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multiple functions The ADAMs family of metalloproteases
multiple functions The ADAMs family of metalloproteases

... 19, 22, 23, 28, and 33) show a more broad somatic distribution. Yet, there are clear differences in the pattern of expression of these enzymes (Table 1). ADAMs 9, 12, and 19 were originally cloned from myoblasts (Yagami-Hiromasa et al. 1995), but have been shown subsequently to be more broadly expre ...
Unit 3 This scheme of work suggests possible teaching and learning
Unit 3 This scheme of work suggests possible teaching and learning

... possible to teach. It is intended that teachers should select activities appropriate to their candidates and the curriculum time available. The first two columns summarise the specification references, whilst the Learning Outcomes indicate what most candidates should be able to achieve after the wor ...
Gram-Negative Bacteria: “Inner” vs. “Cytoplasmic” or “Plasma
Gram-Negative Bacteria: “Inner” vs. “Cytoplasmic” or “Plasma

... that different pathways leading to an additional protective layer were discovered (or even re-discovered) independently by various types of bacteria. This author suggests that the very different outer membranes evolved as a response to antibiotic production by other microorganisms such as Actinomyce ...
contribution of the secondary circulatory system to acid
contribution of the secondary circulatory system to acid

... lymphatic system in fish. Close inspection of vascular casts of five species of fish (Vogel, 1981; Vogel and Claviez, 1981) as well as in vivo observation of the microcirculatory system in the transparent glass catfish (Steffensen et al. 1986) revealed the so-called lymphatic vessels to be the drain ...
Medicinal Chemistry of Antifungal Agents
Medicinal Chemistry of Antifungal Agents

... Eukaryotes, like mammalian cells, with many similar biochemical structures: • DNA is organized into chromosomes within the nucleus • Distinct cytoplasmic organelles: endoplasmic reticulum, Golgi apparatus, mitochondria, and storage vacuoles. • Cell membrane This homology to mammalian cells also exte ...
A primer on the mouse basal body
A primer on the mouse basal body

... While it is unclear whether basal bodies of distinct types of cilia contain sets of proteins unique to that ciliary type, the structure of the cilium itself can vary in ways that may be dependent on the basal body [17]. One example is the transition zone, a region between the basal body and cilium c ...
TE MS Skin, Bones, and Muscles
TE MS Skin, Bones, and Muscles

... The heart beats about 3 billion times in the average person’s lifetime. Blood is a liquid tissue. ...
Year 11 ATAR HUMAN BIOLOGY
Year 11 ATAR HUMAN BIOLOGY

... Finish Cardiovascular System Revision for Systems Test (Week 2) Musculoskeletal System: ...
Decreased argyrophilic nucleolar organiser region
Decreased argyrophilic nucleolar organiser region

... medulla oblongata) were made at intervals of 60 micron. The cerebellum was excised from the pons by dividing the peduncles. Sections at the same 60 mm intervals were obtained from both the cerebellar hemispheres, including the vermis and hilum of the dentate nucleus. For each level, from both the br ...
Formation of Earlywood, Latewood, and Heartwood Regulation of
Formation of Earlywood, Latewood, and Heartwood Regulation of

... • Cytokinins are substances promoting cell division, and many physiological effects of cytokinins are known. • When cytokinins are added externally to tree stems, cambial activity is stimulated, and the stimulation is promoted by IAA. • Cytokinins are essential for tissue and cell cultures. • Native ...
Chapter 21: Blood Vessels and Circulation
Chapter 21: Blood Vessels and Circulation

... – Because: • A change in ECF spreads throughout body and affects many or all cells • A change in ICF in one cell does not affect distant cells ...
Cell Wall Polysaccharides are Mislocalized to the Vacuole in
Cell Wall Polysaccharides are Mislocalized to the Vacuole in

... Pectins accumulate within echidna seed coat mucilage secretory cells The mucilage secretory cells of the Arabidopsis thaliana seed coat epidermis provide a model secretory system in which large amounts of cell wall polysaccharides are secreted as pectic mucilage (Western et al. 2000). In order to de ...
Leukemia 2011 TOM CLARKE
Leukemia 2011 TOM CLARKE

... Repeated exposure to the chemical benzene can be a factor in AML development. Benzene damages the DNA of normal marrow cells. According to the Agency for Toxic Substances and Disease Registry, despite the fact that petroleum products contribute to the majority of benzene in the atmosphere, half of t ...
Next-generation proteomics: towards an integrative view of
Next-generation proteomics: towards an integrative view of

... the output spectra owing to their distinctive mass. In recent years, several strategies have been developed that use the incorporation of stable isotopes27, for which minimal variability is achieved using metabolic labelling in cell culture28 or even in whole organisms29,30. A drawback of metabolic ...
The Influence of the Host Cell on the Inhibition of Virus Protein
The Influence of the Host Cell on the Inhibition of Virus Protein

... Plaque assay of viruses. Both VSV and mengovirus were plaqued on L-929 cells. Appropriate Io-fold dilutions of the virus sample were made in PBS and o.2 ml was added per 6o mm plate of confluent cells in duplicate. Virus was adsorbed for 3o min at 36 °C with periodic agitation of the plates to ensur ...
Reversal of Physiological Stress
Reversal of Physiological Stress

... Department of Pharmacology, The George Washington University Medical Center, Washington, DC Received March 2, 2001; accepted May 22, 2001 ...
Class Notes
Class Notes

... o An important exception is portal veins, which carry blood between pairs of capillary beds outside of the heart and lungs.  For example, the hepatic portal vein carries blood from capillary beds in the digestive system to capillary beds in the liver. Within organs, arteries branch into arterioles, ...
Endocytosis unplugged: multiple ways to enter the cell
Endocytosis unplugged: multiple ways to enter the cell

... Endocytosis occurs at the cell surface and involves internalization of the plasma membrane (PM) along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various processes initiated at the cell surface. These ...
Red Blood Cells - Aplastic Anemia and MDS International Foundation
Red Blood Cells - Aplastic Anemia and MDS International Foundation

... production of all three types of blood cells. Bone marrow damage may be caused by exposure to toxins, chemicals, viruses, or drugs. In most cases, the exact cause is not known but likely related to an autoimmune attack against the bone marrow stem cells. MDS also involves injury to the stem cells i ...
Distinct Protease Requirements for Antigen Presentation In Vitro and
Distinct Protease Requirements for Antigen Presentation In Vitro and

... destructive processing by this enzyme can occur. In contrast, an aspartyl protease inhibitor suppressed the presentation of OVA, an effect attributed to the blockade of cathepsin E (10). AEP is an unusually specific cysteine protease homologous to the plant vacuole enzyme legumain (11). It cleaves a ...
Morphology and physiology of the marine straminipilan fungi, the
Morphology and physiology of the marine straminipilan fungi, the

... the equatorial Indian Ocean. None of the samples yielded thraustochytrids in culture, suggesting that aplanochytrids might be more prevalent in the zooplankton samples of these waters than thraustochytrids. Fourteen isolates of aplanochytrids were studied with reference to their colony and cell morp ...
Effect of Steroid Hormones and Retinoids on the Formation of
Effect of Steroid Hormones and Retinoids on the Formation of

... NJ) and 9-cis retinoic acid (9-cis RA) and the retinoic acid receptor a (RARa) antagonist, Ro 41-5253, were kindly provided by Drs M. Klaus and C. Apfel (Hoffmann-LaRoche, Basel, Switzerland). Hydroxyflutamide was a gift from Dr T. Lavecchia (Schering-Plough, Kenilworth, NJ). 4-[1-(3,5,5,8,8-pentame ...
microcircuitry of bipolar cells in cat retina1
microcircuitry of bipolar cells in cat retina1

... the strata of the inner plexiform layer (Sl to S5) in which each arborized. Because we reconstructed a small portion of the bipolar cells in this strip of retina (perhaps 5 to 20% of the total), it was not possible to determine the relative abundance of any one type. Profiles in the inner plexiform ...
Excretory System
Excretory System

... Through the production/formation of perspiration (sweat), the skin gets rid of excess water, salts and urea through the pores. ...
Differing Infection Patterns of Dengue and Yellow Fever Viruses in a
Differing Infection Patterns of Dengue and Yellow Fever Viruses in a

... of the flavivirus genus in the family Flaviviridae. They are positive-strand RNA viruses associated with a capsid protein and have an envelope assembled by budding through intracellular membranous structures [1]. These agents cause the most significant arthropodborne viral diseases in tropical count ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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