Genome-wide histone modification patterns in
... bioRxiv preprint first posted online Feb. 15, 2016; doi: http://dx.doi.org/10.1101/039776. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license. ...
... bioRxiv preprint first posted online Feb. 15, 2016; doi: http://dx.doi.org/10.1101/039776. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license. ...
PhenoLink - a web-tool for linking phenotype Lactobacillus plantarum strains
... technologies allows revealing cellular mechanisms underlying an organism’s phenotype. ~Omics datasets are often very large and noisy with many features (e.g., genes, metabolite abundances). Thus, associating phenotypes to ~omics data requires an approach that is robust to noise and can handle large ...
... technologies allows revealing cellular mechanisms underlying an organism’s phenotype. ~Omics datasets are often very large and noisy with many features (e.g., genes, metabolite abundances). Thus, associating phenotypes to ~omics data requires an approach that is robust to noise and can handle large ...
PPT File
... chromosome sets from diploid to haploid • Like mitosis, meiosis is preceded by the replication of chromosomes • Meiosis takes place in two sets of cell divisions, called meiosis I and meiosis II • The two cell divisions result in four daughter cells, rather than the two daughter cells in ...
... chromosome sets from diploid to haploid • Like mitosis, meiosis is preceded by the replication of chromosomes • Meiosis takes place in two sets of cell divisions, called meiosis I and meiosis II • The two cell divisions result in four daughter cells, rather than the two daughter cells in ...
Fine mapping of Noonan/cardio-facio cutaneous syndrome
... the same yeast artificial chromosome (YAC) (920g2).12 The exact position of D12S129 in relation to D12S809 is not known.11 No other markers were available for a more precise mapping of the crossover. Another crossover was observed in an unaffected individual (III1) between the NS/CFC locus and marke ...
... the same yeast artificial chromosome (YAC) (920g2).12 The exact position of D12S129 in relation to D12S809 is not known.11 No other markers were available for a more precise mapping of the crossover. Another crossover was observed in an unaffected individual (III1) between the NS/CFC locus and marke ...
Relationship among phenotypic plasticity
... estimated by this variance. If Vg is smaller, genetic change gives little influence on the phenotype, and larger genetic (or mutational) robustness is implied. Phenotypic plasticity, on the other hand, represents the degree of change in phenotype against variation in environment. Quantitatively, one ...
... estimated by this variance. If Vg is smaller, genetic change gives little influence on the phenotype, and larger genetic (or mutational) robustness is implied. Phenotypic plasticity, on the other hand, represents the degree of change in phenotype against variation in environment. Quantitatively, one ...
Heliconius wing patterns: an evo-devo model for understanding
... Figure 2 The genetic basis of polymorphism in H. numata. Crosses between sympatric forms show inheritance of the whole colour pattern at the single Mendelian locus P, and a largely linear dominance series of the P alleles which avoids non-mimetic heterozygotes (Brown and Benson, 1974; Joron, 2000). ...
... Figure 2 The genetic basis of polymorphism in H. numata. Crosses between sympatric forms show inheritance of the whole colour pattern at the single Mendelian locus P, and a largely linear dominance series of the P alleles which avoids non-mimetic heterozygotes (Brown and Benson, 1974; Joron, 2000). ...
DNA MUTATION, REPAIR, AND TRANSPOSITION
... 2. Silent mutations are those that do not produce a detectable phenotypic change. They can occur in the region between genes, in introns, in the 5' and 3' untranslated regions of a gene, and in the wobble position of a codon. 4. Both types of mutation restore the wild-type function of a gene without ...
... 2. Silent mutations are those that do not produce a detectable phenotypic change. They can occur in the region between genes, in introns, in the 5' and 3' untranslated regions of a gene, and in the wobble position of a codon. 4. Both types of mutation restore the wild-type function of a gene without ...
Abundance and distribution of Macrolide
... Macrolides, which could inhibit a wide range of bacteria, are a group of antibiotics frequently used in clinics and feedlots (Iacoviello and Zinner, 2002). Macrolides share an overlapping binding site on bacterial ribosome with structurally distinct lincosamides and streptogramins, leading to cluste ...
... Macrolides, which could inhibit a wide range of bacteria, are a group of antibiotics frequently used in clinics and feedlots (Iacoviello and Zinner, 2002). Macrolides share an overlapping binding site on bacterial ribosome with structurally distinct lincosamides and streptogramins, leading to cluste ...
(a) (b)
... though this wasn’t known at the time • Today we can show that genes are located on chromosomes • The location of a particular gene can be seen by tagging isolated chromosomes with a fluorescent dye that highlights the gene ...
... though this wasn’t known at the time • Today we can show that genes are located on chromosomes • The location of a particular gene can be seen by tagging isolated chromosomes with a fluorescent dye that highlights the gene ...
Genomic Predictors of Outcome in Prostate Cancer
... PTEN deleted on chromosome 10 is one of the most frequently mutated genes in human cancer. It dephosphorylates lipid-signaling intermediates, resulting in deactivation of PI3K signaling, and thus controls proliferation and growth [43]. In a landmark study by Saal and coworkers in 2007, PTEN loss was ...
... PTEN deleted on chromosome 10 is one of the most frequently mutated genes in human cancer. It dephosphorylates lipid-signaling intermediates, resulting in deactivation of PI3K signaling, and thus controls proliferation and growth [43]. In a landmark study by Saal and coworkers in 2007, PTEN loss was ...
Genetic and epigenetic risks of intracytoplasmic sperm injection
... Other studies by Anway and Skinner [8] confirmed the transfer of abnormal phenotypes (through epigenetic actions on the male germ line) to subsequent generations analyzed. Mouse models with reproductive defects as a major phenotype have been created and now hold over 200 [9]. These models are helpin ...
... Other studies by Anway and Skinner [8] confirmed the transfer of abnormal phenotypes (through epigenetic actions on the male germ line) to subsequent generations analyzed. Mouse models with reproductive defects as a major phenotype have been created and now hold over 200 [9]. These models are helpin ...
Title: Statistical Evidence for Common Ancestry
... species could provide strong evidence of their common ancestry. Our method uses the observed variation in codon sequences at amino acid invariant sites as a test statistic, and compares such variation to that which is expected under three different models of codon frequency under the alternative hyp ...
... species could provide strong evidence of their common ancestry. Our method uses the observed variation in codon sequences at amino acid invariant sites as a test statistic, and compares such variation to that which is expected under three different models of codon frequency under the alternative hyp ...
Calcitonin
... therefore the production of CAMP (Norris, Carr 54). The alpha subunit will then recombine with both Lambda and beta subunits to wait for the next ligand to bind to the G protein Coupled receptor (Norris, Carr 5). It is important to note that in this signal transduction pathway CAMP act as a secon ...
... therefore the production of CAMP (Norris, Carr 54). The alpha subunit will then recombine with both Lambda and beta subunits to wait for the next ligand to bind to the G protein Coupled receptor (Norris, Carr 5). It is important to note that in this signal transduction pathway CAMP act as a secon ...
Dynamic Changes in Aromatic Hydrocarbon Associated Catabolic
... degradation appears to be facilitated by facultative anaerobes, such as Thauera spp and Azoarcus spp [1] that functionalise the aromatic substrate via formation of a benzoyl CoA derivative before further ring degradation using reductive biochemistry [8]. Microcosms are widely used to both facilitate ...
... degradation appears to be facilitated by facultative anaerobes, such as Thauera spp and Azoarcus spp [1] that functionalise the aromatic substrate via formation of a benzoyl CoA derivative before further ring degradation using reductive biochemistry [8]. Microcosms are widely used to both facilitate ...
Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice
... dantly expressed in the thymus as compared with other organs (8). Several lines of evidence suggest that the relative amount of GR expressed within a cell determines the magnitude and nature of the response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mR ...
... dantly expressed in the thymus as compared with other organs (8). Several lines of evidence suggest that the relative amount of GR expressed within a cell determines the magnitude and nature of the response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mR ...
Unit VII - S2TEM Centers SC
... activities and questions are included. This could be used after the introduction of the lesson. ...
... activities and questions are included. This could be used after the introduction of the lesson. ...
A Novel Multigene Family May Encode Odorant Receptors: A
... shared distinctive sequence motifs not found in other superfamily members, indicating they were all members of a new family of receptors. To obtain full-length cDNA clones, cDNA libraries prepared from olfactory epithelium RNA or from RNA of an enriched population of olfactory sensory neurons were s ...
... shared distinctive sequence motifs not found in other superfamily members, indicating they were all members of a new family of receptors. To obtain full-length cDNA clones, cDNA libraries prepared from olfactory epithelium RNA or from RNA of an enriched population of olfactory sensory neurons were s ...
Epigenetic Regulation ofbdnfGene Transcription in the
... 60°C for 1 min. Detection of the fluorescent products occurred at the end of the 15 s temperature step. For a melting curve analysis, PCR products were melted by increasing the temperature in 1°C increments beginning at 60°C. To further verify specificity of the final product, 10 l of the amplified ...
... 60°C for 1 min. Detection of the fluorescent products occurred at the end of the 15 s temperature step. For a melting curve analysis, PCR products were melted by increasing the temperature in 1°C increments beginning at 60°C. To further verify specificity of the final product, 10 l of the amplified ...
Single-strain improved oral cholera vaccine : scientific report
... strain (MS1342) was achieved by the insertion into the chromosome of a parent Inaba strain, a wild-type wbeT gene that was stably expressed at low levels [2]. A disadvantage of this approach was the presence of two copies of the wbeT gene in the constructed strain with a low risk for instability due ...
... strain (MS1342) was achieved by the insertion into the chromosome of a parent Inaba strain, a wild-type wbeT gene that was stably expressed at low levels [2]. A disadvantage of this approach was the presence of two copies of the wbeT gene in the constructed strain with a low risk for instability due ...
Understanding Genetics and the Sire Summaries
... When discussing different traits of animals and how genes are expressed and measured, there are a few more terms to learn. First, understand the difference between an animal’s genotype and phenotype. The genotype is the actual genes an organism, such as a dairy cow, possesses for a given trait. The ...
... When discussing different traits of animals and how genes are expressed and measured, there are a few more terms to learn. First, understand the difference between an animal’s genotype and phenotype. The genotype is the actual genes an organism, such as a dairy cow, possesses for a given trait. The ...
by Vanessa Di Gioacchino A thesis submitted to the Department of Biology
... Mental illness encompasses a wide variety of disorders that affect diverse subsets of the population. Despite their prevalence, the underlying causes of many of these illnesses are still poorly understood. For example, schizophrenia affects approximately 1% of the population (Carpenter and Buchanan, ...
... Mental illness encompasses a wide variety of disorders that affect diverse subsets of the population. Despite their prevalence, the underlying causes of many of these illnesses are still poorly understood. For example, schizophrenia affects approximately 1% of the population (Carpenter and Buchanan, ...
Multiple Roles of the Y Chromosome in the Biology of
... It is generally accepted that the sex chromosomes of most animals arose from a couple of homologous autosomes after the acquisition of a dominant sex determination gene[17,18] and that the Y chromosome is the result of the degeneration of one of them[19,20,21]. Its degeneration would be a consequenc ...
... It is generally accepted that the sex chromosomes of most animals arose from a couple of homologous autosomes after the acquisition of a dominant sex determination gene[17,18] and that the Y chromosome is the result of the degeneration of one of them[19,20,21]. Its degeneration would be a consequenc ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse