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A Comparative Gene Map of the Horse (Equus caballus)
A Comparative Gene Map of the Horse (Equus caballus)

... Andersson et al. 1996; Wakefield and Graves 1996). This information forms the basis for comparative genome mapping, a discipline that allows the prospect of using information from highly characterized genomes to study genetic phenomena in map-poor species (O’Brien et al. 1993; Georges and Andersson ...
C1. The start codon begins at the fifth nucleotide. The amino acid
C1. The start codon begins at the fifth nucleotide. The amino acid

... C11. An anticodon that was 3′–UUG–5′ would recognize the two codons. To recognize 5′–AAA–3′, it would have to be modified to 3′–UUI–5′. C12. All tRNA molecules have some basic features in common. They all have a cloverleaf structure with three stemloop structures. The second stem-loop contains the a ...
Heredity and Math - Computer Science
Heredity and Math - Computer Science

... were wrinkled or smooth appeared to be passed down from the parent plant to the offspring. Mendel did not know about DNA or chromosomes, and he could not explain how these traits were passed down. His work was mostly ignored for many years. Mendel's work became the basis for the field of genetics, t ...
- University of Bath Opus
- University of Bath Opus

... To understand the genetic basis of how species adapt to changes in their living environment is one of the basic objectives in evolutionary biology. How genomes evolve through time and how they change in response to selective pressures are long standing questions in genomics and evolutionary biology. ...
The importance of chromosomes from the sixth homeologic group in
The importance of chromosomes from the sixth homeologic group in

... al. 2011). This study was aimed at the application of DArT markers for mapping the triticale genome, as well as the utilisation of a developed linkage map for the localisation of genes restoring male fertility in plants carrying the T. timopheevii cytoplasm. The F2 population used in this study cons ...
Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, and Tilghman SM. Genes Dev. 1999 Dec 1;13(23):3115-24. Oppositely imprinted genes p57Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, and Tilghman SM. Genes Dev. 1999 Dec 1;13(23):3115-24. Oppositely imprinted genes p57Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.

... manners to control cell proliferation during development of human fetuses; that is, that a gain of function of IGF2 would act similarly to a loss of function of p57KIP2. We reasoned that if IGFII and p57 act antagonistically during development, a double mutant in which both BWS-potentiating mutation ...
Darwinian Populations and Natural Selection Homunculi Rule
Darwinian Populations and Natural Selection Homunculi Rule

... the parallel mistake of thinking that genes are strands of nucleotides; they are the information carried by those sequences of codons. I had thought that this perspective was widely accepted as enlightened, but PGS will have none of it, so I will deal with his mistrust of information first, and then ...
Simplified Insertion of Transgenes Onto Balancer Chromosomes via
Simplified Insertion of Transgenes Onto Balancer Chromosomes via

... ABSTRACT Balancer chromosomes are critical tools for Drosophila genetics. Many useful transgenes are inserted onto balancers using a random and inefficient process. Here we describe balancer chromosomes that can be directly targeted with transgenes of interest via recombinase-mediated cassette exchan ...
Analyzing the Changes in DNA Flexibility Due to Base Modifications
Analyzing the Changes in DNA Flexibility Due to Base Modifications

... issues. To strip water, we will first make a psf and pdb without water. We will then make an index file and feed the dcd and the index file into catdcd, which will produce a new dcd without water that takes up much less space. The vmd script, strip.tcl, accomplishes these tasks and takes as input a ...
1 Introduction
1 Introduction

... figure 1. All type II enzymes are able to relax supercoiled DNA, but gyrase from Escherichia coli is unique, because the enzyme can introduce negative supercoiling, not only in relaxed DNA but also in positively supercoiled DNA (Osheroff et al, 1983; Schomburg & Grosse, 1986). As a model for this s ...
Chapter 6 Gregor Mendel and Genetics Worksheets
Chapter 6 Gregor Mendel and Genetics Worksheets

... _____ 4. In a cross between two homozygous dominant individuals, 25% of the offspring may have the recessive phenotype. _____ 5. A parent cell makes gametes through the process of mitosis. _____ 6. It is entirely likely for a gene to have more than two alleles. _____ 7. Incomplete dominance occurs wh ...
Nucleotide sequence and genome organization of foot-and
Nucleotide sequence and genome organization of foot-and

... direct sequencing of the cDNA extending into the poly(C) tract (7). It is different, but shows similarities to the sequence ..T(C)2AUUCCAAG... determined for the 3' end ot a T1 oligo nucleotide containing the poly(C) tract from FMDV O-V1 and A61 (17). Coding regions and translation initiation sites ...
Gene tree reconstruction and orthology analysis based on
Gene tree reconstruction and orthology analysis based on

... gene trees are constructed precisely for the purpose of estimating the corresponding species tree. However, in the presence of duplications it is necessary to use gene trees from several gene families. The integration then gives a biologically sound supertree construction method that in the presence ...
Mapping of the Recessive White Locus and
Mapping of the Recessive White Locus and

... melanins, tyrosinase-induced oxidation of Tyr, which is the first biochemical step, leads to production of dihydroxyphenylalanine and then, via oxidation of dihydroxyphenylalanine, the production of dopaquinone (Lerner and Fitzpatrick, 1950). In addition, tyrosinase is associated with formation of e ...
Chpt2_Struc_Nucleic_Acids.doc
Chpt2_Struc_Nucleic_Acids.doc

... mice (Fig. 2.1.A.). Smooth (S) strains produce a capsular polysaccharide on their surface, which allow the Pneumococi to escape destruction by the mouse, and the infection proceeds, i.e. they are virulent. This polysaccaride can be type I, II, or III. Virulent S strains can be killed by heat (i.e., ...
Clinical application of High throughput sequencing (HTS) analysis
Clinical application of High throughput sequencing (HTS) analysis

... of the List of Analysis. This explains why some disorders like Friedreich’s Ataxia (caused by triplet repeats) or Cri-du-Chat syndrome already have a HTS position although at the moment these disorders are more efficiently detected by traditional methods due to technical limitations or high costs of ...
DNA Pre-ConceptionStu - the Biology Scholars Program Wiki
DNA Pre-ConceptionStu - the Biology Scholars Program Wiki

... 4. The basic unit or monomer of DNA is composed of a(n): A. Lipid, a molecule of nitrate and one of four amino acids B. Lipid, a molecule of phosphate and one of four amino acids C. Protein, a molecule of nitrate and one of four nitrogen containing bases D. Sugar, a molecule of phosphate and one of ...
Notification of a Notifiable Low Risk Dealing
Notification of a Notifiable Low Risk Dealing

... modified trait? The primary interest here is in the gene or genes under study and the function of these gene(s). Please list this information if known. Such details are not required about gene(s) commonly used as markers, for selection and/or any other routine procedures. However it is of interest t ...
shRNA FAQ - Functional Genomics Facility
shRNA FAQ - Functional Genomics Facility

... Can I extract the vector directly from the lentiviral particle? No, this is not possible. The vector is used to make the particles in the packaging or producer cells. The viral genome contains only the RNA version of the region found between the 5' and 3' LTRs of pLKO.1 (promoter, hairpin sequence, ...
Tasting Phenylthiocarbamide (PTC): A New Integrative
Tasting Phenylthiocarbamide (PTC): A New Integrative

... the case for tasters (T-), and the tasters in the class will be curious about whether they are homozygotes (TT) or heterozygotes (Tt). Until recently there have been two approaches to answering this question: one that involves using the class allele frequencies to calculate the conditional probabili ...
Quick Overview of Bioinformatics - What's New?
Quick Overview of Bioinformatics - What's New?

... affected by infrastructure, economics, etc than other areas of biological research • ‘Critical mass’ issues less critical – a world-wide community is within reach ...
association study of 37 genes suggests involvement of DDC
association study of 37 genes suggests involvement of DDC

... Objectives. Neurotransmitter systems and neurotrophic factors can be considered strong candidates for autism spectrum disorder (ASD). The serotoninergic and dopaminergic systems are involved in neurotransmission, brain maturation and cortical organization, while neurotrophic factors (NTFs) participa ...
Cloning of the Papaya Chromoplast-Specific
Cloning of the Papaya Chromoplast-Specific

... Our group constructed a high-density genetic map of papaya using amplified fragment length polymorphism (AFLP) markers, and the flesh color locus was mapped near the end of linkage group 7 (LG7) and the two flanking markers were 3.4 and 3.7 centimorgan (cM), respectively (Ma et al., 2004). These clo ...
Quick Overview of Bioinformatics
Quick Overview of Bioinformatics

... affected by infrastructure, economics, etc than other areas of biological research • ‘Critical mass’ issues less critical – a world-wide community is within reach ...
Fundamentals of Genetics
Fundamentals of Genetics

... • This alligator is one of 18 white alligators discovered southwest of New Orleans in 1987 by a fisherman. • How is he different from alligators you have seen? • It is not a different species and it is not albino. • Albinos have off-white or yellowish skin and colorless irises or look pink • This al ...
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Gene



A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.
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