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Species tree
Species tree

... • Bininda-Emonds ORP (2005). Supertree Construction in the Genomic Age. Methods in Enzymology 395: p.745-757. • Bininda-Emonds,OPRP, John L. Gittleman, Mike A. Steel (2002) The (super)Tree Of Life: Procedures, Problems, and Prospects. Annual Review of Ecology and Systematics, Vol. 33: 265-289. • Dag ...
RNA-seq presentation
RNA-seq presentation

... – Overlapping genes from opposite strands can be detected by not allowing reverse complements in De Bruijn graph and using odd k-mers. – Higher eukaryotes more challenging due to larger datasets and difficulties in identifying alternative ...
Leukaemia Section Lymphomatoid papulosis (LyP) with 6p25.3 rearrangement Atlas of Genetics and Cytogenetics
Leukaemia Section Lymphomatoid papulosis (LyP) with 6p25.3 rearrangement Atlas of Genetics and Cytogenetics

Practical English (2)
Practical English (2)

... geologic timescale that extends from about 199.6 ± 0.6 to 145.4 ± 4.0 million years ago. It is known as the “Age of Dinosaurs” 2 DNA: Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms. ...


... sensitivity to UV-C, continuous light, H2O2 and ionising radiation and exhibits early senescence and reduced seed yield. Expressed in all tissues examined Identification of mutant: Jiang et al. (1997), Hefner et al. (2003). Gene isolation: Hefner et al. At3g05210 (UVR7/AtERCC1) (2003). Mutants are s ...


... sensitivity to UV-C, continuous light, H2O2 and ionising radiation and exhibits early senescence and reduced seed yield. Expressed in all tissues examined Identification of mutant: Jiang et al. (1997), Hefner et al. (2003). Gene isolation: Hefner et al. At3g05210 (UVR7/AtERCC1) (2003). Mutants are s ...
Genetically Essential and Nonessential a-Tubulin Genes Specify Functionally Interchangeable Proteins.
Genetically Essential and Nonessential a-Tubulin Genes Specify Functionally Interchangeable Proteins.

... Using the molecular clones of the S. cerevisiae a-tubulin genes, TUB] and TUB3, we tested the relative function of two members of this simple gene family by manipulating their copy numbers in vivo. Given the level of divergence (10%) between the TUB] and TUB3 gene products, one might predict that th ...
Sample pages 2 PDF
Sample pages 2 PDF

... The genetic information defining gender is typically contained in sex chromosomes. Among diploid organisms, the XX/XY sex-determination system is the most common. In this system, females have two sex chromosomes of the same kind (XX), while males have two distinct sex chromosomes (XY). The X and Y s ...
`Am not I a fly like thee?` From genes in fruit flies to behavior in humans
`Am not I a fly like thee?` From genes in fruit flies to behavior in humans

... regulatory loop in which each cell counts out its own 24 h period by means of an oscillating cycle of transcription and translation. Several other genes complete the basic cycling mechanism—per and tim repress their own transcription which requires activation by the transcription factors Clock and c ...
Cellular basis of reproduction and inheritance packet B
Cellular basis of reproduction and inheritance packet B

... Standards that all students are expected to achieve in the course of their studies. Genetics 2. Mutation and sexual reproduction lead to genetic variation in a population. As a basis for understanding this concept: a. Students know meiosis is an early step in sexual reproduction in which the pairs o ...
Lab_6_Part3
Lab_6_Part3

... light. This is not a normal phenotype (characteristic) for E.coli. You were then asked to figure out a way to determine which molecule was becoming fluorescent under UV light. After determining that the pGLO plasmid DNA was not responsible for the fluorescence under the W light, you concluded that i ...
Information Encoding in Biological Molecules: DNA and
Information Encoding in Biological Molecules: DNA and

... • MySQL database directly accessible • APIs for Perl and Java ...
Exercise 1 - EuPathDB Workshop
Exercise 1 - EuPathDB Workshop

... a. The first thing we will need to do is get a sequence to use for BLAST. Search for the keyword "dihydrofolate" (without quotations). (Hint: use the Gene Text Search on the upper right hand side of the EuPathDB home page). b. You should get multiple hits. Find the first one that is annotated as "di ...
Name - cloudfront.net
Name - cloudfront.net

... 27. What does it mean to be a carrier? ...
mutations - Cloudfront.net
mutations - Cloudfront.net

...  Non-disjunction-failure of chromosomes to separate properly during Meiosis. ...
Leukaemia Section T-cell prolymphocytic leukemia (T-PLL) Atlas of Genetics and Cytogenetics
Leukaemia Section T-cell prolymphocytic leukemia (T-PLL) Atlas of Genetics and Cytogenetics

VANDERBILT STUDENT VOLUNTEERS
VANDERBILT STUDENT VOLUNTEERS

emboj7601952-sup
emboj7601952-sup

... and 3; also called RNF 28-30; or TRIM 63, 55, 54). The three MuRFs share highly conserved N-terminal RING finger domains, followed C-terminally by a MuRF family conserved motif (MFC), a B-box, and a coiled-coil region. The MuRF1Bcc fragment expressed in E. coli corresponds to residues 109-315, MuRFc ...
MITOCHONDRIAL INHERITANCE
MITOCHONDRIAL INHERITANCE

... • Conditions due to having faulty mitochondrial genes create complexities when assessing the risk the mother has for passing on the faulty mitochondrial genes to a child and if, or how severely, the child would be affected • While it is possible to test for the presence or absence of some faulty m ...
Document
Document

... Assume for this cross that all mice have one B allele (B- = black) and there are no brown mice (bb). ...
RNA Detection and quantitation
RNA Detection and quantitation

... • A profile of the PCR is then generated charting the progress through the exponential phase to the plateau phase. • A point in the linear phase may be chosen to examine gene expression differences between samples. • The earlier this line is reached the more copies of that particular transcript was ...
Better Living Through Genetics
Better Living Through Genetics

... is concentrated in less than one one-thousandth of your genes. What's more, even within that tiny fraction of DNA that varies between people, the differences between populations aren't as dramatic as the researchers expected. In fact, the overwhelming majority of genetic differences between individu ...
Handout 25-27 - U of L Class Index
Handout 25-27 - U of L Class Index

... 3.The fully expressed allele is the dominant allele, the other that has no noticeable effect on the organism’s appearance is the recessive allele 4.Males and females contribute equally to the traits in their offspring. Mendel's law of segregation. Mendel's model for monohybrid inheritance. The purpl ...
Essential Cell Biology chapter 5 excerpt
Essential Cell Biology chapter 5 excerpt

... genetic instructions required to make and maintain a living organism. This hereditary information is passed on from a cell to its daughter cells at cell division, and from generation to generation in multicellular organisms through the reproductive cells. These instructions are stored within every l ...
Massachusetts Institute of Technology
Massachusetts Institute of Technology

... levels, nucleotides and amino acids, to the question of whole-genome duplication. Our major goal will be to have you become familiar with modern methods for detecting natural selection at the level of genes and proteins, as well as to engage some current recent questions in gene duplication. The lab ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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