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Biol 1309 - Adaptations Adaptation – what does it mean?
Biol 1309 - Adaptations Adaptation – what does it mean?

... Promiscuous Proteins (enzymes) • Promiscuous enzymes usually do one job REALLY well and other jobs less well • There is a constraint to the evolution of new protein enzyme functions, thus an organism might benefit from a protein doing something new • The protein might carry out one process faster t ...
slides
slides

... •  Mendel’s  three  postulates   •  Mendel’s  two  laws  of  inheritance   –  Recombina
SSSA_Poster_Straathof_finalv
SSSA_Poster_Straathof_finalv

... • Further investigation to determine treatment effect on cumulative N2O emissions • Molecular quantification of several additional genes responsible for nitrification and denitrification (N2O production) at various points of the N-cycle including amo, nirK, nosZ, norB and ammonia-oxidizing archaea • ...
Application of PCR-technique in biological labs
Application of PCR-technique in biological labs

... When these genes are expressed in prokaryotic cells for protein production or purification, the RNA produced from transcription need not undergo splicing as it contains only exons. ...
Identification of an Insertion Sequence Located
Identification of an Insertion Sequence Located

... sequences (IS). These mobile genetic elements, by definition, contain genes related only to insertion functions (4). Despite this definition, the phenotype of the recipient bacterium can be changed if the IS is inserted into a structural gene or if the insertion in front of a gene affects the expres ...
AP Biology: Evolution
AP Biology: Evolution

... ______Big Idea 3 Investigation 9: Biotechnology: Restriction Enzyme Analysis of DNA Lab Objective: Digest lambda DNA with 4 different enzymes; analyze the digestion results by gel electrophoresis on agarose gels. ...
SHORT COMMUNICATION Genetical Analysis of a
SHORT COMMUNICATION Genetical Analysis of a

... strain would grow under these conditions, but heterozygous diploids were expected to do so provided all the lethal or auxotrophic mutations present were recessive. A few prototrophic colonies were observed after 5 d incubation, several of which were judged to be diploid on the basis of their large c ...
Predicted vs. Observed Results
Predicted vs. Observed Results

... 2. How did your expected results compare to your observed results? 3. How did the class expected results compare to the class observed results? 4. Explain what each side of the penny represented, what the flipping of the penny represented, how it relates to the chromosomes, and what the sides ...
Split hand/foot malformations with microdeletions at chromosomes
Split hand/foot malformations with microdeletions at chromosomes

... Numerous human gene defects can cause SHFMs. For example, the SHFM1 gene is associated with deletions of varying extent on chromosome 7q21eq22 [1], whereas SHFM2 is associated with genes localized at Xq26eq26.16 [2]. Previous research has reported multiple types of syndromic or nonsyndromic ectrodac ...
Leukaemia Section Chronic Myelomonocytic Leukemia (CMML) Atlas of Genetics and Cytogenetics
Leukaemia Section Chronic Myelomonocytic Leukemia (CMML) Atlas of Genetics and Cytogenetics

1. The ability to roll the tongue is dominant over the inability to do so
1. The ability to roll the tongue is dominant over the inability to do so

... smooth seeds are crossed, what are the genotypes and phenotypes of the offspring? 5. As a genetic counselor, you routinely advise couples about the possibility of genetic disease in their offspring based on their family histories. This morning you met with an engaged couple, both of whom are phenoty ...
Ch15 PowerPoint LN
Ch15 PowerPoint LN

... Nervous and muscular systems are the most susceptible to energy losses so mitochondrial diseases show up the most in these body systems. ...
The novel mutation of CYP21A2 gene and congenital adrenal
The novel mutation of CYP21A2 gene and congenital adrenal

... CYP21A2 gene [2,14]. As there are relevance between the 21hydroxylase activity caused by the mutation of CYP21A2 and severity of the clinic physical signs, genotyping CYP21A2 mutations has been proven to be a valuable manner for diagnosis and predicting phenotype in CAH [4,15]. The most severe SW ty ...
power point presentation
power point presentation

... • A gene that is located on either sex chromosome is called a sex-linked gene • Genes on the Y chromosome are called Y-linked genes; there are few of these • Genes on the X chromosome are called X-linked genes – Fathers- x-linked to all daughters/no sons – Mothers-x-linked to sons and daughters ...
DNA
DNA

Linkage Analysis
Linkage Analysis

...  Negative values (<1) suggest that linkage is less likely  Conventionally a combined Lod score of +3 or greater (equivalent to greater than 1000/1 odds in favor of linkage) is considered definitive evidence of linkage ...
Chapter Eleven: Chromosome Structure and Transposable Elements
Chapter Eleven: Chromosome Structure and Transposable Elements

... circumstances would this insertion sequence be able to transpose? Without a functional transposase gene of its own, the transposon would be able to transpose only if another transposon of the same type were in the cell and able to express a functional transposase enzyme. This transposase enzyme will ...
Wnt Genes Review - Stanford University
Wnt Genes Review - Stanford University

... of Writ genes and the structural determinants of their expression. Of the several genes that have been sequenced, most have three introns in corresponding positions; however, a Caenorhabditis-elegans Writ gene has a radically different distribution of exonsand introns (G. Shackleford, L. Shiue, H. E ...
2013 Holiday Lectures on Science Medicine in the Genomic Era
2013 Holiday Lectures on Science Medicine in the Genomic Era

... resulting daughter cells with that mutation, which are dividing quickly, are more likely to accumulate additional mutations. Additional mutations that affect cell division may cause those cells to divide even faster. Eventually, a cell may acquire enough mutations that it starts to grow and divide u ...
Beyond the ABCs: ternary complex formation in the control of
Beyond the ABCs: ternary complex formation in the control of

... above MADS factors, in common with most characterized plant MADS factors, can be divided into four or five domains. The MADS box (M) is always at or near to the N terminus and is mainly involved in DNA binding. The I region (I), which is of variable length and sequence composition, and the K box (K) ...
Gene Section SLC16A1 (solute carrier family 16, member 1
Gene Section SLC16A1 (solute carrier family 16, member 1

1d Mapping lab
1d Mapping lab

... A FASTQ file contains the sequences of the reads and their corresponding quality information. It does not contain any information about the origin of the reads, i.e. to which transcript they belong. To find that out we could use a Blast search for each of the reads. 1. Take the first read in the ...
06BIO201 Exam 1 KEY
06BIO201 Exam 1 KEY

... You are a mouse geneticist and you believe that you have isolated the gene that controls ear size. You isolate mutant mice that have exceptionally large ears, and you have named the gene that encodes ear size the “dumbo gene”. You have also established a pure breeding strain of these dumbo mice that ...
The genes on the X and Y chromosomes: Sex linkage inheritance
The genes on the X and Y chromosomes: Sex linkage inheritance

... * X-linked recessive traits are expressed in all heterogametics and homogametics that are homozygous for the recessive allele. - Because females inherit two copies of the X chromosome, they can be homozygous for a disease allele at a given locus, heterozygous, or homozygous for the normal allele at ...
A Connective Tissue Disorders NGS Panel: Development
A Connective Tissue Disorders NGS Panel: Development

... or skeletal dysplasias which may affect the development of the bones. Making a specific diagnosis can be important in determining the appropriate medical management. Many of these conditions can have life-threatening complications (i.e., aortic root rupture, bowel rupture, etc.), many require regula ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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