Ceftolozane (as sulfate) / Tazobactam (as sodium salt)
... subjects with mild, moderate, and severe renal impairment, respectively, compared to healthy subjects with normal renal function. The respective tazobactam dose normalized geometric mean AUC increased approximately up to 1.3-fold, 2-fold, and 4-fold. In subjects with end stage renal disease (ESRD) o ...
... subjects with mild, moderate, and severe renal impairment, respectively, compared to healthy subjects with normal renal function. The respective tazobactam dose normalized geometric mean AUC increased approximately up to 1.3-fold, 2-fold, and 4-fold. In subjects with end stage renal disease (ESRD) o ...
product monograph
... from 17 to 24 hours. The accumulation indices, calculated by Cmax and the area under the curve (AUC) ratios did not change after the 5th day, indicating little or no accumulation of either loratadine or its metabolite after a multiple once per day dosage regimen. The T1/2β at steady state levels for ...
... from 17 to 24 hours. The accumulation indices, calculated by Cmax and the area under the curve (AUC) ratios did not change after the 5th day, indicating little or no accumulation of either loratadine or its metabolite after a multiple once per day dosage regimen. The T1/2β at steady state levels for ...
AusPAR: Rifaximin - Therapeutic Goods Administration
... Rifaximin is a non‐systemic, oral antibiotic derived from rifamycin, which has a broad spectrum of activity against Gram‐positive and Gram‐negative, aerobic and anaerobic enterobacteria. This class of antibiotics inhibits the Deoxyribonucleic acid (DNA) dependent ribonucleic acid (RNA) polymerase of ...
... Rifaximin is a non‐systemic, oral antibiotic derived from rifamycin, which has a broad spectrum of activity against Gram‐positive and Gram‐negative, aerobic and anaerobic enterobacteria. This class of antibiotics inhibits the Deoxyribonucleic acid (DNA) dependent ribonucleic acid (RNA) polymerase of ...
EFFICACY OF ALBENDAZOLE AGAINST EXPERIMENTAL INFECTIONS OF COENURUS CEREBRALIS IN GOATS.
... earlier and in higher concentrations than ABZSO2 in the first 24 h, but after 48 hours, the plasma concentrations of ABZSO2 were greater than ABZSO. This suggest that ABZ can induce the ABZSO metabolism to ABZSO2 In a controlled trial with experimental T. multiceps-infected goats, two months after i ...
... earlier and in higher concentrations than ABZSO2 in the first 24 h, but after 48 hours, the plasma concentrations of ABZSO2 were greater than ABZSO. This suggest that ABZ can induce the ABZSO metabolism to ABZSO2 In a controlled trial with experimental T. multiceps-infected goats, two months after i ...
View Full Prescribing Information
... --------------------------- INDICATIONS AND USAGE---------------------------ANTHIM® is a monoclonal antibody directed against the protective antigen of Bacillus anthracis. It is indicated in adult and pediatric patients for treatment of inhalational anthrax due to B. anthracis in combination with ap ...
... --------------------------- INDICATIONS AND USAGE---------------------------ANTHIM® is a monoclonal antibody directed against the protective antigen of Bacillus anthracis. It is indicated in adult and pediatric patients for treatment of inhalational anthrax due to B. anthracis in combination with ap ...
XP13512 [()-1-([(α-Isobutanoyloxyethoxy
... intestine of humans and animals by a low-capacity, solute transporter localized in the upper small intestine (Stewart et al., 1993; Uchino et al., 2002). This absorption pathway is apparently saturated at doses normally used to treat neuropathic pain. As a result, the plasma exposure to gabapentin i ...
... intestine of humans and animals by a low-capacity, solute transporter localized in the upper small intestine (Stewart et al., 1993; Uchino et al., 2002). This absorption pathway is apparently saturated at doses normally used to treat neuropathic pain. As a result, the plasma exposure to gabapentin i ...
Data Sheet Name of Medicine Presentation
... primarily from a placebo controlled study in which Naltrexone Hydrochloride was administered to obese subjects at a dose approximately five-fold that recommended for the blockade of opiate receptors (300 mg per day). In that study, 5 of 26 Naltrexone Hydrochloride recipients developed elevations of ...
... primarily from a placebo controlled study in which Naltrexone Hydrochloride was administered to obese subjects at a dose approximately five-fold that recommended for the blockade of opiate receptors (300 mg per day). In that study, 5 of 26 Naltrexone Hydrochloride recipients developed elevations of ...
Zosyn® (Piperacillin and Tazobactam for Injection, USP) The
... aeruginosa (Nosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycoside). (See DOSAGE AND ADMINISTRATION.) ZOSYN (piperacillin and tazobactam for injection, USP) is indicated only for the specified conditions listed above. Infections caused by piperacillin-su ...
... aeruginosa (Nosocomial pneumonia caused by P. aeruginosa should be treated in combination with an aminoglycoside). (See DOSAGE AND ADMINISTRATION.) ZOSYN (piperacillin and tazobactam for injection, USP) is indicated only for the specified conditions listed above. Infections caused by piperacillin-su ...
effect of piperine, a major component of black pepper, on the
... The time needed to reach Cmax (Tmax), however, was not changed. The intraperitoneal pharmacokinetics of domperidone (20 mg/kg) in the presence and absence of piperine (30 mg/kg, p.o.) were also evaluated in rats. Fig. 2 shows the mean plasma concentration- time profiles following the administration ...
... The time needed to reach Cmax (Tmax), however, was not changed. The intraperitoneal pharmacokinetics of domperidone (20 mg/kg) in the presence and absence of piperine (30 mg/kg, p.o.) were also evaluated in rats. Fig. 2 shows the mean plasma concentration- time profiles following the administration ...
they look for answers. Men don’t look for excuses.
... Metabolism and Excretion: Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity pro ...
... Metabolism and Excretion: Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity pro ...
mesna injection, 100 mg/ml
... concomitant disease or other drug therapy. However, the ratio of ifosfamide to mesna should remain unchanged. ADVERSE REACTIONS Mesna injection adverse reaction data are available from phase 1 studies in which single IV bolus doses of 600-1200 mg mesna injection without concurrent chemotherapy were ...
... concomitant disease or other drug therapy. However, the ratio of ifosfamide to mesna should remain unchanged. ADVERSE REACTIONS Mesna injection adverse reaction data are available from phase 1 studies in which single IV bolus doses of 600-1200 mg mesna injection without concurrent chemotherapy were ...
STAXYN PRODUCT MONOGRAPH
... Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently with the use of PDE5 inhibitors, including vardenafil. The incidence of priapism may increase when PDE5 inhibitors are used in combination with intrapenile inject ...
... Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently with the use of PDE5 inhibitors, including vardenafil. The incidence of priapism may increase when PDE5 inhibitors are used in combination with intrapenile inject ...
Fortaz - GlaxoSmithKline
... contribute to the development of CDAD. CDAD may cause significant morbidity and mortality. CDAD can be refractory to antimicrobial therapy. If the diagnosis of CDAD is suspected or confirmed, appropriate therapeutic measures should be initiated. Mild cases of CDAD usually respond to discontinuation ...
... contribute to the development of CDAD. CDAD may cause significant morbidity and mortality. CDAD can be refractory to antimicrobial therapy. If the diagnosis of CDAD is suspected or confirmed, appropriate therapeutic measures should be initiated. Mild cases of CDAD usually respond to discontinuation ...
vancomycin 500mg and 1000mg powder for concentrate for solution
... For intravenous infusion only. For preparation of solution for infusion please refer to section 6.6. Concentrations of no more than 5mg/ml are recommended. In selected patients in need of fluid restriction, a concentration up to 10mg/ml may be used; use of such higher concentrations may increase the ...
... For intravenous infusion only. For preparation of solution for infusion please refer to section 6.6. Concentrations of no more than 5mg/ml are recommended. In selected patients in need of fluid restriction, a concentration up to 10mg/ml may be used; use of such higher concentrations may increase the ...
Evaluation of Pharmacokinetic Interaction between PA
... believed similar to that of Delamanid, a drug currently under review for market approval by the regulatory authorities (3). PA-824 interferes with M. tuberculosis cell wall biosynthesis by inhibiting the oxidation of hydroxymycolate to ketomycolate. A deazaflavin (F420)-dependent nitroreductase has ...
... believed similar to that of Delamanid, a drug currently under review for market approval by the regulatory authorities (3). PA-824 interferes with M. tuberculosis cell wall biosynthesis by inhibiting the oxidation of hydroxymycolate to ketomycolate. A deazaflavin (F420)-dependent nitroreductase has ...
labetalol hydrochloride injection usp
... At rest, labetalol slightly reduces the heart rate, increases the stroke volume but does not significantly affect cardiac output. It reduces exercise-induced increases in systolic pressure and heart rate, again without significantly influencing cardiac output. Following oral administration to hypert ...
... At rest, labetalol slightly reduces the heart rate, increases the stroke volume but does not significantly affect cardiac output. It reduces exercise-induced increases in systolic pressure and heart rate, again without significantly influencing cardiac output. Following oral administration to hypert ...
Erythromycin delayed release capsules USP
... experiments have demonstrated that binding sites for erythromycin, lincomycin, clindamycin and chloramphenicol overlap and competitive inhibition may occur. Triazolam/Midazolam: Erythromycin has been reported to decrease the clearance of triazolam and midazolam and thus may increase the pharmacologi ...
... experiments have demonstrated that binding sites for erythromycin, lincomycin, clindamycin and chloramphenicol overlap and competitive inhibition may occur. Triazolam/Midazolam: Erythromycin has been reported to decrease the clearance of triazolam and midazolam and thus may increase the pharmacologi ...
Product Monograph Template - Standard - GlaxoSmithKline
... Particular care is needed in patients who are transferred from systemically active corticosteroids to inhaled corticosteroids because deaths due to adrenal insufficiency have occurred in patients with asthma during and after transfer. For the transfer of patients being treated with oral corticostero ...
... Particular care is needed in patients who are transferred from systemically active corticosteroids to inhaled corticosteroids because deaths due to adrenal insufficiency have occurred in patients with asthma during and after transfer. For the transfer of patients being treated with oral corticostero ...
10 mg/5 mL Morphine Sulfate Oral Solution
... • Keep Morphine Sulfate Oral Solution out of the reach of children. Accidental overdose by a child is a medical emergency and can lead to death. General information about Morphine Sulfate Oral Solution Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do ...
... • Keep Morphine Sulfate Oral Solution out of the reach of children. Accidental overdose by a child is a medical emergency and can lead to death. General information about Morphine Sulfate Oral Solution Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do ...
Morphine Sulfate Oral Solution
... • Keep Morphine Sulfate Oral Solution out of the reach of children. Accidental overdose by a child is a medical emergency and can lead to death. General information about Morphine Sulfate Oral Solution Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do ...
... • Keep Morphine Sulfate Oral Solution out of the reach of children. Accidental overdose by a child is a medical emergency and can lead to death. General information about Morphine Sulfate Oral Solution Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do ...
Inderal (propranolol hydrochloride) Tablets Rx only
... centers (plus one in Canada) in 3,837 persons without history of severe congestive heart failure or presence of recent heart failure; certain conduction defects; angina since infarction, who had survived the acute phase of myocardial infarction. Propranolol was administered at either 60 or 80 mg t.i ...
... centers (plus one in Canada) in 3,837 persons without history of severe congestive heart failure or presence of recent heart failure; certain conduction defects; angina since infarction, who had survived the acute phase of myocardial infarction. Propranolol was administered at either 60 or 80 mg t.i ...
1 EC-NAPROSYN (naproxen delayed
... Naproxen and naproxen sodium are rapidly and completely absorbed from the gastrointestinal tract with an in vivo bioavailability of 95%. The different dosage forms of NAPROSYN are bioequivalent in terms of extent of absorption (AUC) and peak concentration (Cmax); however, the products do differ in t ...
... Naproxen and naproxen sodium are rapidly and completely absorbed from the gastrointestinal tract with an in vivo bioavailability of 95%. The different dosage forms of NAPROSYN are bioequivalent in terms of extent of absorption (AUC) and peak concentration (Cmax); however, the products do differ in t ...
MICROMEDEX® Healthcare Series OXCARBAZEPINE
... 30 milligrams/kilogram/day (mg/kg/day) over 1 to 3 weeks (Gaily et al, 1997a). In those switching from carbamazepine, an overnight change of 1.5 times their carbamazepine dose has been utilized. The mean effective dose for children achieving at least a 50% decrease in seizures has been 47 mg/kg/day ...
... 30 milligrams/kilogram/day (mg/kg/day) over 1 to 3 weeks (Gaily et al, 1997a). In those switching from carbamazepine, an overnight change of 1.5 times their carbamazepine dose has been utilized. The mean effective dose for children achieving at least a 50% decrease in seizures has been 47 mg/kg/day ...
Prescribing Information Only Fluticasone Propionate Nasal Spray
... gene expression afforded 50% responses at 1.25 and 0.17 nM concentrations, respectively. Fluticasone propionate was 3-fold to 5-fold more potent than dexamethasone in these assays. Data from the McKenzie vasoconstrictor assay in man also support its potent glucocorticoid activity. In preclinical stu ...
... gene expression afforded 50% responses at 1.25 and 0.17 nM concentrations, respectively. Fluticasone propionate was 3-fold to 5-fold more potent than dexamethasone in these assays. Data from the McKenzie vasoconstrictor assay in man also support its potent glucocorticoid activity. In preclinical stu ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.