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Case-It - South. Blot.
Case-It - South. Blot.

... Case-It: Southern Blotting Sickle cell anemia Background: Sickle cell anemia is a disease of red blood cells. It is caused by a mutation in the hemoglobin gene. A single base change results in a single amino acid substitution. This mutation causes the hemoglobin to change its conformation to a more ...
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... aging.” Botox—injected into the faces of hundreds of thousands of Americans each year, it is one of the deadliest toxins on earth. To understand how it functions on a microscopic level is to realize just how desperate its proponents are to erase from their foreheads any evidence of the passage of ti ...
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...  Start with haploid spores formed by meiosis  Spores released by fruiting body  Spores germinate and grow into haploid mycelia  Cells haploid, undergo mitosis to form fungal body  Mating types? II. The Dikaryotic (binucleate) Phase  Fusion of two mating types, exchange of nuclei  Result in bi ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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