![Drug Interactions](http://s1.studyres.com/store/data/008262910_1-e539a1859de33287445209e3e063e01a-300x300.png)
Drug Interactions
... decline in serum levels below that required for therapeutic effect. Carbamazepine induces metabolism of many antidepressants ...
... decline in serum levels below that required for therapeutic effect. Carbamazepine induces metabolism of many antidepressants ...
5. Prodrug Metabolism (2013)
... 1. L-DOPA (levodopa) is administered orally for the treatment of Parkinsonism and is inactive. Parkinsonism is caused by the destruction of dopaminergic cells in the substantia nigra. The goal of treatment is to increase levels of the neurotransmitter dopamine in the central nervous system (CNS). L- ...
... 1. L-DOPA (levodopa) is administered orally for the treatment of Parkinsonism and is inactive. Parkinsonism is caused by the destruction of dopaminergic cells in the substantia nigra. The goal of treatment is to increase levels of the neurotransmitter dopamine in the central nervous system (CNS). L- ...
Company meeting with Janssen - UK-CAB
... Treatment of Pulmonary Tuberculosis Active TB Global standard of care: ...
... Treatment of Pulmonary Tuberculosis Active TB Global standard of care: ...
biotransformation - USU OCW - Universitas Sumatera Utara
... competitive inhibitor • inhibitor binds at active site; blocks substrate binding • inhibitor may be metabolized • easier i tto design d i non-competitive inhibitor • binds at different (allosteric) site • changes enzyme conformation to prevent binding or turnover • difficult to design ...
... competitive inhibitor • inhibitor binds at active site; blocks substrate binding • inhibitor may be metabolized • easier i tto design d i non-competitive inhibitor • binds at different (allosteric) site • changes enzyme conformation to prevent binding or turnover • difficult to design ...
(TLC) Usage to Identity Counterfeit Drugs
... Identification of counterfeit drugs has become a serious international issue. By definition counterfeit drugs are mislabeled medicines with substandard safety, quality and effectiveness. Counterfeit products include drugs with the correct or wrong ingredients, without active ingredients, with insuff ...
... Identification of counterfeit drugs has become a serious international issue. By definition counterfeit drugs are mislabeled medicines with substandard safety, quality and effectiveness. Counterfeit products include drugs with the correct or wrong ingredients, without active ingredients, with insuff ...
OPTION D: CORE ENVIRONMENTAL CHEMISTRY
... This section studies the effect of some aspects of chemical structure on drug action: Stereo-isomerism: geometric and optical. Strain in a ring structure. Polarity of a molecule Importance of geometrical (cis-trans) isomerism in drug action, e.g. cisplatin Like in organic compounds, cis- and t ...
... This section studies the effect of some aspects of chemical structure on drug action: Stereo-isomerism: geometric and optical. Strain in a ring structure. Polarity of a molecule Importance of geometrical (cis-trans) isomerism in drug action, e.g. cisplatin Like in organic compounds, cis- and t ...
Antiretroviral Resistance Testing in the Management of HIV
... • Initial ART is more likely to fail in patients with a resistant strain • In patients treated with ART, resistance mutations, especially those affecting the NNRTIs and PIs, have been found to persist for up to two years after discontinuation of ART • Resistance testing is becoming more common in ch ...
... • Initial ART is more likely to fail in patients with a resistant strain • In patients treated with ART, resistance mutations, especially those affecting the NNRTIs and PIs, have been found to persist for up to two years after discontinuation of ART • Resistance testing is becoming more common in ch ...
Technical PP on How HIV resistance develops
... • In patients treated with ART, resistance mutations, especially those affecting the NNRTIs and PIs, have been found to persist for up to two years after discontinuation of ART • Resistance testing is becoming more common in chronicallyinfected patients in North America who acquired their infection ...
... • In patients treated with ART, resistance mutations, especially those affecting the NNRTIs and PIs, have been found to persist for up to two years after discontinuation of ART • Resistance testing is becoming more common in chronicallyinfected patients in North America who acquired their infection ...
Peer-reviewed Article PDF
... HIV genetic material remains in two forms, as two copies of single stranded RNA inside the intact viral particles and as a double stranded DNA integrated in the host genome. This double stranded DNA also known as proviral DNA. The size of HIV genome is around 9.7 KB. The proviral DNA have two long t ...
... HIV genetic material remains in two forms, as two copies of single stranded RNA inside the intact viral particles and as a double stranded DNA integrated in the host genome. This double stranded DNA also known as proviral DNA. The size of HIV genome is around 9.7 KB. The proviral DNA have two long t ...
Recommendation and Reasons
... • The Committee discussed the potential listing of raltegravir for use in treatment-naive patients with virologic failure due to resistance to at least one agent from each of the three major classes of antiretroviral agents (nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reve ...
... • The Committee discussed the potential listing of raltegravir for use in treatment-naive patients with virologic failure due to resistance to at least one agent from each of the three major classes of antiretroviral agents (nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reve ...
Drug Resistance - World Health Organization
... >> Antimicrobial drugs are a precious resource for everyone on the planet. Like any global good, we have a responsibility to protect this resource and to use it responsibly. Consumers can help by only using antibiotics and other antimicrobial drugs when they are prescribed for use, and always comple ...
... >> Antimicrobial drugs are a precious resource for everyone on the planet. Like any global good, we have a responsibility to protect this resource and to use it responsibly. Consumers can help by only using antibiotics and other antimicrobial drugs when they are prescribed for use, and always comple ...
antiepileptic drug selection for people with hiv/aids
... This is an educational service of the American Academy of Neurology. It is designed to provide members with evidence-based guideline recommendations to assist the decision making in patient care. It is based on an assessment of current scientific and clinical information and is not intended to exclu ...
... This is an educational service of the American Academy of Neurology. It is designed to provide members with evidence-based guideline recommendations to assist the decision making in patient care. It is based on an assessment of current scientific and clinical information and is not intended to exclu ...
Designed chemical libraries for hit/lead optimisation
... SAR around a hit/lead compound in an efficient manner - that is, maximum information from a given number of compounds synthesised. ChemSpace design can also be valuable when patenting a series of active compounds by highlighting those compounds around a lead which are likely to show similar biologic ...
... SAR around a hit/lead compound in an efficient manner - that is, maximum information from a given number of compounds synthesised. ChemSpace design can also be valuable when patenting a series of active compounds by highlighting those compounds around a lead which are likely to show similar biologic ...
Antimicrobials and Resistance
... - Beta-lactam antibiotics with Beta-lactam ring - Two types: 1. Penicillinases 2. Cephalosporinases ...
... - Beta-lactam antibiotics with Beta-lactam ring - Two types: 1. Penicillinases 2. Cephalosporinases ...
Back to the future: Research renewed on the clinical utility of
... had their initially promising development abruptly halted for reasons of toxicity before being revived successfully. Clozapine’s initial development was interrupted by a series of fatalities caused by drug-induced agranulocytosis (Alvir et al., 1993) before being resumed a decade later after its sup ...
... had their initially promising development abruptly halted for reasons of toxicity before being revived successfully. Clozapine’s initial development was interrupted by a series of fatalities caused by drug-induced agranulocytosis (Alvir et al., 1993) before being resumed a decade later after its sup ...
1st and 2nd Lectures
... is unstable in aqueous solution, so impractical to administer to patients ...
... is unstable in aqueous solution, so impractical to administer to patients ...
Chemistry - Central Lyon CSD
... Purpose: Individually, you will observe the formation of new ionic compounds and then write the chemical formula and determine its chemical name. ...
... Purpose: Individually, you will observe the formation of new ionic compounds and then write the chemical formula and determine its chemical name. ...
Drug Metabolism
... The monoethyl ester of enalaprilat Enalaprilate was first discovered as an inhibitor of angiotensin converting enzyme (ACE) and used to treat hypertension. Due to its high polarity, note two COOH’s, it was not orally bioavailable, and thus needed to be administered by injection. ...
... The monoethyl ester of enalaprilat Enalaprilate was first discovered as an inhibitor of angiotensin converting enzyme (ACE) and used to treat hypertension. Due to its high polarity, note two COOH’s, it was not orally bioavailable, and thus needed to be administered by injection. ...
drug metabolism
... pills is found to have tuberculosis. She is started on treatment and suffers contraceptive failure soon after. ...
... pills is found to have tuberculosis. She is started on treatment and suffers contraceptive failure soon after. ...
Untitled
... Revised II semester syllabus paper-II (2014-2015) Unit:I Drug Design and Drug Discovery (15 periods) Introduction to drug discovery. Folklore drugs, stages involved in drug discovery- disease, drug targets, bioassay. Chiral drugs: Role of chirality on biological activity: examples of Distomers – a) ...
... Revised II semester syllabus paper-II (2014-2015) Unit:I Drug Design and Drug Discovery (15 periods) Introduction to drug discovery. Folklore drugs, stages involved in drug discovery- disease, drug targets, bioassay. Chiral drugs: Role of chirality on biological activity: examples of Distomers – a) ...
Conformational aspects of drug-DNA interactions: Studies on
... DNA- binding mechanism Due to their chemical structure, an intercalative binding mechanism might be reasonably expected for all compounds considered in this work (figure 1), except perhaps for compound V, which exhibits a planar moiety of only two condensed rings and is therefore expected to overlap ...
... DNA- binding mechanism Due to their chemical structure, an intercalative binding mechanism might be reasonably expected for all compounds considered in this work (figure 1), except perhaps for compound V, which exhibits a planar moiety of only two condensed rings and is therefore expected to overlap ...
Principle of antimicrobial use (MD4) 2549
... and cost-effectiveness of the antibiotic in the disease and in patient populations similar to that of the presenting patient Side effect profile of the drug: Allergic reaction Direct adverse effects of drug Drug-drug and drug-food interaction Use least expensive and narrowest-spectrum drug possible ...
... and cost-effectiveness of the antibiotic in the disease and in patient populations similar to that of the presenting patient Side effect profile of the drug: Allergic reaction Direct adverse effects of drug Drug-drug and drug-food interaction Use least expensive and narrowest-spectrum drug possible ...
Discovery and development of non-nucleoside reverse-transcriptase inhibitors
![](https://en.wikipedia.org/wiki/Special:FilePath/RTenzyme-hand.jpg?width=300)
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of HIV. RT is one of the most popular targets in the field of antiretroviral drug development.Discovery and development of NNRTIs began in the late 1980s and in the end of 2009 four NNRTI had been approved by regulatory authorities and several others were undergoing clinical development. Drug resistance develops quickly if NNRTIs are administered as monotherapy and therefore NNRTIs are always given as part of combination therapy, the highly active antiretroviral therapy (HAART).