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Xylitol production using recombinant Saccharomyces
Xylitol production using recombinant Saccharomyces

... reductase genes (XYL1 ) of Pichia stipitis at chromosomal d-sequences. S. cere6isiae 2805-39-40, which contains about 40 copies of the XYL1 gene on the chromosome, was obtained by a sequential transformation using a dominant selection marker neo r and an auxotrophic marker URA3. The multiple XYL1 ge ...
Genome Projector: zoomable genome map with multiple views
Genome Projector: zoomable genome map with multiple views

... much longer than the actual length of tRNAs. Therefore, the exact locations of tRNAs are also marked with perpendicular stripes, similar to the representation of genes in the outer rings. The stripe is blue for the direct strand and green for the complementary strand. rRNAs are represented by pink a ...
Structural and molecular differentiation of sex
Structural and molecular differentiation of sex

... individuals developed in males (Munday et al. 2006). Similarly, in an echiuran worm, Bonellia viridis, larva develops in a male, if it has undergone a contact with a female, otherwise becomes a female itself (Jaccarini et al. 1983). Haplodiploidy, a feature well known in Hymenoptera, but present als ...
The Evolutionary History of Human and Chimpanzee Y
The Evolutionary History of Human and Chimpanzee Y

... The initial comparisons of human and chimpanzee (Pan troglodytes) Y-chromosome sequences revealed that although there are no lineage-specific gene-disruptive mutations in the X-degenerate portion of the Y-chromosome fixed within humans, surprisingly, 4 genes, CYorf15B, TBL1Y, TMSB4Y, and USP9Y, are ...
Female Male Human chromosomal abnormalities may be numerical
Female Male Human chromosomal abnormalities may be numerical

... What can you conclude? At least two things: 1. The presence in the affected child of two different maternal alleles for SSR 21.1 indicates that ...
Yan D et al., 2014 - Drosophila RNAi Screening Center
Yan D et al., 2014 - Drosophila RNAi Screening Center

... example, three genes involved in RNA splicing were identified: pUf68 (the homolog of human PUF60), U2A and CG9667 (the ISY1 splicing factor homolog) (Figure 4A). Although previous reports suggest that pUf68 mutants display striking defects in the splicing of otu, they only show late oogenesis and eg ...
ELMER: An R/Bioconductor Tool Inferring Regulatory Element
ELMER: An R/Bioconductor Tool Inferring Regulatory Element

... capture changes in individual molecular subtypes occurring in 20% or more of the cases. This number can be set arbitrarily as an input to the get.diff.meth function in the ELMER, and should be tuned based on sample sizes in individual studies. The one tailed t-test was used to rule out the null hyp ...
Functions of DNA methylation: islands, start sites, gene bodies and
Functions of DNA methylation: islands, start sites, gene bodies and

... Hprt gene on the inactive X chromosome occurred after the chromosome had been inactivated. In other words, methylation appeared to serve as a ‘lock’ to reinforce a previously silenced state of X-linked genes. Although most CGIs on autosomal genes remain unmethylated in somatic cells, a small number ...
The Origin of Subfunctions and Modular Gene Regulation
The Origin of Subfunctions and Modular Gene Regulation

... assume that modularity confers a selective advantage. However, our results suggest that even in the absence of any direct selective advantage, genotypic modularity may increase through the formation of new subfunctions under near-neutral processes. Two subfunctions may be formed from a single ancest ...
Mapping the histone code at hMLH1. - JScholarship
Mapping the histone code at hMLH1. - JScholarship

... 2002). More recently, it was shown that induction of a heat shock gene displaces both H3.3 and H3, followed by selective deposition of H3.3 (Wirbelauer et al., 2005). When comparing histone tail modification profiles of H3 and H3.3, although none of the modifications examined were exclusive to eithe ...
n - MrBrock.com
n - MrBrock.com

... heritable character separate (segregate) during gamete formation and end up in different gametes • Thus, an egg or a sperm gets only one of the two alleles that are present in the somatic cells of an organism • This segregation of alleles corresponds to the distribution of homologous chromosomes to ...
Mendel brought an experimental and quantitative approach to
Mendel brought an experimental and quantitative approach to

... codominance in which two alleles affect the phenotype in separate, distinguishable ways. • For example, the M, N, and MN blood groups of humans are due to the presence of two specific molecules on the surface of red blood cells. • People of group M (genotype MM) have one type of molecule on their re ...
The role of chromosome rearrangements in reproductive isolation
The role of chromosome rearrangements in reproductive isolation

... - the exact relationship between chromosomal rearrangement and speciation remains unclear in plants! ...but more evidence is emerging (new methods available) - seems that sunflowers (Helianthus) are only example: hybridization between two divergent diploid species appears to have provoked speciation ...
Molecular Evolution of the Endosperm Starch Synthesis Pathway
Molecular Evolution of the Endosperm Starch Synthesis Pathway

... the roles of various forces of evolution, such as selection and drift, in shaping patterns of genetic variation (Clegg 1997). Numerous studies have been conducted to understand their relative roles in evolution (Wright and Gaut 2005; Ramos-Onsins et al. 2008). However, most of this work focuses on i ...
Lecture 3 The chromosome theory of inheritance
Lecture 3 The chromosome theory of inheritance

... then traits determined by the gene should be transmitted with the chromosome. • T.H. Morgan’s experiments demonstrating sex-linked inheritance of a gene determining eye-color demonstrate the transmission of traits with chromosomes. • 1910 – T.H. Morgan discovered a white – ...
Evolution of antifreeze glycoprotein gene from a trypsinogen gene in
Evolution of antifreeze glycoprotein gene from a trypsinogen gene in

... and amplification events did not need to occur in the order given. Indeed, an AFGPytrypsinogen hybrid protein coding region formed by some amount of duplication of the 9-nt Thr-Ala-Ala coding element before bulk deletion of trypsinogen sequence might in fact be a more stable structure for the evolvi ...
MGF 360-17R Missing
MGF 360-17R Missing

EIN4 and ERS2 Are Members of the Putative Ethylene Receptor
EIN4 and ERS2 Are Members of the Putative Ethylene Receptor

... et al., 1993; Hua et al., 1995; Sakai et al., 1998). The C-terminal domains of these proteins show homology to the bacterial two-component regulators that are widely involved in adaptive responses in bacteria (Parkinson and Kofoid, 1992). The N-terminal domains of these proteins are very similar, an ...
Chapter 13
Chapter 13

... • A gamete (sperm or egg) contains a single set of chromosomes, and is haploid (n) • For humans, the haploid number is 23 (n = 23) • Each set of 23 consists of 22 autosomes and a single sex chromosome • In an unfertilized egg (ovum), the sex chromosome is X • In a sperm cell, the sex chromosome may ...
Comparative Genetics of Nucleotide Binding Site
Comparative Genetics of Nucleotide Binding Site

Review Game
Review Game

... A. An allele for tallness from each parent B. An allele for tallness from the tall parent and an allele for shortness from the short parent C. An allele for shortness from each parent D. An allele from only the tall parent Scoreboard ...
Severe oligozoospermia resulting from deletions
Severe oligozoospermia resulting from deletions

... had variant Y chromosomesand these variants may resemble the de-novo AZF-region deletions we describe. However, since the fathers of the two Japanese men were not studied, the functional significance of their Y variants remains unclear. A small set of Y-DNA markers was used to study the Japanese men ...
Chapter 13 Meiosis
Chapter 13 Meiosis

... • A gamete (sperm or egg) contains a single set of chromosomes, and is haploid (n) • For humans, the haploid number is 23 (n = 23) • Each set of 23 consists of 22 autosomes and a single sex chromosome • In an unfertilized egg (ovum), the sex chromosome is X • In a sperm cell, the sex chromosome may ...
Familial nonrandom inactivation linked to the X inactivation
Familial nonrandom inactivation linked to the X inactivation

... cell.13 The fact that human females are heterozygous at so many X-linked loci sets up a growth competition between the cell lineages, and one lineage can outgrow the other. Women, heterozygous for mutations causing Lesch – Nyhan syndrome or adrenoleukodystrophy, often have extremely skewed inactivat ...
Expression analysis of Arc in mouse brain Theresa Köhler
Expression analysis of Arc in mouse brain Theresa Köhler

... Arc, an immediate early gene, expressed in the brain of mice encodes the activity regulated cytoskeletal-associated protein (ARC) that is found on dendrites of neurons. It regulates cell development and plays an important role in neuronal plasticity and formation of long-term memory. Arc is induced ...
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Genomic imprinting

Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. Genomic imprinting is a fairly rare phenomenon in mammals; most genes are not imprinted.In insects, imprinting affects entire chromosomes. In some insects the entire paternal genome is silenced in male offspring, and thus is involved in sex determination. The imprinting produces effects similar to the mechanisms in other insects that eliminate paternally inherited chromosomes in male offspring, including arrhenotoky.Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These epigenetic marks are established (""imprinted"") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism.Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndrome and Prader–Willi syndrome.
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