Australian public assessment for everolimus
... everolimus does not generally result in tumour regression and it is not effective against all human breast carcinomas tested in vitro. In vitro studies in aromatase expressing breast cancer cell lines (MCF7/Aro) showed increased anti proliferation activity for the everolimus/letrozole combination co ...
... everolimus does not generally result in tumour regression and it is not effective against all human breast carcinomas tested in vitro. In vitro studies in aromatase expressing breast cancer cell lines (MCF7/Aro) showed increased anti proliferation activity for the everolimus/letrozole combination co ...
Review Advances in nucleoside monophosphate prodrugs as anti
... have been approved by the US Food and Drug Administration for chronic HCV are limited to pegylated interferon-α alone or in combination with ribavirin [10]. Unfortunately, these treatments have limited efficacy with response rates of only 40–50% for the genotype-1-infected population, which is the m ...
... have been approved by the US Food and Drug Administration for chronic HCV are limited to pegylated interferon-α alone or in combination with ribavirin [10]. Unfortunately, these treatments have limited efficacy with response rates of only 40–50% for the genotype-1-infected population, which is the m ...
Paritaprevir / Ritonavir / Ombitasvir and Dasabuvir
... © Commonwealth of Australia 2017 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
... © Commonwealth of Australia 2017 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
Albuterol Sulfate Inhalation Solution 0.5%
... discerned, a relationship between albuterol use and congenital anomalies has not been established. Use in Labor and Delivery: Because of the potential for betaagonist interference with uterine contractility, use of albuterol sulfate inhalation solution for relief of bronchospasm during labor should ...
... discerned, a relationship between albuterol use and congenital anomalies has not been established. Use in Labor and Delivery: Because of the potential for betaagonist interference with uterine contractility, use of albuterol sulfate inhalation solution for relief of bronchospasm during labor should ...
Effects of Acute and Repeated Administration of Oxycodone and
... Intracranial self-stimulation (ICSS) is a preclinical procedure that can be predictive of abuse-related effects of drugs (Wise, 2005; Negus and Miller, 2014; Bespalov et al., 2015). During ICSS, animal subjects are trained to emit a response (e.g., lever pressing) reinforced with electrical stimulat ...
... Intracranial self-stimulation (ICSS) is a preclinical procedure that can be predictive of abuse-related effects of drugs (Wise, 2005; Negus and Miller, 2014; Bespalov et al., 2015). During ICSS, animal subjects are trained to emit a response (e.g., lever pressing) reinforced with electrical stimulat ...
Practical tips for warfarin dosing and monitoring
... Once a patient makes the transition from the initial dosing phase to the maintenance phase, more consideration to the multiple factors that may affect the INR should be given when interpreting low or high INR values. The key is to individualize the dosage according to these factors and the target IN ...
... Once a patient makes the transition from the initial dosing phase to the maintenance phase, more consideration to the multiple factors that may affect the INR should be given when interpreting low or high INR values. The key is to individualize the dosage according to these factors and the target IN ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than morphine.8 –11 However, recent data showed th ...
... O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than morphine.8 –11 However, recent data showed th ...
Product Monograph
... As with levodopa, SINEMET® may cause involuntary movements and mental disturbances. These reactions are thought to be due to increased brain dopamine following administration of levodopa. Because carbidopa permits more levodopa to reach the brain and thus, more dopamine to be formed, dyskinesias may ...
... As with levodopa, SINEMET® may cause involuntary movements and mental disturbances. These reactions are thought to be due to increased brain dopamine following administration of levodopa. Because carbidopa permits more levodopa to reach the brain and thus, more dopamine to be formed, dyskinesias may ...
Taclonex - LEO Pharma
... HPA axis suppression. Factors that predispose a patient using a topical corticosteroid to HPA axis suppression include the use of more potent steroids, use over large surface areas, use over prolonged periods, use under occlusion, use on an altered skin barrier, and use in patients with liver failur ...
... HPA axis suppression. Factors that predispose a patient using a topical corticosteroid to HPA axis suppression include the use of more potent steroids, use over large surface areas, use over prolonged periods, use under occlusion, use on an altered skin barrier, and use in patients with liver failur ...
Levitra
... vardenafil, AUC and Cmax increase almost dose proportionally over the recommended dose range (5 mg – 20 mg). When vardenafil was taken with a high fat meal (~57% fat), the mean Cmax was reduced by approximately 20%, median tmax was delayed by approximately 1 hour, and mean AUC was not affected. Afte ...
... vardenafil, AUC and Cmax increase almost dose proportionally over the recommended dose range (5 mg – 20 mg). When vardenafil was taken with a high fat meal (~57% fat), the mean Cmax was reduced by approximately 20%, median tmax was delayed by approximately 1 hour, and mean AUC was not affected. Afte ...
Desmopressin Acetate Nasal Spray, 10 mcg per 0.1 mL
... according to the diurnal pattern of response. Response should be estimated by two parameters: adequate duration of sleep and adequate, not excessive, water turnover. Patients with nasal congestion and blockage have often responded well to intranasal Desmopressin Acetate. The usual dosage range in ad ...
... according to the diurnal pattern of response. Response should be estimated by two parameters: adequate duration of sleep and adequate, not excessive, water turnover. Patients with nasal congestion and blockage have often responded well to intranasal Desmopressin Acetate. The usual dosage range in ad ...
Safety and Side Effects of CBD
... extensive survey performed by Bergamaschi and colleagues in 2011. Apart from updating the literature, this paper focuses on clinical studies and CBD’s potential interactions with other drugs. In general, the often described excellent safety profile of CBD in humans was confirmed and extended by the ...
... extensive survey performed by Bergamaschi and colleagues in 2011. Apart from updating the literature, this paper focuses on clinical studies and CBD’s potential interactions with other drugs. In general, the often described excellent safety profile of CBD in humans was confirmed and extended by the ...
NEW ZEALAND DATA SHEET TOPIRAMATE ACTAVIS 15, 25, 50
... In animal studies, topiramate exhibits anticonvulsant activity in rat and mouse maximal electroshock seizure (MES) tests and is effective in rodent models of epilepsy, which include tonic and absence like seizures in the spontaneous epileptic rat (SER) and tonic and clonic seizures induced in rats b ...
... In animal studies, topiramate exhibits anticonvulsant activity in rat and mouse maximal electroshock seizure (MES) tests and is effective in rodent models of epilepsy, which include tonic and absence like seizures in the spontaneous epileptic rat (SER) and tonic and clonic seizures induced in rats b ...
... increases in the LSD (dysphoria), stimulant (A) and marijuana (M) scales. Similar increases were observed with smoked cannabis. Several participants did not experience psychological effects following oral dronabinol at these doses. Psychological and psychomotor effects only appear if an individually ...
Product Monograph
... RAS, such as ARBs or aliskiren-containing drugs, is generally not recommended in other patients, since such treatment has been associated with an increased incidence of severe hypotension, renal failure, and hyperkalemia (see DRUG INTERACTIONS). Cardiovascular Aortic Stenosis There is concern, on th ...
... RAS, such as ARBs or aliskiren-containing drugs, is generally not recommended in other patients, since such treatment has been associated with an increased incidence of severe hypotension, renal failure, and hyperkalemia (see DRUG INTERACTIONS). Cardiovascular Aortic Stenosis There is concern, on th ...
PRODUCT MONOGRAPH CEFAZOLIN FOR INJECTION 500 mg, 1
... There are instances of patients who have had reactions to both penicillins and cephalosporins (including fatal anaphylaxis after parenteral use). Clinical and laboratory evidence of partial cross-allergenicity of the two drug classes exists. Cefazolin sodium should be administered cautiously and the ...
... There are instances of patients who have had reactions to both penicillins and cephalosporins (including fatal anaphylaxis after parenteral use). Clinical and laboratory evidence of partial cross-allergenicity of the two drug classes exists. Cefazolin sodium should be administered cautiously and the ...
19529550 Albuterol PI
... cardiovascular differentiation between the two drugs was also seen. Preclinical: Intravenous studies in rats with albuterol sulfate have demonstrated that albuterol crosses the blood-brain barrier and reaches brain concentrations that are amounting to approximately 5.0% of the plasma concentrations. ...
... cardiovascular differentiation between the two drugs was also seen. Preclinical: Intravenous studies in rats with albuterol sulfate have demonstrated that albuterol crosses the blood-brain barrier and reaches brain concentrations that are amounting to approximately 5.0% of the plasma concentrations. ...
Prescribing Information
... 14.1 Clinical Trial to Evaluate Reduction of Risk of Preterm Birth In a multicenter, randomized, double-blind, vehicle (placebo)-controlled clinical trial, the safety and effectiveness of Makena for the reduction of the risk of spontaneous preterm birth was studied in women with a singleton pregna ...
... 14.1 Clinical Trial to Evaluate Reduction of Risk of Preterm Birth In a multicenter, randomized, double-blind, vehicle (placebo)-controlled clinical trial, the safety and effectiveness of Makena for the reduction of the risk of spontaneous preterm birth was studied in women with a singleton pregna ...
Comparison of the Effects of Pilocarpine Solution and Tablet on
... Purpose: Pilocarpine has the effects on improvement of salivary flow and subjective symptoms for xerostomic patients. Because of unwanted side effects following its systemic administration, topical pilocarpine has been paid attention as an alternative. This study aimed to investigate effects of pilo ...
... Purpose: Pilocarpine has the effects on improvement of salivary flow and subjective symptoms for xerostomic patients. Because of unwanted side effects following its systemic administration, topical pilocarpine has been paid attention as an alternative. This study aimed to investigate effects of pilo ...
Apo-Amoxi
... childbearing age without any proven increase in the frequency of malformations or other direct or amoxicillin for use in indirect harmful harmful effects effects on the foetus having having been been observed. observed. The The safety safety of amoxicillin human pregnancy pregnancy has been establis ...
... childbearing age without any proven increase in the frequency of malformations or other direct or amoxicillin for use in indirect harmful harmful effects effects on the foetus having having been been observed. observed. The The safety safety of amoxicillin human pregnancy pregnancy has been establis ...
Comparison of Inhaled Corticosteroids: An Update
... It has been well established that chemical changes in the basic corticosteroid molecule produce significant differences in potency, usually measured as binding affinity at the glucocorticoid receptor. The relative receptor affinities are provided in Table 2.2,7,9-14 The affinities have been compiled ...
... It has been well established that chemical changes in the basic corticosteroid molecule produce significant differences in potency, usually measured as binding affinity at the glucocorticoid receptor. The relative receptor affinities are provided in Table 2.2,7,9-14 The affinities have been compiled ...
Ann N Y Acad Sci
... Abstracts were screened for relevance and publications relating to chronic pain use were obtained. Levels of evidence were stratified according to accepted guidelines (level I-IV). For central pain, there is level II and level IV evidence of efficacy for parenteral and oral ketamine. For complex reg ...
... Abstracts were screened for relevance and publications relating to chronic pain use were obtained. Levels of evidence were stratified according to accepted guidelines (level I-IV). For central pain, there is level II and level IV evidence of efficacy for parenteral and oral ketamine. For complex reg ...
PRODUCT MONOGRAPH COMBIGAN®
... Results from pivotal trials indicate that the mean change from baseline IOP was significantly lower (p < 0.001) with COMBIGAN® than with either brimonidine tartrate alone or timolol maleate alone for both patients with diabetes and those without diabetes. See Warnings and Precautions for considerati ...
... Results from pivotal trials indicate that the mean change from baseline IOP was significantly lower (p < 0.001) with COMBIGAN® than with either brimonidine tartrate alone or timolol maleate alone for both patients with diabetes and those without diabetes. See Warnings and Precautions for considerati ...
TECTONA GRANDIS Research Article NEHA KHERA
... contraction of hind limbs. The hind limbs contractions that occurred over a period of 10 min were counted. A reduction in time of ...
... contraction of hind limbs. The hind limbs contractions that occurred over a period of 10 min were counted. A reduction in time of ...
ACCELERATED INDUCTION OF ETORPHINE IMMOBILIZATION IN BLUE WILDEBEEST BY THE ADDITION OF HYALURONIDASE
... At present, no one immobilizing agent is able to achieve all the above mentioned properties.40 As a result the primary immobilization agent (the primary agent is the one that produces the most marked central nervous system (CNS) depression, such as the opioid compounds or the cyclohexamines) needs t ...
... At present, no one immobilizing agent is able to achieve all the above mentioned properties.40 As a result the primary immobilization agent (the primary agent is the one that produces the most marked central nervous system (CNS) depression, such as the opioid compounds or the cyclohexamines) needs t ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.