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A Lite Introduction toComparative Genomics
A Lite Introduction toComparative Genomics

... Application: Phenotyping Using SNPs • SNP: Single Nucleotide Polymorphism - change in one base between two instances of the same gene • Used as genetic flags to identify traits, esp. for genetic diseases • CG goal: Identify as many SNPs as possible • Challenges – Data: need sequenced genomes from m ...
Genetics: Day 5
Genetics: Day 5

... Objectives for Linked Genes 1. Define linkage group 2. Explain an example of a cross between two linked genes 3. Identify which of the offspring are recombinants in a dihybrid cross involving linked genes. ...
Mutations are any changes in the genetic material
Mutations are any changes in the genetic material

... fluorescent tags. It is also possible to apply this technique to compare genomes of different species ...
The Practical Reach of Pharmacogenomics: are Custom Drugs a Possibility?
The Practical Reach of Pharmacogenomics: are Custom Drugs a Possibility?

... how to treat a disease. The problem is that if the platforms cannot sufficiently capture all of the variations those very same researchers and medical practitioners would fail to identify some of the causative variants that lead to phenotype expression. The figures above show just how few disease ...
Checkpoints
Checkpoints

Data Integration: An Example Using GenePattern
Data Integration: An Example Using GenePattern

... 8. Finally, click on the network diagram figure in the upper right. This provides a graphical overview of individual genes predicted to be functionally related to RUNX3 and their neighbors (still in the context of the cellular defense response). Clicking on an edge will again provide a list of the i ...
Dia 1 - BeSHG
Dia 1 - BeSHG

... involved in oxydative phosphorylation and apoptosis -22 encode tRNAs and 2 rRNA’s necessary for synthesis of these enzymes ...
The Evolution of Homosexuality
The Evolution of Homosexuality

... on copies of their genes From the parents’ point of view, it doesn’t matter which of their children pass on gene copies, as long as the number of gene copies transmitted are maximized Parents decide to allocate their resources to their children on the basis of their reproductive efforts – because th ...
Chapter 11 Exam Review Key
Chapter 11 Exam Review Key

... 6. When you flip a coin, what is the probability that it will come up tails? (use a fraction) 1/2. 7. The principles of probability can be used to predict the traits of offspring produced by a genetic cross. 8. Organisms that have two identical alleles for a particular trait are said to be homozygou ...
Variation handout - University of Leicester
Variation handout - University of Leicester

... variation is in fact heritable, i.e. that it is possible to pass the variation on to the next generation. Genetic variation is capable of being inherited by the next generation, whereas environmental variation will not be seen in the next generation1. An example of environmental variation is the var ...
Slajd 1
Slajd 1

... 1 – Detection of the polymorphisms 2 – Diagnostics of hereditary diseases 3 – Sequencing (detection of mutations, paternity tests) 4 – Detection of viruses, parasites and bacteria 5 – Detection of GMOs 6 – In situ PCR (detection of given sequences ...
GM?
GM?

... Where is GM food from? Some crops, plants are modified in the lab to gain desired traits such as “increased resistance to herbicides” or “improved nutrition.” In the past, to improve the quality of crops is very time-consuming and not all successful. But right now, scientists have the techniques to ...
Poliammine, evoluzione e patogenicità in Shigella spp
Poliammine, evoluzione e patogenicità in Shigella spp

... expression of virulence genes residing on a large plasmid and on the chromosome. The genomes of Shigella and E. coli, its commensal ancenstor, are colinear and highly homologous. Critical events in the evolution of Shigella have been the acquisition of the virulence plasmid through lateral gene tran ...
PowerPoint File
PowerPoint File

...  Neomorph – expressed in cells normally not expressed (transgenic approach)  Phenotypic analysis – development, morphology, behavior, fertility, etc.  Gene regulation  Examine how mutation in Gene A influences expression of other genes ...
Using Animal Models to Understand Aging
Using Animal Models to Understand Aging

... Environmental factors such as diet have a huge impact on aging. Reducing levels of food by 30—50% has  been shown to significantly extend lifespan and reduce age–related diseases in mice and rats. This led to  the theory of Caloric Restriction (CR) – that by manipulating the nutrition of the organis ...
Genes – environment interactions
Genes – environment interactions

... Organizers: Danuta Mielżyńska and Korneliusz Miksch) Maria Dusińska (Kjeller, Norway): Challenges with gene-environment interactions: Where we are and where we need to go? Sofia Pavanello (Padova, Italy): Monitoring of exposures to carcinogens: current status and new perspectives ...
BIOL 1101 Introduction to Human Genetics
BIOL 1101 Introduction to Human Genetics

... The Human Genome Project (HGP) a. The techniques used by the HGP: DNA cloning and DNA sequencing b. Ethical, legal, and social issues related to the HGP c. Eugenics The Genetics of Immunity a. The immune response b. Abnormal immunity and AIDS The Genetics of Cancer a. Genes that cause cancer: oncoge ...
Integrated Programme Sec 2 SBGE, LSS Biology Module Topic
Integrated Programme Sec 2 SBGE, LSS Biology Module Topic

... o Except in sex cells o All animals and plants of the same species have the same number of chromosomes  A human cell contains 23 pairs (2n=46) of chromosomes o Except in the sex cells (n=23) B. Chromosomes-Genes-DNA Chromosomes  Chromatin is a nuclear material that contains the genetic code.  Het ...
In Sickness and In Health
In Sickness and In Health

... Identify a famous person, or member of popular culture, who suffers from this disease? If this is not possible think of or a similar condition, or a condition that affects a similar organ. Demonstrate how their life has been affected by the condition. Example Case Study: ID Gene: PKD1 Describe the f ...
Leukaemia Section t(2;8)(p23;p11) KAT6A/ASXL2 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(2;8)(p23;p11) KAT6A/ASXL2 Atlas of Genetics and Cytogenetics in Oncology and Haematology

2.3 Review PBS
2.3 Review PBS

... • Insulin pumps use a catheter that is inserted into fatty tissue • They can be used to deliver insulin constantly so that insulin is always present to help control glucose • They can also be used deliver more insulin around meals to help counteract the influx of glucose. • These still require that ...
Heredity Chapter 5-2
Heredity Chapter 5-2

...  Mendel came to 3 important conclusions from his experimental results: 1. The inheritance of each trait is determined by “units” or “factors” that are passed on to descendants (these units were later called genes) 2. An individual inherits one such gene from each parent for each trait. 3. A trait m ...
William’s syndrome: gene expression is related to ORIGINAL ARTICLE
William’s syndrome: gene expression is related to ORIGINAL ARTICLE

... As an approach toward understanding the role of the deleted genes in WS, we have characterized WS subjects according to genetic, social/ emotional, neurocognitive, neurophysiological and neuroanatomical features. Previous work from this laboratory also used molecular cytogenetic, microsatellite and ...
Betpag2 - Eubios Ethics Institute
Betpag2 - Eubios Ethics Institute

... these was Dolly, the sheep. Many countries rushed to outlaw the possibility of reproductive cloning in humans. Most mammalian embryos can only be split into 2-4 clones, after that the cells lack the ability to start development into a human being. Therapeutic cloning is the cloning of embryos contai ...
Genetics Notes
Genetics Notes

... 3. Gregor Mendel experimented with pea plants to see how different traits (characteristics) are handed down from one generation to the next. He is known as the Father of Genetics. 4. Traits are the overall appearance, or characteristic of an organism. a. pea plant traits - height of the plant, color ...
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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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