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Negative regulation of the interferon response by
Negative regulation of the interferon response by

... ABSTRACT Long non-coding RNAs (lncRNAs) play critical roles in diverse cellular processes; however, their involvement in many critical aspects of the immune response including the interferon (IFN) response remains poorly understood. To address this gap, we compared the global gene expression pattern ...
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... CrRLK1L gene family, as combining the1 with herk1 and/or herk2 mutations, single mutants that are also aphenotypic, resulted in strong effects on cell expansion, including decreased petiole length and shoot growth (Guo et al., 2009a, 2009b), similar to the effects of the fer mutation. The overall de ...
Collagen Binding Proteins Derived from the Embryonic Fibroblast
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... The discovery of the Arg-Gly-Asp (RGD) peptide and its role in cell surface-ECM binding was a major advance in the understanding of substrate adhesion (Pierschbacher and Ruoslahti, 1984). The RGD receptors comprise a superfamily of translation products termed the Integrins (Hynes, 1987; Buck and Hor ...
division plane control in plants: new players in the band
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... actin depolymerizing drugs applied during mitosis or cytokinesis. However, KDZs were no longer seen when early PPB microtubules were depolymerized. After drug washout, most cells reformed both a PPB and a KDZ, but some failed to reconstitute a PPB or a KDZ, suggesting that KDZ formation depends on t ...
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Full-Text PDF
Full-Text PDF

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... occur in the more central parts of the cell-body (figs, i, D; 2, A). These lighter areas measure about o-i to 0-2 /x across and contain small numbers of delicate fibres 20 to 40 A in diameter. The general appearance is similar to that of the chromatin bodies of bacteria (see Glauert, 1962). No inter ...
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... and Walz, 2001). The outer nuclear envelope is continuous with the rough ER, and the rough ER is distinguished from smooth ER by the presence of ribosomes on the cytosolic side of the membrane. The ER forms a dynamic polygonal network composed of tubules, sheets, and three-way junctions. In addition ...
Transcription- and translation-dependent changes in membrane
Transcription- and translation-dependent changes in membrane

... Thus, high-level expression of a gene encoding a membrane protein may result in the formation of a compact region (domain) in the membrane, which is highly enriched by this protein and its preferred phospholipid (Fig. 1). Nascent polypeptides are kept together in such a domain by the dynamic structu ...
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Cell nucleus



In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel) is a membrane-enclosed organelle found in eukaryotic cells. Eukaryotes usually have a single nucleus, but a few cell types have no nuclei, and a few others have many.Cell nuclei contain most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these chromosomes are the cell's nuclear genome. The function of the nucleus is to maintain the integrity of these genes and to control the activities of the cell by regulating gene expression—the nucleus is, therefore, the control center of the cell. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm, and the nucleoskeleton (which includes nuclear lamina), a network within the nucleus that adds mechanical support, much like the cytoskeleton, which supports the cell as a whole.Because the nuclear membrane is impermeable to large molecules, nuclear pores are required that regulate nuclear transport of molecules across the envelope. The pores cross both nuclear membranes, providing a channel through which larger molecules must be actively transported by carrier proteins while allowing free movement of small molecules and ions. Movement of large molecules such as proteins and RNA through the pores is required for both gene expression and the maintenance of chromosomes. The interior of the nucleus does not contain any membrane-bound sub compartments, its contents are not uniform, and a number of sub-nuclear bodies exist, made up of unique proteins, RNA molecules, and particular parts of the chromosomes. The best-known of these is the nucleolus, which is mainly involved in the assembly of ribosomes. After being produced in the nucleolus, ribosomes are exported to the cytoplasm where they translate mRNA.
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