![Pharmacology](http://s1.studyres.com/store/data/010385718_1-d0f884f76d590cc33c673d6df1c84908-300x300.png)
Pharmacology
... pediatrics) and many other disciplines. Pharmacology is characterized by wide range of contents and profound theories, making it an indispensable course for medical and pharmaceutical research as well as clinical and production practice. The goal of pharmacology includes: 1) to clarify the action of ...
... pediatrics) and many other disciplines. Pharmacology is characterized by wide range of contents and profound theories, making it an indispensable course for medical and pharmaceutical research as well as clinical and production practice. The goal of pharmacology includes: 1) to clarify the action of ...
Identifying Unexpected Impurities in Drug Products
... impurities profiling study can be completed in less than a week, if necessary. However, it should be noted that, although the TOX-RAY database is a very useful instrument in identifying impurities very rapidly, there is no absolute guarantee that the unexpected compound of interest will be fully ide ...
... impurities profiling study can be completed in less than a week, if necessary. However, it should be noted that, although the TOX-RAY database is a very useful instrument in identifying impurities very rapidly, there is no absolute guarantee that the unexpected compound of interest will be fully ide ...
Prediction of pharmacokinetic properties using experimental
... progress in linking ‘in silico’ and higher throughput physicochemical methods with in vitro approaches, progress is being made in predicting PK properties [5]. Such high(er)throughput screening (HTS) efforts require rapid methods and the use of minimum amounts of compounds, so that new molecules can ...
... progress in linking ‘in silico’ and higher throughput physicochemical methods with in vitro approaches, progress is being made in predicting PK properties [5]. Such high(er)throughput screening (HTS) efforts require rapid methods and the use of minimum amounts of compounds, so that new molecules can ...
Isolation of antibacterials from the mangrove, Avicennia marina and
... folklore medicines and extracts have proven activity against human, animal and plant pathogens. Secondary metabolites like alkaloids, phenolics, steroids, terpenoids have been characterized from mangroves and have toxicological, pharmacological and ecological importance [6, 7]. There is a continuous ...
... folklore medicines and extracts have proven activity against human, animal and plant pathogens. Secondary metabolites like alkaloids, phenolics, steroids, terpenoids have been characterized from mangroves and have toxicological, pharmacological and ecological importance [6, 7]. There is a continuous ...
Versatile Oligo(N-Substituted) Glycines: The
... to substantial lengths. For instance, peptoids up to 48 residues long have been synthesized with reasonable yields of the full-length target sequence [6]. ...
... to substantial lengths. For instance, peptoids up to 48 residues long have been synthesized with reasonable yields of the full-length target sequence [6]. ...
Understanding and Managing Drug Interactions in HIV Disease
... benefit. This is especially problematic, given that cross-class resistance among PIs is common. In general, patients failing therapy with one PI often do not experience sustained benefit from switching to another PI; (NB: an exception to this is with nelfinavir, where the presence of an isolated D30 ...
... benefit. This is especially problematic, given that cross-class resistance among PIs is common. In general, patients failing therapy with one PI often do not experience sustained benefit from switching to another PI; (NB: an exception to this is with nelfinavir, where the presence of an isolated D30 ...
CHROMATOGRAPHIC AND MASS SPECTRAL STUDIES ON MASS
... well. The methylenedioxyamphetamines, (MDMA, MDA and MDEA) are all novel psychoactive compounds with structural similarities to amphetamine and the psychedelic phenethylamine, mescaline. The methylenedioxy derivatives of amphetamine and methamphetamine represent the largest group of “designer drugs” ...
... well. The methylenedioxyamphetamines, (MDMA, MDA and MDEA) are all novel psychoactive compounds with structural similarities to amphetamine and the psychedelic phenethylamine, mescaline. The methylenedioxy derivatives of amphetamine and methamphetamine represent the largest group of “designer drugs” ...
DEVELOPMENT OF A NEW RP-HPLC METHOD FOR THE ESTIMATION OF... TABLET DOSAGE FORM Research Article
... and validation of a precise, sensitive, rapid and accurate HPLC method for the determination of NVP in bulk drug and in pharmaceutical dosage forms. In order to achieve remarkable retention time and peak asymmetry, a C18 stationary phase column (250mm X 4.6mm i.d, 5 μm particle size) and mobile phas ...
... and validation of a precise, sensitive, rapid and accurate HPLC method for the determination of NVP in bulk drug and in pharmaceutical dosage forms. In order to achieve remarkable retention time and peak asymmetry, a C18 stationary phase column (250mm X 4.6mm i.d, 5 μm particle size) and mobile phas ...
... and heart failure for over 10 years, information has accumulated not only on ACE inhibitors as a therapeutic class but also on a number of individual drugs. Many more have been studied in pre-clinical and early clinical research (up to 70 compounds) in addition to the ten agents currently licensed f ...
Jennifer Olson 1 Psychotropic Medication: Magic Bullet to Treat
... “magic bullet” medications, like antihistamines and insulin.20 During the flurry of drug testing at this time, some drugs were discovered to have side effects that researchers thought could be useful in psychology.21 The shift from viewing psychotropic medications as causing potentially useful side ...
... “magic bullet” medications, like antihistamines and insulin.20 During the flurry of drug testing at this time, some drugs were discovered to have side effects that researchers thought could be useful in psychology.21 The shift from viewing psychotropic medications as causing potentially useful side ...
nderzko - Harvard DASH
... uncontrollable bacterial disease. The many bacterial diseases which in this century became treatable by antibiotics are once again becoming as uncontrollable and dangerous as AIDS. The cause ...
... uncontrollable bacterial disease. The many bacterial diseases which in this century became treatable by antibiotics are once again becoming as uncontrollable and dangerous as AIDS. The cause ...
New strategies to optimize treatment for HIV-1 infection Polyana Monteiro d’Albuquerque
... Effects of uncontrolled viral replication leading to immune activation, inflammation, coagulation, and lipoprotein particle changes is thought to contribute to higher rates of cardiovascular and other end-organ damage reported in HIV-1-infected cohorts. HIV-1 replication and activation of lymphocyte ...
... Effects of uncontrolled viral replication leading to immune activation, inflammation, coagulation, and lipoprotein particle changes is thought to contribute to higher rates of cardiovascular and other end-organ damage reported in HIV-1-infected cohorts. HIV-1 replication and activation of lymphocyte ...
Protein Ligand Interactions: A Method and its Application to Drug Discovery
... • The truth is we know very little about how the major drugs we take work – receptors are unknown • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to mar ...
... • The truth is we know very little about how the major drugs we take work – receptors are unknown • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to mar ...
Paul G. King Consulting
... Then, for any process change including change in source of raw materials, the API manufacturer would need to confh-m that the product produced after the change had the same impurity profile and physical-state structure as before the change, no matter how minor the change. [After all, based on the pu ...
... Then, for any process change including change in source of raw materials, the API manufacturer would need to confh-m that the product produced after the change had the same impurity profile and physical-state structure as before the change, no matter how minor the change. [After all, based on the pu ...
Biomarkers and surrogate endpoints: How and when might they
... to look at that downstream protein or its mRNA to make a go/no go decision with regards to its mechanism of action. The extent of ACE inhibition, even though it may not have clear and distinct relationship with clinical outcome, has been used by pharmaceutical companies to evaluate their NME with th ...
... to look at that downstream protein or its mRNA to make a go/no go decision with regards to its mechanism of action. The extent of ACE inhibition, even though it may not have clear and distinct relationship with clinical outcome, has been used by pharmaceutical companies to evaluate their NME with th ...
443 - The AIDS InfoNet
... Saquinavir, also called Invirase, is a drug used as part of antiretroviral therapy (ART). There used to be a version called Fortovase that is no longer made. Saquinavir is manufactured by Roche Laboratories. Saquinavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HI ...
... Saquinavir, also called Invirase, is a drug used as part of antiretroviral therapy (ART). There used to be a version called Fortovase that is no longer made. Saquinavir is manufactured by Roche Laboratories. Saquinavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HI ...
Intro to systemic enzyme therapy
... Enzymes as proteins are more susceptible to denaturation at higher moisture content. Enzyme powders typically have lower (5-10%) moisture content. However, even with lower moisture content, enzyme powders will lose some of their activity over time, resulting in a loss of up to 20% of activity over a ...
... Enzymes as proteins are more susceptible to denaturation at higher moisture content. Enzyme powders typically have lower (5-10%) moisture content. However, even with lower moisture content, enzyme powders will lose some of their activity over time, resulting in a loss of up to 20% of activity over a ...
Systemic enzymes - World Nutrition, Inc.
... Supplementation with systemic enzymes may help the body to more efficiently regulate the metabolism, thereby reducing the physiological effects of aging. Physicians in Europe and Asia have long prescribed enzyme supplements to restore enzyme levels and promote natural healing. Systemic enzymes are f ...
... Supplementation with systemic enzymes may help the body to more efficiently regulate the metabolism, thereby reducing the physiological effects of aging. Physicians in Europe and Asia have long prescribed enzyme supplements to restore enzyme levels and promote natural healing. Systemic enzymes are f ...
Covalent inhibitors in drug discovery: from accidental discoveries to
... Unacceptable toxicity and insufficient efficacy are frequently cited reasons for the attrition of drug candidates during large-scale clinical trials [31]. While pharmaceutical teams continue to hedge against attrition by careful target and patient selection [32], the main defense of medicinal chemis ...
... Unacceptable toxicity and insufficient efficacy are frequently cited reasons for the attrition of drug candidates during large-scale clinical trials [31]. While pharmaceutical teams continue to hedge against attrition by careful target and patient selection [32], the main defense of medicinal chemis ...
Antifilarial Lead Molecules Isolated from Trachyspermum ammi
... activity. Trachyspermum ammi (Ajwain caroway, family Apiaceae) is known for its antiviral [7], antiinflammatory [8], antifungal [9-13], molluscicidal [14-16], antihelminthic (in sheep) [17], plant nematicidal [18], antipyretic [19], antiaggregatory [20] and antimicrobial activity [21-22]. This study ...
... activity. Trachyspermum ammi (Ajwain caroway, family Apiaceae) is known for its antiviral [7], antiinflammatory [8], antifungal [9-13], molluscicidal [14-16], antihelminthic (in sheep) [17], plant nematicidal [18], antipyretic [19], antiaggregatory [20] and antimicrobial activity [21-22]. This study ...
Document
... four-drug TB regimen and a three-drug ART regimen at the same time. The patient’s adherence is spotty and one week later she complains of severe nausea and vomiting. All of the following statements are correct except: A. B. C. D. ...
... four-drug TB regimen and a three-drug ART regimen at the same time. The patient’s adherence is spotty and one week later she complains of severe nausea and vomiting. All of the following statements are correct except: A. B. C. D. ...
Lecture Notes
... are Synergistic The synergism permits use of smaller doses than if either drug were used alone The use of two drugs together reduces the frequency of resistance The two drugs are marketed as a combination in the fixed ratio of 5 parts sulfamethoxazole to 1 part trimethoprim There are only a fe ...
... are Synergistic The synergism permits use of smaller doses than if either drug were used alone The use of two drugs together reduces the frequency of resistance The two drugs are marketed as a combination in the fixed ratio of 5 parts sulfamethoxazole to 1 part trimethoprim There are only a fe ...
The Clinical Utility of Pharmacogenetic Tests in HIV Therapy
... associated renal toxicity.43 On the other hand, a small case-control study by Izzedine et al (2006)44 found that the G1249A single nucleotide polymorphism and four polymorphism haplotype, CATC, of the ABCC2 gene (encoding MRP2) are both associated with tenofovir-induced renal tubulopathy. In support ...
... associated renal toxicity.43 On the other hand, a small case-control study by Izzedine et al (2006)44 found that the G1249A single nucleotide polymorphism and four polymorphism haplotype, CATC, of the ABCC2 gene (encoding MRP2) are both associated with tenofovir-induced renal tubulopathy. In support ...
Molecular Basis of Multidrug Transport by ATP
... spectrum of drugs, the transporter does exhibit drug specificity. This drug specificity is strongly dependent on the primary structure of the protein (Gottesman et al., 1995). The presence of specific drug binding site(s) in the Pglycoprotein and LmrA would enable the transport of drug molecules tha ...
... spectrum of drugs, the transporter does exhibit drug specificity. This drug specificity is strongly dependent on the primary structure of the protein (Gottesman et al., 1995). The presence of specific drug binding site(s) in the Pglycoprotein and LmrA would enable the transport of drug molecules tha ...
Pharmacologically Active Metabolites of Currently - J
... including pollutants, dietary components and drugs. To defense the body against xenobiotic substances, an array of biotransformation reactions (or metabolic reactions) is undergone. Due to the biotransformation, the molecular structure of a drug is commonly changed to be more hydrophilic and the sub ...
... including pollutants, dietary components and drugs. To defense the body against xenobiotic substances, an array of biotransformation reactions (or metabolic reactions) is undergone. Due to the biotransformation, the molecular structure of a drug is commonly changed to be more hydrophilic and the sub ...
Discovery and development of non-nucleoside reverse-transcriptase inhibitors
![](https://en.wikipedia.org/wiki/Special:FilePath/RTenzyme-hand.jpg?width=300)
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of HIV. RT is one of the most popular targets in the field of antiretroviral drug development.Discovery and development of NNRTIs began in the late 1980s and in the end of 2009 four NNRTI had been approved by regulatory authorities and several others were undergoing clinical development. Drug resistance develops quickly if NNRTIs are administered as monotherapy and therefore NNRTIs are always given as part of combination therapy, the highly active antiretroviral therapy (HAART).