::: Gene Set Enrichment Analysis - GSEA
... into a single gene vector, which is identified by its HUGO gene symbol. In this case, you are using HUGO gene symbols for the analysis. The gene sets that you use for the analysis must use HUGO gene symbols to identify the genes in the gene sets. 2. Choose false to use your expression dataset "as is ...
... into a single gene vector, which is identified by its HUGO gene symbol. In this case, you are using HUGO gene symbols for the analysis. The gene sets that you use for the analysis must use HUGO gene symbols to identify the genes in the gene sets. 2. Choose false to use your expression dataset "as is ...
Tombola, a tesmin/TSO1-family protein, regulates
... western blotting with anti-HA antibodies showed that Tomb coimmunoprecipitated with Aly (Fig. 1A). This was confirmed with the reciprocal experiment – immunoprecipitation with anti-HA followed by blotting with anti-FLAG. We detected no coimmunoprecipitation in cells co-expressing HA-Tomb and FLAGKr ...
... western blotting with anti-HA antibodies showed that Tomb coimmunoprecipitated with Aly (Fig. 1A). This was confirmed with the reciprocal experiment – immunoprecipitation with anti-HA followed by blotting with anti-FLAG. We detected no coimmunoprecipitation in cells co-expressing HA-Tomb and FLAGKr ...
Molecular Signatures of Natural Selection for Polymorphic Genes of
... that can be distinct both from positive selection and from neutral processes: deep coalescence times for gene genealogies, characteristic allele frequency spectra, with alleles maintained at intermediate frequencies, or even polymorphisms shared among species that predate their speciation (Key et al ...
... that can be distinct both from positive selection and from neutral processes: deep coalescence times for gene genealogies, characteristic allele frequency spectra, with alleles maintained at intermediate frequencies, or even polymorphisms shared among species that predate their speciation (Key et al ...
Somatic MEN1 gene mutation does not contribute
... sequence of MEN1 (10). Recently, in a sample of 31 sporadic tumours, Tanaka et al. detected only 1 nonsense mutation in a GH/PRL adenoma with LOH in 11q13 (11). These results are disturbing taking into account that Boggild et al. found LOH on chromosome 11 in as many as about 20% of 88 sporadic aden ...
... sequence of MEN1 (10). Recently, in a sample of 31 sporadic tumours, Tanaka et al. detected only 1 nonsense mutation in a GH/PRL adenoma with LOH in 11q13 (11). These results are disturbing taking into account that Boggild et al. found LOH on chromosome 11 in as many as about 20% of 88 sporadic aden ...
Bot-genetics basis of inheritance
... Gene - It is a particular segment of DNA which is responsible for the inheritance and expression of that characterwhich carries information from one generation to next , Gene is equivalent to mendelian factor.. Homologous chromosomes - The morphologically and structurally similar chromosomes pre ...
... Gene - It is a particular segment of DNA which is responsible for the inheritance and expression of that characterwhich carries information from one generation to next , Gene is equivalent to mendelian factor.. Homologous chromosomes - The morphologically and structurally similar chromosomes pre ...
The murine homologue of HIRA, a DiGeorge
... commonly deleted region (17). The two SRDOs are mutually exclusive. At present it is not clear whether the CATCH22 phenotype is the result of haploinsufficiency of one or more genes. The balanced t(2;22)(q14.1;q11.1) translocation breakpoint in DGS patient ADU (20) was the major target of positional ...
... commonly deleted region (17). The two SRDOs are mutually exclusive. At present it is not clear whether the CATCH22 phenotype is the result of haploinsufficiency of one or more genes. The balanced t(2;22)(q14.1;q11.1) translocation breakpoint in DGS patient ADU (20) was the major target of positional ...
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... <10 µM between 125 and 1000 m in the northern locations (stations 1 and 2) and between 200 and 800 m in the southern location (station 23, Figure 2). The SNM occurred within a narrow band within this zone (≥0.5 µM nitrite) [Naqvi, 1991]. The SNM was much thicker (125–400 m) in the northeastern regio ...
... <10 µM between 125 and 1000 m in the northern locations (stations 1 and 2) and between 200 and 800 m in the southern location (station 23, Figure 2). The SNM occurred within a narrow band within this zone (≥0.5 µM nitrite) [Naqvi, 1991]. The SNM was much thicker (125–400 m) in the northeastern regio ...
Tumour necrosis factor family genes in a phenotype of COPD
... subjects among COPD were not typed for LtaNcoI because of insufficient deoxyribonucleic acid. All comparisons were nonsignificant. ...
... subjects among COPD were not typed for LtaNcoI because of insufficient deoxyribonucleic acid. All comparisons were nonsignificant. ...
SNPs
... • The genomes of individuals in a population contain a particular base at some position most of the time. • That is, there is a “normal” sequence • A SNP is a deviation from the normal sequence. – Many people require that a variation occur in at least 1% of the population, to be considered a SNP • B ...
... • The genomes of individuals in a population contain a particular base at some position most of the time. • That is, there is a “normal” sequence • A SNP is a deviation from the normal sequence. – Many people require that a variation occur in at least 1% of the population, to be considered a SNP • B ...
Evaluation of the Water Stress-Inducible
... Each year more than 50% of global crop yields are lost due to abiotic stresses (Valliyodan and Nguyen, 2006), with water deficit stresses such as drought and high salinity being major contributors. Globally, water deficit stresses have been estimated to be responsible for over $10 billion in lost cr ...
... Each year more than 50% of global crop yields are lost due to abiotic stresses (Valliyodan and Nguyen, 2006), with water deficit stresses such as drought and high salinity being major contributors. Globally, water deficit stresses have been estimated to be responsible for over $10 billion in lost cr ...
Section 2
... for a single trait exist, some alleles may be dominant and others may be recessive. 3. Principle of Segregation- In most sexually reproducing organisms, each adult has two alleles of each gene—one from each parent. These alleles segregate from each other randomly and independently when gametes are f ...
... for a single trait exist, some alleles may be dominant and others may be recessive. 3. Principle of Segregation- In most sexually reproducing organisms, each adult has two alleles of each gene—one from each parent. These alleles segregate from each other randomly and independently when gametes are f ...
Spatially restricted domains of homeo-gene
... a segmentally restricted manner and that their expression presages morphological differentiation of segmental structures (e.g. Levine et a|.1983; Akam & Martinez-Arias, 1985; Chadwick & McGinnis, 1987). The discovery of homeo-genes in a wide variety of metazoz, including vertebrates, led to the sugg ...
... a segmentally restricted manner and that their expression presages morphological differentiation of segmental structures (e.g. Levine et a|.1983; Akam & Martinez-Arias, 1985; Chadwick & McGinnis, 1987). The discovery of homeo-genes in a wide variety of metazoz, including vertebrates, led to the sugg ...
early RNs, crossing over initiates, then synapsis begins Chiasmata
... sequence elements in the region, they sequenced the entire 140 kb region from both parents. ...
... sequence elements in the region, they sequenced the entire 140 kb region from both parents. ...
Natural variation in monoterpene synthesis in kiwifruit
... signaling (Kou et al., 2012). Studies in banana have shown that expression levels of several ...
... signaling (Kou et al., 2012). Studies in banana have shown that expression levels of several ...
Linking Cognitive Neuroscience and Molecular Genetics: New Perspectives from Williams... Ursula Bellugi and Marie St. George (Eds.)
... in 7q22. As shown in the more extended DNA of interphase cells (b), BAC* 239C10 signals (red) flank the signals from BAC 592D8 (green) that carries the gene encoding elastin. (c) BAC* 611E3 (green) yields two clear signals within chromosome band 7q11.23, representing duplicated regions. The duplicat ...
... in 7q22. As shown in the more extended DNA of interphase cells (b), BAC* 239C10 signals (red) flank the signals from BAC 592D8 (green) that carries the gene encoding elastin. (c) BAC* 611E3 (green) yields two clear signals within chromosome band 7q11.23, representing duplicated regions. The duplicat ...
Breeding Policy for the RagaMuffin Cat
... The Colourpointed RagaMuffin Variant is essential to the breed. It is the only way, when combined with the Burmese pattern, to produce Mink (Darker Pointed). At this time, it is not eligible to be shown but is invaluable in its use in a breeding programme. All RagaMuffins and Colourpointed RagaMuffi ...
... The Colourpointed RagaMuffin Variant is essential to the breed. It is the only way, when combined with the Burmese pattern, to produce Mink (Darker Pointed). At this time, it is not eligible to be shown but is invaluable in its use in a breeding programme. All RagaMuffins and Colourpointed RagaMuffi ...
Signal Transduction and the Chemically Addressed Nervous System
... and GABA (gamma-aminobutyric acid). These six are sometimes considered the "classic" neurotransmitters because they were discovered first and also because they have developed into the major target systems for psychotropic drugs. Classic neurotransmitters are relatively low-molecular weight amines or ...
... and GABA (gamma-aminobutyric acid). These six are sometimes considered the "classic" neurotransmitters because they were discovered first and also because they have developed into the major target systems for psychotropic drugs. Classic neurotransmitters are relatively low-molecular weight amines or ...
Figure 1000G Allele Frequencies
... a. Alternative translation start side: If the lost-of-function variant is near the beginning of the protein, translation could be initiated by a downstream in-frame AUG [30]. In our study, if the indel is in the first 25 codons (first 75 bp of translated cDNA) or within 5th percentile of the coding ...
... a. Alternative translation start side: If the lost-of-function variant is near the beginning of the protein, translation could be initiated by a downstream in-frame AUG [30]. In our study, if the indel is in the first 25 codons (first 75 bp of translated cDNA) or within 5th percentile of the coding ...
K -Channel Transgenes Reduce K Currents in Paramecium
... PAK1 were determined through successful RT-PCR amplification from the wild type using different gene-specific primer pairs. Within the very large superfamily of K⫹ channels with six transmembrane ␣-helices, the PAKs studied here most closely resemble the AKT/EAG/ERG group of K⫹ channels that have po ...
... PAK1 were determined through successful RT-PCR amplification from the wild type using different gene-specific primer pairs. Within the very large superfamily of K⫹ channels with six transmembrane ␣-helices, the PAKs studied here most closely resemble the AKT/EAG/ERG group of K⫹ channels that have po ...
LEGS – Part 2 - Aviculture Europe
... between size and length of feathers on the 4th toe. Often the birds with best foot feathering are also those who have the 4th toe shorter. Because of these correlations, Schmalhausen proposed only one gene as cause of the different phenotypes, hypothesizing that the growth of the feathers in legs ca ...
... between size and length of feathers on the 4th toe. Often the birds with best foot feathering are also those who have the 4th toe shorter. Because of these correlations, Schmalhausen proposed only one gene as cause of the different phenotypes, hypothesizing that the growth of the feathers in legs ca ...
me-6 - Genetics
... reversal of polarity depending on propinquity of sites to one or the other end of the paired region. The Fixed Pairing Region model predicts that among prototrophic recombinants selected as random spores, the more frequent class having flanking markers of parental combination represents conversion o ...
... reversal of polarity depending on propinquity of sites to one or the other end of the paired region. The Fixed Pairing Region model predicts that among prototrophic recombinants selected as random spores, the more frequent class having flanking markers of parental combination represents conversion o ...
NIH Public Access - University of Chicago
... The transcription factors EBF and Pax5 play major roles in B cell fate specification and commitment by activating B lineage genes and concomitantly repressing genes of alternate lineages8,19,20. EBF initiates restriction of alternate lineage options and B cell fate commitment independently of Pax5 ( ...
... The transcription factors EBF and Pax5 play major roles in B cell fate specification and commitment by activating B lineage genes and concomitantly repressing genes of alternate lineages8,19,20. EBF initiates restriction of alternate lineage options and B cell fate commitment independently of Pax5 ( ...
Phosphate Utilization Efficiency Correlates with Expression of Low
... genome (Mudge et al., 2002) and 13 in rice (Oryza sativa; Paszkowski et al., 2002). Functional characterization shows that some of the PHT1 members, such as AtPHT1;1, AtPHT1;4 (Shin et al., 2004), and OsPHT1;6 (Ai et al., 2009), are high-affinity transporters while others are low-affinity transporte ...
... genome (Mudge et al., 2002) and 13 in rice (Oryza sativa; Paszkowski et al., 2002). Functional characterization shows that some of the PHT1 members, such as AtPHT1;1, AtPHT1;4 (Shin et al., 2004), and OsPHT1;6 (Ai et al., 2009), are high-affinity transporters while others are low-affinity transporte ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.