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OglIb~3 Integrin Dissociation Induced by EDTA Results in
OglIb~3 Integrin Dissociation Induced by EDTA Results in

... which protect the complex from EDTA induced dissociation, (c) appear only at alkaline pH and at 37~ which corresponds to the range of pH and temperature where EDTA can dissociate GPIIb-IIIa complexes, (d) are accompanied by the disappearance in fluorescence flow cytometry of the heterodimer complex- ...
Donohoe, B.S., B. - University of Colorado-MCDB
Donohoe, B.S., B. - University of Colorado-MCDB

... Golgi stacks are assembled from lipids and proteins produced in the endoplasmic reticulum (ER) and transported in COPII vesicles to the cis-side of the Golgi (1–4). COPII vesicles (5) also deliver ER-synthesized cargo molecules to the Golgi, where they are modified by different sets of enzymes as th ...
SCARFACE Encodes an ARF-GAP That Is Required for Normal
SCARFACE Encodes an ARF-GAP That Is Required for Normal

... an adjacent PH domain, have been implicated as membrane curvature sensors (Peter et al., 2004). PH domains bind to inositol phosphates and can confer binding to specific membranes (Lemmon et al., 1995; Falasca et al., 1998). The ARF-GAP domain activates latent ATPase activity of ARFs, which then lea ...
Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for
Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for

... the following observations in mammalian tissue culture and Drosophila cells. After MT-attachment, Mad2 and Rod stream off kinetochores along kinetochore MTs (kMTs), resulting in the reduction of kinetochore-associated Mad2 and Rod levels (Howell et al., 2000; Basto et al., 2004). Interference with t ...
Differential recruitment of Dishevelled provides signaling specificity
Differential recruitment of Dishevelled provides signaling specificity

... (Zw3, also known as Shaggy), a serine/threonine kinase homologous to GSK3, phosphorylates Armadillo (Arm, a homolog of b-catenin), destabilizing the cytoplasmic form of the protein. In the presence of Wg, the receptor acts through Dsh to antagonize Zw3 activity, and Arm is stabilized, resulting in i ...
Isolation and characterization of the Pin1/Ess1p homologue in
Isolation and characterization of the Pin1/Ess1p homologue in

... activation (Liu et al., 2001). Recently, Pin1 has been shown to be overexpressed in breast cancer, and to increase expression of cyclin D1 as a result of its ability to bind to c-Jun phosphorylated at the Ser63/73.Pro motifs in its transactivation domain, and thereby stimulate cyclin D1 promoter act ...
Adeno-Associated Virus Vectors for Gene Therapy - diss.fu
Adeno-Associated Virus Vectors for Gene Therapy - diss.fu

... high seroprevalence of AAV (about 80%) in the human population [6] no diseases or pathogenic properties have been associated with AAV infection. ...
The potential for toxin and antitoxin gene
The potential for toxin and antitoxin gene

... phylogeny could be due to differences in tendency to exhibit PSK in different environments. This connection between distribution and PSK was explored by experimentally testing a computationally described operon, plasmid_Toxin-ptaRNA1, that exhibited structural and distributional similarities to a mo ...
Surface modification of PLGA nanoparticles via human serum
Surface modification of PLGA nanoparticles via human serum

... conjugated with human serum albumin. Fourier transform infrared spectrum was used to confirm the conjugation reaction where nuclear magnetic resonance was utilized for conjugation ratio determination. In addition, transmission electron microscopy showed two different contrast media in conjugated nan ...
as Hotspot Ca 2+ Signaling Units
as Hotspot Ca 2+ Signaling Units

... Fig. 17.1 Intracellular Ca2+ signaling. Schematic model of intracellular Ca2+ homeostasis. Plasma membrane G-protein coupled receptors activate phospholipase C-b (PLC-b) to promote the generation of inositol 1,4,5-trisphosphate (IP3) and the release of Ca2+ from the endoplasmic reticulum (ER) into ...
Biochemical Similarity of Expressed Human Prorenin
Biochemical Similarity of Expressed Human Prorenin

... SUMMARY Prorenin is secreted by mammalian cells transfected with a human preprorenin expression construct. The purpose of this investigation was to compare the physicochemical properties of expressed prorenin in culture medium with the known characteristics of human inactive renin, which accounts fo ...
Three distinct ribosome assemblies modulated by translation are the
Three distinct ribosome assemblies modulated by translation are the

... Figure 1.  Native human polysomes observed by AFM preserve their in vivo organization and reveal tight ribosome interactions. (a) Typical sedimentation profile of polysomes from MCF-7 cell lysates obtained in a concave 15–50% sucrose gradient. The absorbance peaks corresponding to 40S and ribonucleo ...
physiology 625 - University of Mississippi Medical Center
physiology 625 - University of Mississippi Medical Center

... assignments for the missed class will be at the discretion of the course coordinator. Failure to complete a missed class assignment in the time designated by the course coordinator will result in a failing grade (50) for that assignment. Failure to report an absence to the course coordinator prior t ...
VEGFR2 but not VEGFR3 governs integrity and remodeling of
VEGFR2 but not VEGFR3 governs integrity and remodeling of

... cells, and VEGFR2- or VEGFR3-expressing ECs. Dynamic changes in angiofollicular unit and number of endothelial fenestrae in thyroid glands by circulating TSH To get an insight about how the dynamic changes in thyroid capillaries occur, we determined the influence of TSHR signaling on the thyroid gla ...
Regulation of reactive oxygen species homeostasis
Regulation of reactive oxygen species homeostasis

... as by ABA and SA hormones (Lee et al., 1999; Pei et al., 2000; Khokon et al., 2011). Therefore, we tested whether H2O2 is also an important secondary messenger in CK-mediated stomatal immunity. We monitored H2O2 production in epidermal strips treated with 1 µM t-Z or 5 µM flg22 using the fluorescen ...
NCAM Polypeptides in Heart Development: Association with Z Discs
NCAM Polypeptides in Heart Development: Association with Z Discs

... on almost all of these cells (Crossin and Hoffman, 1991; Linask, 1992). Some of these precardiac cells deadhere as they downregulate expression of these adhesion molecules, convert into mesenchymal cells, and migrate into the basement membrane. The primordia then fuse to form one doublelayered tube ...
Mechanical motion promotes expression of Prg4
Mechanical motion promotes expression of Prg4

... (C) Sections of the knee joints depicted in B (n = 6 running or 6 control mice). For each mouse, the total number of b-galactosidaseexpressing cells in five sections of the lateral condyles and five sections of the medial condyles in both knees was quantitated. (D) The knees of either control or run ...
Author`s post-print  - Cardiff Metropolitan University
Author`s post-print - Cardiff Metropolitan University

... clinicians relied on antibiotics and more sophisticated dressings started to become available. Within the past ten years honey has been re-introduced into modern medicine in many developed countries. Although varying types of floral honey have been used clinically, manuka honey from New Zealand is t ...
special paper calcium function and distribution during fertilization in
special paper calcium function and distribution during fertilization in

... by reversible ionic binding, effectively controlling the free calcium concentration. The effective Ksp of the binding molecule, which is often a protein, may be dramatically altered in binding and functionality by changes in molecular or ionization state, including those induced by pH and other envi ...
www.drmichaellevin.org
www.drmichaellevin.org

... Wood, 1997; Levin, 1998; Levin and Mercola, 1998]. Within the last few years, some understanding of the molecular basis for LR patterning has been gained through the characterization of a cascade of asymmetrically expressed genes in the chick [Levin et al., 1995, 1997; Isaac et al., 1997]. The most ...
A genetic framework for fruit patterning in
A genetic framework for fruit patterning in

... Fig. 3. FIL and YAB3 are necessary for proper SHP2 and FUL expression. GUS expression driven by the SHP2 promoter (A-E) or the ful-1 enhancer trap line (F-I). All plants stained for FUL GUS activity are heterozygous for ful-1. (A) In wild-type fruit, the SHP2::GUS reporter is active in the valve mar ...
Induction of floor plate differentiation by contact
Induction of floor plate differentiation by contact

... In the spinal cord of chick embryos from which the notochord has earlier been removed, neurons characteristic of the dorsal spinal cord differentiate but floor plate cells and motor neurons do not (Yamada et al., 1991; Placzek et al., 1991; Ericson et al., 1992). We therefore examined whether the ne ...
Maternal mRNAs are regulated by diverse P body
Maternal mRNAs are regulated by diverse P body

... The diverse translation patterns in the C. elegans gonad and embryo are mediated by different sets of RNA-binding proteins that are expressed at distinct developmental stages (Fig. 1 B; Lee and Schedl, 2006). At least some of these RNA-binding proteins bind to specific UTR elements in mRNAs. The KH ...
Sears JC and Broihier HT
Sears JC and Broihier HT

... Dendrite architecture is established during development and lays the groundwork for neuronal connectivity and function. Dendrites acquire simple or complex morphologies depending on the degree of branching and growth of their arbors. Regulation of dendrite branching and growth requires accurate inte ...
Cenp-A Presence in Drosophila - Institute of Molecular Life Sciences
Cenp-A Presence in Drosophila - Institute of Molecular Life Sciences

... specified epigenetically by incorporation of a centromerespecific histone H3 variant (CenH3). After chromosome replication, the centromeres in the resulting two sister chromatids might be expected to be composed of a mixture of pre-existing CenH3 evenly distributed onto the two copies during replica ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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