Young Innovators 2009
... The models were used for VS of the World Drug Index database to identify putative ligands. 12 common hits from QSAR/VS and cmap studies were subjected to parallel binding assays against a panel of GPCRs. All compounds were found to bind to at least one receptor with binding affinities between 1.7 90 ...
... The models were used for VS of the World Drug Index database to identify putative ligands. 12 common hits from QSAR/VS and cmap studies were subjected to parallel binding assays against a panel of GPCRs. All compounds were found to bind to at least one receptor with binding affinities between 1.7 90 ...
Document
... four-drug TB regimen and a three-drug ART regimen at the same time. The patient’s adherence is spotty and one week later she complains of severe nausea and vomiting. All of the following statements are correct except: A. B. C. D. ...
... four-drug TB regimen and a three-drug ART regimen at the same time. The patient’s adherence is spotty and one week later she complains of severe nausea and vomiting. All of the following statements are correct except: A. B. C. D. ...
Mona Sayed Ahmed Mohammed Ellithey S12000541
... Background: HIV/AIDS is one of the most devastating diseases in the world with approximately 36 million people living with the virus in 2012 and approximately 2.7 million new infections in that same year. Antiretroviral therapy (ART) successfully reduce infection and decrease symptoms; but, the emer ...
... Background: HIV/AIDS is one of the most devastating diseases in the world with approximately 36 million people living with the virus in 2012 and approximately 2.7 million new infections in that same year. Antiretroviral therapy (ART) successfully reduce infection and decrease symptoms; but, the emer ...
The Design and Synthesis of Novel Antimicrobial Agents for Use in
... Domagk in 1935.1-3 Prontosil was later found to be a prodrug that was metabolized in vivo to its active metabolite sulfanilamide (Figure 1.1).4 Prontosil was the first of the “sulfa” drugs discovered, and its discovery ushered in the era of antibiotics. Antibacterial agents, or antibiotics, are a cl ...
... Domagk in 1935.1-3 Prontosil was later found to be a prodrug that was metabolized in vivo to its active metabolite sulfanilamide (Figure 1.1).4 Prontosil was the first of the “sulfa” drugs discovered, and its discovery ushered in the era of antibiotics. Antibacterial agents, or antibiotics, are a cl ...
Antimicrobial Agents
... Drug interaction • Ciprofloxacin is a liver enzyme inhibitor and may cause life-threatening interaction with theophylline. ...
... Drug interaction • Ciprofloxacin is a liver enzyme inhibitor and may cause life-threatening interaction with theophylline. ...
Pathways of drug metabolism
... Drugs more targeted to specific diseases, maximising therapeutic effects while decreasing damage to nerby healthy cells ...
... Drugs more targeted to specific diseases, maximising therapeutic effects while decreasing damage to nerby healthy cells ...
Beware: Clinically Significant Drug Interactions in the Treatment of HIV
... interactions with non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and integrase strand transfer inhibitors (INSTIs). Evaluate the consequences of drug interactions associated with antiretroviral drugs and determine the incidence of clinical adverse effects from i ...
... interactions with non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and integrase strand transfer inhibitors (INSTIs). Evaluate the consequences of drug interactions associated with antiretroviral drugs and determine the incidence of clinical adverse effects from i ...
Title of presentation - Delaware Valley Drug Metabolism Discussion
... are the major transporters that mediate DDI and all NME should routinely be evaluated …. as substrates for these transporters…. Those voting no agreed the proposed transporters are reasonable, but cited the absence of appropriate tools to conduct the studies. "Throwing this out there to the pharmace ...
... are the major transporters that mediate DDI and all NME should routinely be evaluated …. as substrates for these transporters…. Those voting no agreed the proposed transporters are reasonable, but cited the absence of appropriate tools to conduct the studies. "Throwing this out there to the pharmace ...
HIV/AIDS and Hepatitis C
... Now, onset of treatment is delayed till CD4 count is decreasing (e.g., <350) – This change due to high rate of side effects and diminished effectiveness if used for many years – May take years of infection before current treatment criteria are met ...
... Now, onset of treatment is delayed till CD4 count is decreasing (e.g., <350) – This change due to high rate of side effects and diminished effectiveness if used for many years – May take years of infection before current treatment criteria are met ...
HIGHLIGHTS OF PRESCRIBING INFORMATION ----------------------- WARNINGS AND PRECAUTIONS -----------------------
... and other suspected agents immediately if signs or symptoms of severe skin or hypersensitivity reactions develop (including, but not limited to, severe rash or rash accompanied by fever, malaise, muscle or joint aches, blisters, oral lesions, conjunctivitis, facial edema, lip swelling, eosinophilia) ...
... and other suspected agents immediately if signs or symptoms of severe skin or hypersensitivity reactions develop (including, but not limited to, severe rash or rash accompanied by fever, malaise, muscle or joint aches, blisters, oral lesions, conjunctivitis, facial edema, lip swelling, eosinophilia) ...
Herbs and HIV: caveat emptor
... potentially emotive subject, not just because there are so few data on the interactions between prescription medicines and herbal remedies, but also because belief in all kinds of complementary medicine appears to be stronger now than at any time since the Great Plague of the 17th Century. Herbs and ...
... potentially emotive subject, not just because there are so few data on the interactions between prescription medicines and herbal remedies, but also because belief in all kinds of complementary medicine appears to be stronger now than at any time since the Great Plague of the 17th Century. Herbs and ...
HIPAA: Research Applications
... material because . . . the government would not have paid [them] if it had known the use for which they were being submitted.” (Emphasis added.) ...
... material because . . . the government would not have paid [them] if it had known the use for which they were being submitted.” (Emphasis added.) ...
Binding Studies of Type I, II, and III Kinase Inhibitors against Bcr
... found in the P-loop of the protein near residues that are in direct contact with the drug. The degree of resistance varies from a few fold for some of the A-loop mutants to complete resistance for the T315I mutation which precludes imatinib from binding. The steady rate of developing resistance to i ...
... found in the P-loop of the protein near residues that are in direct contact with the drug. The degree of resistance varies from a few fold for some of the A-loop mutants to complete resistance for the T315I mutation which precludes imatinib from binding. The steady rate of developing resistance to i ...
new-local anaethetic
... • Tetracaine is one of the most easily absorbed drugs due to the presence of nonpolar n-butyl group. • Its solutions are more stable to hydrolysis than procaine and it may be sterilized by boiling. • *Mixture of sulfonamide and p-aminobenzoic acid local anesthetics should be avoided because of thei ...
... • Tetracaine is one of the most easily absorbed drugs due to the presence of nonpolar n-butyl group. • Its solutions are more stable to hydrolysis than procaine and it may be sterilized by boiling. • *Mixture of sulfonamide and p-aminobenzoic acid local anesthetics should be avoided because of thei ...
Optimal Serial Dilutions Designs for Drug Discovery Experiments
... or to compare a standard compound to one or more new candidate drugs, it is useful to define the minimum significant ratio (MSR) between IC50 values of different compounds, or the minimum significant difference (MSD) between LogIC50 values of different compounds that can be detected using each of th ...
... or to compare a standard compound to one or more new candidate drugs, it is useful to define the minimum significant ratio (MSR) between IC50 values of different compounds, or the minimum significant difference (MSD) between LogIC50 values of different compounds that can be detected using each of th ...
Powerpoint - UCLA School of Public Health
... • Preclinical work shows efficacy in protecting against HIV transmission in mice and nonhuman primates • 2,441 MSM followed to 12-months for seroconversion ...
... • Preclinical work shows efficacy in protecting against HIV transmission in mice and nonhuman primates • 2,441 MSM followed to 12-months for seroconversion ...
Regulatory Considerations in the Post-Vioxx Era
... Celebrex, Vioxx and Bextra, all COX-2 selective inhibitors, are differentiated from other NSAIDs (e.g., naproxen, ibuprofen, ketoprofen) by limiting selectivity for the COX-1 inhibitor, which helps to maintain a normal stomach lining. Before the development of COX-2 selective inhibitors, NSAIDs inhi ...
... Celebrex, Vioxx and Bextra, all COX-2 selective inhibitors, are differentiated from other NSAIDs (e.g., naproxen, ibuprofen, ketoprofen) by limiting selectivity for the COX-1 inhibitor, which helps to maintain a normal stomach lining. Before the development of COX-2 selective inhibitors, NSAIDs inhi ...
Metabolic Activation and Idiosycratic Drug Toxicity
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause ...
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause ...
Reactive Metabolites - New England Drug Metabolism Discussion
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause for ...
... • Unrelated to primary pharmacology • Dose independent (with the exception of some drugs) – can occur at any dose within the therapeutic range • Temporal relationship - Symptoms subsides after cessation of treatment; rapid onset upon re-challenge • Can be severe - maybe fatal - most common cause for ...
Role of cytochrome P450 in drug interactions | SpringerLink
... factors, including the drug half-life and enzyme turnover, which determine the time-course of induction. A complicating factor is that the time-course of induction depends on the time required for enzyme degradation and new enzyme production. The short half-life of rifampicin results in enzyme induc ...
... factors, including the drug half-life and enzyme turnover, which determine the time-course of induction. A complicating factor is that the time-course of induction depends on the time required for enzyme degradation and new enzyme production. The short half-life of rifampicin results in enzyme induc ...
Biotransformations Leading to Toxic Metabolites: Chemical Aspect
... reduction, which yields radical structures that may be backoxidized to the parent compound. During this reoxidation, oxygen is reduced into superoxide anion. The oxygen reduction products are highly reactive entities that attack all the cellular components, especially when their normal degradation s ...
... reduction, which yields radical structures that may be backoxidized to the parent compound. During this reoxidation, oxygen is reduced into superoxide anion. The oxygen reduction products are highly reactive entities that attack all the cellular components, especially when their normal degradation s ...
here - National Medicinal Chemistry Symposium
... multiple clinical programs. This presentation will highlight select case study examples of clinical failures due to poor oral drug exposure and unexpected toxicology, as well as the many confounding factors associated with confirming a role for AO in the metabolism of a candidate d ...
... multiple clinical programs. This presentation will highlight select case study examples of clinical failures due to poor oral drug exposure and unexpected toxicology, as well as the many confounding factors associated with confirming a role for AO in the metabolism of a candidate d ...
Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human
... is the mainstay therapy for HIV. The standard recommended treatments for naive patients with HIV-1 infection usually consist of two nucleoside/nucleotide reverse transcriptase inhibitors, in combination with a nonnucleoside reverse transcriptase inhibitor, a ritonavir-boosted protease inhibitor, or ...
... is the mainstay therapy for HIV. The standard recommended treatments for naive patients with HIV-1 infection usually consist of two nucleoside/nucleotide reverse transcriptase inhibitors, in combination with a nonnucleoside reverse transcriptase inhibitor, a ritonavir-boosted protease inhibitor, or ...
HIV-associated Dementia Avindra Nath and Justin McArthur
... Epidemiology of HIV Dementia The World Health Organization (WHO) estimates that worldwide there are 40 million people living with HIV/AIDS in 2003, and there were 3 million AIDS deaths in 2003. This total does not include the 20 million people around the world who have already died of AIDS. There we ...
... Epidemiology of HIV Dementia The World Health Organization (WHO) estimates that worldwide there are 40 million people living with HIV/AIDS in 2003, and there were 3 million AIDS deaths in 2003. This total does not include the 20 million people around the world who have already died of AIDS. There we ...
EUROPRISE SCIENCE UPDATE N° 12
... Immunology 11 Immunology, other vaccines Microbicides 20 Other prevention, circumcision Other prevention, condoms Other prevention, PrEP 25 Pathology, cellular & molecular Pathology, coinfections 32 Therapeutic vaccines 33 Therapy, ART 34 Therapy, cell 35 Vaccines ...
... Immunology 11 Immunology, other vaccines Microbicides 20 Other prevention, circumcision Other prevention, condoms Other prevention, PrEP 25 Pathology, cellular & molecular Pathology, coinfections 32 Therapeutic vaccines 33 Therapy, ART 34 Therapy, cell 35 Vaccines ...
Discovery and development of non-nucleoside reverse-transcriptase inhibitors
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of HIV. RT is one of the most popular targets in the field of antiretroviral drug development.Discovery and development of NNRTIs began in the late 1980s and in the end of 2009 four NNRTI had been approved by regulatory authorities and several others were undergoing clinical development. Drug resistance develops quickly if NNRTIs are administered as monotherapy and therefore NNRTIs are always given as part of combination therapy, the highly active antiretroviral therapy (HAART).