characterized adipokine was cloned in 1994 and identified as the product of the ob gene responsible for genetic obesity in deficient mice (ob/ob mice) [18]. Shortly after it was given the name leptin after “leptos” Greek for thin, as injections of a recombinant form of the protein reversed ...
Cell polarity in early C. elegans development
... Early development in C. elegans is shown in Figs 1 and 2 (see Wood, 1988 for review). The sperm enters at the future posterior end of the embryo, opposite the end where the oocyte pronucleus resides. The oocyte pronucleus, which was arrested in meiotic prophase, resumes meiosis and both polar bodies ...
... Early development in C. elegans is shown in Figs 1 and 2 (see Wood, 1988 for review). The sperm enters at the future posterior end of the embryo, opposite the end where the oocyte pronucleus resides. The oocyte pronucleus, which was arrested in meiotic prophase, resumes meiosis and both polar bodies ...
in Thymocytes and Mature T Cells Transduction Pathways to Induce
... GC-induced apoptosis of T lymphocytes is mediated by the GR and requires de novo gene expression It has previously been shown that GC-induced thymocyte apoptosis involves gene activation by the GR (6). However, the mechanism underlying initiation of apoptosis in mature T lymphocytes is not clear. Th ...
... GC-induced apoptosis of T lymphocytes is mediated by the GR and requires de novo gene expression It has previously been shown that GC-induced thymocyte apoptosis involves gene activation by the GR (6). However, the mechanism underlying initiation of apoptosis in mature T lymphocytes is not clear. Th ...
Intranasal Immunization With an Apolipoprotein B
... The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response. Methods and Results—A peptide comprising amino acids 3136 to 3155 of apoB-1 ...
... The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response. Methods and Results—A peptide comprising amino acids 3136 to 3155 of apoB-1 ...
The Journal of Experimental Medicine
... review see reference 16). Classical Hodgkin’s lymphoma (cHL), a common human lymphoma, has been proposed to be derived from GC B cells in the majority of cases (17). Currently, the molecular pathogenesis of cHL remains unclear. Our group identified the transcription factors nuclear factor (NF)-B (f ...
... review see reference 16). Classical Hodgkin’s lymphoma (cHL), a common human lymphoma, has been proposed to be derived from GC B cells in the majority of cases (17). Currently, the molecular pathogenesis of cHL remains unclear. Our group identified the transcription factors nuclear factor (NF)-B (f ...
Research Interests
... These principles will also have direct relevance for our understanding of human developmental pathologies that is based on research in model organisms. Our understanding of morphogenic mechanisms and morphogenic diseases depends on inferences from model systems; thus learning how and where homologou ...
... These principles will also have direct relevance for our understanding of human developmental pathologies that is based on research in model organisms. Our understanding of morphogenic mechanisms and morphogenic diseases depends on inferences from model systems; thus learning how and where homologou ...
MICROTUBULE ORGANIZATION 1 Regulates
... and rid5 alleles are clearly valuable tools for understanding the function of the wild-type protein. In the initial study of mor1 mutants, obvious defects in cortical microtubule arrays of interphase and terminally differentiating cells developed rapidly at 29°C, but mitotic and cytokinetic microtub ...
... and rid5 alleles are clearly valuable tools for understanding the function of the wild-type protein. In the initial study of mor1 mutants, obvious defects in cortical microtubule arrays of interphase and terminally differentiating cells developed rapidly at 29°C, but mitotic and cytokinetic microtub ...
equisetum - Natuurtijdschriften
... trichoblast is helicoidalwith the sive lamellae and with the ...
... trichoblast is helicoidalwith the sive lamellae and with the ...
Beyond the meristems: similarities in the
... and between the generation and loss of organs. To do this, plants must maintain a population of stem cells within the meristems, and at the same time, closely control the identity and position of cells at the meristem boundaries as they differentiate to new leaf or flower primordia. Once developed, ...
... and between the generation and loss of organs. To do this, plants must maintain a population of stem cells within the meristems, and at the same time, closely control the identity and position of cells at the meristem boundaries as they differentiate to new leaf or flower primordia. Once developed, ...
Dimensional analysis of Expansive Growth of Cells with Walls
... Additional insight into expansive growth can be obtained by using dimensional analysis. Dimensional analyses is a mathematical tool used in the physical sciences and engineering [20] to obtain insight into relationships between variables involved in processes of interest, to organize large quantitie ...
... Additional insight into expansive growth can be obtained by using dimensional analysis. Dimensional analyses is a mathematical tool used in the physical sciences and engineering [20] to obtain insight into relationships between variables involved in processes of interest, to organize large quantitie ...
In all vertebrate embryos examined so far, the first
... efficient when applied to whole fixed zebrafish embryos, larvae, and even juvenile (over 1-month old) fish (Figure 1). At medium magnification, the staining nicely delineates the often amoeboid granulocytes throughout the embryo, leaving their nucleus unstained (Figure 1A,b-c; B,d, C,b-c). At high m ...
... efficient when applied to whole fixed zebrafish embryos, larvae, and even juvenile (over 1-month old) fish (Figure 1). At medium magnification, the staining nicely delineates the often amoeboid granulocytes throughout the embryo, leaving their nucleus unstained (Figure 1A,b-c; B,d, C,b-c). At high m ...
Culturability of Mycobacterium tuberculosis cells isolated from
... several days post-infection in vivo. The resulting bacterial suspensions contained a range of morphological types including rods, ovoid forms and coccoid forms. Bacterial viability measured using the MPN method (dilution to extinction in liquid medium) was often much higher than that measured by CFU ...
... several days post-infection in vivo. The resulting bacterial suspensions contained a range of morphological types including rods, ovoid forms and coccoid forms. Bacterial viability measured using the MPN method (dilution to extinction in liquid medium) was often much higher than that measured by CFU ...
Embryo_seedling
... also be stored in thickened cell walls (of endosperm or cotyledons) composed mostly of hemicelluloses. Protein is stored in granules enclosed in membrane derived from the tonoplast and may consist of globulins. Oil is stored as triglyceride in cytoplasmic granules, which may be bound by a unit membr ...
... also be stored in thickened cell walls (of endosperm or cotyledons) composed mostly of hemicelluloses. Protein is stored in granules enclosed in membrane derived from the tonoplast and may consist of globulins. Oil is stored as triglyceride in cytoplasmic granules, which may be bound by a unit membr ...
Ethanol Induces Heterotopias in Organotypic
... more superficial CP and in the MZ fibers became more randomly oriented. On occasion, thin fibers could be seen coursing through the MZ and into the suprapial wart. Ventricular warts also contained nestin-positive fibers (data not shown). ...
... more superficial CP and in the MZ fibers became more randomly oriented. On occasion, thin fibers could be seen coursing through the MZ and into the suprapial wart. Ventricular warts also contained nestin-positive fibers (data not shown). ...
A Triad of Costimulatory Molecules Synergize to
... was demonstrated by flow cytometry (Fig. 1). Uninfected cells (data not shown) and cells infected with wild-type vaccinia virus (V-WT) failed to express any of the three costimulatory molecules (Fig. 1). This observation was confirmed by PCR (data not shown). In contrast, cells infected with rV-B7-1 ...
... was demonstrated by flow cytometry (Fig. 1). Uninfected cells (data not shown) and cells infected with wild-type vaccinia virus (V-WT) failed to express any of the three costimulatory molecules (Fig. 1). This observation was confirmed by PCR (data not shown). In contrast, cells infected with rV-B7-1 ...
Fast lysis of Escherichia coli filament cells requires
... septation is reached and FtsZ assembles into new Zrings, SMS is triggered again and the whole process repeats. The consequences are that diffuse and zonal modes of murein synthesis alternate and that filaments of ftsA, ftsQ or ftsI, but not ftsZ, mutants develop rings of ‘ all new ’ murein at the po ...
... septation is reached and FtsZ assembles into new Zrings, SMS is triggered again and the whole process repeats. The consequences are that diffuse and zonal modes of murein synthesis alternate and that filaments of ftsA, ftsQ or ftsI, but not ftsZ, mutants develop rings of ‘ all new ’ murein at the po ...
Ianello A, Raulet DH. 2013. Immune Surveillance of Unhealthy Cells by Natural Killer Cells. Cold Spring Harbor symposia on quantitative biology.
... mediated by induction and/or activation of E2F transcription factors. Oncogene activation may also indirectly activate p53, which augments transcription of certain human NKG2D ligands (ULBP1 and ULBP2). Heat shock stress results in the activation of the MICA and MICB promoters, via the action of HSF ...
... mediated by induction and/or activation of E2F transcription factors. Oncogene activation may also indirectly activate p53, which augments transcription of certain human NKG2D ligands (ULBP1 and ULBP2). Heat shock stress results in the activation of the MICA and MICB promoters, via the action of HSF ...
Translationally controlled tumor protein (TCTP
... three important elements: the distal enhancer, the proximal enhancer and the proximal promoter (16). Oct4 and Sox2 activated the Oct4 transcription by binding an Oct4/Sox2 element in the distal enhancer (17). The caudal-type homeobox transcription factor 2 (Cdx2) suppressed Oct4 gene by binding to t ...
... three important elements: the distal enhancer, the proximal enhancer and the proximal promoter (16). Oct4 and Sox2 activated the Oct4 transcription by binding an Oct4/Sox2 element in the distal enhancer (17). The caudal-type homeobox transcription factor 2 (Cdx2) suppressed Oct4 gene by binding to t ...
CH-5 Lecture - Horizon Medical Institute
... • Chemotherapeutic drugs. • Surgical excision (used in 90% of the cases). • Irradiation or chemosurgery. ...
... • Chemotherapeutic drugs. • Surgical excision (used in 90% of the cases). • Irradiation or chemosurgery. ...
What are plastids and where did they come from?
... eukaryotic-type ribosomes found in the cytoplasm of the cell. 6. Plastids are capable of division within the plant cell and divide by a process of binary fission, similar in many ways to the division process of bacteria. The theory of endosymbiosis has been supported extensively by the avalanche of ...
... eukaryotic-type ribosomes found in the cytoplasm of the cell. 6. Plastids are capable of division within the plant cell and divide by a process of binary fission, similar in many ways to the division process of bacteria. The theory of endosymbiosis has been supported extensively by the avalanche of ...
PDF file - Via Medica Journals
... in a hydrated form, methylene glycol (OH-CH2-OH), in solution. Condensing of the methylol group (CH2OH) with another compound containing active hydrogen ions leads to the production of the cross-links. The most common formaldehyde-based fixative is neutral buffered formalin (FA) solution, which was ...
... in a hydrated form, methylene glycol (OH-CH2-OH), in solution. Condensing of the methylol group (CH2OH) with another compound containing active hydrogen ions leads to the production of the cross-links. The most common formaldehyde-based fixative is neutral buffered formalin (FA) solution, which was ...
Therapies for sarcopenia and regeneration of old skeletal muscles
... aged 27–29 mo13 showed a marked delay in inflammation (and hence no initiation of myogenesis) at 5 d after transplantation for old autografts, a time when new myotubes were conspicuous in young autografts and there were no adverse effects of the old host on young autografts. Thus age-related delays ...
... aged 27–29 mo13 showed a marked delay in inflammation (and hence no initiation of myogenesis) at 5 d after transplantation for old autografts, a time when new myotubes were conspicuous in young autografts and there were no adverse effects of the old host on young autografts. Thus age-related delays ...
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.