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LATHYROIDES, encoding a WUSCHEL
LATHYROIDES, encoding a WUSCHEL

... was mapped in the linkage group VII between molecular marker Pgm and Fabtin (Figure 3A). In a parallel experiment in L. japonicus, mapping of nao1 was conducted by constructing an F2 population (number of mutants=1683). DNA pools, each of which consisted of fifteen randomly-selected mutant plants w ...
i A Thesis Entitled A Visual Screen for Centriolar Mutants in
i A Thesis Entitled A Visual Screen for Centriolar Mutants in

... in the next section, then migrate away from the centriole leaving a unique cytoplasmic cilium in its wake (Enjolras et al., 2012; Basiri et al., 2014; Malicki and Avidor-Reiss, 2014). Shortly after the cilium begins to elongate, an unusual centriolar precursor called the proximal centriole-like (PCL ...
The Parasexual Cycle in Candida albicans Provides an
The Parasexual Cycle in Candida albicans Provides an

... overall cell ploidy (unpublished data). PCR of the MTL loci was also used to detect possible jackpot effects, where several gal1 progeny might have been derived from a single cell having undergone a chromosome loss event. Where possible, progeny cells with different combinations of MTL alleles were ...
Forche et al. 2008 PLoS Biology
Forche et al. 2008 PLoS Biology

... overall cell ploidy (unpublished data). PCR of the MTL loci was also used to detect possible jackpot effects, where several gal1 progeny might have been derived from a single cell having undergone a chromosome loss event. Where possible, progeny cells with different combinations of MTL alleles were ...
GSEA - Bioinformatics Unit
GSEA - Bioinformatics Unit

... 1. Choose true (default) to have GSEA collapse each probe set in your expression dataset into a single gene vector, which is identified by its HUGO gene symbol. In this case, you are using HUGO gene symbols for the analysis. The gene sets that you use for the analysis must use HUGO gene symbols to i ...
Inverse correlation between SMN1 and SMN2 copy numbers
Inverse correlation between SMN1 and SMN2 copy numbers

... population, indicating the presence of chromosome 5s with two copies of SMN1.4,10 We meta-analyzed published data,3,4,8,10,13,14 and updated deduced SMN1 allele frequencies5 as follows: ‘zero-copy allele’ (chromosome 5 lacking SMN1 exon 7), 9.83  10 3; ‘one-copy allele’, 9.57  10 1; ‘two-copy alle ...
15_chapter 5
15_chapter 5

... representations have restriction on size of evolving programs. If there is no restriction, then it would lead to increase in size of evolving programs and further lead to swamping of available computational resources. Size restriction is implemented in two ways. Depth limitation restricts the size o ...
Properties of Mitotic and Meiotic Recombination in the
Properties of Mitotic and Meiotic Recombination in the

... can be measured by using selectable drug resistance markers flanking the array. Thus, a direct comparison of inter-sister and inter-homolog events can be made. We found that inter-sister recombination events are >10-fold more frequent than inter-homolog events. Most of these inter-sister events do n ...
How to recognize and diagnose chromosome rearrangements. David D. Perkins Background
How to recognize and diagnose chromosome rearrangements. David D. Perkins Background

... rearrangements are unique among rearrangement types in producing 6B:2W asci, as was first recognized by St. Lawrence (1959) and de Serres (1957). The frequency of 6B:2W asci depends on the distance of breakpoints from centromeres. 4B:0W and 4B:4W asci are equally frequent, while 2B:6W and 0B:8W asci ...
Genetic Determinants Differences between Vibrio cholerae Biotypes
Genetic Determinants Differences between Vibrio cholerae Biotypes

... dissemination of this bacteriophage may be associated with the derivation of toxigenic V. cholerae strains from nontoxigenic progenitors (28). Multiple copies of CTX prophage are arranged randomly in El Tor strains of V. cholerae, however, the number and arrangement of the CTX elements and their ass ...
Chapter 15
Chapter 15

... and females of aa genotypes generally exhibited greater longevity than non-aa genotypes when reared on various concentrations of dry yeast in the food medium (Thomas, 1991). This life-span extension was observed for all yeast concentrations, except for the concentration used by Templeton (1982, 1983 ...
Translation of Drug Metabolic Enzyme and Transporter (DMET) Genetic Variants into Star Allele Notation using SAS.
Translation of Drug Metabolic Enzyme and Transporter (DMET) Genetic Variants into Star Allele Notation using SAS.

... DNA can be thought of as a sequence of nucleotides denoted by A, C, G and T. Locations along the DNA sequence that differ from person to person in the nucleotide(s) present at that location are called genetic variants. Currently, relatively inexpensive genotyping platforms can readily determine poin ...
A Physical Gene Map of the Bacteriophage P22 Late
A Physical Gene Map of the Bacteriophage P22 Late

... permuted, the cleavage map is circular (Jackson et al., 1978b). These mature chromosomes are generated by sequential headful packaging from a unique initiation site called pat (Jackson et al., 1978a; Tye et al., 1974). The fragment present in low molar yield in the EcoRI digest has been shown to ari ...
KaryoNIM Postnatal EN
KaryoNIM Postnatal EN

... CGH allows a larger number of diagnoses, which translates into cost savings. This is due to a decrease in the number of additional conventional genetic tests that are usually required to achieve a diagnosis. Although intellectual disabilities or developmental delays are not curable, a diagnosis that ...
Identification of genes that interact with glp-1, a gene
Identification of genes that interact with glp-1, a gene

... few gametes produced by glp-1 mutant hermaphrodites are sperm and the animals are sterile. If glp-1 (ts) is shifted to restrictive temperature at any time during postembryonic development, germ cells at the distal end of the gonad that would normally be mitotic enter meiosis; therefore the glp-1 pro ...
PPT
PPT

... Simplifying the Complexity of Genomes: Global Surveys of a Finite Set of Parts from Many Perspectives ...
Strains of Salmonella typhimurium and Other
Strains of Salmonella typhimurium and Other

... and absent in some “wild” isolates of S. typhimurium). Very useful derivatives of strain LT2 were derived by Ames et al. for the widely used tests of mutagens and carcinogens (2). Analysis of wild-type strains of S. typhimurium by multilocus enzyme electrophoresis shows that LT2 belongs to electroph ...
Tansley Review No. 103 Biological clocks in
Tansley Review No. 103 Biological clocks in

... 1. Components of the circadian system The biological mechanism responsible for circadian rhythms is known as the circadian system or circadian clock : a basic model is shown in Fig. 1b. The three functional domains of the system are identified as the oscillator, which generates a period of approxima ...
Gene Section ATF4 (activating transcription factor 4 (tax responsive enhancer element B67)) -
Gene Section ATF4 (activating transcription factor 4 (tax responsive enhancer element B67)) -

... Metabolism: ATF4 is a conserved regulator of metabolism and carbohydrate homeostasis, and provides a mechanistic link between nutrients, insulin resistance, and diabetes, and has been described as a major mediator of nutrition-sensing response pathway, regulating the expression of asparagine synthet ...
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami

... Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual’s life with Huntington’s disease or myotonic dystrophy. Broad ranges of repeat instability arise between individuals with expanded repeats, suggestin ...
Seed Dormancy and Germination
Seed Dormancy and Germination

... Isogenic Lines (NILs) (L. Bentsink, unpublished results). These NILs are being used to clone the QTL and also for further mutagenesis experiments that may lead to mutations in the respective QTL or in genes acting elsewhere in the dormancy/germination pathways. It is expected that the analysis of mo ...
univERsity oF copEnhAGEn
univERsity oF copEnhAGEn

... phenotypic variation requires a phenotype with detailed molecular and quantitative genetic information. Metabolic phenotypes are ideal for these studies, because these traits are highly variable and can be accurately measured using highthroughput techniques [5,19,20]. Knowledge of biochemical pathwa ...
GENETIC AND MOLECULAR ANALYSIS OF THE garnet EYE
GENETIC AND MOLECULAR ANALYSIS OF THE garnet EYE

... which facilitated cloning of the garnet gene was isolated by R. Wennberg, in the laboratory of Dr. T. Grigliatti. The program used to analyze the pigment data was written by Dr. J. Berger. As with any genetic work, I am indebted to the fly stock centres, at Bloomington, Indiana, Bowling Green and Um ...
oto`s role in head and trunk development
oto`s role in head and trunk development

... midline of the telencephalon (Fig. 3A,B). The commissural plate (CP) is a structure at the anterior midline of the telencephalon that expresses Fgf8, a signaling molecule with important roles in a number of developmental processes including an early role in regulating telencephalic development (Shim ...
Lesson Overview
Lesson Overview

... Mendel’s second conclusion is called the principle of dominance. This principle states that some alleles are dominant and others are recessive. An organism with at least one dominant allele for a particular form of a trait will exhibit that form of the trait. An organism with a recessive allele for ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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