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Xror2 modulates convergent extension
Xror2 modulates convergent extension

... a non-canonical pathway similar to that involved in planar cell polarity (PCP) signaling in Drosophila (Heisenberg et al., 2000; Tada and Smith, 2000). Components of Wnt signaling for the PCP pathway include Frizzled 7 (Xfz7), Strabismus (Stbm), Dishevelled, a Formin Homology Protein called Daam1, a ...
Leaf development - The Virtual Plant
Leaf development - The Virtual Plant

... The vascular cambium is unlike the primary meristems of the plant (root and shoot apex) in that it produces new cells and tissues which add to the axial system (i.e. the conducting system) as well as to the radial system (i.e. the lateral transport pathway). The apical meristems of the shoot and roo ...
Positive and Negative Action Potentials in Paramecium
Positive and Negative Action Potentials in Paramecium

... generation is given in Fig. 2. Mechanosensitive Ca2+ channels are at the forward part of body. Voltage dependent Ca2+ channels are assumed at the central and at the backward parts of body. For mechanical stimulation at the forward part (input), reception potential appears by influx of Ca2+ through C ...
Handbook on Sickle Cell Disease - English
Handbook on Sickle Cell Disease - English

... In India, the sickle cell gene is distributed across the country, predominantly in Chhattisgarh, Madhya Pradesh, Orissa, Jharkhand, Maharashtra, Gujarat, Andhra Pradesh, Kerala, Karnataka, Tamil Nadu and some Northeastern states. Initial screening for sickle cell allele across the state of Chhattisg ...
KLF4 N-Terminal Variance Modulates Induced Reprogramming to
KLF4 N-Terminal Variance Modulates Induced Reprogramming to

... role of transcription factor coordination in driving somatic cells toward pluripotency. Early mechanistic studies using mouse embryonic fibroblasts (MEFs) were conducted through de novo introduction of viral vectors, each expressing an individual (monocistronic) reprogramming factor (Brambrink et al ...
WAVE/Scars in platelets
WAVE/Scars in platelets

... against 1 of the 3 isoforms of WAVE recognizes a single band in platelet lysates. The relative molecular weights of plateletassociated WAVE1, WAVE2, and WAVE3 were approximately 80, 85, and 70 kDa, respectively. However, in most experiments, WAVE1 and WAVE2 migrated very closely in the gel. It was r ...
Bursting thalamic responses in awake monkey contribute to visual
Bursting thalamic responses in awake monkey contribute to visual

... All experiments followed the guidelines of the International Council for Laboratory Animal Science and the European Union (statute nr 86/809) and the protocols were approved by the University of Coruña Committee on Animal Care (CEUDC30/1/09). Two male rhesus monkeys (Macaca mulatta) were trained to ...
STEROIDOGENESIS IN THECA CELLS OF CHICKEN FOLLICLES
STEROIDOGENESIS IN THECA CELLS OF CHICKEN FOLLICLES

... The aim of this study was to assess and compare the steroidogenic response to luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in cells of the theca interna and theca externa isolated from follicles at different stages of maturation. Cells of the theca interna and theca externa isolat ...
Chapter 3: Anatomy and Physiology
Chapter 3: Anatomy and Physiology

... A cell contains 3 basic parts: Nucleus control center of cell activities ...
Chapter 22 Gas Exchange
Chapter 22 Gas Exchange

... B) They aid in reproduction. C) Because of their efficiency, they only need a small surface area. D) They have a poor blood supply. E) Like lungs, they have an exhale/inhale function. Answer: A 13) The chief advantage of gas exchange in water is that A) water can contain more oxygen than air. B) car ...
Cloning, Expression, and Functional Characterization of TL1A-Ig
Cloning, Expression, and Functional Characterization of TL1A-Ig

... 1.1 The immune system: innate and adaptive arms The immune system consists of molecules and cells that work together to protect the individual from microbial infection and maintain homeostasis. The immune system is comprised of the innate and adaptive immune responses. Together these responses fulfi ...
Human microcephaly ASPM protein is a spindle pole
Human microcephaly ASPM protein is a spindle pole

... Merdes et al., 2000; Walczak et al., 1998). The relative contribution of these factors appears to vary depending on the cell type. A previous study in Drosophila S2 cells showed that spindle MT focusing at the pole was ensured by the independent actions of kinesin-14 and Asp (Ito and Goshima, 2015). ...
Correlative Fluorescence and Electron Microscopy on Ultrathin
Correlative Fluorescence and Electron Microscopy on Ultrathin

... In addition to confocal and deconvolution microscopy, one can minimize problems associated with z-axis resolution (i.e., 500 nm) by imaging thin sections (100–150 nm in thickness) (Ishiko et al. 1998; Takizawa et al. 1998; Pombo et al. 1999). In this case, all fluorescence signals must come from wi ...
The Type II Arabidopsis Formin14 Interacts with Microtubules and
The Type II Arabidopsis Formin14 Interacts with Microtubules and

... cage around the spindle, and very few filaments remained in the spindle (Figure 3A). In addition, the microfilament band in control cells was thinner than the microtubule band in phragmoplasts (Figure 3B). Interestingly, in cells overexpressing AFH14-GFP, microfilaments codistributed with AFH14-GFP ...
Answer
Answer

... What is a double loop system? Back ...
From the regulation of peptidoglycan synthesis to bacterial growth
From the regulation of peptidoglycan synthesis to bacterial growth

... erial to the sacculus by transpeptidation thickens the sacculus without elongating it, suggesting that peptidoglycan growth requires the cleavage of covalent bonds in the sacculus to allow the newly attached material to insert into the layer without increasing its thickness. Peptidoglycan cleavage i ...
PDF - Potter Lab
PDF - Potter Lab

... be missed if mutations result in early homozygous lethality. The Drosophila adult eye facilitates such screens since it is an ordered array of ommatidia. A mutant clone induced by mitotic recombination can be directly compared with its marked wild-type twin-spot clone for changes in growth. Thus, in ...
toxins
toxins

... 2.3. Actin cytoskeleton and small GTPases in exocytotic mechanisms Many other proteins play key roles in synaptic vesicle trafficking and priming of tethered synaptic vesicles. Inside nerve terminals, vesicles traffic along actin filaments and this implicates molecular motors like myosins II or V, a ...
Mast Cell-Derived Exosomes Induce Phenotypic and Functional
Mast Cell-Derived Exosomes Induce Phenotypic and Functional

... BSA, transferrin (Tf), and OVA were purchased from Sigma-Aldrich (St. Louis, MO). IFN-␥ was obtained from Immugenex (Los Angeles, CA). Mouse rIL-3 was purchased from BioSys (Compiegne, France). PE-labeled rat anti-mouse mAbs directed against CD40 (clone 3/23), CD80 (clone RMMP-2), and CD86 (clone RM ...
ITO - Université catholique de Louvain
ITO - Université catholique de Louvain

Regulation of phospholipase D activity, membrane targeting and
Regulation of phospholipase D activity, membrane targeting and

... by PtdIns(4,5)P2 with a potency and efficacy that is indistinguishable from that of their wild-type counterparts [22–24]. Although we now know that the PLD PX and PH domains can bind phosphoinositides and play important roles in targeting the enzymes to different membrane compartments in the cell, w ...
True Posterior Communicating Artery Aneurysm
True Posterior Communicating Artery Aneurysm

... PCoA aneurysm.7) Yoshida is known to have firstly nominated a PCoA aneurysm 2-3 mm apart from ICA-PCoA junction as ‘true’ PCoA aneurysm in 1979.9) The authors could find a domestic report of a similar case4) as well as several international reports.1-3)5)6)8)9) Its incidence is reported to be 0-3.3% ...
Plasma membrane repair in plants
Plasma membrane repair in plants

... resealing in animal cells are the annexins [56,57]. These are widely expressed Ca2+- and phospholipid-binding proteins that are implicated in membrane trafficking, transmembrane channel activity, inhibition of phospholipase A2 and cell–matrix interactions [58,59]. The annexin domain responsible for ...
Investigating Animal Diversity
Investigating Animal Diversity

... animals. While the protostome-deuterostome dichotomy seems very logical and easy to apply, it is often difficult to make the distinction in practice. The embryology of many animals is difficult to observe to make a determination of the fate of the blastopore, let alone to determine how the mesoderm ...
Lats kinase is involved in the intestinal apical
Lats kinase is involved in the intestinal apical

... Defecation assays were performed as previously described with some modifications (Liu and Thomas, 1994). We used L1 animals ~5-7 hours after hatching. The defecation behavior was observed for 10 minutes. ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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