Activation of proto-oncogenes by disruption of
... GM12878 lymphoblastoid, Jurkat cells and K562 CML cells (24) were identified for comparison (Fig. 4A, S11, Table S8). The boundaries of these neighborhoods were examined for somatic point mutations found in cancer genomes using the ICGC database containing data for ~50 cancer types, ~2300 WGS sample ...
... GM12878 lymphoblastoid, Jurkat cells and K562 CML cells (24) were identified for comparison (Fig. 4A, S11, Table S8). The boundaries of these neighborhoods were examined for somatic point mutations found in cancer genomes using the ICGC database containing data for ~50 cancer types, ~2300 WGS sample ...
cbb752-mg-spr09-bioinfo
... What is Bioinformatics? • One idea for a definition? Bioinformatics is conceptualizing biology in terms of molecules (in the sense of physical-chemistry) and then applying “informatics” techniques (derived from disciplines such as applied math, CS, and statistics) to understand and organize the inf ...
... What is Bioinformatics? • One idea for a definition? Bioinformatics is conceptualizing biology in terms of molecules (in the sense of physical-chemistry) and then applying “informatics” techniques (derived from disciplines such as applied math, CS, and statistics) to understand and organize the inf ...
Integrative Genome-wide Analysis of the Determinants of RNA
... The analysis of gene expression and the identification of expression quantitative trait loci (eQTLs) has become a standard part of the analyses performed in many population genetics studies. However, the variability in expression levels is only one of the factors shaping the complexity of the transc ...
... The analysis of gene expression and the identification of expression quantitative trait loci (eQTLs) has become a standard part of the analyses performed in many population genetics studies. However, the variability in expression levels is only one of the factors shaping the complexity of the transc ...
Expression of phosphofructokinase in Neisseria meningitidis
... during the evolution of the species this activity was lost (Bapteste et al., 2003), the question of why N. meningitidis lost PFK activity remains. In particular, since glucose is present within nasopharyngeal tissue (Exley et al., 2005), the presence of PFK can yield one additional ATP per unit of s ...
... during the evolution of the species this activity was lost (Bapteste et al., 2003), the question of why N. meningitidis lost PFK activity remains. In particular, since glucose is present within nasopharyngeal tissue (Exley et al., 2005), the presence of PFK can yield one additional ATP per unit of s ...
Evolution of meiosis genes in sexual vs. asexual Potamopyrgus
... Sur et al 2013, Yampolsky & Bouzinier 2014,) and after the loss of ancestral characters such as opsin genes in cave fish (Yokoyama et al 1995) or tooth loss in birds (Meredith et al 2014) . These studies indicate the common fate of a gene under relaxed selection is pseudogenization followed by seque ...
... Sur et al 2013, Yampolsky & Bouzinier 2014,) and after the loss of ancestral characters such as opsin genes in cave fish (Yokoyama et al 1995) or tooth loss in birds (Meredith et al 2014) . These studies indicate the common fate of a gene under relaxed selection is pseudogenization followed by seque ...
v7a29-zhu pgmkr - Molecular Vision
... We have cloned and characterized Xenopus cry homologs with high sequence similarity to the mammalian crys. However, in contrast to the two cry genes found in both mouse and human, we identified three distinct clones from the Xenopus retinal cDNA library. One of the clones, xcry1, is most similar to ...
... We have cloned and characterized Xenopus cry homologs with high sequence similarity to the mammalian crys. However, in contrast to the two cry genes found in both mouse and human, we identified three distinct clones from the Xenopus retinal cDNA library. One of the clones, xcry1, is most similar to ...
Sequence ID: ref|WP_006700522.1
... Kinetic and Spectroscopic Studies of Bicupin Oxalate Oxidase and Putative Active Site Mutants ...
... Kinetic and Spectroscopic Studies of Bicupin Oxalate Oxidase and Putative Active Site Mutants ...
Modeling Spatial Correlation of DNA Deformation
... model shows a very good agreement between theory and experiment with lP ∼ 150 bps ∼ 50 nm for double-stranded DNA under physiological conditions18 as well as in a flow field.19 Detailed variations of this model have been proposed over the years by introducing a small number of additional independent p ...
... model shows a very good agreement between theory and experiment with lP ∼ 150 bps ∼ 50 nm for double-stranded DNA under physiological conditions18 as well as in a flow field.19 Detailed variations of this model have been proposed over the years by introducing a small number of additional independent p ...
A possible association between panic disorder
... The polymorphism rs4684677 has previously been studied in relation to alcohol dependence (Landgren et al., 2010), hypertension and atherosclerosis (Berthold et al., 2010), body composition and serum lipids (Martin et al., 2008), adult stature (Gueorguiev et al., 2007), metabolic syndrome (Steinle et ...
... The polymorphism rs4684677 has previously been studied in relation to alcohol dependence (Landgren et al., 2010), hypertension and atherosclerosis (Berthold et al., 2010), body composition and serum lipids (Martin et al., 2008), adult stature (Gueorguiev et al., 2007), metabolic syndrome (Steinle et ...
Aucun titre de diapositive - Universidad Nacional De Colombia
... The algorithm looks for the co-occurrence of n-length words (n = 6) in a window of size 150 bases having at least 96% identity. Sequences shorter than 50 bases are excluded from the clustering process. Clusters highly related sequences. Clusters also sequences related by rearrangements or alternativ ...
... The algorithm looks for the co-occurrence of n-length words (n = 6) in a window of size 150 bases having at least 96% identity. Sequences shorter than 50 bases are excluded from the clustering process. Clusters highly related sequences. Clusters also sequences related by rearrangements or alternativ ...
Lecture Notes
... (a) Usually do not affect the individual, but may interfere with chromosome pairing during meiosis: a cause of multiple spontaneous abortions or abnormal liveborns. (b) Pericentric inversions include the centromere. (c) Paracentric inversions do not include the centromere. 5) Translocations: Breaks ...
... (a) Usually do not affect the individual, but may interfere with chromosome pairing during meiosis: a cause of multiple spontaneous abortions or abnormal liveborns. (b) Pericentric inversions include the centromere. (c) Paracentric inversions do not include the centromere. 5) Translocations: Breaks ...
Modified PDF
... (Kanellopoulos et al. 1996) shows that the protein chain can adopt different conformations. What is the significance of this flexibility for the function of DBP? When proline residues were introduced in the hinge region to reduce flexibility, elongation was not possible and unwinding was severely im ...
... (Kanellopoulos et al. 1996) shows that the protein chain can adopt different conformations. What is the significance of this flexibility for the function of DBP? When proline residues were introduced in the hinge region to reduce flexibility, elongation was not possible and unwinding was severely im ...
annotation_tutorial
... right that HSP 2 and 3 belong to the same exon. It seems we were also right in extending HSP5 in both directions and HSP7 to the 5’ end. Off course we’ll need to check this more carefully later. This is it for the tBLASTx data, so you can click it off or remove the entry with “Entries > Remove An En ...
... right that HSP 2 and 3 belong to the same exon. It seems we were also right in extending HSP5 in both directions and HSP7 to the 5’ end. Off course we’ll need to check this more carefully later. This is it for the tBLASTx data, so you can click it off or remove the entry with “Entries > Remove An En ...
Pedigree Analysis
... (because two alleles of a recessive trait are required for an individual to be affected) (4) When a trait is X-linked, a single recessive allele is sufficient for a male to be affected. (because the male is hemizygous – he only has one allele of an X-linked trait) (5) A father transmits his allele o ...
... (because two alleles of a recessive trait are required for an individual to be affected) (4) When a trait is X-linked, a single recessive allele is sufficient for a male to be affected. (because the male is hemizygous – he only has one allele of an X-linked trait) (5) A father transmits his allele o ...
Chapter 2. Structures of Nucleic Acids
... mice (Fig. 2.1.A.). Smooth (S) strains produce a capsular polysaccharide on their surface, which allow the Pneumococi to escape destruction by the mouse, and the infection proceeds, i.e. they are virulent. This polysaccaride can be type I, II, or III. Virulent S strains can be killed by heat (i.e., ...
... mice (Fig. 2.1.A.). Smooth (S) strains produce a capsular polysaccharide on their surface, which allow the Pneumococi to escape destruction by the mouse, and the infection proceeds, i.e. they are virulent. This polysaccaride can be type I, II, or III. Virulent S strains can be killed by heat (i.e., ...
Category 2000
... coactivator 1 (PPARGC1A) is a versatile coactivator with many functions, but is primarily involved in fat and energy metabolism. Therefore, it is a very interesting candidate gene for meat quality, which is one of the most important criteria in pig selection today. PPARGC1A however, does not have th ...
... coactivator 1 (PPARGC1A) is a versatile coactivator with many functions, but is primarily involved in fat and energy metabolism. Therefore, it is a very interesting candidate gene for meat quality, which is one of the most important criteria in pig selection today. PPARGC1A however, does not have th ...
Human Ig heavy chain CDR3 regions in adult
... The combined variation in sequence and size of the HCDR3 generates an enormous diversity in Ig antigen binding sites, especially in humans (7,14–17). The importance of HCDR3 diversity is illustrated by the fact that this region forms the center of the antigen binding site and provides essential resi ...
... The combined variation in sequence and size of the HCDR3 generates an enormous diversity in Ig antigen binding sites, especially in humans (7,14–17). The importance of HCDR3 diversity is illustrated by the fact that this region forms the center of the antigen binding site and provides essential resi ...
Ch 4 : Heredity
... If you flip a coin, what are the chances that it will land on heads? tails? Suppose that you flipped the coin and got heads. What are the chances that you will get heads again? Record your answers in your science journal. ...
... If you flip a coin, what are the chances that it will land on heads? tails? Suppose that you flipped the coin and got heads. What are the chances that you will get heads again? Record your answers in your science journal. ...
Genetic distance between the Polish Red, Czech Red and
... programmes as in the past they have been eliminated from mass breeding by high producing and specialized breeds. Only after some years it proved that red cattle are ideal for breeding in the mountains or in regions lacking good pastures, where the use of contemporary, highly specialized breeds did n ...
... programmes as in the past they have been eliminated from mass breeding by high producing and specialized breeds. Only after some years it proved that red cattle are ideal for breeding in the mountains or in regions lacking good pastures, where the use of contemporary, highly specialized breeds did n ...
Alu Human Polymorphism
... • Each Alu insertion is a unique event and is inherited from each parent – Most occurred millions of years ago and are often on both pairs of chromosomes – There are Alu elements that have occurred since humans branched from other primates – This gives rise to dimorphic Alus from the last hundreds o ...
... • Each Alu insertion is a unique event and is inherited from each parent – Most occurred millions of years ago and are often on both pairs of chromosomes – There are Alu elements that have occurred since humans branched from other primates – This gives rise to dimorphic Alus from the last hundreds o ...
Document
... • Single CpG methylation model – distinct DNA elements [usually transcription factor (TF)-binding sites] whose methylation or demethylation usually leads to gene silencing or activation ...
... • Single CpG methylation model – distinct DNA elements [usually transcription factor (TF)-binding sites] whose methylation or demethylation usually leads to gene silencing or activation ...
evolution of protein function by domain swapping
... possesses all the characteristics of a complete globular protein’’ (Schultz and Schirmer, 1979). The term subdomain usually refers to units smaller than a domain that can be described as having a particular function or structure (i.e., some rationale for being grouped together). What distinguishes t ...
... possesses all the characteristics of a complete globular protein’’ (Schultz and Schirmer, 1979). The term subdomain usually refers to units smaller than a domain that can be described as having a particular function or structure (i.e., some rationale for being grouped together). What distinguishes t ...
A Dnmt2-like protein mediates DNA methylation in
... (unmethylated, negative control) and Drosophila embryos were spotted onto a membrane and stained for 5methylcytosine and DNA, respectively. This revealed a clearly differential staining pattern for 5-methylcytosine, while the DNA staining pattern was equal for all samples (Fig. 1E). As an additional ...
... (unmethylated, negative control) and Drosophila embryos were spotted onto a membrane and stained for 5methylcytosine and DNA, respectively. This revealed a clearly differential staining pattern for 5-methylcytosine, while the DNA staining pattern was equal for all samples (Fig. 1E). As an additional ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.