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visualization of charged groups on the surface of rat liver nuclei
visualization of charged groups on the surface of rat liver nuclei

... the author suggested that sialic acid was present on the nuclear surface. However, in one fundamental respect the experimental conditions used by Bosmann differed from those used here: the solutions he used in electrophoresis lacked divalent cations. This probably caused detachment of the ribosomes ...
PDF
PDF

... stimulates β cell insulin secretion (Kawai et al., 1995; Kawamori and Kulkarni, 2009). Dysregulation of insulin and glucagon signaling consequent to β cell dysfunction or destruction causes diabetes mellitus, a devastating disease that afflicts more than 360 million people worldwide (Whiting et al., ...
National Guidelines for Stem Cell Research (2013)
National Guidelines for Stem Cell Research (2013)

... Preamble Use of stem cells in regenerative medicine holds promise for improving human health by restoring the function of cells and organs damaged due to degeneration or injury. Stem cell biology has potential application in several areas of biomedical research that includes drug development, toxici ...
Chemotaxis
Chemotaxis

... • some nonmetabolizable chemicals are attractants • mutants that cannot metabolize chemical are still attracted to it • essentially nonmetabolizable analogs attract bacteria (D-fucose) • chemicals attract even in the presence of metabolizable chemicals • attractants related in structure to each othe ...
MAP Kinase Pathways
MAP Kinase Pathways

... Activation of Raf Kinase This inactive conformation is stabilized by a dimer of the 143-3 protein, which binds phosphoserine residues in a number of important signaling proteins. Each 14-3-3 monomer binds to a phosphoserine residue in Raf, one to phosphoserine-259 in the N-terminal domain and the o ...
fungal infections and the kidney - Department of Internal Medicine
fungal infections and the kidney - Department of Internal Medicine

... *Unilateral involvement , nephrectomy(2 ...
1. Composition of the Toxic Agent
1. Composition of the Toxic Agent

...  There are two principal patterns of cell death:  Necrosis (occurs after ischemia and chemical injury it is always pathologic).  Apoptosis (occurs when a cell dies through activation of an internally controlled suicide program. It is designed to eliminate unwanted cells during embryogenesis and i ...
Langerhans Cell Histiocytosis in Adults: An Interdisciplinary Challenge
Langerhans Cell Histiocytosis in Adults: An Interdisciplinary Challenge

... usually reveal symmetrical involvement of both lungs. Typically, the costophrenic angle is spared. There are usually nodular foci of disease with blurred margins. There are also reticular changes with cavitation, sometimes appearing as sharply demarcated ring structures in a diffuse pattern of distr ...
Unicellular vs. Multicellular
Unicellular vs. Multicellular

... live together and all the cells of the colony is the same. All the process of life is carried out in each cell in order for the cell to survive. Simplest multicellular organisms are made of cells that dependent on each other for their survival. Most of the multicellular organism are microscopic and ...
PHL 419 Word - KSU Faculty Member websites
PHL 419 Word - KSU Faculty Member websites

...  There are two principal patterns of cell death:  Necrosis (occurs after ischemia and chemical injury it is always pathologic).  Apoptosis (occurs when a cell dies through activation of an internally controlled suicide program. It is designed to eliminate unwanted cells during embryogenesis and i ...
Guidelines for Stem Cell Research
Guidelines for Stem Cell Research

... Preamble Use of stem cells in regenerative medicine holds promise for improving human health by restoring the function of cells and organs damaged due to degeneration or injury. Stem cell biology has potential application in several areas of biomedical research that includes drug development, toxici ...
Renal Mechanisms of Acid-Base Balance
Renal Mechanisms of Acid-Base Balance

... follow it High aldosterone levels will cause Na absorption. For the water to be absorbed ADH must also be present Adrenal cortical cells are also directly stimulated to release aldosterone by elevated K+ levels in the ECF Aldosterone brings about its effects (diminished urine output and increased bl ...
Protists Coloring
Protists Coloring

... considered an animal-like protist because it moves and consumes its food. Protists are classified by how they move, some have cilia or flagella, but the amoeba has an unusual way of creeping along by stretching its cytoplasm into fingerlike extensions called pseudopodia. The word "pseudopodia" means ...
44_Lecture_Presentation
44_Lecture_Presentation

... • Urine is much more concentrated than blood • The cooperative action and precise arrangement of the loops of Henle and collecting ducts are largely responsible for the osmotic gradient that concentrates the urine • NaCl and urea contribute to the osmolarity of the interstitial fluid, which causes r ...
Recombinant Anti-CD4 antibody 13B8 - HAL
Recombinant Anti-CD4 antibody 13B8 - HAL

... The classical concept of plasma membrane, proposed by Singer and Nicolson [1], wherein proteins diffuse freely in two-dimensional homogeneous bi-layers, has been drastically modified during the last decade. Indeed, membrane rafts, which are “discrete” domains with a mean diameter of 10–200 nm, can b ...
Get cached PDF
Get cached PDF

... experimental manipulation the deep mesodermal cells that drive convergence and extension. Using this system, we described the radial and mediolateral cell intercalations driving convergence and extension during gastrulation (Wilson and Keller, 1991) and neurulation (Wilson et al., 1989; Keller et al ...
microbiology-1st-edition-wessner-test-bank
microbiology-1st-edition-wessner-test-bank

... 18) If cells are placed into a hypertonic solution, what reaction would you expect? a) The cell would lose water. b) The cell would gain water. c) The cell would pump out ions. d) The cell would lyse. e) The cell would increase in size. Answer: a Difficulty: Easy Learning Objective: LO 2.4 Identify ...
Gumbo JR and Cloete TE
Gumbo JR and Cloete TE

... We have hypothesised that the first phase in the lysis process is the bacterial attachment onto the Microcystis. At this encounter the large bacteria numbers create conditions of ‘shading’ over the Microcystis cells, thus creating an environment of low light irradiance. Within 2 h with insufficient ...
BCL-6 regulates chemokine gene transcription in macrophages
BCL-6 regulates chemokine gene transcription in macrophages

... RNA was prepared from macrophages either maintained in culture medium without M-CSF, restimulated with M-CSF or stimulated with lipopolysaccahride (LPS) for 5 h. We observed that stimulation of both wild-type and BCL-6–/– macrophages by LPS led to the very strong induction of multiple chemokine gene ...
Dentistry_-_Test_questions_2016
Dentistry_-_Test_questions_2016

... i. is present on basophils and mast cells in allergic people 51. Which of the following statements are true for IgG? a. secreted form is a pentamer of the basic H2L2 unit b. binds to Fc receptors on mast cells c. multimeric forms have a J chain d. present on the surface of mature, unprimed B cells ...
Neurosurgical
Neurosurgical

... Substance that kills or inhibits the growth of micro-organisms Prevents unwanted drainage or transfer of a liquid Having joints or jointed segments and able to rotate the head of the device around the central axis A product made up of multiple components Made from tissue harvested from animals or hu ...
Bod} @
Bod} @

... such as the heart or bones, we are observing gross anatomy; that is, we are studying large, easily observable structures. Indeed, the term anatomy, derived from the Greek words meaning to cut (tomy) apart (aria), is related most closely to gross anatomical studies because in such studies preserved a ...
2/6/12 Bacterial Growth
2/6/12 Bacterial Growth

... • Typically, the cytoplasm has a higher solute concentration than the surrounding environment, thus the tendency is for water to move into the cell (positive water balance) • When a cell is in an environment with a higher external solute concentration, water will flow out unless the cell has a mecha ...
Translational control of meiotic cell cycle progression
Translational control of meiotic cell cycle progression

... Translational control plays a key role in temporal regulation of developmental events that must be executed largely in the absence of transcription. For example, in metazoan organisms with large yolk-rich eggs, in which early stages of embryonic development commonly take place before onset of zygoti ...
Scrapie-like prion protein is translocated to the nuclei of infected
Scrapie-like prion protein is translocated to the nuclei of infected

... their aggregation. These data are in agreement with our experiments in ScN2a cells nuclei: they suggest that nuclear PrP binds to DNA in vivo and that liberation of nuclear PrP from DNA induces aggregation of the protein into an insoluble form. The extractability of nuclear PrP from chromatin in Tri ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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