Annexin-Phospholipid Interactions. Functional Implications
... Inside each domain, a sequence of 17 amino acid residues is found which presents an even higher
degree of conservation. Annexin A5 was the first member of this family to be crystallized and its
structure to be studied by X-ray diffraction [6,7]. Since then, several other annexins have been
Uptake of Galactose and Lactose by Kluyvevomyces
... Induction of'the galactose uptake system
Galactose permease activity of K. lactis 2359 was measured after growth to late-exponential
phase on different carbon substrates. The rate of galactose entry into the cell was measured by
following the uptake of [lSC]galactose(5 mM) during the first 2 min (Ta ...
Receptor-regulated Dynamic S-Nitrosylation of Endothelial Nitric
... eNOS functions as an obligate homodimer through an association mediated by a cysteine-complexed Zn2⫹ (zinc-tetrathiolate) at the dimer interface (4 – 6). eNOS activity is regulated by
several dynamic phosphorylations and protein-protein interactions (reviewed in Ref. 7) that can be modulated followi ...
The functional relationship between ectodermal and mesodermal
... the primary segmented tissue was the ectoderm or the mesoderm
in a common segmented ancestor. One way of resolving this issue is
to examine other arthropods, since the initial step of Drosophila segmentation utilizes a derived mechanism and may not accurately represent segmentation mechanisms in all ...
- the University of Huddersfield Repository
... metabolites over the first 30 minutes and 24 hours respectively. The 2-fold difference
between Qvar and Clenil is consistent with related clinical and pharmacokinetic studies.
The low inter and intra-subject variability of the study confirms the reproducibility of
this method. When compared to the i ...
Decision making by p53: life, death and cancer
... modification is phosphorylation, shown long ago to impact on
the promoter selectivity of p53.26 A more recent striking
example involves phosphorylation of serine 46, which is
specifically required for the efficient transactivation of the
proapoptotic p53AIP1 gene,27 and perhaps a small subset of
Sample of - Test Bank Instant
... 61. Shivering to try to raise your body temperature back to normal would be an example of:
a. the body trying to maintain homeostasis.
b. a positive feedback mechanism.
c. a negative feedback mechanism.
d. both A and C.
REF: Page 18 (Box 1-1)
TOP: Homeostasis/Negative Feedback ...
Vitreous and Developmental Vitreoretinopathies
... the basal lamina of Müller cells (62,63) (Fig. 3.6) (see
also Chapter 4). The ILL is composed of type IV collagen
closely associated with glycoproteins (64–66). Immediately adjacent to the Müller cells is the lamina rara,
which is 0.03 to 0.06 µm thick and demonstrates no species variations nor chan ...
Epithelium and mucus
... Sahlgrenska Academy, University of Gothenburg, Sweden
The intestine is covered by mucus that is the first line of defence of the epithelium. The
main structural component of the intestinal mucus is the MUC2 mucin. This is a large
glycoprotein with two long and heavily O-glycosylated mucin domains. O ...
... required technology from many disciplines beyond pharmaceutical sciences, such as
polymer chemistry, adhesion sciences, mass transport, web film coating, and printing
(Potts and Cleary, 1995). Electrotransport is another example where the science
developed in other disciplines can be used to expand ...
The anaphase promoting complex/ cyclosome: a
... Selective substrate recognition by APC/C
How are substrates recognized by APC/C? It has long
been suspected that the essential role of co-activator proteins in APC/C activation might be to recruit substrates
to APC/C, analogously to the role of adaptor proteins
in SCF complexes. This view was suppor ...
Plant hormones and growth regulators
... Ca2+ is an essential element; however, its role is elusive. When examining total Ca2+ in plants,
the concentration is quite large (mM), but its requirement is that of a micronutrient (µM). Ca2+ is
not usually limiting in field conditions, still there are several defects that can be associated with
Navodaya Vidyalaya Samiti – Bhopal Region.
... level at the middle of the cycle. Rapid secretion of LH induces ovulation and is followed by
luteal phase in which corpus luteum is formed. Menstrual cycles ceases completely around
50 years of age called menopause.
Fertilization & Implantation: Fertilization is the process of fusion of a sperm with ...
The Influence of Certain Trace Metals on Bacterial
... The uptake of Mg2+ in Mg2+-limited cultures of the Gram-negative
Escherichia coli is rapid and is complete some time before the onset of the
stationary phase. In similar cultures of the Gram-positive Bacillus megaterium
and B. subtilis ~3 growth and Mg2+ assimilation cease at the same time and
The contractile apparatus and mechanical properties of airway smooth muscle
... Membrane-associated dense plaques. In electron micrographs, bundles of actin filaments and intermediate filaments can be seen penetrating the inner surface of electron
dense areas of the membrane termed "dense bands" or
"dense plaques" [4, 6, 18, 19]. Dense plaques (sometimes
described as ribs) are ...
Auxin transport routes in plant development
... The plant hormone auxin (the predominant form of which is indole3-acetic acid; IAA) is a major coordinating signal in the regulation
of plant development. Many aspects of auxin action depend on its
differential distribution within plant tissues, where it forms local
maxima or gradients between cells ...
A Comprehensive Integrative Medical approach to Mercury
... will shut down the blood flow to the toxic bodily components (hypo-perfusion). Often the detox
organs become dys-functional because of the chronic toxic load. All patients with chronic
health problems have dys-autonomia or dysfunction of the Autonomic Nervous System (the
body’s energetic information ...
375 Na+/Ca2+ ANTIPORT IN THE MAMMALIAN HEART
... Thus, the cardiac isoform is A-C-D-E-F, the predominant patterns in brain are A-D or AD-F, and in smooth muscle the pattern is principally B-D (Nakasaki et al. 1993). This
mechanism accounts for all of the isoforms of the cardiac type antiporter thus far reported.
The reasons for the existence of ti ...
Influence of the 4G/5G PAI-1 genotype on angiotensin II
... Background: We examined the influence of the 4G/5G PAI-1 (plasminogen activator inhibitor) genotype on Angiotensin II (Ang II)induced PAI-1 expression by human endothelial cells (HUVEC) in the presence and absence of AT1-receptor blocker losartan, and screened
for this polymorphism in relation to pl ...
2004__MORRIS_et_al_Transpor... - Institute of Experimental Botany
... Auxin exported by the apical tissues of intact dicotyledonous plants moves
downwards through the stem and root by a mechanism that has all the
characteristics of the slow, polar transport first described from coleoptile and
stem segments (33, 59). In stems, this transport occurs basipetally, but not ...
EAP actuators aid the quest for the "Holy Braille" of tactile displays
... Slow tactile display setup or response times have been found unacceptable by users, and several prototype
braille display units16 have progressed too far down costly development paths before discovering that.
Most of the thermally actuated braille display approaches require excessive peak drive powe ...
Control of Pre-mRNA Splicing by the General Splicing Factors
... ligated in order to make mature mRNA. Disease-causing
mutations that affect the splicing process are common, and testify
to the importance of splicing for normal cellular function. The
splicing process is made more complex by the fact that many premRNAs can be spliced in more than one way to give ma ...
... Smo556-625, Smo679-1035 and SmoCT⌬626-678, did not pull
down HA-tagged PP4 when co-expressed in S2 cells (see Fig. S3A,
lanes 2, 5 and 6, top panel in the supplementary material), suggesting
that amino acids 626-678 of Smo is responsible for either direct or
indirect association between SmoCT and PP ...
An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.