CAVATAS STUDY 5 years restenosis rate: 30% HR 0.43 (stent
... After vascular reconstruction, luminal narrowing is in part caused by intimal thickening, the consequence of endothelial injury and inflammation, smooth muscle cell hyperplasia, and extracellular matrix accumulation. It may be possible to induce these lesions to shrink. ...
... After vascular reconstruction, luminal narrowing is in part caused by intimal thickening, the consequence of endothelial injury and inflammation, smooth muscle cell hyperplasia, and extracellular matrix accumulation. It may be possible to induce these lesions to shrink. ...
Pass the bicarb: the importance of HCO3 – for mucin release
... Accumulation of thick, sticky mucus is a hallmark of the genetic disease cystic fibrosis (CF) and has a central role in CF pathophysiology. Mutations in the CF transmembrane regulator (CFTR) ion channel are known to result in abnormally thick and sticky mucus; however, why mucus accumulates in CF is ...
... Accumulation of thick, sticky mucus is a hallmark of the genetic disease cystic fibrosis (CF) and has a central role in CF pathophysiology. Mutations in the CF transmembrane regulator (CFTR) ion channel are known to result in abnormally thick and sticky mucus; however, why mucus accumulates in CF is ...
Overview of the Lymphatic System
... Interstitial fluid • Complex, organized fluid that fills the spaces between the cells and is part of the extracellular matrix • Resembles blood plasma in composition with a lower percentage of protein • Along with blood plasma, constitutes the extracellular fluid ...
... Interstitial fluid • Complex, organized fluid that fills the spaces between the cells and is part of the extracellular matrix • Resembles blood plasma in composition with a lower percentage of protein • Along with blood plasma, constitutes the extracellular fluid ...
How Have Plant Cell Walls Evolved?1
... The accurate mapping of cell wall diversity is important because it underpins much of our thinking about cell wall evolution and informs our interpretation of emerging genetic data. Although CoMPP is a useful new high-throughput method for cell wall analysis, it is limited by the availability of pro ...
... The accurate mapping of cell wall diversity is important because it underpins much of our thinking about cell wall evolution and informs our interpretation of emerging genetic data. Although CoMPP is a useful new high-throughput method for cell wall analysis, it is limited by the availability of pro ...
Selective Binding of the Scavenger Receptor C
... reacted with 50 Ci of 125I-Bolton-Hunter reagent for 15 min at room temperature (20). Labeled protein was repurified by affinity chromatography on galactose-Sepharose. For fluorescent labeling, ⬃250 g of protein was dialyzed against water, lyophilized, dissolved in 0.5 ml of 0.5 M NaCl, 20 mM Na-b ...
... reacted with 50 Ci of 125I-Bolton-Hunter reagent for 15 min at room temperature (20). Labeled protein was repurified by affinity chromatography on galactose-Sepharose. For fluorescent labeling, ⬃250 g of protein was dialyzed against water, lyophilized, dissolved in 0.5 ml of 0.5 M NaCl, 20 mM Na-b ...
Melanocytes and melanogenesis - Our Dermatology Online journal
... The Tyrosine, under the influence of Tyrosinase and CU 2+ forms DOPA and then Dopaquinone. This Dopaquinone with the help of Cystathione or Cysteine, forms Cysteine-L-Dopa which further forms pheomelanin. When Cysteine is depleted, the Dopaquinone forms Leucodopachrome which ultimately forms eumelan ...
... The Tyrosine, under the influence of Tyrosinase and CU 2+ forms DOPA and then Dopaquinone. This Dopaquinone with the help of Cystathione or Cysteine, forms Cysteine-L-Dopa which further forms pheomelanin. When Cysteine is depleted, the Dopaquinone forms Leucodopachrome which ultimately forms eumelan ...
The Human Arp2/3 Complex Is Composed of Evolutionarily
... propulsion and lamellipodial protrusion cannot be definitively ruled out, the myosin inhibitor butanedione monoxime (BDM) which inhibits classic myosin-driven processes such as muscle contraction, does not affect either process (Cramer and Mitchison, 1995). The central role of actin polymerization i ...
... propulsion and lamellipodial protrusion cannot be definitively ruled out, the myosin inhibitor butanedione monoxime (BDM) which inhibits classic myosin-driven processes such as muscle contraction, does not affect either process (Cramer and Mitchison, 1995). The central role of actin polymerization i ...
Specialized filopodia direct long-range transport of SHH
... where it accumulates, thereby revealing that actin motors can move along these structures (Fig. 2b and data not shown). Limb bud mesenchymal cytoplasmic extensions also possess distinct cytoskeletal features compared to typical filopodia, commonly characterized as actin-based linear extensions of th ...
... where it accumulates, thereby revealing that actin motors can move along these structures (Fig. 2b and data not shown). Limb bud mesenchymal cytoplasmic extensions also possess distinct cytoskeletal features compared to typical filopodia, commonly characterized as actin-based linear extensions of th ...
Activation of Substantia Nigra Neurons
... firing pattern during AD. These cells fired in bursts of action potentials with the bursts temporally correlated to waveforms recorded in the EEG (Fig. 2). This change in firing pattern was found in both SNPR and SN dopamine neurons. The likelihood that SNPR units would fire in bursts time-locked to ...
... firing pattern during AD. These cells fired in bursts of action potentials with the bursts temporally correlated to waveforms recorded in the EEG (Fig. 2). This change in firing pattern was found in both SNPR and SN dopamine neurons. The likelihood that SNPR units would fire in bursts time-locked to ...
... mobility, sustaining T-cell-APC interaction for formation of the immunological synapse. It was found that the PD1/PD-L1 interaction constrains these signals in a model where blocking of the pathway lowered T cell mobility and enhanced T-cell-APC contacts [24]. Another mechanism highlights that PD-L1 ...
Plant nuclear proteomics inside the cell maestro
... The nucleus harbours two mutually interrelated structures containing nucleic acids: chromatin and the nuclear matrix [16]. The latter is a nonhistone structure that serves as a support for the genome and its activities. Calikowski et al. [17] initially characterized the Arabidopsis thaliana nuclear ...
... The nucleus harbours two mutually interrelated structures containing nucleic acids: chromatin and the nuclear matrix [16]. The latter is a nonhistone structure that serves as a support for the genome and its activities. Calikowski et al. [17] initially characterized the Arabidopsis thaliana nuclear ...
- Wiley Online Library
... Thus, p100 and p105 can also hold their NFjB-subunit partners inactive in the cytoplasm (Hayden and Ghosh, 2004), and perhaps partially compensate for the loss of function of the “typical” IjBs (Tergaonkar et al., 2005). Recently, NFjB independent functions for both IKKa and IKKb have been identifie ...
... Thus, p100 and p105 can also hold their NFjB-subunit partners inactive in the cytoplasm (Hayden and Ghosh, 2004), and perhaps partially compensate for the loss of function of the “typical” IjBs (Tergaonkar et al., 2005). Recently, NFjB independent functions for both IKKa and IKKb have been identifie ...
Final published version - Discovery
... The molecular basis for this ‘activation’ step is not without controversy when extended to amniote embryos. Although inhibition of BMP signalling promotes neural fate in the mouse embryo, for example (Di-Gregorio et al., 2007), BMP inhibition alone is insufficient to induce neural tissue in the chic ...
... The molecular basis for this ‘activation’ step is not without controversy when extended to amniote embryos. Although inhibition of BMP signalling promotes neural fate in the mouse embryo, for example (Di-Gregorio et al., 2007), BMP inhibition alone is insufficient to induce neural tissue in the chic ...
Disruption of Zebrafish Somite Development by Pharmacologic
... been demonstrated. Studies of Hsp90 function during vertebrate embryogenesis are complicated by several factors. These include the multigene nature of the vertebrate hsp90 family, including the presence of several pseudogenes (Gupta, 1995), and the fact that Hsp90 probably plays multiple roles at di ...
... been demonstrated. Studies of Hsp90 function during vertebrate embryogenesis are complicated by several factors. These include the multigene nature of the vertebrate hsp90 family, including the presence of several pseudogenes (Gupta, 1995), and the fact that Hsp90 probably plays multiple roles at di ...
Cell-cell communication mediated by the CAR subgroup of
... In crystals the full extracellular region of CAR forms U-shaped homodimers through the binding of their N-terminally located Ig domains which is reminiscent to JAM-A homodimers (Kostrewa et al., 2001; Patzke et al., 2010; Prota et al., 2003; Verdino et al., 2010). D1 and D2 associate in a head-to-ta ...
... In crystals the full extracellular region of CAR forms U-shaped homodimers through the binding of their N-terminally located Ig domains which is reminiscent to JAM-A homodimers (Kostrewa et al., 2001; Patzke et al., 2010; Prota et al., 2003; Verdino et al., 2010). D1 and D2 associate in a head-to-ta ...
Mechanics and Modeling of Plant Cell Growth
... more hemicellulose threads to become load-bearing, thus resulting in strain-hardening. Wall loosening on the other hand is proposed to occur when the load-bearing hemicellulose threads are cut or become detached from the microfibril because large longitudinal strains break relevant hydrogen bonds. F ...
... more hemicellulose threads to become load-bearing, thus resulting in strain-hardening. Wall loosening on the other hand is proposed to occur when the load-bearing hemicellulose threads are cut or become detached from the microfibril because large longitudinal strains break relevant hydrogen bonds. F ...
MamPhysioDryPeriod
... period, but never completely disappear. Lactose concentrations decline rapidly (Aslam et al. 1994; Hurley and Rejman 1986; Hurley 1987; Hurley et al. 1987). Proteins of serum origin (immunoglobulins, serum albumin) increase in concentration during the first week of involution. All classes of immunog ...
... period, but never completely disappear. Lactose concentrations decline rapidly (Aslam et al. 1994; Hurley and Rejman 1986; Hurley 1987; Hurley et al. 1987). Proteins of serum origin (immunoglobulins, serum albumin) increase in concentration during the first week of involution. All classes of immunog ...
Twins take the job
... that the genome from human beings and some other higher eukaryotes encodes three DIS3 paralogs: hDIS3, DIS3-like 1 (hDIS3L1) and DIS3-like 2 (hDIS3L2). Functional analysis indicates that these proteins have different functions as only hDIS3 complements a yeast DIS3 deletion. By using two biochemical ...
... that the genome from human beings and some other higher eukaryotes encodes three DIS3 paralogs: hDIS3, DIS3-like 1 (hDIS3L1) and DIS3-like 2 (hDIS3L2). Functional analysis indicates that these proteins have different functions as only hDIS3 complements a yeast DIS3 deletion. By using two biochemical ...
Review of Bruce H. Lipton`s Book: The Biology Of Belief
... activating, a direct contradiction of the Central Dogma where information flows out of DNA but not back into DNA. Proteins are found necessary for activating DNA, but they are affected by the environment. Lipton (page 67) writes: "epigenetic research has established that DNA blueprints passed down t ...
... activating, a direct contradiction of the Central Dogma where information flows out of DNA but not back into DNA. Proteins are found necessary for activating DNA, but they are affected by the environment. Lipton (page 67) writes: "epigenetic research has established that DNA blueprints passed down t ...
Endoplasmic Reticulum Stress and Pancreatic Cancer
... for cancer cell survival. Several findings suggest that there is an association between ER stress and cancer. One of them is the tumor-specific microenvironment that causes activation of ER stress. Because of hypoxia (which is a general consequence of solid tumors), ATF4 becomes activated, resulting ...
... for cancer cell survival. Several findings suggest that there is an association between ER stress and cancer. One of them is the tumor-specific microenvironment that causes activation of ER stress. Because of hypoxia (which is a general consequence of solid tumors), ATF4 becomes activated, resulting ...
The Role of Lipid Domains in Bacterial Cell Processes
... concentrations, CL and the osmoregulatory protein ProP fails to localize to the cell poles [22,23]. Interestingly, significantly enhanced levels of CL have been found in the membrane of E. coli minicells, which are derived from the cell poles [24], and in the engulfment and forespore membranes of B. ...
... concentrations, CL and the osmoregulatory protein ProP fails to localize to the cell poles [22,23]. Interestingly, significantly enhanced levels of CL have been found in the membrane of E. coli minicells, which are derived from the cell poles [24], and in the engulfment and forespore membranes of B. ...
Heat Shock Responses for Understanding Diseases of
... Shock Response; MAPK; Misfolding of Protein; ROS; Ubiquitin-Proteasome System. ...
... Shock Response; MAPK; Misfolding of Protein; ROS; Ubiquitin-Proteasome System. ...
Thermal Diffusion as a Mechanism for Biological
... temperature gradient that could result from the above heat production combined with heat removal by conduction, the living cell will be approxim ated by a sphere of radius R with a homogeneous source strength A0. This sphere is in contact with a sur rounding medium having an energy source strength ...
... temperature gradient that could result from the above heat production combined with heat removal by conduction, the living cell will be approxim ated by a sphere of radius R with a homogeneous source strength A0. This sphere is in contact with a sur rounding medium having an energy source strength ...
MLAB 1415-Hematology Keri Brophy
... Pallor Fatigue Cardiac symptoms Gallstones Dark or red urine Splenomegaly ...
... Pallor Fatigue Cardiac symptoms Gallstones Dark or red urine Splenomegaly ...
