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Template for Learner`s Guide RCY Subjects
Template for Learner`s Guide RCY Subjects

... donations to help save her life. There are people who need blood more than you do. Like your mum, these people are dependent on living donors to survive. Hopefully, one day you will also donate blood like them too.” It was from then onwards that I started donating blood on a regular basis after fini ...
BIOL242 Bloodtyping
BIOL242 Bloodtyping

... If very high numbers of antibody molecules bind to high concentration of antigen, “clumping” (also called agglutination) may occur as the mixture becomes insoluble and large. “Clumping” in the blood plasma is not a beneficial response as it can lead to kidney damage, kidney failure, and even death. ...
Automated Ambulatory Blood Pressure Monitoring for the Diagnosis
Automated Ambulatory Blood Pressure Monitoring for the Diagnosis

... There are a number of potential applications of ABPM. One of the most common is evaluating suspected WCH, which is defined as an elevated office BP with normal BP readings outside the physician’s office. The etiology of WCH is poorly understood but may be related to an “alerting” or anxiety reaction ...
acute myeloid leukemia
acute myeloid leukemia

... (eg, Fanconi’s anemia, ataxia telangiectasia, neurofibromatosis, and Bloom syndrome) as well as congenital immunodeficiency disorders (including infantile X-linked agammaglobulinemia and Down syndrome) have been associated with an increased incidence of AML.8 Environmental exposures have also been i ...
The Story of Coumadin
The Story of Coumadin

... Eisenhower had a heart attack while on vacation at his in-laws' house in Denver. Coumadin was used to prevent clots from forming in President Eisenhower’s damaged and weakened heart. Eisenhower's long term treatment included Coumadin 35 mg per week. Since then, it has been one of the most widely pre ...
Not Yet Time to Change the Guidelines for Monitoring Methotrexate
Not Yet Time to Change the Guidelines for Monitoring Methotrexate

... analyzed for the guidelines in several other clinically relevant ways. First, the published guidelines cohort was actually younger than the HSS cohort (mean age of 54 compared with 59.7 in the HSS patients), which might be expected to result in less hepatotoxicity, not more. Second, the mean weekly ...
MIDBIO14_EXAM
MIDBIO14_EXAM

... When a tissue is damaged or injured it can trigger the release of histamines. This causes the blood vessels to dilate and consequent leakage of fluid that leads to swelling. It also attracts white blood cells called phagocytes and causes an increase in temperature. What is the name of this process? ...
THE IMPACT OF CHRONIC KIDNEY DISEASE IN WEST VIRGINIA
THE IMPACT OF CHRONIC KIDNEY DISEASE IN WEST VIRGINIA

... GFR filtration. GFR is estimated from the blood’s level of creatinine, a waste product that comes from muscle tissue. The creatinine level in the blood increases if kidney function is abnormal, due to decreased filtration of creatinine into the urine. Blood creatinine levels vary according to size, ...
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

... In India found that of the 3000 apparently normal people who signed or with Delhi based MaxMed centre preventive health checkup programme. A sample 300 was analyzed to evaluate the life style diseases among urban middle class Indians 85 had high pressure, sugar counts 58 had hypertension clients and ...
Effects of maternal serum IgG anti-A (B) and
Effects of maternal serum IgG anti-A (B) and

... Notes: Compare with free antibody, *P<0.05; Compared with red cell antibody,#P<0.05 ...
The RH Antigen
The RH Antigen

... When the fetus becomes a mother herself and exposed to a new load of D antigen from her fetus (hence the grandmother connection) the immune memory is recalled and a secondary immune response occur. ...
Thrombophilia: Practice Aspects
Thrombophilia: Practice Aspects

... same for patients with and without inherited thrombophilia – Anticoagulation with warfarin for 3-6 months – There is no evidence that heritable thrombophilia should influence the intensity of therapy (Schulman & Tengborn, TH 1992; Kearon et al, Blood 2008) ...
The RH Antigen
The RH Antigen

... hemorrhage exceeds 30 mL, utilizing the Kleihauer-Betke test to quantitate the volume of fetal blood in the maternal circulation and administer the appropriate amount of anti-D. ...
Blood Safety in the Age of AIDS - Federation of American Societies
Blood Safety in the Age of AIDS - Federation of American Societies

... Treat anemia; provide oxygen to tissues; replace blood lost during surgery ...
Methylglyoxal concentrations differ in standard and washed
Methylglyoxal concentrations differ in standard and washed

... explained by the decline in glucose consumption during the latter parts of storage, effective detoxification by GLO-I, and ongoing binding of MG to form AGEs, although the formation of the latter was not measured in this study. The rising d-lactate levels within the packed RBC units suggest that a d ...
Pseudo–Pelger-Huët Anomaly Induced by Medications
Pseudo–Pelger-Huët Anomaly Induced by Medications

... morphologic abnormalities, granulocyte function, including neutrophilic chemotaxis, phagocytosis, and cytolytic activity, remains normal, and people with hereditary PHA do not have increased susceptibility to bacterial infections.3 In contrast, pseudo–Pelger-Huët anomaly (PPHA) is an acquired altera ...
Serum antioxidants as predictors of adult respiratory stress
Serum antioxidants as predictors of adult respiratory stress

... the factors reflect various processes that occur in septic patients with ARDS rather than in ARDS itself. This study focused on sepsis-induced ARDS, and different mechanisms may be present in ARDS that develops after trauma or in other conditions. It is not clear where the markers are produced. Lung ...
A case-control study to assess the risk of immune
A case-control study to assess the risk of immune

... similar seasons and therefore had similar opportunities to be vaccinated against influenza. Controls were recruited during the same calendar time period as the ITP cases. A maximum of 5 controls were matched to each case using an iterative matching process, with a control being dropped from the pool ...
Volume 24 - No 18: Bacteroides
Volume 24 - No 18: Bacteroides

... by B. fragilis (6). Infections are also prevalent in patients who are immunosuppressed or on antibiotic (aminoglycoside) therapy. Some antibiotics select for Bacteroides by facilitating the overgrowth of facultative bacteria (i.e. E. coli), which decreases the oxygen tension to a level tolerated by ...
Secretion of Blood Group-specific Substances in the Saliva of
Secretion of Blood Group-specific Substances in the Saliva of

... Several poorly understood factors influence the transmission of leprosy and clinical manifes tations of this disease. Genetic factors have been considered significant ('" G), and were recentl y the subject of discussion 4). Studies at an international conference on the occurrence of leprosy in diffe ...
Perioperative hypertension: Diagnosis and Treatment
Perioperative hypertension: Diagnosis and Treatment

... - not an emergency - as it doesn’t involve end organ damage and there is usually enough time to reduce the blood pressure [13]. It has been suggested that a DBP of 110mmHg or above is considered a preoperative marker of perioperative cardiac complications in patients with chronic hypertension [8,11] ...
Improvement of ECG Changes in Patients with Cholelithiasis
Improvement of ECG Changes in Patients with Cholelithiasis

... reported to have preoperative ECG changes. The ischemic changes, isolated or combined, are reported in 16 of them. About half of the patients (51.7%) with ischemic ECG changes showed disappearance of the changes in the immediate postoperative ECG which persisted in the consequent ECG two weeks after ...
Oxygen Transport Properties in Malaria-Infected
Oxygen Transport Properties in Malaria-Infected

... The infection of young female rats with P berghei b resulted in marked changes in hematologic parameters that govern oxygen transport (Table 1). In WB, [Hb] was decreased by 62% and Hct by 44%, reflecting a decrease in MCHC of 32%. The MCHC of NIE was in the normal range, whereas it was dramatically ...
A comparison of bivalirudin to heparin with protamine reversal in
A comparison of bivalirudin to heparin with protamine reversal in

... surgery.1,2 UFH is also highly antigenic, provoking an antibody response in approximately 40% of patients after cardiac surgery and heparin-induced thrombocytopenia and thrombosis syndrome (HIT/TS) in 1% to 2% of patients.3 The variable and dose-dependent clearance of UFH requires reversal with prot ...
Pedigree Powerpoint
Pedigree Powerpoint

... in a family. Is this trait dominant or recessive? recessive 14. How do you know? Because parents III-4 and III-5 had to have kids IV-2 and IV-4 15. How are individuals III-1 and III-2 related? mating 16. Name 2 individuals that have hitchhiker’s thumb. IV-2 and IV-4 17. Name 2 individuals that were ...
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Hemolytic-uremic syndrome



Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized by hemolytic anemia (anemia caused by destruction of red blood cells), acute kidney failure (uremia), and a low platelet count (thrombocytopenia). It predominantly, but not exclusively, affects children. Most cases are preceded by an episode of infectious, sometimes bloody, diarrhea acquired as a foodborne illness or from a contaminated water supply and caused by E. coli O157:H7, although Shigella, Campylobacter and a variety of viruses have also been implicated. It is now the most common cause of acquired acute renal failure in childhood. It is a medical emergency and carries a 5–10% mortality; of the remainder, the majority recover without major consequences but a small proportion develop chronic kidney disease and become reliant on renal replacement therapy.The primary target appears to be the vascular endothelial cell. This may explain the pathogenesis of HUS, in which a characteristic renal lesion is capillary microangiopathy.HUS was first defined as a syndrome in 1955. The more common form of the disease, Shiga-like toxin-producing E. coli HUS (STEC-HUS), is triggered by the infectious agent E. coli O157:H7. Certain Shiga toxin secreting strains of Shigella dysenteriae can also cause HUS. Approximately 5% of cases are classified as pneumococcal HUS, which results from infection by Streptococcus pneumoniae, the agent that causes traditional lobar pneumonia. There is also a rare, chronic, and severe form known as atypical hemolytic uremic syndrome (aHUS), which is caused by genetic defects resulting in chronic, uncontrolled complement activation. Both STEC-HUS and aHUS cause endothelial damage, leukocyte activation, platelet activation, and widespread inflammation and multiple thromboses in the small blood vessels, a condition known as systemic thrombotic microangiopathy (TMA), which leads to thrombotic events as well as organ damage/failure and death.
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