• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
What IS a population???
What IS a population???

...  Natural selection acts on individuals differential survival (“survival of the fittest”)  differential reproductive success (who bears more offspring?)  True adaptation and ...
Transformation Lab
Transformation Lab

... The concept of cell transformation raises the following questions, among others:  To transform an organism to express new genetic information, do you need to insert the new gene into every cell in a multicellular organism or just one?  For laboratory study, which organism is best suited for total ...
mutations - Schule.at
mutations - Schule.at

Experiment - people.vcu.edu
Experiment - people.vcu.edu

... Unfortunately, injury to the human heart does not regenerate but rather results in scarring (Laflamme and Murry). Conveniently, zebrafish are also transparent in the embryo stage which makes it very easy to study heart development or heart regeneration. The T-box family of transcription factors is a ...
epilepsy are reviewed from the Faculty of Medicine and Research
epilepsy are reviewed from the Faculty of Medicine and Research

... Medicine, Reston, MD. The mode of inheritance in most ...
Lec 10 - Regulation of Gene
Lec 10 - Regulation of Gene

... Each cell of a living organism contains thousands of genes. But all genes do not function at a time. Genes function according to requirements of the cell. Genes control the phenotypic expression of various characters through the production of specific enzymes. Enzymes are special proteins which cata ...
Slide 1
Slide 1

... Antibody staining indicates that the mushroom bodies contain the molecular components that are key for learning: ...
Variation and Genetics.
Variation and Genetics.

... • This can lead to the problems of inbreeding as all the animals or plants that are left are genetically closely related to each other. • Also, once an allele has been lost from a population it is gone forever, so if tastes change, or a new disease arrives the old “best” may not be good enough anymo ...
2007/2008 Biology Curriculum Calendar and Testing
2007/2008 Biology Curriculum Calendar and Testing

... global warming/ozone layer greenhouse effect biological magnification Explain the difference between explanations that currently have the support of science and those explanations that may be emerging as possible new ones Are there questions that scientific investigations cannot answer? energy pyram ...
The origin of oncogenic mutations: where is the
The origin of oncogenic mutations: where is the

... genes, caused by random ‘hits’ in its DNA, a ‘hit’ being an error in DNA replication or a reaction of the DNA with free radicals or other chemical species of exogenous or endogenous origin. It is not obvious how the epidemiological data on cancer incidence can be interpreted within the framework of ...
Giant chromosomes and mendl`s Laws
Giant chromosomes and mendl`s Laws

... gland contain about 1024 copies of the DNA, or ten doublings from the normal 2n condition, of each of the three chromosomes.. The pattern of condensed regions (heterochromatin 85 ٪), and transcribed regions (euchromatin 15 ٪) gives a series of about 5000 light and dark bands when the chromosomes are ...
PowerPoint Presentation - University of Evansville Faculty Web sites
PowerPoint Presentation - University of Evansville Faculty Web sites

... Overview ...
DNA Replication and DNA Repair Study Guide Focus on the
DNA Replication and DNA Repair Study Guide Focus on the

... i. Beginning point of replication ii. Prokaryotes (bacteria)- 1 origin of replication iii. Eukaryotes- 1 to 2000 origins of replication per chromosome b. Direction- two forks proceed in opposite directions c. Forks i. Replication sites ii. Proceed in one direction (one for each direction) iii. Repli ...
gene-expression-text
gene-expression-text

...  Timing and location (i.e. Different homeotic (Hox) genes regulation) of gene (colors) are turned on (expressed) expression is more at specific time during development important than the actual and lead to the formation of specific number of genes. body structures. CHMI 2227 - E.R. Gauthier, Ph.D. ...
Cancer Prone Disease Section Familial tylosis Atlas of Genetics and Cytogenetics
Cancer Prone Disease Section Familial tylosis Atlas of Genetics and Cytogenetics

Slide 1
Slide 1

... Infants with the disorder:  have soft, fragile bones that may appear bent or crumpled  Bones are easily broken  and multiple fractures can occur even ...
intervention session 3 biology 1 - science
intervention session 3 biology 1 - science

... Let’s review theEXAM key points REVIEWfor Variation •Genetic information from parents are past onto their offspring these are contained within the male & female sex cells (gametes). This occurs by DNA (a large molecules made up of smaller molecules). DNA makes genes, genes make chromosomes. These g ...
AP Biology
AP Biology

... In the 1990’s when scientists began to compile a list of genes and DNA sequences in the human genome it became abundantly clear that we were eventually going to need a place to put all of these sequences. One of the systems developed was BLAST, or Basic Local Alignment Search Tool. The BLAST compute ...
A Novel Chimeric Low-Molecular-Weight Glutenin
A Novel Chimeric Low-Molecular-Weight Glutenin

... possessed characteristics of both LMW-i (1–43 residues) and LMW-m (44–298 residues) type genes. Five cloned LMW-GS genes were expressed in E. coli by two kinds of expression vectors (pGEX-4T-2 and pET-30a) to confirm their authenticity. The nucleotide sequences coding for mature proteins and complet ...
Mendelian Inheritance
Mendelian Inheritance

... Why are people with type O blood considered “universal donors”? Why are those with type AB considered “universal acceptors”? ...
Power Point Presentation - The Sleepy Hollow German Shorthaired
Power Point Presentation - The Sleepy Hollow German Shorthaired

towards synthetic plant genomes, transcriptomes and epigenomes
towards synthetic plant genomes, transcriptomes and epigenomes

... of the two RNAs, a single guide (sg) RNA was constructed for biotechnological applications (Jinek et al., 2012). Up to now, most scientists use the CRISPR/Cas system as sequence-specific nuclease for genome engineering. In its most prominent application a DSB is induced in a gene of interest. As the ...
Division 4.qxd
Division 4.qxd

... eymour Benzer's work changed our notion of the concept of the gene, by demonstrating that the gene had a fine structure consisting of a linear array of subelements. At the time Benzer began his classic work, the concept of the gene was different from what it is today. Genes were thought to be indivi ...
Molybdenum cofactor-deficient mice resemble the phenotype of
Molybdenum cofactor-deficient mice resemble the phenotype of

... A murine MOCS1 cDNA was used to identify a genomic cosmid clone containing the murine MOCS1 gene. This revealed an exon/intron structure identical to that in the human genome (3). We chose to eliminate exon 3 of the murine MOCS1 gene by homologous recombination in embryonic stem cells, since it enco ...
Chapter 6 – Microbial Growth
Chapter 6 – Microbial Growth

... a. Transposase gene to facilitate recombination. Can cut and paste DNA strands. b. Inverted repeats – sequences that target new location and also is recognized by transposase. Chapter 8 Problems: Review 1, 2, 4, 7-9. MC 1, 2, 4-10. CT 1, 3. CA 2, 3. ...
< 1 ... 542 543 544 545 546 547 548 549 550 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report