Hemophilia
... RR stands for dominant alleles. rr is a recessive allele. Rr is the dominant gene over the recessive gene. The dominant gene produces the same phenotype in the organism whether or not its allele identical. The recessive gene produces its characteristic phenotype only when its allele is identical. ...
... RR stands for dominant alleles. rr is a recessive allele. Rr is the dominant gene over the recessive gene. The dominant gene produces the same phenotype in the organism whether or not its allele identical. The recessive gene produces its characteristic phenotype only when its allele is identical. ...
Evidence, Mechanisms and Models for the Inheritance of Acquired
... In unicellular asexual organisms, cellular heredity is identical with between-generation heredity, and it is often difficult to distinguish between genetic and epigenetic inheritance. In some cultured cell lines, hereditary variations which were initially assumed to be classical mutations, turned ou ...
... In unicellular asexual organisms, cellular heredity is identical with between-generation heredity, and it is often difficult to distinguish between genetic and epigenetic inheritance. In some cultured cell lines, hereditary variations which were initially assumed to be classical mutations, turned ou ...
Loss of heterozygosity analysis defines a 3-cM region of
... Figure 1 Pattern of LOH in MMs exhibiting deletions in 15q. Thick vertical bar, designated by SRO, indicates the minimal region of overlapping deletion. Markers, with corresponding cM distances, are shown in the predicted order from the centromere to the telomere. For each locus, the overall frequen ...
... Figure 1 Pattern of LOH in MMs exhibiting deletions in 15q. Thick vertical bar, designated by SRO, indicates the minimal region of overlapping deletion. Markers, with corresponding cM distances, are shown in the predicted order from the centromere to the telomere. For each locus, the overall frequen ...
RELATIONSHIPS BETWEEN HEMATOLOGICAL PARAMETERS AND GLOBIN TYPES IN GENTILE DI PUGLIA OVINE BREED
... Seven different β-globin [1, 2, 3, 4] and four α-globin chains [5, 6, 7] have been described in domestic sheep. Moreover the presence of a quantitative polymorphism must be considered due to the fact that non allelic loci produce unequal amounts of α-globin. In sheep as in humans and most other mamm ...
... Seven different β-globin [1, 2, 3, 4] and four α-globin chains [5, 6, 7] have been described in domestic sheep. Moreover the presence of a quantitative polymorphism must be considered due to the fact that non allelic loci produce unequal amounts of α-globin. In sheep as in humans and most other mamm ...
Self-incompatibility: How to Stay Incompatible
... population than those carrying common alleles, which will often arrive on a recipient plant whose stigma expresses the same incompatibility type and consequently be rejected. There is thus an advantage for new specificities to arise, and once present, alleles are only rarely eliminated from a specie ...
... population than those carrying common alleles, which will often arrive on a recipient plant whose stigma expresses the same incompatibility type and consequently be rejected. There is thus an advantage for new specificities to arise, and once present, alleles are only rarely eliminated from a specie ...
Comprehensive Cardiomyopathy Panel
... Next Generation Sequencing: All coding exons and the flanking 15 bases (splice sites or untranslated regions of the genes listed in the panel, as well as 22 reported non-coding region mutations in DMD, are enriched from the patient’s genomic DNA and sequenced using a solid-state sequencing-by-synthe ...
... Next Generation Sequencing: All coding exons and the flanking 15 bases (splice sites or untranslated regions of the genes listed in the panel, as well as 22 reported non-coding region mutations in DMD, are enriched from the patient’s genomic DNA and sequenced using a solid-state sequencing-by-synthe ...
Gentile, Margaret: Computational Methods for the Design of PCR Primers for the Amplification of functional Markers from Environmental Samples
... Challenges of primer design for unknown, diverse sequences The design of a primer to amplify a gene of interest from all species present differs from the applications described above, because the sequence to be amplified is not actually known and can be quite different from known sequences of the ge ...
... Challenges of primer design for unknown, diverse sequences The design of a primer to amplify a gene of interest from all species present differs from the applications described above, because the sequence to be amplified is not actually known and can be quite different from known sequences of the ge ...
Lec 02 - Mendel`s laws of Inheritance
... gametes are therefore considered assorted independently. As such, the gamete can end up with any combination of paternal or maternal chromosomes. Any of the possible combinations of gametes formed from maternal and paternal chromosomes will occur with equal frequency. For human gametes, with 23 pair ...
... gametes are therefore considered assorted independently. As such, the gamete can end up with any combination of paternal or maternal chromosomes. Any of the possible combinations of gametes formed from maternal and paternal chromosomes will occur with equal frequency. For human gametes, with 23 pair ...
Meiosis forms variable gametes
... • Homologous chromosomes are pairs of chromosomes of the same size, same centromere position and with the same genes at the same loci. Each homologous chromosome is inherited from a different parent; therefore the alleles of the genes of homologous chromosomes may be different. • Crossing over occur ...
... • Homologous chromosomes are pairs of chromosomes of the same size, same centromere position and with the same genes at the same loci. Each homologous chromosome is inherited from a different parent; therefore the alleles of the genes of homologous chromosomes may be different. • Crossing over occur ...
Document
... • typically clustered, clusters may contain monoallelic expression of genes from each parent. • clusters contain imprint control regions and a non-coding RNA is often found associated with it (H19, Air …) • ICRs show parent-of-origin dependent epigenetic modifications (methylation) • many related to ...
... • typically clustered, clusters may contain monoallelic expression of genes from each parent. • clusters contain imprint control regions and a non-coding RNA is often found associated with it (H19, Air …) • ICRs show parent-of-origin dependent epigenetic modifications (methylation) • many related to ...
The Drosophila Gene Disruption Project: Progress
... insertions, because some lines disrupting major hotspots appear to have been culled by Exelixis. However, we found many cases where at least two lines bearing identical piggyBac insertion sites had been retained, suggesting that such culling was limited or incomplete. Most of these stocks, as well a ...
... insertions, because some lines disrupting major hotspots appear to have been culled by Exelixis. However, we found many cases where at least two lines bearing identical piggyBac insertion sites had been retained, suggesting that such culling was limited or incomplete. Most of these stocks, as well a ...
Pathway and Gene Set Analysis of Microarray Data
... incorporate biological knowledge into microarray analysis • The type of knowledge we deal with is rather simple: We know groups/sets of genes that for example – Belong to the same pathway – Have a similar function – Are located on the same chromosome, etc… ...
... incorporate biological knowledge into microarray analysis • The type of knowledge we deal with is rather simple: We know groups/sets of genes that for example – Belong to the same pathway – Have a similar function – Are located on the same chromosome, etc… ...
"Positive Selection on Genes in Humans as Compared to
... did not affect the results, codons containing low-quality bases in the chimp sequence were eliminated. The results of this study show that significantly more genes evolved under positive selection in chimpanzee than in human (Table 1), contrary to the common belief that an enhancement of positive sele ...
... did not affect the results, codons containing low-quality bases in the chimp sequence were eliminated. The results of this study show that significantly more genes evolved under positive selection in chimpanzee than in human (Table 1), contrary to the common belief that an enhancement of positive sele ...
Hemoglobular Anemia
... o HbA= 2 alpha + 2 beta chains o Molecule held together by interactions between the chains Each Hb chain has a heme moiety (carries O2) o Heme bound to globin chains by covalent bonds o Iron in Fe2+ form (changes to Fe3+ form results in inability to carry O2) Alpha1 beta2 interface is an important r ...
... o HbA= 2 alpha + 2 beta chains o Molecule held together by interactions between the chains Each Hb chain has a heme moiety (carries O2) o Heme bound to globin chains by covalent bonds o Iron in Fe2+ form (changes to Fe3+ form results in inability to carry O2) Alpha1 beta2 interface is an important r ...
Role of microRNA in Skeleton Development
... the upregulation of osteogenic genes. In this context, it may be useful to look at the two roles played by the muscle-specific miR-133 in myocyte and osteoblast differentiation. In myocyte differentiation, miR-133 is up regulated downstream of the transcription factors myogenin, MyoD, SRF, and Mef2 ...
... the upregulation of osteogenic genes. In this context, it may be useful to look at the two roles played by the muscle-specific miR-133 in myocyte and osteoblast differentiation. In myocyte differentiation, miR-133 is up regulated downstream of the transcription factors myogenin, MyoD, SRF, and Mef2 ...
Illumina Infinium HumanMethylation450 BeadChip Data
... dot-plots, profile trellis, chromosome view, and more • Integrate with other data-types, such as mRNA/miRNA expression, SNP/CNV, and ChIP • Interpret biological meaning with pathway and gene ontology analysis ...
... dot-plots, profile trellis, chromosome view, and more • Integrate with other data-types, such as mRNA/miRNA expression, SNP/CNV, and ChIP • Interpret biological meaning with pathway and gene ontology analysis ...
Document
... Here, we present a high-efficiency and easily-used analysis pipeline called MeRIP-PF, which is a publicly available open source and specially developed for MeRIP-Seq peak-calling with control samples. MeRIP-PF achieves m6A regions detection and annotation, and powerful graphical display which are us ...
... Here, we present a high-efficiency and easily-used analysis pipeline called MeRIP-PF, which is a publicly available open source and specially developed for MeRIP-Seq peak-calling with control samples. MeRIP-PF achieves m6A regions detection and annotation, and powerful graphical display which are us ...
Research Project Final Report
... the second parent. These lines have been used to make a genetic map that will inform future studies of quantitative variation in seed bleaching under field conditions. Besides this ‘open’ approach to gene identification, we have studied variation in two candidate genes, either or both of which may i ...
... the second parent. These lines have been used to make a genetic map that will inform future studies of quantitative variation in seed bleaching under field conditions. Besides this ‘open’ approach to gene identification, we have studied variation in two candidate genes, either or both of which may i ...
Using the CATMOD Procedure to Estimate Linkage between Pairs of Gene Loci from Offspring of Selfed Heterozygotes
... Recombination values can be estimated in several different ways but are most commonly estimated using maximum likelihood methods (Fisher and Balmukand, 1928; Allard 1956; Weir 1990). Computer programs are available that estimate r based on the type of linkage experiment (Suiter et ai, 1983); however ...
... Recombination values can be estimated in several different ways but are most commonly estimated using maximum likelihood methods (Fisher and Balmukand, 1928; Allard 1956; Weir 1990). Computer programs are available that estimate r based on the type of linkage experiment (Suiter et ai, 1983); however ...
Inheritance of Nuclear DNA Markers in Gynogenetic Haploid Pink
... problems are likely to be even more serious in organisms such as salmonids that, as a result of their polyploid ancestry, have more duplicated loci. PCR primers designed without detailed knowledge of differences between paralogous loci may or may not amplify sequences from both loci. Moreover, even ...
... problems are likely to be even more serious in organisms such as salmonids that, as a result of their polyploid ancestry, have more duplicated loci. PCR primers designed without detailed knowledge of differences between paralogous loci may or may not amplify sequences from both loci. Moreover, even ...
A xylem-specific cellulose synthase gene from aspen (Populus
... additional plant CesA genes. Arioli et al. (1998) and Taylor et al. (1999) then mapped and cloned the Arabidopsis CesA homologs RSW1 and IRX3. Complementation of rsw1 and irx3 mutants with wild-type RSW1 and IRX3 genes, respectively, restored the wild-type phenotype, providing genetic proof of the i ...
... additional plant CesA genes. Arioli et al. (1998) and Taylor et al. (1999) then mapped and cloned the Arabidopsis CesA homologs RSW1 and IRX3. Complementation of rsw1 and irx3 mutants with wild-type RSW1 and IRX3 genes, respectively, restored the wild-type phenotype, providing genetic proof of the i ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse