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Introduction to Genetics and Genomics
Introduction to Genetics and Genomics

... • I will attempt to provide as much help as possible ...
Key Terms Foldable CH. 5 Heredity
Key Terms Foldable CH. 5 Heredity

... A process in cell division during which the number of chromosomes decreases to half the original number by two divisions of the nucleus, which results in the production of sex cells (gametes or spores). One of the pair of chromosomes that determines the sex of an individual. ...
The Origins of Variation
The Origins of Variation

... mitochondrial rRNAs are more similar to endosymbiotic bacterial (Rickettsia) rRNAs than to nuclear rRNAs of eukaryotes, and ongoing movement of genetic material from mitochondria (and chloroplast) genomes to the nuclear genome (numt's) resulting in obligate endosymbiosis e.g., plasmids in bacteria - ...
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... 3, the order must be g…r…n. Comparing chromosomes 4, 6 and 7, the order must be c…s. 3) Using the genes already mapped, con nue the logic: e.g. comparing chromosomes 2, 4, and 7, the order must be a…v…m….x. 6. (b): c and s are the closest genes to one another from this map. 7. Expected characteristi ...
Ramamoorthy, Krithika : Critical Review of Methods available for Microarray Data Analysis
Ramamoorthy, Krithika : Critical Review of Methods available for Microarray Data Analysis

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... gene function demands rather speci c composition of the gene products which restricts not only the nucleotide composition of genes but, which is more important, the proper length of the coding sequence. The stability of the gene as a coding unit depends on both its nucleotide composition and its len ...
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Statistical Analysis of Gene Expression Data (A Large Number of

... First step of making a story: Statistical significance of a particular "Functional cluster" •Suppose we have analyzed total of N genes, n of which turned out to be differentially expressed/co-expressed (experimentally identified - call them significant) - form the Cluster 1 •Suppose that y out of N ...
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... – Morgan studied more and more genes • Discovered genes fell into distinct linkage groups of genes that always tended to be inherited together • The linkage groups (chromosomes) assorted independently, but all genes on one group were inherited together • Because homologous chromosomes contain the sa ...
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TOXICOGENOMICS

... Difficulty in analysis of high density data. Difficulty in integration of data obtained by different technologies. Difficulty in linking “omics” data to specific adverse effects. Difficulty in translation statistical assessments into biological understanding. Limitations of incomplete functional ann ...
TOXICOGENOMICS
TOXICOGENOMICS

... Difficulty in analysis of high density data. Difficulty in integration of data obtained by different technologies. Difficulty in linking “omics” data to specific adverse effects. Difficulty in translation statistical assessments into biological understanding. Limitations of incomplete functional ann ...
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Adoption Studies
Adoption Studies

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Visualizing gene expression and function at the cellular level
Visualizing gene expression and function at the cellular level

... • Genotyping is the procedure used to determine differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference sequence. • In our experiment we wanted to know the diffe ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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