Genetic association between the PRKCH gene encoding protein
... number of potentially important non-HLA loci were identified. Several loci (e.g., 1p, 1q, 2q, 5q, 13q, 14q, 16p, 18p, and Xq) overlapped ⱖ2 genome screens (8); however, other than the HLA region, no obvious consensus regarding which chromosomal regions would be most likely to contain RA susceptibili ...
... number of potentially important non-HLA loci were identified. Several loci (e.g., 1p, 1q, 2q, 5q, 13q, 14q, 16p, 18p, and Xq) overlapped ⱖ2 genome screens (8); however, other than the HLA region, no obvious consensus regarding which chromosomal regions would be most likely to contain RA susceptibili ...
Xiong, N., C.H. Kang, and D.H. Raulet. 2002. Redundant and unique roles of two enhancer elements in the TCR gamma locus in gene regulation and gamma delta T cell development. Immunity 16:453-463.
... elements had little or no effect, it has been proposed that the multiple elements in the locus are at least partially redundant in function. Consistent with this possibility, examples have been reported of two elements acting at least partially redundantly in ectopically integrated transgenes (Baker ...
... elements had little or no effect, it has been proposed that the multiple elements in the locus are at least partially redundant in function. Consistent with this possibility, examples have been reported of two elements acting at least partially redundantly in ectopically integrated transgenes (Baker ...
Identification and temporal expression of putative circadian clock
... values (transcripts per million) were calculated following Wagner, Kin & Lynch (2012). Quantitative PCR methods for TPM validation are given in File S1 and primers in Table S1. All data files for time-course RNAseq can be found on the NCBI SRA data base, bioproject Accession No. 297565. ...
... values (transcripts per million) were calculated following Wagner, Kin & Lynch (2012). Quantitative PCR methods for TPM validation are given in File S1 and primers in Table S1. All data files for time-course RNAseq can be found on the NCBI SRA data base, bioproject Accession No. 297565. ...
Modifiers of epigenetic reprogramming show paternal effects in the mouse
... Smarca5MommeD4 allele with yellow C57BL/6J females heterozygous for the Avy allele. As reported previously, in offspring that inherit the Smarca5MommeD4 allele, we observed a shift in penetrance at Avy in a manner consistent with its role as an enhancer of variegation at the transgene locus. In othe ...
... Smarca5MommeD4 allele with yellow C57BL/6J females heterozygous for the Avy allele. As reported previously, in offspring that inherit the Smarca5MommeD4 allele, we observed a shift in penetrance at Avy in a manner consistent with its role as an enhancer of variegation at the transgene locus. In othe ...
Basic reading, writing and informatics skills for biomedical research
... Minicourses page and do one of the courses described there. These resources are also valuable if you are interested in the molecular biology of disease • If you are a medicinal chemist, or a pharmacologist take a look at the PubChem resource and find out how you can find links from a given compound ...
... Minicourses page and do one of the courses described there. These resources are also valuable if you are interested in the molecular biology of disease • If you are a medicinal chemist, or a pharmacologist take a look at the PubChem resource and find out how you can find links from a given compound ...
There is an old saying
... Uses a traditional temperature color cycle (blue-green-yellowred-white) to indicate relative temperature factors for each atom where blue is lowest and white highest temperature ...
... Uses a traditional temperature color cycle (blue-green-yellowred-white) to indicate relative temperature factors for each atom where blue is lowest and white highest temperature ...
Ancestry of neuronal monoamine transporters in the Metazoa
... assessed on 3–5 plates of cells. The uptake data were corrected for Na+-independent uptake by exposing the cells to an identical treatment except for the substitution of choline+ for Na+ in the saline. Sf9 cells also have an endogenous low-affinity Na+dependent uptake mechanism for amines that contr ...
... assessed on 3–5 plates of cells. The uptake data were corrected for Na+-independent uptake by exposing the cells to an identical treatment except for the substitution of choline+ for Na+ in the saline. Sf9 cells also have an endogenous low-affinity Na+dependent uptake mechanism for amines that contr ...
Document
... repressor to bind to two operator sites simultaneously. There are two further operator sites in the initial region of the lac operon. The original operator, O1, is located just at the start of the lacZ gene. It has the strongest affinity for repressor. Weaker operator sequences (sometimes called p ...
... repressor to bind to two operator sites simultaneously. There are two further operator sites in the initial region of the lac operon. The original operator, O1, is located just at the start of the lacZ gene. It has the strongest affinity for repressor. Weaker operator sequences (sometimes called p ...
An homologous pair of chromosomes…
... Increases genetic variation through recombination of linked alleles. ...
... Increases genetic variation through recombination of linked alleles. ...
RNA polymerase II
... RNA are: • Ribosomal RNA (rRNA), which is the most abundant type of RNA in the cell. • Transfer RNA (tRNA), which is the second most abundant type of RNA. • Messenger RNA (mRNA), which carries the information specifying the amino acid sequence of a protein to the ribosome. Messenger RNA is the only ...
... RNA are: • Ribosomal RNA (rRNA), which is the most abundant type of RNA in the cell. • Transfer RNA (tRNA), which is the second most abundant type of RNA. • Messenger RNA (mRNA), which carries the information specifying the amino acid sequence of a protein to the ribosome. Messenger RNA is the only ...
Genetics: The Science of Heredity
... ~Punnet Square - A tool we use for predicting the traits of an offspring ~Letters are used as symbols to designate genes ~Capital letters are used for dominant genes ~Lower case letters are used for recessive genes ~Genes always exist in pairs ...
... ~Punnet Square - A tool we use for predicting the traits of an offspring ~Letters are used as symbols to designate genes ~Capital letters are used for dominant genes ~Lower case letters are used for recessive genes ~Genes always exist in pairs ...
A pseudogene cluster in the leader region of the Euglena
... base pairing 1n stem regions. These alternations rendered 1t unable to function normally, and thus this gene was identified as a pseudogene. Similar consideration might also be possible for the DNA segment corresponding to the tRNA Ala gene region, although, in this case, the tRNA A1a anticodon 1s a ...
... base pairing 1n stem regions. These alternations rendered 1t unable to function normally, and thus this gene was identified as a pseudogene. Similar consideration might also be possible for the DNA segment corresponding to the tRNA Ala gene region, although, in this case, the tRNA A1a anticodon 1s a ...
Origin and evolution of Y chromosomes: Drosophila tales
... mentioning a caveat. Ideally, the complete gene set of the Y chromosomes in the 12 species should be available before starting a comparative analysis, similar to the approach used (at least approximately) for analysing the euchromatic portion of the other chromosomes. However, given the notorious di ...
... mentioning a caveat. Ideally, the complete gene set of the Y chromosomes in the 12 species should be available before starting a comparative analysis, similar to the approach used (at least approximately) for analysing the euchromatic portion of the other chromosomes. However, given the notorious di ...
Usher`s Syndrome
... from parents to their children through genes. Some genes specify traits such as hair color. Other genes are involved in the development of body parts, such as the ear. Still others determine how parts of the body work. Each person inherits two copies of each gene, one from each parent. ...
... from parents to their children through genes. Some genes specify traits such as hair color. Other genes are involved in the development of body parts, such as the ear. Still others determine how parts of the body work. Each person inherits two copies of each gene, one from each parent. ...
Defects in Protein Glycosylation Cause SHO1-Dependent
... for protein glycosylation. Double-mutant studies argue that a distinct signaling pathway that begins with the membrane protein Sho1 for the HOG pathway and culminates at Ste12 from the pheromone response pathway is required for enhanced FUS1 transcription. In addition, we found that mutations that d ...
... for protein glycosylation. Double-mutant studies argue that a distinct signaling pathway that begins with the membrane protein Sho1 for the HOG pathway and culminates at Ste12 from the pheromone response pathway is required for enhanced FUS1 transcription. In addition, we found that mutations that d ...
Journal of Bacteriology
... with the Foscm-TCF and Foscm-TCR primers bearing 70-bp side arms that bind to the flanking regions of the cat gene of pCC1fos. For inactivation of the pmxE gene, a chloramphenicol resistance gene-kanamycin resistance gene (cat-kan) cassette was introduced into the pmxE structural gene of pPmx-Tc usi ...
... with the Foscm-TCF and Foscm-TCR primers bearing 70-bp side arms that bind to the flanking regions of the cat gene of pCC1fos. For inactivation of the pmxE gene, a chloramphenicol resistance gene-kanamycin resistance gene (cat-kan) cassette was introduced into the pmxE structural gene of pPmx-Tc usi ...
Bio 102 Practice Problems Mendelian Genetics and Extensions
... with another whose genotype is AaBBCcddEEFF. What fraction of its offspring will show the phenotype produced by the c allele? Again, looks hard but isn't very. Although there are six genes shown here, the problem only asks about one of them, the "C" gene. Because different genes assort independently ...
... with another whose genotype is AaBBCcddEEFF. What fraction of its offspring will show the phenotype produced by the c allele? Again, looks hard but isn't very. Although there are six genes shown here, the problem only asks about one of them, the "C" gene. Because different genes assort independently ...
Mixed modelling to characterize genotype-phenotype
... dramatically has been demonstrated [22]. Combining dimension reduction techniques and permutation testing is described for microarray data [24] and HIV genetics data [25]. The former utilizes a permutation test procedure to test for association while the latter is based on a condence band for a nor ...
... dramatically has been demonstrated [22]. Combining dimension reduction techniques and permutation testing is described for microarray data [24] and HIV genetics data [25]. The former utilizes a permutation test procedure to test for association while the latter is based on a condence band for a nor ...
An In Silico Investigation Into the Discovery of Novel Cis
... Abstract: PAX3 and PAX7 are homologous paired box family members expressed during early neural and myogenic development. Assays of mRNA expression have proven conclusively that PAX3 and PAX7 transcripts are present in embryonal and alveolar rhabdomyosarcoma, neuroblastoma, Ewing’s sarcoma, and melan ...
... Abstract: PAX3 and PAX7 are homologous paired box family members expressed during early neural and myogenic development. Assays of mRNA expression have proven conclusively that PAX3 and PAX7 transcripts are present in embryonal and alveolar rhabdomyosarcoma, neuroblastoma, Ewing’s sarcoma, and melan ...
Proteomics of spermatogenesis: from protein lists to understanding
... line, tissue or organism.13 Generally, there are two strategies for proteomics: protein expressional proteomics and functional proteomics.14 The former identifies the entire protein expression level in samples via high throughput technology designed to generate a global view of the organism’s biolog ...
... line, tissue or organism.13 Generally, there are two strategies for proteomics: protein expressional proteomics and functional proteomics.14 The former identifies the entire protein expression level in samples via high throughput technology designed to generate a global view of the organism’s biolog ...
Notification of a Notifiable Low Risk Dealing
... The primary interest here is in the gene or genes under study and the function of these gene(s). Please list this information if known. Such details are not required about gene(s) commonly used as markers, for selection and/or any other routine procedures. However it is of interest to identify gener ...
... The primary interest here is in the gene or genes under study and the function of these gene(s). Please list this information if known. Such details are not required about gene(s) commonly used as markers, for selection and/or any other routine procedures. However it is of interest to identify gener ...
Stage- and Tissue-Specific Expression of Ethylene Receptor
... and RP-ERS1 (Vriezen et al., 1997) is up-regulated by ethylene, whereas that of ETR1 (Chang et al., 1993) and eTAE1 (Zhou et al., 1996; corresponding to LeETR1) is not affected by ethylene treatment. RP-ERS1 is under environmental control, and the mRNA level increases after submergence at low O2 con ...
... and RP-ERS1 (Vriezen et al., 1997) is up-regulated by ethylene, whereas that of ETR1 (Chang et al., 1993) and eTAE1 (Zhou et al., 1996; corresponding to LeETR1) is not affected by ethylene treatment. RP-ERS1 is under environmental control, and the mRNA level increases after submergence at low O2 con ...
Transgenic Plastids in Basic Research and Plant Biotechnology
... chromoplasts (present in some ¯owers and fruits) as well as several other plastid types specialized in storage of starch, lipids or proteins. In spite of the small size of plastid genomes as compared with higher plant nuclear genomes, chloroplast DNA typically makes up as much as 10-20 % of the tota ...
... chromoplasts (present in some ¯owers and fruits) as well as several other plastid types specialized in storage of starch, lipids or proteins. In spite of the small size of plastid genomes as compared with higher plant nuclear genomes, chloroplast DNA typically makes up as much as 10-20 % of the tota ...
Database resources of the National Center for Biotechnology
... Searches of the NCBI taxonomy may be made on the basis of whole, partial or phonetically spelled organism names, but links to organisms commonly used in biological research are provided. The Entrez Taxonomy system adds the ability to display custom taxonomic trees representing user-de®ned subsets of ...
... Searches of the NCBI taxonomy may be made on the basis of whole, partial or phonetically spelled organism names, but links to organisms commonly used in biological research are provided. The Entrez Taxonomy system adds the ability to display custom taxonomic trees representing user-de®ned subsets of ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.