Polysialic acid controls NCAM signals at cell–cell contacts to
... from four to eight independent experiments for each condition. One-way ANOVA indicated significant differences (P,0.001) for cells in contact. ***P,0.001 versus all other groups (Newman–Keuls post test); n.s., not significant (P.0.01), t-test. (D,E) LSAM1PST cells immunolabelled for FAK (red), NCAM ...
... from four to eight independent experiments for each condition. One-way ANOVA indicated significant differences (P,0.001) for cells in contact. ***P,0.001 versus all other groups (Newman–Keuls post test); n.s., not significant (P.0.01), t-test. (D,E) LSAM1PST cells immunolabelled for FAK (red), NCAM ...
UVA radiation causes DNA strand breaks, chromosomal
... The role of UVA-radiation—the major fraction in sunlight—in human skin carcinogenesis is still elusive. We here report that different UVA exposure regime (4 5 J/cm2 per week or 1 20 J/cm2 per week) caused tumorigenic conversion (tumors in nude mice) of the HaCaT skin keratinocytes. While tumorig ...
... The role of UVA-radiation—the major fraction in sunlight—in human skin carcinogenesis is still elusive. We here report that different UVA exposure regime (4 5 J/cm2 per week or 1 20 J/cm2 per week) caused tumorigenic conversion (tumors in nude mice) of the HaCaT skin keratinocytes. While tumorig ...
ROS signaling as common element in low oxygen and heat stresses
... genes, these HSPs are not constitutively expressed in the N-end rule Arabidopsis mutants such as ate1/2 and prt6 that lack some of the recognition steps required for proteasomal degradation [30,31]. ate1/2 lacks the arginyl-tRNA-protein transferase (ATE1 and ATE2) required to arginylate the oxidized ...
... genes, these HSPs are not constitutively expressed in the N-end rule Arabidopsis mutants such as ate1/2 and prt6 that lack some of the recognition steps required for proteasomal degradation [30,31]. ate1/2 lacks the arginyl-tRNA-protein transferase (ATE1 and ATE2) required to arginylate the oxidized ...
the Essential Standards of Biology
... support the theory of evolution. Bio.3.4.2 Explain how natural selection influences the changes in species over time. Bio.3.4.3 Explain how various disease agents (bacteria, viruses, chemicals) can influence natural selection. Bio.3.5.1 Explain the historical development and changing nature of class ...
... support the theory of evolution. Bio.3.4.2 Explain how natural selection influences the changes in species over time. Bio.3.4.3 Explain how various disease agents (bacteria, viruses, chemicals) can influence natural selection. Bio.3.5.1 Explain the historical development and changing nature of class ...
Multiple Poliovirus-Induced Organelles Suggested By
... exception of 3BC, which cannot be cleaved, products of the minor pathway were essentially unchanged [42]. For EG PV, the products of both pathways were the same as observed for wild type (see EG in Fig. 1B). However, the rate of cleavage at the 3BC junction was reduced, causing a ...
... exception of 3BC, which cannot be cleaved, products of the minor pathway were essentially unchanged [42]. For EG PV, the products of both pathways were the same as observed for wild type (see EG in Fig. 1B). However, the rate of cleavage at the 3BC junction was reduced, causing a ...
Powerpoint
... methionine, thus this amino acid is found in most proteins. Methionine is considered to be an antioxidant. Methionine residues on protein surfaces can protect against oxidation of other amino acids that are important for the function of the proteins. If a protein with a spherical diameter of 60 Å ha ...
... methionine, thus this amino acid is found in most proteins. Methionine is considered to be an antioxidant. Methionine residues on protein surfaces can protect against oxidation of other amino acids that are important for the function of the proteins. If a protein with a spherical diameter of 60 Å ha ...
Site-Directed Mutagenesis of Predicted Active Site Residues in
... study by Robinson et al. (1987). Enzymatic activity of GCP II in 2 mg of total protein from the cell lysate was assayed in a final volume of 250 ml using 30 nM N-acetyl-L-aspartyl-L-[3,4-3H]glutamate in 50 mM Tris, pH 7.4, at 37°C, 0.1% Triton X-100, 150 mM potassium phosphate, and 1 mM CoCl2 (Robin ...
... study by Robinson et al. (1987). Enzymatic activity of GCP II in 2 mg of total protein from the cell lysate was assayed in a final volume of 250 ml using 30 nM N-acetyl-L-aspartyl-L-[3,4-3H]glutamate in 50 mM Tris, pH 7.4, at 37°C, 0.1% Triton X-100, 150 mM potassium phosphate, and 1 mM CoCl2 (Robin ...
Study of the role of estrogen receptor variant, ER36, in non genomic
... Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation Aisling M Redmond, Soleilmane Omarjee, Muriel Le Romancer, Jason S Carroll (In Prep for Submission to Oncogene) Identification and characterization of PRMT1 as a target for the treatment of bre ...
... Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation Aisling M Redmond, Soleilmane Omarjee, Muriel Le Romancer, Jason S Carroll (In Prep for Submission to Oncogene) Identification and characterization of PRMT1 as a target for the treatment of bre ...
Alfred G. Gilman - Nobel Lecture
... gave birth to the concepts of transmembrane signaling and of hormoneregulated synthesis of intracellular second messengers (Fig. 1). Both men were trained as biochemists (Sutherland with Carl Cori, Rall with Albert Lehninger), and together they initiated a classical reductionistic approach to deciph ...
... gave birth to the concepts of transmembrane signaling and of hormoneregulated synthesis of intracellular second messengers (Fig. 1). Both men were trained as biochemists (Sutherland with Carl Cori, Rall with Albert Lehninger), and together they initiated a classical reductionistic approach to deciph ...
Glucose transporter gene expression in early mouse
... embryos in culture respond to exogenous insulin with increased rates of DNA, RNA and protein synthesis (Harvey and Kaye, 1988; Heyner etal. 1989a; Rappolee et al. 1990) and that insulin receptor gene expression can be detected from the 8-cell stage onwards (Rosenblum et al. 1986; Mattson et al. 1988 ...
... embryos in culture respond to exogenous insulin with increased rates of DNA, RNA and protein synthesis (Harvey and Kaye, 1988; Heyner etal. 1989a; Rappolee et al. 1990) and that insulin receptor gene expression can be detected from the 8-cell stage onwards (Rosenblum et al. 1986; Mattson et al. 1988 ...
Inter-specific scaling of phytoplankton production and cell size in the
... particular location, the mean was calculated and used in subsequent analyses. However, if measurements of the same species were reported for different locations, data were handled separately. In this way, the original dataset, which included more than 200 measurements of in situ carbon fixation or g ...
... particular location, the mean was calculated and used in subsequent analyses. However, if measurements of the same species were reported for different locations, data were handled separately. In this way, the original dataset, which included more than 200 measurements of in situ carbon fixation or g ...
Cytoplasmic and mitochondrial protein translation in axonal and
... initial elaboration of dendritic and axonal terminals, failure to stabilize gars encodes both cytoplasmic and mitochondrial GARS these terminals after initial elaboration or a combination of both. Protein translation is carried out in parallel in the cytoplasm and the During early pupal stages, proj ...
... initial elaboration of dendritic and axonal terminals, failure to stabilize gars encodes both cytoplasmic and mitochondrial GARS these terminals after initial elaboration or a combination of both. Protein translation is carried out in parallel in the cytoplasm and the During early pupal stages, proj ...
The proteomics of plant cell membranes
... In plant cells, as well as in animal cells, the plasma membrane controls many primary cellular functions, such as metabolite and ion transport, endocytosis, and cell differentiation and proliferation. All these processes involve a large number of proteins with highly diverse structures and functions ...
... In plant cells, as well as in animal cells, the plasma membrane controls many primary cellular functions, such as metabolite and ion transport, endocytosis, and cell differentiation and proliferation. All these processes involve a large number of proteins with highly diverse structures and functions ...
Discover the Biology:
... • However no animal model reflects all aspects of the human form of the disease. • Omics analysis across model systems could provide supporting evidence of the value of those animal models. • Metabolic manifestations of diabetes associated with insensitivity to ...
... • However no animal model reflects all aspects of the human form of the disease. • Omics analysis across model systems could provide supporting evidence of the value of those animal models. • Metabolic manifestations of diabetes associated with insensitivity to ...
Chapter 10
... Günter Blobel and David Sabatini first proposed in 1971 that the signal for ribosome attachment to the ER might be an amino acid sequence near the amino terminus of the growing polypeptide chain. This hypothesis was supported by the results of in vitro translation of mRNAs encoding secreted proteins ...
... Günter Blobel and David Sabatini first proposed in 1971 that the signal for ribosome attachment to the ER might be an amino acid sequence near the amino terminus of the growing polypeptide chain. This hypothesis was supported by the results of in vitro translation of mRNAs encoding secreted proteins ...
Regenerated Hair Cells Can Originate from Supporting Cell Progeny
... Sensorineuralhearing loss, commonly known as “nerve deafness,” affects more than 80% of patients who have a significant lossof auditory sensitivity, over 17 million individuals in the United States alone. The primary causeof this disorder is loss of the sensory hair cells that are the initial transd ...
... Sensorineuralhearing loss, commonly known as “nerve deafness,” affects more than 80% of patients who have a significant lossof auditory sensitivity, over 17 million individuals in the United States alone. The primary causeof this disorder is loss of the sensory hair cells that are the initial transd ...
Molecular mechanisms of complement evasion: learning from
... vacuole or in the cytoplasm. Over the past few years it has become clear that, in addition, bacteria can escape recognition by the complement system through the actions of cell-surface or secreted proteins1,2. Complement is one of the most important components of the innate immune system and is comp ...
... vacuole or in the cytoplasm. Over the past few years it has become clear that, in addition, bacteria can escape recognition by the complement system through the actions of cell-surface or secreted proteins1,2. Complement is one of the most important components of the innate immune system and is comp ...
DNA Methylation Changes during Maize Leaf
... DNA methylation is the covalent modification of nucleotides in DNA by addition of a methyl group. In the nuclear genome of higher eukaryotes, 5-methylcytosine (5-mC) is the most important DNA modification (Goll and Bestor, 2005). It is a phenomenon of ancient origin predating plant-animal diversifi ...
... DNA methylation is the covalent modification of nucleotides in DNA by addition of a methyl group. In the nuclear genome of higher eukaryotes, 5-methylcytosine (5-mC) is the most important DNA modification (Goll and Bestor, 2005). It is a phenomenon of ancient origin predating plant-animal diversifi ...
Guard cells in albino leaf patches do not respond to
... albino plants (Henson 1984). In these albino plants, plastidogenesis is also destroyed and causes decreased transcription numbers of nuclear-encoded chloroplast genes (Oelmüller & Mohr 1986; Strand et al. 2003; McCormac & Terry 2004a). In addition, Nf affects the transcription rates of a large numbe ...
... albino plants (Henson 1984). In these albino plants, plastidogenesis is also destroyed and causes decreased transcription numbers of nuclear-encoded chloroplast genes (Oelmüller & Mohr 1986; Strand et al. 2003; McCormac & Terry 2004a). In addition, Nf affects the transcription rates of a large numbe ...
Expression and function of cell adhesion molecules during neural
... types. NC cell-cell and cell-matrix interactions are an essential part of the migration ...
... types. NC cell-cell and cell-matrix interactions are an essential part of the migration ...
PDF
... morpholinos to combinatorially knock down gata5 and gata6. We have previously shown that these double morphants are essentially a triple knockdown, as gata4 is no longer expressed, which was reconfirmed here (see Fig. S1A in the supplementary material) (Peterkin et al., 2007). In gata5 and gata6 mor ...
... morpholinos to combinatorially knock down gata5 and gata6. We have previously shown that these double morphants are essentially a triple knockdown, as gata4 is no longer expressed, which was reconfirmed here (see Fig. S1A in the supplementary material) (Peterkin et al., 2007). In gata5 and gata6 mor ...
Lysis of Human Monocytic Leukemia Cells by
... to ADP. Only IFN-y-treated cells showed a slight sensitivity (10.4% k 0.2% specific lysis) to ADP at 1.25 mmol/L, which was unlike human IFN-treated macrophages in which no susceptibility to ADP-mediated lysis was noted.5 Time course of IFN-y-induced efects. The timing of the addition of IFN-y to th ...
... to ADP. Only IFN-y-treated cells showed a slight sensitivity (10.4% k 0.2% specific lysis) to ADP at 1.25 mmol/L, which was unlike human IFN-treated macrophages in which no susceptibility to ADP-mediated lysis was noted.5 Time course of IFN-y-induced efects. The timing of the addition of IFN-y to th ...
Isoflavone and Pterocarpan Malonylglucosides and ß -l,3
... good viability after incubation with fluoresceine diacetate. Residual cell wall fragments could not be detected after calcofluor white staining. For vacuole isolation the protoplasts were rou tinely used directly after isolation. Satisfactory lysis of the protoplasts was obtained by incubation in 5 ...
... good viability after incubation with fluoresceine diacetate. Residual cell wall fragments could not be detected after calcofluor white staining. For vacuole isolation the protoplasts were rou tinely used directly after isolation. Satisfactory lysis of the protoplasts was obtained by incubation in 5 ...
Dubrulle and Pourquie, 2004 - Development
... a periodic process, where a new boundary is invariably formed after a given amount of time. Therefore, counting the number of somites is a very reliable way to stage an embryo. Somitogenesis also has two other striking properties. The vertebrate body shows bilateral symmetry; this is true for the pa ...
... a periodic process, where a new boundary is invariably formed after a given amount of time. Therefore, counting the number of somites is a very reliable way to stage an embryo. Somitogenesis also has two other striking properties. The vertebrate body shows bilateral symmetry; this is true for the pa ...