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slides - Max-Planck
slides - Max-Planck

... prognosis of ovarian cancer, we first used Cox proportional hazard model to perform the regression analysis between each feature and the patients’ survival time. In total we selected 4,526 features as hazard factors (P < 0.05), including 1,651 genes’ expression changes, 455 genes’ promoter DNA methy ...
S-8-2-2_Genetics and Heredity: Vocabulary Worksheet and KEY
S-8-2-2_Genetics and Heredity: Vocabulary Worksheet and KEY

... Directions: Fill in the blanks with vocabulary terms from the list below. All organisms reproduce, or make more organisms that are similar to themselves. ______________________ also involves the passing of traits from one parent to offspring. The passing of traits from parents to offspring is called ...
Viral Lytic and Lysogenic Cycles
Viral Lytic and Lysogenic Cycles

l(1)sc
l(1)sc

... Is there another gene missing from scB57 deletion that contributes to phenotype? ...
Imprinted gene detection in Arabidopsis thaliana
Imprinted gene detection in Arabidopsis thaliana

... the egg) and one paternal (from the sperm) allele per gene, while a cell of the endosperm hosts two maternal (from the polar nuclei) alleles and one paternal (from the sperm) allele. Fertile tetraploid and hexaploid A.thaliana plants can be generated and crossed with normal diploid plants (interploi ...
What is bioinformatics? - The British Association of Sport and
What is bioinformatics? - The British Association of Sport and

... The genomes for many prokaryote, eukaryote, plant, invertebrate and vertebrate model species have now been sequenced. The DNA sequences of these genomes have been posted online. However, these websites contain much more than just the “naked” DNA sequence which has limited use. With the help of speci ...
Nature Reviews Genetics, 10
Nature Reviews Genetics, 10

... reconstruction is being used as the ‘gold standard’ against which to test computational methods. The authors compared genome data from the Yeast Gene Order Browser (YGOB) of five post-WGD yeast species (descended from the ancestor that underwent WGD) and six non-WGD yeast species. They visually comp ...
The Nature of Progress - Yau Chung Hei
The Nature of Progress - Yau Chung Hei

Magic Square
Magic Square

... Match each term to its definition. Put the number of the term in the proper square marked by the letter of its definition. If your answers are correct, the numerical total will be the same across each row and down each column. Definitions: A. A variation of a trait or gene. B. Two alleles that are t ...
Molecular Mechanism of Shoot Determinacy and Flowering in
Molecular Mechanism of Shoot Determinacy and Flowering in

... content, etc.. These factors or signals are perceived and transmitted to the nucleus to cause changes in gene expression that would lead to flower development. Flower development is usually preceded by changes in shoot development. In Arabidopsis, the vegetative shoot does not undergo internode el*on ...
Functional Analysis of Developmental Genes
Functional Analysis of Developmental Genes

... • Requires special vectors – contains flanking sequences to permit homologous recombination between construct and chromosome – Contains selectable marker to permit survival only of homologous recombination and not non-homologous ...
2 points - Triton Science
2 points - Triton Science

... • Twins share the same genes but their environments become more different as they age. • This causes each of the epigenomes to react differently and change the regulation of specific genes over time. ...
MicroRNA-330 acts as tumor suppressor and induces apoptosis of
MicroRNA-330 acts as tumor suppressor and induces apoptosis of

... prostate cancer cell lines and a prostate cancer specimen by miRquantitative RT–PCR and miRNA microarray analysis, respectively. These data supported our hypothesis that miR-330 was a tumorsuppressive miRNA in prostate cancer. In this study, we aimed to determine the role of miR-330 in determining t ...
GROWING UP WITH US... Caring For Children
GROWING UP WITH US... Caring For Children

... genes on the X chromosome have no counterpart on the Y chromosome. Therefore, characteristics determined by a gene on the X chromosome are always expressed in the male. One of the significant aspects of X-linked inheritance is the absence of father-to-son inheritance. The defective gene is passed to ...
Activity Overview
Activity Overview

... The traits you have are determined by the genes in the chromosomes you inherit from your parents. A gene is a specific place on a chromosome that is responsible for a trait (characteristic). Every trait is controlled by at least one gene from Mom and at least one gene from Dad, thus it takes at leas ...
Other Patterns of Inheritance
Other Patterns of Inheritance

... This is Mendel’s law of segregation. Therefore, a heterozygous parent can give either the dominant or the recessive allele to its offspring ...
Genetics 314 – Spring 2004
Genetics 314 – Spring 2004

... the inheritance of genes. a) What are Mendel’s two laws and how do they relate to the inheritance of alleles/genes? Law of segregation stated that the pair of alleles for a given gene (trait) separate or segregate in the gametes equally. Law of independent assortment states that the allelic gene pai ...
7.1 Chromosomes and Phenotype
7.1 Chromosomes and Phenotype

The Hammond Lab is primarily interested in an epigenetic process
The Hammond Lab is primarily interested in an epigenetic process

Genetics 7 - Mr. Davros` Wiki
Genetics 7 - Mr. Davros` Wiki

... external environment ...
Heterologous Protein Production in Eukaryotic Cells
Heterologous Protein Production in Eukaryotic Cells

... selectable gene marker and yeast specific transcription and translation control sequences. Its survival depends on intergration into yeast chromosomal DNA. Typically, YIp vectors integrate as a single copy. However, methods to integrate multiple copies and stable cell lines with up to 15-20 copies o ...
Genetic variation in a population is determined by mutations, natural
Genetic variation in a population is determined by mutations, natural

... the same genetic structure to drift apart into two divergent populations. ...
Leukaemia Section t(19;21)(q13.4;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(19;21)(q13.4;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology

Gene-Hunting in ALS and Related Disorders
Gene-Hunting in ALS and Related Disorders

... motion. And researchers believe that attacking the disease at the beginning of the cascade— stopping that first domino from falling—is the best hope for effective treatments that can alter the course of the disease process. While some proportion of cases are likely to be due to environmental factors ...
Gene Section MIR191 (microRNA 191) Atlas of Genetics and Cytogenetics
Gene Section MIR191 (microRNA 191) Atlas of Genetics and Cytogenetics

... NDUFAF3 with spermatogenesis has been suggested. These genes are strongly co-expressed in sperm cells of normal individuals, whereas they are turned off in patients with teratozoospermia. These miRNAs, directly associated with co-transcription of DALRD3 and NDUFAF3, might be involved in a negative f ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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