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November 2013 Life Science Strand
November 2013 Life Science Strand

... decisions about these areas arise from studying science. For example, understanding what an “empty calorie” means can lead to decisions about healthier food choices. Researching the negative health consequences of lead paint, often found in older housing, can help students explore various protection ...
Chapter 27
Chapter 27

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280_2015_2915_MOESM1_ESM

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HIV-1 Infection of Nondividing Cells: C-Terminal

... viral particle formation, yet for 1% of the molecules, it becomes recessive once HIV-1 enters target cells. This suggests a model in which some modification of MA, during or after assembly, is responsible for silencing the influence of myristoylation, thereby revealing the NLS effect. Interestingly, ...
Sites of Location of Ribosomes in the Bacterial Cell
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Lecture 6- Medical Mycology

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Biology: Cells the Fundamental Unit of Life

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...  Are all made of proteins  Are over 1000 different enzymes in the human body  Most names of enzymes end in ase  Function as catalysts. A catalyst speeds up chemical reactions but are not altered by the reaction and can be used over and over again.  They only accelerate the rates of chemical rea ...
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... This project sets out to investigate the role of time in the left-right organizer (LRO). This transient embryonic organ is crucial for determining the left-right identity of the vertebrate body-plan. Inside this organ there are exciting biophysical mechanisms of development to be investigated. Namel ...
Membrane dynamics of dividing cells imaged by lattice light
Membrane dynamics of dividing cells imaged by lattice light

... illumination in an LLSM is confined to a very thin plane, and the emitted fluorescence signal is observed along an optical axis orthogonal to the illumination plane. Exposure (and consequent photodamage) is thus restricted to the thin slice of the cell being imaged at any moment, and the image is un ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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